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1. 发明申请

US20070179565A1 SYSTEM FOR GENERATING A COCHLEAR IMPLANT PROGRAM USING MULTI-ELECTRODE STIMULATION TO ELICIT THE ELECTRICALLY-EVOKED COMPOUND ACTION POTENTIAL 失效
标题翻译：使用多电极刺激来产生电击移植程序以制定电动化复合作用电位的系统
公开(公告)号：US20070179565A1
公开(公告)日：2007-08-02
申请号：US11697605
申请日：2007-04-06
申请人： Edward Overstreet , Leonid Litvak , Michael Faltys
发明人： Edward Overstreet , Leonid Litvak , Michael Faltys
IPC分类号： A61N1/36
CPC分类号： A61N1/37241 , A61N1/0541 , A61N1/36036 , A61N1/37247
摘要： A multichannel cochlear implant system spatially spreads the excitation pattern in the target neural tissue by either: (1) rapid sequential stimulation of a small group of electrodes, or (2) simultaneously stimulating a small group of electrodes. Such multi-electrode stimulation stimulates a greater number of neurons in a synchronous manner, thereby increasing the amplitude of the extra-cellular voltage fluctuation and facilitating its recording. The electrical stimuli are applied simultaneously (or sequentially at a rapid rate) on selected small groups of electrodes while monitoring the evoked compound action potential (ECAP) on a nearby electrode. The presence of an observable ECAP not only validates operation of the implant device at a time when the patient may be unconscious or otherwise unable to provide subjective feedback, but also provides a way for the magnitude of the observed ECAP to be recorded as a function of the amplitude of the applied stimulus. From this data, a safe, efficacious and comfortable threshold level can be obtained which may be used thereafter as the initial setting of the stimulation parameters of the neurostimulation device, or to guide the setting of the stimulation parameters of the neurostimulation device.
摘要翻译：多通道人工耳蜗植入系统通过以下方式之一空间扩展靶神经组织中的激发图案：（1）对一小组电极的快速连续刺激，或（2）同时刺激一小组电极。这种多电极刺激以同步方式刺激更多数量的神经元，从而增加细胞外电压波动的幅度并促进其记录。电刺激同时（或以快速顺序）施加在选定的小组电极上，同时监测附近电极上的诱发化合物动作电位（ECAP）。可观察到的ECAP的存在不仅在患者无意识或不能提供主观反馈的时候验证植入装置的操作，而且还提供了将所观察到的ECAP的大小记录为作为施加的刺激的幅度。从该数据可以获得安全，有效和舒适的阈值水平，其可以随后用作神经刺激装置的刺激参数的初始设置，或者指导神经刺激装置的刺激参数的设置。

2. 发明申请

US20060096163A1 Slurry dewatering and conversion of biosolids to a renewable fuel 有权
公开(公告)号：US20060096163A1
公开(公告)日：2006-05-11
申请号：US11269499
申请日：2005-11-07
申请人： Norman Dickinson , Kevin Bolin , Edward Overstreet , Brian Dooley
发明人： Norman Dickinson , Kevin Bolin , Edward Overstreet , Brian Dooley
IPC分类号： C10L5/42
CPC分类号： C10G1/02 , C02F11/10 , C02F2103/001 , C10G1/00 , C10G2300/1003 , C10G2300/1011 , C10G2300/4043 , C10G2300/4081 , C10G2300/805 , C10G2300/807 , C10L5/46 , C10L9/086 , F23G7/001 , Y02E20/16 , Y02E50/10 , Y02E50/30 , Y02E50/343 , Y02P30/20 , Y02P30/446 , Y02W10/37 , Y02W30/47
摘要： In the processes for treating municipal sewage and storm water containing biosolids to discharge standards, biosolids, even after dewatering, contain typically about 80% water bound in the dead cells of the biosolids, which gives biosolids a negative heating value. It can be incinerated only at the expense of purchased fuel. Biosolids are heated to a temperature at which their cell structure is destroyed and, preferably, at which carbon dioxide is split off to lower the oxygen content of the biosolids. The resulting char is not hydrophilic, and it can be efficiently dewatered and/or dried and is a viable renewable fuel. This renewable fuel can be supplemented by also charging conventional biomass (yard and crop waste, etc.) in the same or in parallel facilities. Similarly, non-renewable hydrophilic fuels can be so processed in conjunction with the processing of biosolids to further augment the energy supply.

