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1. 发明申请

US20090050819A1 Laser-Accelerated Proton Therapy Units And Superconducting Electromagnet Systems For Same 有权
标题翻译：激光加速质子治疗单元和超导电磁体系统相同
公开(公告)号：US20090050819A1
公开(公告)日：2009-02-26
申请号：US11720873
申请日：2005-12-21
申请人： Chang Ming Ma , Eugene S. Fourkal , Jinsheng Li , Wei Luo
发明人： Chang Ming Ma , Eugene S. Fourkal , Jinsheng Li , Wei Luo
IPC分类号： H01J3/14 , A61N5/00 , H01F6/00
CPC分类号： A61N5/10 , A61N2005/1087 , A61N2005/1088 , G21K1/093 , G21K5/04 , H05H15/00
摘要： Compact particle selection and collimation devices are disclosed for delivering beams of protons with desired energy spectra. These devices are useful with laser-accelerated proton therapy systems, in which the initial protons have broad energy and angular distributions. Superconducting magnet systems produce a desired magnetic field configuration to spread the protons with different energies and emitting angles for particle selection. The simulation of proton transport in the presence of the magnetic field shows that the selected protons are successfully refocused on the beam axis after passing through the magnetic field with the optimal magnet system. Dose distributions are also provided using Monte Carlo simulations of the laser-accelerated proton beams for radiation therapy applications.
摘要翻译：公开了紧凑的粒子选择和准直装置，用于以期望的能谱输送质子束。这些装置对于激光加速质子治疗系统是有用的，其中初始质子具有宽的能量和角分布。超导磁体系统产生期望的磁场结构，以用不同的能量和发射角来扩散质子用于粒子选择。在存在磁场的情况下，质子传输的模拟表明，所选择的质子在通过具有最佳磁体系统的磁场之后成功地重新聚焦在光束轴上。使用激光加速质子束的蒙特卡罗模拟也可以提供剂量分布，用于放射治疗应用。

2. 发明申请

US20100320394A1 METHODS AND SYSTEMS FOR INCREASING THE ENERGY OF POSITIVE IONS ACCELERATED BY HIGH-POWER LASERS 有权
标题翻译：增加大功率激光加速放电能量的方法与系统
公开(公告)号：US20100320394A1
公开(公告)日：2010-12-23
申请号：US12742769
申请日：2008-11-13
申请人： Chang-ming Ma , Iavor Veltchev , Eugene S. Fourkal
发明人： Chang-ming Ma , Iavor Veltchev , Eugene S. Fourkal
IPC分类号： H05H15/00 , H01J27/00
CPC分类号： H05H15/00
摘要： The energy of positive ions accelerated in laser-matter interaction experiments can be significantly increased by providing a plurality of laser pulses, e.g., through the process of splitting the incoming laser pulse, to form multiple laser-matter interaction stages. From a thermodynamic point of view, the splitting procedure can be viewed as an effective way of increasing the efficiency of energy transfer from the laser light to positive ions, which energy peaks for processes having the least amount of entropy gain. A 100% increase in the energy efficiency is achieved for a six-stage laser positive ion accelerator compared to a single-stage laser positive ion accelerator.
摘要翻译：激光物质相互作用实验中加速的正离子的能量可以通过提供多个激光脉冲，例如通过分离入射的激光脉冲的过程形成多个激光物质相互作用阶段来显着增加。从热力学的角度来看，分裂过程可以被看作是提高从激光到正离子的能量转移效率的有效方式，对于具有最小熵增益的过程的能量峰值。与单级激光正离子加速器相比，六级激光正离子加速器的能量效率提高了100％。

3. 发明授权

US08269189B2 Methods and systems for increasing the energy of positive ions accelerated by high-power lasers 有权
标题翻译：用于增加高功率激光加速的正离子能量的方法和系统
公开(公告)号：US08269189B2
公开(公告)日：2012-09-18
申请号：US12742769
申请日：2008-11-13
申请人： Chang-ming Ma , Iavor Veltchev , Eugene S. Fourkal
发明人： Chang-ming Ma , Iavor Veltchev , Eugene S. Fourkal
IPC分类号： H01J49/06
CPC分类号： H05H15/00
摘要： The energy of positive ions accelerated in laser-matter interaction experiments can be significantly increased by providing a plurality of laser pulses, e.g., through the process of splitting the incoming laser pulse, to form multiple laser-matter interaction stages. From a thermodynamic point of view, the splitting procedure can be viewed as an effective way of increasing the efficiency of energy transfer from the laser light to positive ions, which energy peaks for processes having the least amount of entropy gain. A 100% increase in the energy efficiency is achieved for a six-stage laser positive ion accelerator compared to a single-stage laser positive ion accelerator.
摘要翻译：激光物质相互作用实验中加速的正离子的能量可以通过提供多个激光脉冲，例如通过分离入射的激光脉冲的过程形成多个激光物质相互作用阶段来显着增加。从热力学的角度来看，分裂过程可以被看作是提高从激光到正离子的能量转移效率的有效方式，对于具有最小熵增益的过程的能量峰值。与单级激光正离子加速器相比，六级激光正离子加速器的能量效率提高了100％。

