专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09274129B2 Methods and reagents for detecting bioactive lipids 有权
标题翻译：检测生物活性脂质的方法和试剂
公开(公告)号：US09274129B2
公开(公告)日：2016-03-01
申请号：US11755699
申请日：2007-05-30
申请人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen
发明人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen
IPC分类号： C07K17/14 , C07K17/06 , G01N33/532 , G01N33/92 , C07K16/18 , C07K16/30 , G01N33/68 , A61K39/00
CPC分类号： G01N33/92 , A61K2039/505 , C07K16/18 , C07K16/30 , C07K2317/24 , C07K2317/56 , C07K2317/73 , G01N33/6854
摘要： Compositions and methods for producing monoclonal antibodies and their derivatives reactive against bioactive lipid targets are described. These compositions include derivatized lipids, each of which comprises a bioactive lipid that having a polar head group and at least one hydrocarbon chain (e.g., a lysolipid such as lysophosphatidic acid or sphingosine-1-phosphate) in which a carbon atom has been derivatized with a pendant reactive group; immunogens made by linking a derivatized lipid to a carrier moiety (e.g., a carrier protein, polyethylene glycol, colloidal gold, alginate, or a silicone bead); monoclonal antibodies and derivatives produced by immunizing an animal with such an immunogen; and therapeutic and diagnostic compositions containing such antibodies and antibody derivatives. Methods for making such derivatized lipids, immunogens, and monoclonal antibodies and derivatives, methods for detecting such antibodies once generated, and therapeutic and diagnostic methods for using such antibodies and derivatives, are also described.
摘要翻译：描述了用于产生针对生物活性脂质靶标的反应性的单克隆抗体及其衍生物的组合物和方法。这些组合物包括衍生的脂质，其各自包含具有极性头基团和至少一个烃链的生物活性脂质（例如溶血磷脂酸或鞘氨醇-1-磷酸酯等溶血磷脂酸或鞘氨醇-1-磷酸酯），其中碳原子已被衍生化，吊坠反应组; 通过将衍生的脂质与载体部分（例如载体蛋白，聚乙二醇，胶体金，藻酸盐或硅酮珠）连接而制备的免疫原; 通过用这种免疫原免疫动物产生的单克隆抗体和衍生物; 以及含有此类抗体和抗体衍生物的治疗和诊断组合物。还描述了制备这种衍生化脂质，免疫原和单克隆抗体及其衍生物的方法，一旦产生的检测此类抗体的方法，以及使用这些抗体和衍生物的治疗和诊断方法。

2. 发明授权

US08796429B2 Bioactive lipid derivatives, and methods of making and using same 有权
标题翻译：生物活性脂质衍生物及其制备和使用方法
公开(公告)号：US08796429B2
公开(公告)日：2014-08-05
申请号：US11755352
申请日：2007-05-30
申请人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen
发明人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen
IPC分类号： C07K17/14 , C07K17/06 , G01N33/532 , A61K47/48 , G01N33/92
CPC分类号： C07K16/00 , A61K47/544 , A61K47/60 , A61K47/643 , A61K2039/505 , C07K16/18 , C07K16/3076 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N2500/44 , G01N33/6854 , G01N33/92
摘要： Compositions and methods for producing monoclonal antibodies and their derivatives reactive against bioactive lipid targets are described. These compositions include derivatized lipids, each of which comprises a bioactive lipid that having a polar head group and at least one hydrocarbon chain (e.g., a lysolipid such as lysophosphatidic acid or sphingosine-1-phosphate) in which a carbon atom has been derivatized with a pendant reactive group; immunogens made by linking a derivatized lipid to a carrier moiety (e.g., a carrier protein, polyethylene glycol, colloidal gold, alginate, or a silicone bead); monoclonal antibodies and derivatives produced by immunizing an animal with such an immunogen; and therapeutic and diagnostic compositions containing such antibodies and antibody derivatives. Methods for making such derivatized lipids, immunogens, and monoclonal antibodies and derivatives, methods for detecting such antibodies once generated, and therapeutic and diagnostic methods for using such antibodies and derivatives, are also described.
摘要翻译：描述了用于产生针对生物活性脂质靶标的反应性的单克隆抗体及其衍生物的组合物和方法。这些组合物包括衍生的脂质，其各自包含具有极性头基团和至少一个烃链的生物活性脂质（例如溶血磷脂酸或鞘氨醇-1-磷酸酯等溶血磷脂酸或鞘氨醇-1-磷酸酯），其中碳原子已被衍生化，吊坠反应组; 通过将衍生的脂质与载体部分（例如载体蛋白，聚乙二醇，胶体金，藻酸盐或硅酮珠）连接而制备的免疫原; 通过用这种免疫原免疫动物产生的单克隆抗体和衍生物; 以及含有此类抗体和抗体衍生物的治疗和诊断组合物。还描述了制备这种衍生化脂质，免疫原和单克隆抗体及其衍生物的方法，一旦产生的检测此类抗体的方法，以及使用这些抗体和衍生物的治疗和诊断方法。