3. 发明授权

US08409303B2 Slurry dewatering and conversion of biosolids to a renewable fuel 有权
标题翻译：泥浆脱水和生物固体转化为可再生燃料
公开(公告)号：US08409303B2
公开(公告)日：2013-04-02
申请号：US13025544
申请日：2011-02-11
申请人： Norman L. Dickinson , Kevin M. Bolin , Edward Overstreet , Brian Dooley
发明人： Norman L. Dickinson , Kevin M. Bolin , Edward Overstreet , Brian Dooley
IPC分类号： C10L1/10
CPC分类号： C10G1/02 , C02F11/10 , C02F2103/001 , C10G1/00 , C10G2300/1003 , C10G2300/1011 , C10G2300/4043 , C10G2300/4081 , C10G2300/805 , C10G2300/807 , C10L5/46 , C10L9/086 , F23G7/001 , Y02E20/16 , Y02E50/10 , Y02E50/30 , Y02E50/343 , Y02P30/20 , Y02P30/446 , Y02W10/37 , Y02W30/47
摘要： In the processes for treating municipal sewage and storm water containing biosolids to discharge standards, biosolids, even after dewatering, contain typically about 80% water bound in the dead cells of the biosolids, which gives biosolids a negative heating value. It can be incinerated only at the expense of purchased fuel. Biosolids are heated to a temperature at which their cell structure is destroyed and, preferably, at which carbon dioxide is split off to lower the oxygen content of the biosolids. The resulting char is not hydrophilic, and it can be efficiently dewatered and/or dried and is a viable renewable fuel. This renewable fuel can be supplemented by also charging conventional biomass (yard and crop waste, etc.) in the same or in parallel facilities. Similarly, non-renewable hydrophilic fuels can be so processed in conjunction with the processing of biosolids to further augment the energy supply.
摘要翻译：在处理含有生物固体排放标准的城市污水和暴雨水的过程中，即使在脱水后，生物固体通常在生物固体的死细胞中含有约80％的水结合，这给生物固体带来负热值。它只能以所购燃料为代价来焚烧。将生物固体加热到其细胞结构被破坏的温度，并且优选地将二氧化碳分解以降低生物固体的氧含量。所得到的炭不是亲水的，并且可以有效地脱水和/或干燥并且是可行的可再生燃料。这种可再生燃料可以通过在相同或并行设施中装载常规生物质（院子和作物废物等）来补充。类似地，不可再生的亲水燃料可以与生物固体的加工一起被加工以进一步增加能量供应。

4. 发明申请

US20060287609A1 Methods and systems for automatically identifying whether a neural recording signal includes a neural response signal 有权
标题翻译：用于自动识别神经记录信号是否包括神经反应信号的方法和系统
公开(公告)号：US20060287609A1
公开(公告)日：2006-12-21
申请号：US11142152
申请日：2005-06-01
申请人： Leonid Litvak , Edward Overstreet
发明人： Leonid Litvak , Edward Overstreet
IPC分类号： A61B5/04 , A61B5/05
CPC分类号： A61B5/04001 , A61B5/4041 , A61B5/7217 , A61N1/36036
摘要： Methods of automatically identifying whether a neural recording signal includes a neural response signal include fitting an artifact model to a neural recording signal to produce a fitted artifact model signal, determining a strength-of-response (SOR) metric that describes a distance of the neural recording signal from the fitted artifact model signal, and identifying the neural recording signal as including a neural response signal if the strength-of-response metric is above a pre-determined threshold. Systems for automatically identifying whether a neural recording signal includes a neural response signal include one or more devices configured to fit an artifact model to a neural recording signal to produce a fitted artifact model signal, determine a strength-of-response (SOR) metric that describes a distance of the neural recording signal from the fitted artifact model signal, and automatically identify the neural recording signal as including a neural response signal if said strength-of-response metric is above a pre-determined threshold.
摘要翻译：自动识别神经记录信号是否包括神经反应信号的方法包括将伪像模型拟合到神经记录信号以产生拟合的伪像模型信号，确定描述神经元的距离的响应强度（SOR）度量记录来自拟合假象模型信号的信号，并且如果响应强度度量高于预定阈值，则将神经记录信号识别为包括神经响应信号。用于自动识别神经记录信号是否包括神经反应信号的系统包括被配置为将神经记号模型拟合到神经记录信号以产生拟合假象模型信号的一个或多个装置，确定响应强度（SOR）度量，描述了神经记录信号与拟合假象模型信号的距离，并且如果所述响应强度度量高于预定阈值，则将神经记录信号自动识别为包括神经响应信号。