4. 发明授权

US07755068B2 Laser-accelerated proton therapy units and superconducting electromagnet systems for same 有权
标题翻译：激光加速质子治疗单元和超导电磁体系统相同
公开(公告)号：US07755068B2
公开(公告)日：2010-07-13
申请号：US11720873
申请日：2005-12-21
申请人： Chang Ming Ma , Eugene S Fourkal , Jinsheng Li , Wei Luo
发明人： Chang Ming Ma , Eugene S Fourkal , Jinsheng Li , Wei Luo
IPC分类号： G21K5/04
CPC分类号： A61N5/10 , A61N2005/1087 , A61N2005/1088 , G21K1/093 , G21K5/04 , H05H15/00
摘要： Compact particle selection and collimation devices are disclosed for delivering beams of ions with desired energy spectra. These devices are useful with laser-accelerated ion therapy systems, in which the initial ions have broad energy and angular distributions. Superconducting electromagnet systems produce a desired magnetic field configuration to spread the ions with different energies and emitting angles for particle selection. The simulation of ion transport in the presence of the magnetic field shows that the selected ions are successfully refocused on the beam axis after passing through the magnetic field. Dose distributions are also provided using Monte Carlo simulations of the laser-accelerated ion beams for radiation therapy applications.
摘要翻译：公开了紧凑的粒子选择和准直装置，用于以期望的能谱输送离子束。这些装置对于激光加速离子治疗系统是有用的，其中初始离子具有宽的能量和角分布。超导电磁体系统产生期望的磁场结构，以便以不同的能量和发射角来扩散离子以进行粒子选择。在存在磁场的情况下，离子迁移的模拟表明，所选择的离子在通过磁场后成功地重新聚焦在光束轴上。使用激光加速离子束的蒙特卡罗模拟也可以提供剂量分布，用于放射治疗应用。

5. 发明申请

US20090230318A1 TARGET DESIGN FOR HIGH-POWER LASER ACCELERATED IONS 审中-公开
标题翻译：大功率激光加速离子的目标设计
公开(公告)号：US20090230318A1
公开(公告)日：2009-09-17
申请号：US11720886
申请日：2005-12-22
申请人： Eugene S Fourkal , Iavor Veltchev , Chang Ming Ma
发明人： Eugene S Fourkal , Iavor Veltchev , Chang Ming Ma
IPC分类号： H01J27/00 , G21K1/00 , A61N5/00
CPC分类号： H01J27/24 , G21B1/19 , H01L21/268 , Y02E30/16
摘要： Methods for designing a laser-accelerated ion beam are disclosed. The methods include modeling a system including a heavy ion layer, an electric field, and high energy light positive ions having a maximum light positive ion energy, correlating physical parameters of the heavy ion layer, the electric field, and the maximum light positive ion energy using the model, and varying the parameters of the heavy ion layer to optimize the energy distribution of the high energy light positive ions. One method includes analyzing the acceleration of light positive ions, for example protons, through interaction of a high-power laser pulse with a double-layer target using two-dimensional particle-in-cell (PIC) simulations and a one-dimensional analytical model. The maximum energy acquired by the accelerated light positive ions, e.g., protons, in this model depends on the physical characteristics of the heavy-ion layer—the electron-ion mass ratio and effective charge state of the ions. The hydrodynamic equations for both electron and heavy ion species solved and the test-particle approximation for the protons is applied. It was found that the heavy ion motion modifies the longitudinal electric field distribution, thus changing the acceleration conditions for the light positive ions.
摘要翻译：公开了设计激光加速离子束的方法。所述方法包括对包括重离子层，电场和具有最大的光正离子能量的高能量的光正离子进行建模，将重离子层的物理参数，电场和最大的光正离子能量相关联使用该模型，改变重离子层的参数，以优化高能光阳离子的能量分布。一种方法包括通过使用二维粒子单元（PIC）模拟的高功率激光脉冲与双层靶的相互作用来分析光正离子（例如质子）的加速度，以及一维分析模型。在该模型中由加速的光正离子（例如质子）获得的最大能量取决于重离子层的物理特性 - 离子的电子 - 离子质量比和有效电荷状态。解决了电子和重离子物质的流体动力学方程，并应用质子的测试粒子近似。发现重离子运动改变纵向电场分布，从而改变光正离子的加速条件。

6. 发明授权

US07268358B2 Method of modulating laser-accelerated protons for radiation therapy 有权
标题翻译：调制激光加速质子放射治疗的方法
公开(公告)号：US07268358B2
公开(公告)日：2007-09-11
申请号：US11445850
申请日：2006-06-01
申请人： Chang-Ming Ma , Eugene S. Fourkal
发明人： Chang-Ming Ma , Eugene S. Fourkal
IPC分类号： H01J37/08 , G21K5/10
CPC分类号： A61N5/1031 , A61N5/1043 , A61N2005/1087 , A61N2005/1088 , G21K5/04 , G21K2201/00
摘要： Methods of optimizing a laser-accelerated proton radiation dose to a targeted region are disclosed. Disclosed methods include providing a plurality of modulated polyenergetic proton beamlets and irradiating the targeted region with the plurality of modulated beamlets.
摘要翻译：公开了将目标区域的激光加速质子辐射剂量优化的方法。公开的方法包括提供多个调制的多能子质子子束并用多个调制子束照射目标区域。

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