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1. 发明授权

US09464310B2 Integrated method for collection and maintenance of detectability of a plurality of microbiological agents in a single clinical sample and for handling a plurality of samples for reporting a sum of diagnostic results for each sample 有权
标题翻译：用于收集和维护单个临床样品中多个微生物试剂的可检测性并用于处理多个样品以报告每个样品的诊断结果总和的综合方法
公开(公告)号：US09464310B2
公开(公告)日：2016-10-11
申请号：US11343822
申请日：2006-01-31
申请人： Martin E. Adelson , Eli Mordechai
发明人： Martin E. Adelson , Eli Mordechai
IPC分类号： C12Q1/04 , G01N33/569 , G06F19/00
CPC分类号： G06F19/366 , C12Q1/04 , C12Q1/045 , C12Q1/689 , C12Q1/6893 , C12Q1/6895 , C12Q1/705 , G01N33/569 , G06F19/00 , G16H10/20 , G16H10/40
摘要： A method and kit related thereto are described for the collection and maintenance of detectability of a plurality of species of microbiological agents in a single clinical sample as well as an integral method for handling a plurality of the samples and managing information associated therewith for reporting a sum of diagnostic results for each sample.
摘要翻译：描述了与其相关的方法和试剂盒，用于收集和维护单个临床样品中多种微生物剂的可检测性，以及用于处理多个样品并管理与之相关的信息以报告总和的整体方法的每个样品的诊断结果。

2. 发明授权

US08932832B2 Methods and compositions related thereto for detecting and identifying distinct species of nucleic acids from causative agents 有权
标题翻译：与之相关的方法和组合物用于检测和鉴定来自致病因子的不同种类的核酸
公开(公告)号：US08932832B2
公开(公告)日：2015-01-13
申请号：US13199380
申请日：2011-08-26
申请人： Martin E. Adelson , Melanie Feola , Jason Trama , Eli Mordechai
发明人： Martin E. Adelson , Melanie Feola , Jason Trama , Eli Mordechai
IPC分类号： C07H21/04 , C12Q1/70
CPC分类号： C12Q1/705
摘要： Methods are described herein for detecting and identifying distinct species of nucleic acids, in a single container, for example, from a certain genus of infectious agents or otherwise causative agents comprising, for example, providing a forward PCR primer common to a homologous gene region between the distinct species, and providing a reverse PCR primer common to a homologous gene region between the distinct species, to thereby define a PCR target region amongst the species, and providing a first oligonucleotide probe specific to a nucleic acid sequence within the target region that is characteristic of a first species, providing a second oligonucleotide probe specific to a nucleic acid sequence within the target region that is characteristic of a second species, wherein the first and second oligonucleotide probes are each detectably labeled with distinctly different detectable labels, conducting a PCR reaction in the container by means of the primers to amplify the target region amongst the species, and detecting the distinct labels, thereby identifying distinct species of nucleic acids corresponding to distinct species of infectious agents. Methods are preferred, for example, wherein the infectious agent is a member of the Herpesviridae family.
摘要翻译：在本文中描述了用于在单个容器中，例如来自某一感染因子或其他致病因子的单个容器中检测和鉴定不同种类的核酸的方法，所述诱导剂包括例如提供在同源基因区域之间共同的正向PCR引物并且提供与不同物种之间的同源基因区域共有的反向PCR引物，从而在物种间限定PCR靶区域，并提供对靶区域内的核酸序列特异的第一寡核苷酸探针，提供对目标区域内具有特征的第二种类的核酸序列特异性的第二寡核苷酸探针，其中第一和第二寡核苷酸探针各自可检测地用明显不同的可检测标记物标记，进行PCR反应在容器中通过引物扩增目标区域amo 并检测不同的标签，从而识别与不同种类的感染因子相对应的不同种类的核酸。方法是优选的，例如，其中感染剂是疱疹病毒科家族的成员。

3. 发明授权

US08859722B2 Hemolysin and its protein fragments in sero-detection of anaplasma phagocytophilum 有权
标题翻译：溶血素及其蛋白质片段在血清检测不育细胞噬菌体中的应用
公开(公告)号：US08859722B2
公开(公告)日：2014-10-14
申请号：US13561624
申请日：2012-07-30
申请人： John G. Hoey , Denise P. Dimitrov , Lisa P. Huang , Martin E. Adelson , Eli Mordechai
发明人： John G. Hoey , Denise P. Dimitrov , Lisa P. Huang , Martin E. Adelson , Eli Mordechai
IPC分类号： C07K14/195 , C07K14/29 , G01N33/569
CPC分类号： C07K14/29 , C07K14/195 , G01N33/56911 , G01N2469/20
摘要： Disclosed is the cloning, expression and purification of a hemolysin protein and its protein fragments in Anaplasma phagocytophilum. The recombinant hemolysin and its protein fragments are useful in the ELISA detection of anaplasma pathogen. The use of same as a kit for ELISA is also disclosed.
摘要翻译：披露了解淀粉蛋白及其蛋白质片段在噬菌体噬菌体中的克隆，表达和纯化。重组溶血素及其蛋白质片段可用于阿片样病原体的ELISA检测。还公开了与ELISA试剂盒相同的用途。

