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1. 发明授权

US10189811B2 Method for preparing the anhydrous crystalline form of isoniazid-derived hydrazone, thus produced cristalline polymorph of the anhydrous form, use thereof for the treatment of Alzheimer's disease, parkinsonism and other neurodegenerative disorders, and pharmaceutical composition 有权
公开(公告)号：US10189811B2
公开(公告)日：2019-01-29
申请号：US15106181
申请日：2014-06-06
申请人： FACULDADES CATÓLICAS, Associação sem fins Lucrativos, Mantenedora da Pontificia Universidade
发明人： Nicolás Adrián Rey , Leonardo Viana de Freitas
IPC分类号： C07D401/12 , C07D215/24
摘要： The present invention relates to the method for preparing the anhydrous crystalline form of isoniazid-derived hydrazone (8-hydroxyquinoline-2-carboxaldehyde isonicotinoyl hydrazone), to the thus produced polymorph and to the use thereof for the treatment of Alzheimer's disease and parkinsonism, inter alia, and to a pharmaceutical composition.

2. 发明申请

US20140093137A1 AUTOMATIC MORPHOMETRY AND CLASSIFICATION OF CRYSTALS OF IRON OXIDES 有权
标题翻译：铁氧化物晶体的自动摩尔分析和分类
公开(公告)号：US20140093137A1
公开(公告)日：2014-04-03
申请号：US14038428
申请日：2013-09-26
申请人： FACULDADES CATÓLICAS , VALE S.A.
发明人： Maria Beatriz VIEIRA , Sidnei PACIORNIK , Otavio de Fonseca Martins GOMES , Júlio Cesar Álvarez IGLESIAS , Aloísio Antônio Melo BORGES
IPC分类号： G01N21/21
CPC分类号： G01N21/21 , G06K9/0014 , G06T7/11
摘要： An automatic method for the classification of crystals of iron oxides, including the measurement of oxide crystal size and shape, by a digital microscopy procedure involving image acquisition, processing, analysis, and classification is described.
摘要翻译：描述了通过涉及图像采集，处理，分析和分类的数字显微镜方法对氧化铁晶体进行分类的自动方法，包括氧化物晶体尺寸和形状的测量。

3. 发明申请

US20190106408A1 METHOD FOR PREPARING THE ANHYDROUS CRYSTALLINE FORM OF ISONIAZID-DERIVED HYDRAZONE, THUS PRODUCED CRYSTALLINE POLYMORPH OF THE ANYHYDROUS FORM, USE THEREOF FOR THE TREATMENT OF ALZHEIMER'S DISEASE, PARKINSONISM AND OTHER NEURODEGENERATIVE DISORDERS, AND PHARAMCEUTICAL COMPOSITION 审中-公开
公开(公告)号：US20190106408A1
公开(公告)日：2019-04-11
申请号：US16209104
申请日：2018-12-04
申请人： FACULDADES CATÓLICAS, Associação sem fins Lucrativos, Mantenedora da Pontifícia Universidade
发明人： Nicolás Adrián Rey , Leonardo Viana de Freitas
IPC分类号： C07D401/12 , C07D215/24
摘要： A method for preparing the anhydrous crystalline form of isoniazid-derived hydrazone (8-hydroxyquinoline-2-carboxaldehyde isonicotinoyl hydrazone), to the thus produced polymorph and to the use thereof for the treatment of Alzheimer's disease and parkinsonism, inter alia, and to a pharmaceutical composition.

4. 发明授权

US09121813B2 Automatic morphometry and classification of crystals of iron oxides 有权
标题翻译：氧化铁晶体的自动形态测定和分类
公开(公告)号：US09121813B2
公开(公告)日：2015-09-01
申请号：US14038428
申请日：2013-09-26
申请人： VALE S.A. , FACULDADES CATÓLICAS
发明人： Maria Beatriz Vieira , Sidnei Paciornik , Otavio de Fonseca Martins Gomes , Júlio Cesar Álvarez Iglesias , Aloísio Antônio Melo Borges
IPC分类号： G01N21/21 , G06T7/00 , G06K9/00
CPC分类号： G01N21/21 , G06K9/0014 , G06T7/11
摘要： An automatic method for the classification of crystals of iron oxides, including the measurement of oxide crystal size and shape, by a digital microscopy procedure involving image acquisition, processing, analysis, and classification is described.
摘要翻译：描述了通过涉及图像采集，处理，分析和分类的数字显微镜方法对氧化铁晶体进行分类的自动方法，包括氧化物晶体尺寸和形状的测量。

