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1. 发明申请

US20230125683A1 Method and system for the amplification of a nucleic acid 有权
公开(公告)号：US20230125683A1
公开(公告)日：2023-04-27
申请号：US16470079
申请日：2017-12-06
申请人： GNA BIOSOLUTIONS GmbH
发明人： Joachim STEHR , Ilse STEMPLINGER , Cordula URBAN , Katja ZIGANN , Aleksander VANESKI , Federico BUERSGENS , Lars ULLERICH
IPC分类号： C12Q1/6844 , B01L7/00
摘要： The invention relates to a system (10) for the amplification of a nucleic acid (22), comprising at least one local heating element (12), which is functionalized with at least one connection nucleic acid (14), and at least one primer nucleic acid (16), which is adapted to bind to the at least one connection nucleic acid (14) and to bind to the nucleic acid (22), and/or at least one primer complementary nucleic acid (30), which is adapted to bind to the at least one connection nucleic acid (14) and to elongate the connection nucleic acid (14) by a primer nucleotide sequence by means of an enzymatic reaction. Furthermore, the invention relates to a primer nucleic acid (16), a primer complementary nucleic acid (30), a local heating element (12) and a method for the amplification of a nucleic acid (22).

2. 发明授权

US11634758B2 Nucleic acid amplification and detection apparatus and method 有权
公开(公告)号：US11634758B2
公开(公告)日：2023-04-25
申请号：US16548643
申请日：2019-08-22
申请人： AXXIN PTY LTD
发明人： William Robb Hopper
IPC分类号： C12Q1/6851 , G01N21/64 , B01L7/00
摘要： A nucleic acid amplification and detection apparatus, including: a support configured to receive a plurality of reaction vessels containing respective samples of one or more nucleic acids to be amplified, the support being rotatable about an axis of rotation and the reaction vessels being received in the support at respective receiving locations distributed about the axis of rotation; a temperature control component thermally coupled to the support and configured to control the temperature of the support in order to amplify the nucleic acids contained in the reaction vessels while received in the support; one or more measurement components configured to measure one or more characteristics of the nucleic acids within the reaction vessels at respective measurement locations distributed about the axis of rotation; an actuator coupled to the support and configured to rotate the support about the axis of rotation; and a sample position controller coupled to the actuator and being configured to rotate the support about the axis of rotation so as to position a selected one of the plurality of reaction vessels to a selected one of the measurement locations to allow a corresponding one of the measurement components to perform a corresponding measurement on the corresponding sample.

3. 发明申请

US20230123901A1 RANDOM ACCESS AUTOMATED MOLECULAR TESTING SYSTEM 有权
公开(公告)号：US20230123901A1
公开(公告)日：2023-04-20
申请号：US17759957
申请日：2021-03-15
申请人： Siemens Healthcare Diagnostics Inc.
发明人： Paul Patt , Roy Barr
IPC分类号： B01L3/00 , B01L7/00
摘要： A random access automated molecular testing system and method is used with a planar polymerase chain reaction (PCR) chip to provide molecular detection covering a wide variety of assays/tests in a small footprint. An automated transport mechanism moves the PCR chip between a pipette loading station, a sealing station and an amplification and detection module to provide batchless and random-access amplification and detection of a biological sample fluid. The PCR chip a planar rectangular body, a U-shaped channel for receiving sample fluid from an inlet port and a gripping feature laterally extending from an upper surface of the body above the inlet port for use by the automated transport mechanism. An amplification and detection module includes a heating block, a clip with a viewing window for retaining the PCR chip and a detection platform for identifying a content characteristic of interest of the sample fluid.

4. 发明申请

US20230120068A1 CLEANROOM-FREE INTEGRATED TRIMODAL SILICON TRANSDUCER FOR GENETIC DETECTION OF PATHOGENS 有权
公开(公告)号：US20230120068A1
公开(公告)日：2023-04-20
申请号：US17906220
申请日：2021-03-12
申请人： IMPERIAL COLLEGE INNOVATIONS LIMITED , MOREDUN RESEARCH INSTITUTE
发明人： Estefania NUNEZ-BAJO , Firat GUDER , Karen STEVENSON
IPC分类号： G01N27/327 , C12Q1/70 , B01L3/00 , B01L7/00 , C25D5/54 , C25D7/00
摘要： A device for detecting a substance in a solution, wherein the device comprises: a substrate comprising silicon; a first electrode for use as a working electrode in an electrochemical cell and coupled to the substrate; and Ohmic contacts coupled to the substrate and configured to pass a current through the substrate when connected to a power source.

5. 发明授权

US11628442B2 Method and system for reaction vessel with multisided energy sources 有权
公开(公告)号：US11628442B2
公开(公告)日：2023-04-18
申请号：US16654484
申请日：2019-10-16
申请人： Kryptos Biotechnologies, Inc.
发明人： Jun Ho Son
IPC分类号： B01L7/00 , B01J19/00 , B01J19/08 , C12M1/00 , C12M1/34
摘要： Embodiments include a reaction vessel having a reaction chamber defined by opposing first and second interior-facing surfaces of the housing; a first light absorbing layer conforming to the first interior-facing surface of the housing component; and a second light absorbing layer conforming to the second interior-facing surface of the housing component; a first energy source configured to direct light through the housing at the first light absorbing layer; and a second energy source configured to direct light through the housing at the second light absorbing layer.