4. 发明申请

US20140095145A1 RESPONDING TO NATURAL LANGUAGE QUERIES 有权
标题翻译：对自然语言查询
公开(公告)号：US20140095145A1
公开(公告)日：2014-04-03
申请号：US13629885
申请日：2012-09-28
申请人： Ohad Assulin , Ira Cohen , Eli Mordechai , Boaz Shor , Alon Sade
发明人： Ohad Assulin , Ira Cohen , Eli Mordechai , Boaz Shor , Alon Sade
IPC分类号： G06F17/28
CPC分类号： G06F17/28 , G06F17/30401
摘要： Disclosed herein are a system, non-transitory computer-readable medium, and method for responding to natural language queries. Keywords likely to appear in a natural language query are determined and each likely keyword is associated with a module. A response to a natural language query comprises information generated by each module associated with a likely keyword appearing in the natural language query.
摘要翻译：本文公开了一种用于响应自然语言查询的系统，非暂时性计算机可读介质和方法。确定可能出现在自然语言查询中的关键字，并且每个可能的关键字与模块相关联。对自然语言查询的响应包括由与自然语言查询中出现的可能关键字相关联的每个模块生成的信息。

5. 发明授权

US08504585B2 Matching a user to a conversation 有权
标题翻译：将用户与会话相匹配
公开(公告)号：US08504585B2
公开(公告)日：2013-08-06
申请号：US13149869
申请日：2011-05-31
申请人： Ira Cohen , Michal Aharon , Eli Mordechai
发明人： Ira Cohen , Michal Aharon , Eli Mordechai
IPC分类号： G06F17/30
CPC分类号： G06F17/30699 , G06Q10/103
摘要： A method for matching a user to a conversation includes, for each of a plurality of documents, mapping the document to one or more of a plurality of topics. The document is associated with a user. For each user, the user is mapped to each of the plurality of topics that are mapped to documents with which the user is associated. One of the users is matched to a conversation according to the mappings of the users to those of the plurality of topics that are also mapped to the conversation.
摘要翻译：用于将用户与对话相匹配的方法包括针对多个文档中的每一个将所述文档映射到多个主题中的一个或多个。该文档与用户相关联。对于每个用户，用户被映射到映射到用户与之关联的文档的多个主题中的每一个。其中一个用户根据用户的映射与被映射到对话的多个主题的映射进行对话。

6. 发明申请

US20120183979A1 PROTEIN FRAGMENTS OF VIRB10 AND SERO-DETECTION OF ANAPLASMA PHAGOCYTOPHILUM 有权
标题翻译： VIRB10的蛋白质片段和ANAPLASMA PHAGOCYTOPHILUM的SERO-DETECTION
公开(公告)号：US20120183979A1
公开(公告)日：2012-07-19
申请号：US13418567
申请日：2012-03-13
申请人： John G. Hoey , Denise P. Dimitrov , Lisa P. Huang , Martin E. Adelson , Eli Mordechai
发明人： John G. Hoey , Denise P. Dimitrov , Lisa P. Huang , Martin E. Adelson , Eli Mordechai
IPC分类号： G01N33/566 , C12P21/02 , C07K14/29
CPC分类号： C07K14/29 , G01N33/56911 , Y10T428/31938
摘要： Disclosed are cloning and expression of a plurality of protein fragments of virB10, a Type IV Secretion System (TIVSS) in Anaplasma phagocytophilum. Such recombinant protein fragments are useful in the ELISA detection of anaplasma pathogen. The use of same as kits for ELISA is also disclosed.
摘要翻译：公开了在Anaplasma phagocytophilum中的多种蛋白质片段的病毒克隆和表达，该蛋白质片段是IVB分泌系统（TIVSS）。这种重组蛋白片段可用于阿片样病原体的ELISA检测。还公开了与ELISA试剂盒相同的用途。