5. 发明申请

US20060276722A1 Methods and systems for automatically determining a neural response threshold current level 有权
标题翻译：自动确定神经反应阈值电流水平的方法和系统
公开(公告)号：US20060276722A1
公开(公告)日：2006-12-07
申请号：US11141825
申请日：2005-06-01
申请人： Leonid Litvak , Gulam Emadi , Edward Overstreet
发明人： Leonid Litvak , Gulam Emadi , Edward Overstreet
IPC分类号： A61B5/05
CPC分类号： A61B5/04001 , A61B5/7217
摘要： Methods of automatically determining a neural response threshold current level include identifying one or more neural response signals at one or more corresponding stimulation current levels, identifying one or more non-response signals at one or more corresponding stimulation current levels, and analyzing a trend between the neural response signals and the non-response signals. Systems for automatically determining a neural response threshold current level include one or more devices configured to identify one or more neural response signals at one or more corresponding stimulation current levels, identify one or more non-response signals at one or more corresponding stimulation current levels; and analyze a trend between the neural response signals and the non-response signals.
摘要翻译：自动确定神经反应阈值电流水平的方法包括以一个或多个相应的刺激电流水平识别一个或多个神经反应信号，识别一个或多个相应刺激电流水平下的一个或多个非响应信号，以及分析神经反应信号和非响应信号。用于自动确定神经反应阈值电流水平的系统包括被配置为在一个或多个相应的刺激电流水平上识别一个或多个神经反应信号的一个或多个装置，以一个或多个对应的刺激电流水平识别一个或多个非响应信号; 并分析神经反应信号与非应答信号之间的趋势。

6. 发明授权

US08498714B2 Methods and systems of conveying fine structure information to a cochlear implant patient 有权
标题翻译：将精细结构信息传送到人工耳蜗患者的方法和系统
公开(公告)号：US08498714B2
公开(公告)日：2013-07-30
申请号：US12559759
申请日：2009-09-15
申请人： Leonid M. Litvak , Aniket Saoji , Anthony J. Spahr , Edward Overstreet
发明人： Leonid M. Litvak , Aniket Saoji , Anthony J. Spahr , Edward Overstreet
IPC分类号： A61N1/18
CPC分类号： A61N1/36032 , A61N1/0541 , A61N1/323 , A61N1/36036 , A61N1/36185
摘要： An exemplary method of conveying fine structure information to a cochlear implant patient includes dividing an audio signal into a plurality of analysis channels, generating electrical stimulation in accordance with the information contained within each of the analysis channels, applying the electrical stimulation to at least one stimulation site within a patient via a plurality of stimulation channels, and at least partially isolating one of the stimulation channels from a rest of the stimulation channels, wherein fine structure information is conveyed to the patient via the isolated stimulation channel. Corresponding methods and systems are also disclosed.
摘要翻译：将精细结构信息传送到耳蜗植入患者的示例性方法包括将音频信号划分成多个分析通道，根据包含在每个分析通道内的信息产生电刺激，将电刺激应用于至少一个刺激通过多个刺激通道在患者体内的位置，并且至少部分地将刺激通道中的一个与其余刺激通道隔离，其中精细结构信息经由隔离的刺激通道传送给患者。还公开了相应的方法和系统。

