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1. 发明授权

US09039993B2 Microfluidic device 有权
标题翻译：微流控装置
公开(公告)号：US09039993B2
公开(公告)日：2015-05-26
申请号：US13803303
申请日：2013-03-14
申请人： Formulatrix, Inc.
发明人： Kabir James Yamana , Sean Yamana-Hayes
IPC分类号： G01N21/75 , C12P19/34 , C12Q1/68
CPC分类号： C12Q1/6806 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2200/0689 , B01L2300/0816 , B01L2300/087 , B01L2400/0406 , B01L2400/0481 , B01L2400/0655 , C12P19/34 , C12Q1/686 , G01N21/75 , C12Q2565/629
摘要： Microfluidic devices of the present disclosure relate to quick and inexpensive microfluidic manipulation/handling. A number of channels may be supplied with fluid ingredient(s). In some embodiments, a number of protrusions as well as a sealing material may be disposed adjacent to the channels. When the channels are supplied with fluid ingredient(s), the channels may be partitioned into a number of separate cavities that are fluidly isolated from one another. For instance, a sealing material may be compressed so as to deform into the channels, obstructing fluid flow. In some embodiments, the channels supply fluid ingredients to a number of pre-formed cavities. Once the cavities are supplied with fluid ingredient, channels connecting the cavities may be sealed off; that is, the cavities may be subject to fluid isolation. When appropriate, contents within reaction chambers may be subject to further processing (e.g., thermal cycling, various analyses).
摘要翻译：本公开的微流体装置涉及快速且廉价的微流体操纵/处理。可以向流体成分提供许多通道。在一些实施例中，可以将多个突起以及密封材料设置成与通道相邻。当通道被供应流体成分时，通道可以被分隔成彼此流体隔离的多个分开的空腔。例如，密封材料可以被压缩以便变形到通道中，阻碍流体流动。在一些实施例中，通道将流体成分供应到多个预先形成的空腔。一旦空腔供应流体成分，连接空腔的通道可以被密封; 也就是说，空腔可以进行流体隔离。适当时，反应室内的物质可以进一步处理（例如，热循环，各种分析）。

2. 发明申请

US20200330976A1 PIPETTE TIP FOR AND METHOD OF AUTOMATICALLY MAINTAINING PIPETTE TIP DEPTH IN A FLUID DURING A FLUID TRANSFER OPERATION 审中-公开
公开(公告)号：US20200330976A1
公开(公告)日：2020-10-22
申请号：US16958999
申请日：2018-12-20
申请人： FORMULATRIX, INC.
发明人： David WIKHOLM , Rasmus LINDBLOM
IPC分类号： B01L3/02 , G01N35/10
摘要： A pipette tip for and method of automatically maintaining pipette tip depth in a fluid during a fluid transfer operation is disclosed. The pipette tip includes, for example, two electrodes that run substantially the full length of the pipette tip for measuring the resistance therebetween when submerged in a conductive fluid. A method is provided of automatically maintaining the depth of the pipette tip in a liquid throughout a pipetting operation, as the liquid surface rises or falls in its container, without any prior knowledge of the container geometry.

3. 发明公开

US20240002918A1 FLUIDIC DETECTION AND CONTROL ALGORITHM FOR PCR ANALYSIS 审中-公开
公开(公告)号：US20240002918A1
公开(公告)日：2024-01-04
申请号：US18032457
申请日：2021-10-19
申请人： FORMULATRIX INC.
发明人： Rasmus LINDBLOM , Michael NILSSON
IPC分类号： C12Q1/6851 , G01N21/05 , B01L3/00 , B01L7/00
CPC分类号： C12Q1/6851 , G01N21/05 , B01L3/502761 , B01L2200/0668 , B01L2300/0654 , B01L2300/0883 , B01L7/52
摘要： Disclosed are various embodiments for systems and methods for detecting and making real-time adjustments to positional control of a fluidic volume moving through an optical detection region in a fluidic channel of a chip on a RT-qPCR system. Said embodiments are disclosed within a RT-qPCR system having a chip and a cartridge for receiving the chip, and further a mechanical instrument for interacting with a membrane of the chip for positional control. Further, example embodiments include systems and methods for capacitive detection of a fluid within a fluidic channel as well as optical detection within an optical detection region of a fluidic channel within a chip.