6. 发明申请

US20230111922A1 TESTING FOR PARTICULATES 有权
公开(公告)号：US20230111922A1
公开(公告)日：2023-04-13
申请号：US18079222
申请日：2022-12-12
申请人： HERO SCIENTIFIC LTD.
发明人： Lazar Fruchter , Arie Oscar Holtz , Robert Eric Levitz
IPC分类号： B01L3/00 , B01L7/00 , C12Q1/14 , C12Q1/24
摘要： Apparatus is provided including a tube and a plunger sized and shaped to be inserted into the tube. A distal end of the plunger is shaped to define one or more first passageways therethrough, and the plunger is shaped to define one or more compartments in fluid communication with the first passageways. A filter is coupled to the distal end of the plunger. The plunger is shaped to define a second passageway that passes through the plunger from a proximal end of the plunger to the distal end of the plunger, and is positioned to facilitate testing of the filter. The apparatus is configured such that while the plunger is advanced within the tube while fluid is within the tube, the fluid in the tube is pushed through the filter, through the first passageways, and into the one or more compartments. Other embodiments are also described.

7. 发明授权

US11627642B2 Flexible heating apparatus 有权
公开(公告)号：US11627642B2
公开(公告)日：2023-04-11
申请号：US16726556
申请日：2019-12-24
申请人： Powergene Technology Co., Ltd., Taiwan Branch
发明人： Hui-Te Hsu
IPC分类号： H05B3/54 , H05B3/34 , H02J50/10 , B01L7/00 , B65D81/38
摘要： A flexible heating apparatus can heat a heated body. The flexible heating apparatus includes a flexible carrier, a heating unit and a control module. The heating unit is at least one layer arranged inside the flexible carrier. The control module is arranged inside the flexible carrier and is electrically connected to the heating unit. Moreover, the control module is connected to an external electric apparatus, and is controlled by the external electric apparatus to control the heating unit to proceed a heating control to the heated body.

8. 发明授权

US11623219B2 Digital microfluidics apparatuses and methods for manipulating and processing encapsulated droplets 有权
公开(公告)号：US11623219B2
公开(公告)日：2023-04-11
申请号：US16499681
申请日：2018-04-04
申请人： MIROCULUS INC.
发明人： Mais J. Jebrail , Alexandra Judy Cho , Foteini Christodoulou
IPC分类号： B01L3/00 , B01L7/00
摘要： Air-matrix digital microfluidics (DMF) apparatuses and methods of using them to prevent or limit evaporation and surface fouling of the DMF apparatus. In particular, described herein are air-matrix DMF apparatuses and methods of using them including thermally controllable regions with a wax material that may be used to selectively encapsulate a reaction droplet in the air gap of the apparatus; additional aqueous droplets may be combined with the encapsulated droplet even after separating from the wax, despite residual wax coating, by merging with an aqueous droplet having a coating of a secondary material (e.g., an oil or other hydrophobic material) that may remove the wax from the droplet and/or allow combining of the droplets.

9. 发明授权

US11618027B2 Molecular diagnostics apparatus 有权
公开(公告)号：US11618027B2
公开(公告)日：2023-04-04
申请号：US16892253
申请日：2020-06-03
申请人： Wistron Corp.
发明人： Yao-Tsung Chang , Wen-Hui Shih , Chen An Sung
IPC分类号： B01L3/00 , H02J7/02 , H02J50/12 , B01L7/00 , C12Q1/686
摘要： A molecular diagnostics apparatus is provided. The molecular diagnostics apparatus is adapted to perform DNA chain replication to one sample. The molecular diagnostics apparatus includes a bracket, a central control module, a motor, a magnetic unit, a rotational carrier, a detection module and at least one power supply coil. The central control module is disposed on the bracket. The motor is disposed on the bracket, wherein the central control module drives the motor. The magnetic unit is disposed on the bracket, wherein the magnetic unit provides a magnetic field. The motor is adapted to rotate the rotational carrier. The rotational carrier is rotated relative to the bracket. The sample is disposed on the rotational carrier. The detection module is disposed on the rotational carrier. The power supply coil is coupled to the detection module, and disposed on the rotational carrier. The molecular diagnostics apparatus of the embodiment has a simpler structure and better reliability.

10. 发明授权

US11609472B2 Electrophoretic chip for electrophoretic applications 有权
公开(公告)号：US11609472B2
公开(公告)日：2023-03-21
申请号：US16473108
申请日：2017-12-28
申请人： ADOR DIAGNOSTICS S.R.L.
发明人： Dalibor Hodko , Howard R. Reese , Vladimir Hurgin
IPC分类号： G02F1/167 , C40B30/10 , B01L3/00 , C12N15/10 , B01L7/00 , C12M1/00 , C40B40/00
摘要： The present invention discloses an electrophoretic chip comprising: (a) a non-conductive substrate designed to support elements of said electrophoretic chip; (b) an electrode structure for conducting current through said electrophoretic chip, printed on said non-conductive substrate and comprising a counter electrode and at least one working electrode, each electrode comprising a conductive low-resistance ink layer printed on the non-conductive substrate, and a carbon ink layer printed on top of and fully or partially covering said conductive low-resistance ink layer; (c) a dielectric ink insulator layer placed on top of, and covering, said electrode structure, said dielectric ink insulator layer having at least one opening above the counter electrode and at least one opening above said at least one working electrode, thereby forming at least one addressable location; and (d) a molecule capturing matrix spotted on and covering said at least one addressable location, thereby creating at least one microgel region.

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