7. 发明申请

US20110192074A1 SLURRY DEWATERING AND CONVERSION OF BIOSOLIDS TO A RENEWABLE FUEL 有权
标题翻译：生物柴油降解和转化为可再生燃料
公开(公告)号：US20110192074A1
公开(公告)日：2011-08-11
申请号：US13025544
申请日：2011-02-11
申请人： Norman L. Dickinson , Kevin M. Bolin , Edward Overstreet , Brian Dooley
发明人： Norman L. Dickinson , Kevin M. Bolin , Edward Overstreet , Brian Dooley
IPC分类号： C10L1/10
CPC分类号： C10G1/02 , C02F11/10 , C02F2103/001 , C10G1/00 , C10G2300/1003 , C10G2300/1011 , C10G2300/4043 , C10G2300/4081 , C10G2300/805 , C10G2300/807 , C10L5/46 , C10L9/086 , F23G7/001 , Y02E20/16 , Y02E50/10 , Y02E50/30 , Y02E50/343 , Y02P30/20 , Y02P30/446 , Y02W10/37 , Y02W30/47
摘要： In the processes for treating municipal sewage and storm water containing biosolids to discharge standards, biosolids, even after dewatering, contain typically about 80% water bound in the dead cells of the biosolids, which gives biosolids a negative heating value. It can be incinerated only at the expense of purchased fuel. Biosolids are heated to a temperature at which their cell structure is destroyed and, preferably, at which carbon dioxide is split off to lower the oxygen content of the biosolids. The resulting char is not hydrophilic, and it can be efficiently dewatered and/or dried and is a viable renewable fuel. This renewable fuel can be supplemented by also charging conventional biomass (yard and crop waste, etc.) in the same or in parallel facilities. Similarly, non-renewable hydrophilic fuels can be so processed in conjunction with the processing of biosolids to further augment the energy supply.
摘要翻译：在处理含有生物固体排放标准的城市污水和暴雨水的过程中，即使在脱水后，生物固体通常在生物固体的死细胞中含有约80％的水结合，这给生物固体带来负热值。它只能以所购燃料为代价来焚烧。将生物固体加热到其细胞结构被破坏的温度，并且优选地将二氧化碳分解以降低生物固体的氧含量。所得到的炭不是亲水的，并且可以有效地脱水和/或干燥并且是可行的可再生燃料。这种可再生燃料可以通过在相同或并行设施中装载常规生物质（院子和作物废物等）来补充。类似地，不可再生的亲水燃料可以与生物固体的加工一起被加工以进一步增加能量供应。

8. 发明申请

US20070244522A1 Gradual Recruitment of Muscle/Neural Excitable Tissue Using High-Rate Electrical Stimulation Parameters 审中-公开
标题翻译：使用高速电刺激参数逐渐招募肌肉/神经激励组织
公开(公告)号：US20070244522A1
公开(公告)日：2007-10-18
申请号：US11762692
申请日：2007-06-13
申请人： Edward Overstreet
发明人： Edward Overstreet
IPC分类号： A61N1/00
CPC分类号： A61N1/36071 , A61N1/32
摘要： A neurostimulator system (170) stimulates excitable muscle or neural tissue through multiple electrodes (E1, E2, . . . En) fast enough to induce stochastic neural firing, thereby acting to restore “spontaneous” neural activity. The type of stimulation provided by the neurostimulator involves the use of a high rate, e.g., greater than about 2000 Hz, pulsatile stimulation signal generated by a high rate pulse generator (172). The stream of pulses generated by the high rate pulse generator is amplitude modulated in an output driver circuit (176) with control information, provided by a modulation control element (178). Such amplitude-modulated pulsatile stimulation exploits the subtle electro physiological differences between cells comprising excitable tissue in order to desynchronize action potentials within the population of excitable tissue. Such desynchronization induces a wider distribution of population thresholds, as well as a wider electrical dynamic range, thereby better mimicking biological recruitment characteristics.
摘要翻译：神经刺激器系统（170）通过多个电极（E 1，E 2，...）刺激可激发的肌肉或神经组织，足以诱导随机神经放电，从而起到恢复“自发”神经活动的作用。由神经刺激器提供的刺激类型涉及使用由高速率脉冲发生器（172）产生的高速率，例如大于约2000Hz的脉动刺激信号。由高速率脉冲发生器产生的脉冲流在具有由调制控制元件（178）提供的控制信息的输出驱动器电路（176）中进行幅度调制。这种幅度调制的脉冲刺激利用包含可兴奋组织的细胞之间的微妙电生理差异，以便使可兴奋组织群体内的动作电位失去同步。这种去同步引起更广泛的人口阈值分布，以及更广泛的电动态范围，从而更好地模仿生物招募特征。