7. 发明申请

US20110312876A1 Method of determining types I, II, III, IV or V or methicillin-resistant staphylococcus aureus (MRSA) in a biological sample 有权
标题翻译：在生物样品中测定I，II，III，IV或V型或耐甲氧西林金黄色葡萄球菌（MRSA）的方法
公开(公告)号：US20110312876A1
公开(公告)日：2011-12-22
申请号：US12930663
申请日：2011-01-13
申请人： Scott Elliot Gygax , Christina Lim Overmyer , Lisa A. DeSalvia , Martin E. Adelson , Eli Mordechai
发明人： Scott Elliot Gygax , Christina Lim Overmyer , Lisa A. DeSalvia , Martin E. Adelson , Eli Mordechai
IPC分类号： A61K38/14 , A61P31/04 , C12Q1/68 , A61K31/5377 , C40B30/00 , C07H21/04
CPC分类号： C12Q1/689 , A61K31/5377 , A61K38/12 , A61K38/14 , C12Q1/6844 , C12Q2600/16
摘要： Disclosed are diagnostic methods for determining a subtype of methicillin-resistant Staphylococcus aureus (MRSA) in a biological sample of a mammal. Methods include providing a biological sample of the mammal, performing a PCR analysis of the biological sample, and analyzing the PCR amplicons with respect to their sizes so as to determine for type I, type II, type III, type IV or type V MRSA that may be present in the biological sample. Further example embodiments include using at least one mecA primer pair and/or using at least one Staphylococcus aureus nuc primer pair in the PCR analysis. Further disclosed are methods for screening populations for MRSA, and methods of treating a mammal testing positive for Type IV MRSA. Also disclosed are kits for determining a MRSA subtype in a mammal and isolated primers that may be used in the present methods and kits.
摘要翻译：公开了用于确定哺乳动物生物样品中耐甲氧西林金黄色葡萄球菌（MRSA）亚型的诊断方法。方法包括提供哺乳动物的生物样品，对生物样品进行PCR分析，并根据其大小对PCR扩增子进行分析，以确定I型，II型，III型，IV型或V型MRSA，可能存在于生物样品中。另外的实施例包括在PCR分析中使用至少一个mecA引物对和/或使用至少一种金黄色葡萄球菌引物对。进一步披露的是用于筛选MRSA群体的方法以及治疗IV型MRSA阳性的哺乳动物的方法。还公开了用于测定哺乳动物中MRSA亚型的试剂盒和可用于本发明方法和试剂盒的分离的引物。

8. 发明申请

US20110016520A1 AUTHENTICATION SYSTEM AND METHODS 有权
标题翻译：认证系统及方法
公开(公告)号：US20110016520A1
公开(公告)日：2011-01-20
申请号：US12503238
申请日：2009-07-15
申请人： Ira Cohen , Eli Mordechai
发明人： Ira Cohen , Eli Mordechai
IPC分类号： H04L9/32 , G06F21/00
CPC分类号： G09C1/00 , G06F21/36 , H04L9/3228
摘要： A system and methods authenticate sensitive information such as passwords. Password characters are transformed into distorted characters and distorted character groups are generated such that each distorted password character is part of a group. An image is created containing the groups and the password or other sensitive information is authenticated when groups are identified within the image that contain the password characters in an expected sequence.
摘要翻译：系统和方法验证密码等敏感信息。密码字符被转换为失真的字符，并且生成失真的字符组，使得每个失真的密码字符是组的一部分。创建包含组的映像，并且在包含期望序列中的密码字符的映像中识别组时，验证密码或其他敏感信息。

9. 发明申请

US20100209936A1 Novel recombinant 15-kDa polypeptide and use of same in detecting human infection with Bartonella henselae 有权
标题翻译：新型重组的15-kDa多肽及其在检测人类Bartonella henselae感染中的用途
公开(公告)号：US20100209936A1
公开(公告)日：2010-08-19
申请号：US12462647
申请日：2009-08-06
申请人： John G. Hoey , Lisa P. Huang , Martin E. Adelson , Eli Mordechai
发明人： John G. Hoey , Lisa P. Huang , Martin E. Adelson , Eli Mordechai
IPC分类号： G01N33/53 , C07K14/195 , C07K17/00 , C07H21/04 , C12N15/63 , C12N1/21 , C12P21/02
CPC分类号： C07K14/195 , G01N33/56911 , G01N33/6893 , G01N2469/20
摘要： Disclosed are the cloning and expression of a novel antigen of Bartonella henselae. The recombinant polypeptide is found to be highly immunogenic and is useful as a diagnostic test antigen. The polypeptide of the present invention provides the basis of a diagnostic assay that is sensitive, rapid and accurate diagnosis of infection with Bartonella henselae using patient's sera. Disclosed also are the ELISA for both IgG and IgM and allows diagnosis of early and late infection.
摘要翻译：披露了巴氏杆菌的新型抗原的克隆和表达。发现重组多肽是高度免疫原性的，并且可用作诊断测试抗原。本发明的多肽提供了使用患者血清敏感，快速和准确诊断感染巴氏杆菌的诊断测定的基础。还公开了IgG和IgM的ELISA，并且可以诊断早期和晚期感染。

10. 发明申请

US20100028884A1 Detection of penicillin tolerance in group B streptococcus: single nucleotide polymorphisms in penicillin binding protein 4 有权
标题翻译： B组链球菌青霉素耐药检测：青霉素结合蛋白单核苷酸多态性4
公开(公告)号：US20100028884A1
公开(公告)日：2010-02-04
申请号：US12454408
申请日：2009-05-18
申请人： Scott Elliott Gygax , Aditya Prasad , Martin E. Adelson , Eli Mordechai
发明人： Scott Elliott Gygax , Aditya Prasad , Martin E. Adelson , Eli Mordechai
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/689 , C12Q2600/156
摘要： Disclosed are methods of detecting penicillin tolerance in Group B Streptococcus by detecting at least one of two single nucleotide polymorphisms (SNP) in penicillin binding protein 4. Also disclosed are primers and hybridization probes that may be used in such methods.
摘要翻译：公开了通过检测青霉素结合蛋白4中的两个单核苷酸多态性（SNP）中的至少一个来检测B组链球菌中的青霉素耐药性的方法。还公开了可用于这些方法的引物和杂交探针。

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