4. 发明申请

US20160050892A1 FLUID DELIVERY SYSTEM, AND ASSOCIATED APPARATUS AND METHOD 审中-公开
标题翻译：流体输送系统及相关设备及方法
公开(公告)号：US20160050892A1
公开(公告)日：2016-02-25
申请号：US14931789
申请日：2015-11-03
申请人： FORMULATRIX, INC.
发明人： Kabir Mukaddam , Pratomo Alimsijah
IPC分类号： A01K45/00
CPC分类号： A01K45/007 , B01L3/50273 , B01L3/502738 , B01L2400/0655 , B01L2400/0666 , G01N21/534 , Y10T137/0318 , Y10T137/86027
摘要： A fluid delivery system for an in ovo injection apparatus is provided. Such a fluid delivery system includes a plurality of fluid pumps each having a select valve, a diaphragm valve, and an outlet valve. The select valves are individually controllable such that each select valve is selectively operated via a pneumatic actuator. The diaphragm valves and the outlet valves are commonly operated via respective pneumatic actuators. An input valve is provided for each fluid pump in instances that require high pressure delivery of a fluid substance via the fluid pumps. In such instances, the input valves and the diaphragm valves are commonly controlled via high pressure solenoid valves, while the select valves are selectively controlled and the outlet valves are commonly controlled via low pressure solenoid valves. An associated apparatus and method are also provided.
摘要翻译：提供了一种用于输液装置的流体输送系统。这种流体输送系统包括多个流体泵，每个流体泵具有选择阀，隔膜阀和出口阀。选择阀是可单独控制的，使得每个选择阀通过气动致动器选择性地操作。隔膜阀和出口阀通常通过相应的气动执行器操作。在需要通过流体泵高压输送流体物质的情况下，为每个流体泵提供输入阀。在这种情况下，输入阀和隔膜阀通常通过高压电磁阀来控制，而选择阀被选择性地控制，并且出口阀通常通过低压电磁阀来控制。还提供了一种相关联的装置和方法。

5. 发明申请

US20150359203A1 FLUID DELIVERY SYSTEM OF AN IN OVO INJECTION APPARATUS 审中-公开
标题翻译： OVO注射装置的流体输送系统
公开(公告)号：US20150359203A1
公开(公告)日：2015-12-17
申请号：US14696510
申请日：2015-04-27
申请人： Formulatrix, Inc.
发明人： Thomas Matthew Hessler , Kabir James Yamana
IPC分类号： A01K45/00 , F04B53/10 , F04B43/02
CPC分类号： A01K45/007 , F04B43/02
摘要： A fluid delivery system implemented within an in ovo injection apparatus is disclosed, wherein the fluid delivery system includes a plurality of membrane valves. In particular, the fluid delivery system includes a diaphragm valve that is used to meter out a precise volume of a treatment substance liquid. Further, the diaphragm valve includes certain standoff features on the surface thereof for reducing or entirely preventing the adhesion of the diaphragm to adjacent surfaces when left idle for an extended period of time, as well as an arrangement of fluid channels in the surface thereof for reducing or entirely preventing the trapping of liquid between the diaphragm and adjacent surfaces. The fluid delivery system includes features contributing to optimized flow characteristics.
摘要翻译：公开了一种在液体注射装置内实施的流体输送系统，其中流体输送系统包括多个膜阀。特别地，流体输送系统包括用于计量处理物质液体的精确体积的隔膜阀。此外，隔膜阀在其表面上包括一些间隔特征，用于在长时间闲置时减少或完全防止膜片相邻表面的粘附，以及在其表面中布置流体通道以减少或完全防止在隔膜和相邻表面之间捕获液体。流体输送系统包括有助于优化的流动特性的特征。

6. 发明申请

US20140014040A1 FLUID DELIVERY SYSTEM, AND ASSOCIATED APPARATUS AND METHOD 有权
标题翻译：流体输送系统及相关设备及方法
公开(公告)号：US20140014040A1
公开(公告)日：2014-01-16
申请号：US13942737
申请日：2013-07-16
申请人： FORMULATRIX, INC.
发明人： Kabir Mukaddam , Pratomo Alimsijah
IPC分类号： A01K45/00
CPC分类号： A01K45/007 , B01L3/50273 , B01L3/502738 , B01L2400/0655 , B01L2400/0666 , G01N21/534 , Y10T137/0318 , Y10T137/86027
摘要： A fluid delivery system for an in ovo injection apparatus is provided. Such a fluid delivery system includes a plurality of fluid pumps each having a select valve, a diaphragm valve, and an outlet valve. The select valves are individually controllable such that each select valve is selectively operated via a pneumatic actuator. The diaphragm valves and the outlet valves are commonly operated via respective pneumatic actuators. An input valve is provided for each fluid pump in instances that require high pressure delivery of a fluid substance via the fluid pumps. In such instances, the input valves and the diaphragm valves are commonly controlled via high pressure solenoid valves, while the select valves are selectively controlled and the outlet valves are commonly controlled via low pressure solenoid valves. An associated apparatus and method are also provided.
摘要翻译：提供了一种用于输液装置的流体输送系统。这种流体输送系统包括多个流体泵，每个流体泵具有选择阀，隔膜阀和出口阀。选择阀是可单独控制的，使得每个选择阀通过气动致动器选择性地操作。隔膜阀和出口阀通常通过相应的气动执行器操作。在需要通过流体泵高压输送流体物质的情况下，为每个流体泵提供输入阀。在这种情况下，输入阀和隔膜阀通常通过高压电磁阀来控制，而选择阀被选择性地控制，并且出口阀通常通过低压电磁阀来控制。还提供了一种相关联的装置和方法。