9. 发明申请

US20050182453A1 Treatment of epilepsy by high frequency electrical stimulation and/or drug stimulation 审中-公开
标题翻译：通过高频电刺激和/或药物刺激治疗癫痫
公开(公告)号：US20050182453A1
公开(公告)日：2005-08-18
申请号：US11103945
申请日：2005-04-12
申请人： Todd Whitehurst , Edward Overstreet , Albert Maltan
发明人： Todd Whitehurst , Edward Overstreet , Albert Maltan
IPC分类号： A61M5/142 , A61N1/18 , A61N1/36
CPC分类号： A61N1/37205 , A61M5/14276 , A61N1/06 , A61N1/36064 , A61N1/36082 , A61N1/36135 , A61N1/36157 , A61N1/36171
摘要： Exemplary methods of treating a patient with epilepsy include applying a stimulus to a stimulation site within the patient with an implanted system control unit in accordance with one or more stimulation parameters. The stimulus includes a stimulation current having a frequency substantially equal to or greater than 400 Hz. Exemplary systems for treating a patient with epilepsy include a system control unit configured to apply a stimulus to a stimulation site within the patient in accordance with one or more stimulation parameters. The stimulus includes a stimulation current having a frequency substantially equal to or greater than 400 Hz.
摘要翻译：治疗患有癫痫患者的示例性方法包括根据一个或多个刺激参数用植入的系统控制单元向患者内的刺激部位施加刺激。刺激包括具有基本上等于或大于400Hz的频率的刺激电流。用于治疗患有癫痫患者的示例性系统包括系统控制单元，其被配置为根据一个或多个刺激参数将刺激应用于患者内的刺激部位。刺激包括具有基本上等于或大于400Hz的频率的刺激电流。

10. 发明授权

US07909895B2 Slurry dewatering and conversion of biosolids to a renewable fuel 有权
标题翻译：泥浆脱水和生物固体转化为可再生燃料
公开(公告)号：US07909895B2
公开(公告)日：2011-03-22
申请号：US11269499
申请日：2005-11-07
申请人： Norman L. Dickinson , Kevin M. Bolin , Edward Overstreet , Brian Dooley
发明人： Norman L. Dickinson , Kevin M. Bolin , Edward Overstreet , Brian Dooley
IPC分类号： C10L5/42
CPC分类号： C10G1/02 , C02F11/10 , C02F2103/001 , C10G1/00 , C10G2300/1003 , C10G2300/1011 , C10G2300/4043 , C10G2300/4081 , C10G2300/805 , C10G2300/807 , C10L5/46 , C10L9/086 , F23G7/001 , Y02E20/16 , Y02E50/10 , Y02E50/30 , Y02E50/343 , Y02P30/20 , Y02P30/446 , Y02W10/37 , Y02W30/47
摘要： In the processes for treating municipal sewage and storm water containing biosolids to discharge standards, biosolids, even after dewatering, contain typically about 80% water bound in the dead cells of the biosolids, which gives biosolids a negative heating value. It can be incinerated only at the expense of purchased fuel.Biosolids are heated to a temperature at which their cell structure is destroyed and, preferably, at which carbon dioxide is split off to lower the oxygen content of the biosolids. The resulting char is not hydrophilic, and it can be efficiently dewatered and/or dried and is a viable renewable fuel. This renewable fuel can be supplemented by also charging conventional biomass (yard and crop waste, etc.) in the same or in parallel facilities. Similarly, non-renewable hydrophilic fuels can be so processed in conjunction with the processing of biosolids to further augment the energy supply.
摘要翻译：在处理含有生物固体排放标准的城市污水和暴雨水的过程中，即使在脱水后，生物固体通常在生物固体的死细胞中含有约80％的水结合，这给生物固体带来负热值。它只能以所购燃料为代价来焚烧。将生物固体加热到其细胞结构被破坏的温度，并且优选地将二氧化碳分解以降低生物固体的氧含量。所得到的炭不是亲水的，并且可以有效地脱水和/或干燥并且是可行的可再生燃料。这种可再生燃料可以通过在相同或并行设施中装载常规生物质（院子和作物废物等）来补充。类似地，不可再生的亲水燃料可以与生物固体的加工一起被加工以进一步增加能量供应。

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