5. 发明申请

US20230134773A1 N-ACYLHYDRAZONIC COMPOUNDS, USE IN THE TREATMENT OF AMYLOID AND NON-AMYLOID DEGENERATIVE AGGREGOPATHIES, AND PHARMACEUTICAL COMPOSITION 有权
公开(公告)号：US20230134773A1
公开(公告)日：2023-05-04
申请号：US17912427
申请日：2021-03-15
申请人： FACULDADES CATÓLICAS
发明人： Nicolás ADRIÁN REY , Daphne SCHNEIDER CUKIERMAN REY
IPC分类号： C07D233/64 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to a family of N-acylhydrazonic compounds structurally derived from 1-methyl-1H-imidazole-2-carboxaldehyde, or pharmaceutically acceptable salts thereof, and the use of said compounds to prevent and/or treat amyloid (such as Alzheimer's, Parkinson's and type 2 diabetes) and non-amyloid (such as cataracts) degenerative aggregopathies These compounds act as attenuators of the metal-protein interaction, preventing and/or decreasing protein oligomerization through competition with the target peptide or protein for the binding of physiological metal ions and, possibly, by modulating the protein-protein interaction itself. The invention also details four compounds specifically described as examples of N-acylhydrazones derived from 1-methyl-1H-imidazole-2-carboxaldehyde, namely: 1-methyl-1H-imidazole carboxaldehyde isonicotinoyl hydrazone, 1-methyl-1H-imidazole-2-carboxaldehyde benzoyl hydrazone, 1-methyl-1H-imidazole-2-carboxaldehyde 2-furoyl hydrazone and 1-methyl-1H-imidazole-2-carboxaldehyde 2-thiophenyl hydrazone. The current application also comprises pharmaceutical compositions.

6. 发明申请

US20200380247A1 METHOD FOR EVALUATING AND SELECTING SAMPLES OF FACIAL IMAGES FOR FACIAL RECOGNITION FROM VIDEO SEQUENCES 审中-公开
公开(公告)号：US20200380247A1
公开(公告)日：2020-12-03
申请号：US16471697
申请日：2017-12-20
申请人： FACULDADES CATÓLICAS, ASSOCIAÇÄO SEM FINS LUCRATIVOS, MANTENEDORA DA PONTIFÍCIA UNIVERSIDADE CATOLI , M.I. MONTREAL INFORMÁTICA LTDA
发明人： Antonio Carlos Censi , José Luiz Buonomo Pinho , Raul Queiroz Feitosa
IPC分类号： G06K9/00
摘要： A method to select facial images taken from video to be submitted to a recognition process. The images are managed based on rules guiding the decisions about the images that are considered or discarded for recognition, thus obtaining a reduction in the associated computational load. The rules dictate that an image taken from each new frame of the processed video will only be selected for recognition if it is significantly different from the images taken from the frames previously processed and admitted for recognition. The method manages the database that contains the selected images as a least recently used (LRU) queue. Each proof image is moved to the end of the LRU queue each time it is viewed as similar to the one being considered for admission. When the queue is full, if it is decided to add a new image, the image ahead in the queue is selected to be replaced.

7. 发明申请

US20170189878A1 TIN DIOXIDE NANOPARTICLES SYNTHESIS APPARATUS AND TIN DIOXIDE NANOPARTICLES PROCESS PRODUCTION 有权
公开(公告)号：US20170189878A1
公开(公告)日：2017-07-06
申请号：US15410293
申请日：2017-01-19
申请人： Faculdades Católicas, Associação sem fins lucrativos, Mantenedora da Pontifícia Universidade
发明人： Diego Manuel Ferreira Lusquinos Fontanez , Francisco Jose Moura
IPC分类号： B01J12/02 , B01J19/24 , C01G19/02 , B01J19/00
CPC分类号： B01J12/02 , B01J19/006 , B01J19/2415 , B01J2219/00763 , C01G19/02 , C01P2002/72 , C01P2002/85 , C01P2002/88 , C01P2004/04 , C01P2004/64
摘要： A new and efficient nanoparticles synthesis apparatus and process production. More particularly, an apparatus and process applied to the synthesis of nanostructured tin dioxide. The benefits provided by the apparatus and process are applied in various gaseous reactions where occurs the formation of solid and gaseous products.