7. 发明公开

US20230405585A1 APPARATUSES WITH FLUIDIC CHANNEL GEOMETRIES FOR SAMPLE TO ANSWER PCR ANALYSIS AND METHODS OF USING SAME 审中-公开
公开(公告)号：US20230405585A1
公开(公告)日：2023-12-21
申请号：US18032463
申请日：2021-10-19
申请人： FORMULATRIX, INC
发明人： Kabir YAMANA , Michael NILSSON
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L3/502761 , B01L2200/027 , B01L2200/10 , B01L2300/044 , B01L2300/0887 , B01L2400/043 , B01L2400/0683 , B01L2300/0672 , B01L2300/0883
摘要： Various embodiments for a chip for use in a real-time qPCR system are disclosed. The chip can include at least one port for receiving a sample into the chip; at least one channel in fluidic communication with the at least port; a plurality of magnetically active beads disposed within the at least one channel that capture DNA/RNA from the sample as the sample passes through the at least one channel; and an optical inspection region in fluidic communication with the at least one channel for performing an optical analysis of the sample containing the eluted DNA/RNA previously captured on the magnetic beads.

8. 发明授权

US11590491B2 Automatic liquid transfer optimization pipetting apparatus and method 有权
公开(公告)号：US11590491B2
公开(公告)日：2023-02-28
申请号：US16959020
申请日：2018-12-27
申请人： FORMULATRIX, INC.
发明人： David Wikholm , Rasmus Lindblom
IPC分类号： B01L3/02
摘要： An automatic liquid transfer optimization pipetting apparatus and method is disclosed. Namely, a liquid handling apparatus includes a pump supplying a nozzle (i.e., a pipette tip) via a conduit, one or more pressure sensors, and an electronic controller, and wherein the pipette tip is submerged in a liquid. Further, a method of automatic liquid transfer optimization pipetting includes the steps of actuating the pump to move a designated volume of liquid and then allowing the system to settle to a steady state after completion of pump actuation.

9. 发明申请

US20220091147A1 LIQUID HANDLING INSTRUMENT AND PIPETTING HEAD FOR AND METHOD OF ASPIRATING AND/OR DISPENSING LIQUIDS 有权
公开(公告)号：US20220091147A1
公开(公告)日：2022-03-24
申请号：US17426226
申请日：2019-12-31
申请人： Formulatrix, Inc.
发明人： Daniel Kurnianto
IPC分类号： G01N35/10 , B01L3/02 , B01L3/00 , G01N35/02 , G01N35/00
摘要： A liquid handling instrument and pipetting head for and method of aspirating and/or dispensing liquids is disclosed. Namely, an automated liquid handling instrument is provided for aspirating and/or dispensing liquids from source media to destination media using at least one pipetting head and by using a positive displacement pipette tip, wherein the positive displacement pipette tip includes a pipette tip and a pipette plunger. A pipetting head of the liquid handling instrument includes an arrangement of plates, threaded rods, motors, timing (or drive) belts, and custom timing pulleys/nuts. The pipetting head further includes an arrangement of pipette plunger clamping mechanisms and pipette tip clamping mechanisms that feature zero-insertion force clamping mechanisms.

10. 发明申请

US20190217298A1 MICROFLUIDIC DEVICE WITH VENTED MICROCHAMBERS 审中-公开
公开(公告)号：US20190217298A1
公开(公告)日：2019-07-18
申请号：US15873722
申请日：2018-01-17
申请人： Formulatrix, Inc.
发明人： Kabir James Yamana , Sean Yamana-Hayes
IPC分类号： B01L3/00 , C12Q1/686
CPC分类号： B01L3/502784 , B01L3/502723 , B01L3/502738 , B01L2200/0684 , B01L2200/10 , B01L2300/0819 , B01L2300/0829 , B01L2300/087 , B01L2300/165 , B01L2400/0688 , C12Q1/686
摘要： A microfluidic device with a microfluidic circuit including an array of fluidly coupled microchambers. Each microchamber includes a reaction chamber and an associated vent chamber. The microfluidic circuit may be arranged so that a fluid sample introduced to microfluidic device flows into the reaction chamber and air or other gas present in the reaction chamber is vented from the microchamber through the vent chamber. The microchamber may be configured to allow only the flow of air into the vent chamber from the reaction chamber until the air has been displaced from the reaction chamber by the fluid sample and/or a predefined volume of the fluid sample has been received in the reaction chamber. The microchamber may be further configured to release the fluid sample to thereafter flow from the reaction chamber into the vent chamber.

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