8. 发明申请

US20160153240A1 DEVICE FOR LASER DRILLING 有权
标题翻译：激光钻孔设备
公开(公告)号：US20160153240A1
公开(公告)日：2016-06-02
申请号：US15013655
申请日：2016-02-02
申请人： Faculdades Católicas, Sociedade Civil Mantenedora da PUC Rio
发明人： Arthur Martins Barbosa Braga , Cicero Martelli
IPC分类号： E21B7/14 , E21B7/06
CPC分类号： E21B7/14 , E21B7/06
摘要： A device for laser drilling, having: (a) a laser module (310), having a plurality of laser subsystems (200), each one of the laser subsystems (200) having an active optical fiber (240), wound in a shape of hollow coil and packaged inside a hollow cylindrical box (210), and at least one diode laser (220) mechanically connected perpendicularly to the hollow cylindrical box (210) and optically coupled to the core of the active optical fiber (240) wound and packaged inside the hollow cylindrical box (210), the laser module (310) having a tubular shape allowing cooling and drilling fluids to flow through the concentric hollow cores of the tubular laser module (310) and of the cylindrical box (210); and (b) an optical drill head (100), the optical drill head having an end (130) with orifices (110 and 120), and a body (140).
摘要翻译：一种用于激光钻孔的装置，具有：（a）具有多个激光子系统（200）的激光模块（310），所述激光子系统（200）中的每一个具有主动光纤（240）空心线圈并封装在中空圆柱形盒（210）内，以及至少一个二极管激光器（220），其垂直于中空圆柱形盒（210）机械地连接并光学耦合到有源光纤（240）的芯部，所述激光模块（310）具有允许冷却和钻井流体流过所述管状激光模块（310）和所述圆柱形盒（210）的同心空心芯的管状形状; 和（b）光学钻头（100），所述光学钻头具有带有孔（110和120）的端部（130）和主体（140）。

9. 发明申请

US20150139894A1 APPARATUS FOR SYNTHETISING TIN DIOXIDE NANOPARTICLES AND METHOD FOR PRODUCING TIN DIOXIDE NANOPARTICLES 审中-公开
标题翻译：用于合成二氧化钛纳米颗粒的方法和用于生产二氧化钛纳米颗粒的方法
公开(公告)号：US20150139894A1
公开(公告)日：2015-05-21
申请号：US14398903
申请日：2013-05-06
申请人： Faculdades Católicas, Associação sem fins lucrativos, Mantenedora da Pontificia Universidade
发明人： Diego Manuel Ferreira Lusquinos Fontanez , Francisco José Moura
IPC分类号： C01G19/02 , B01J19/00 , B01J19/24 , B01J12/02
CPC分类号： C01G19/02 , B01J4/002 , B01J4/005 , B01J12/02 , B01J19/006 , B01J19/2415 , B01J2219/00006 , B01J2219/00777 , B01J2219/24 , B82Y30/00 , B82Y40/00 , C01P2002/72 , C01P2002/85 , C01P2004/04 , C01P2004/64 , Y10S977/773 , Y10S977/896
摘要： The following invention relates to a novel and efficient nanoparticles synthesis reactor and process production. More particularly, the present invention is applied to the synthesis of nanostructured tin dioxide. The benefits provided by the invention can be seen in various gaseous reactions where occurs the formation of solid and gaseous phases.
摘要翻译：以下发明涉及一种新颖有效的纳米粒子合成反应器和工艺生产。更具体地，本发明应用于纳米结构二氧化锡的合成。本发明提供的益处可以在发生固相和气相形成的各种气态反应中看出。

10. 发明申请

US20230120460A1 METHOD OF ASSESSMENT OF THE QUALITY OF THE BURN OF THE GASES IN THE FLARE AND ADJUSTMENT TO THE VAPOR FLOW RATE IN A CONTINUOUS AND CONSTANT WAY 有权
公开(公告)号：US20230120460A1
公开(公告)日：2023-04-20
申请号：US17890539
申请日：2022-08-18
申请人： Petróleo Brasileiro S.A. - Petrobras , Faculdades Católicas
发明人： Andre Seichi Ribeiro Kuramoto , André Davys Carvalho Melo De Oliveira , Pedro Henrique Lopes Torres , William Paulo Ducca Fernandes , Hélio Côrtes Vieira Lopes , Wolfgang Kosteke Schwaner , Bruno Itagyba Paravidino , Cristiane Salgado Pereira , Patrick Nigri Happ , Sidney Comandulli
IPC分类号： F23N5/26 , F23G7/08 , F23L7/00 , G06V20/60 , G06V20/52
摘要： The present invention presents a method of assessing the quality of the burning of the gases in the flare and adjusting the vapor flow rate in a continuous way and with flexibility to integrate with different instrumentation topologies of the flare control system. The state of the flare flame is identified from an image set of the flame, classifying it into one of four: flame with excess vapor, optimized flame, flame with soot or images with insufficient information to classify them as one of the previous states of the flare flame. In addition, it is further able to quantify the height of the flame. The invention comprises the following components: flare, camera, image stream manager, edge computer, data historian, alert manager, information visualization panels, distributed digital control system, DDCS, and cloud storage and computing.

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