3. 发明授权

US08168201B2 Vaccines 有权
标题翻译：疫苗
公开(公告)号：US08168201B2
公开(公告)日：2012-05-01
申请号：US11696131
申请日：2007-04-03
申请人： Leslie Hickle , Abraham Anderson , Robert C. Brown , Paul Budworth , Gordana Djordjevic , Scott Kroken , Peter Luginbuhl , Toby Richardson , Genevieve Hansen
发明人： Leslie Hickle , Abraham Anderson , Robert C. Brown , Paul Budworth , Gordana Djordjevic , Scott Kroken , Peter Luginbuhl , Toby Richardson , Genevieve Hansen
IPC分类号： A61K39/295 , A61K48/00 , A61K39/02 , C12N15/117 , A61K38/00
CPC分类号： A61K39/385 , A61K39/012 , A61K39/08 , A61K2039/552 , A61K2039/55516 , A61K2039/6037 , A61K2039/6075 , C07K2319/55 , C12N2720/10034 , C12N2760/18434 , C12N2770/20034 , Y02A50/489
摘要： The present invention relates to compositions for inducing immune responses, including an antigen and a promiscuous T-cell epitope. Also provided are methods of inducing immune responses in hosts, comprising administering compositions comprising antigens and promiscuous T-cell epitopes to the host.
摘要翻译：本发明涉及用于诱导免疫应答的组合物，包括抗原和混杂T细胞表位。还提供了在宿主中诱导免疫应答的方法，包括向宿主施用包含抗原和混杂的T细胞表位的组合物。

4. 发明授权

US08067549B2 Humanized antibodies and compositions for binding sphingosine-1-phosphate 有权
标题翻译：用于结合鞘氨醇-1-磷酸的人源化抗体和组合物
公开(公告)号：US08067549B2
公开(公告)日：2011-11-29
申请号：US12258337
申请日：2008-10-24
申请人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
发明人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00
CPC分类号： C07K16/44 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to anti-S1P agents, particularly humanized monoclonal antibodies (and antigen binding fragments thereof) specifically reactive with S1P, compositions containing such antibodies (or fragments), and the use of such antibodies (or fragments), for example, to treat diseases and conditions associated with aberrant levels of S1P.
摘要翻译：本发明涉及与S1P特异性反应的抗S1P试剂，特别是人源化单克隆抗体（及其抗原结合片段），含有此类抗体（或片段）的组合物，以及使用这种抗体（或片段），例如治疗与S1P异常水平相关的疾病和病症。

5. 发明授权

US07956173B2 Nucleic acids coding for humanized antibodies for binding sphingosine-1-phosphate 有权
标题翻译：编码用于结合鞘氨醇-1-磷酸的人源化抗体的核酸
公开(公告)号：US07956173B2
公开(公告)日：2011-06-07
申请号：US12258353
申请日：2008-10-24
申请人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
发明人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
IPC分类号： C07H21/04 , C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00
CPC分类号： C07K16/44 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to anti-S1P agents, particularly humanized monoclonal antibodies (and antigen binding fragments thereof) specifically reactive with S1P, compositions containing such antibodies (or fragments), and the use of such antibodies (or fragments), for example, to treat diseases and conditions associated with aberrant levels of S1P.
摘要翻译：本发明涉及与S1P特异性反应的抗S1P试剂，特别是人源化单克隆抗体（及其抗原结合片段），含有此类抗体（或片段）的组合物，以及使用这种抗体（或片段），例如治疗与S1P异常水平相关的疾病和病症。

6. 发明申请

US20090130100A1 METHODS OF USING HUMANIZED ANTIBODIES AND COMPOSITIONS FOR BINDING SPHINGOSINE-1-PHOSPHATE 有权
标题翻译：使用人造抗体和组合物结合磷酸肌磷酸1-磷酸的方法
公开(公告)号：US20090130100A1
公开(公告)日：2009-05-21
申请号：US12258355
申请日：2008-10-24
申请人： Roger A. SABBADINI , William A. GARLAND , Genevieve HANSEN , Steven Tarran JONES , David WILLIAMS
发明人： Roger A. SABBADINI , William A. GARLAND , Genevieve HANSEN , Steven Tarran JONES , David WILLIAMS
IPC分类号： A61K39/395 , A61P9/00 , A61P35/00
CPC分类号： C07K16/44 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to anti-S1P agents, particularly humanized monoclonal antibodies (and antigen binding fragments thereof) specifically reactive with S1P, compositions containing such antibodies (or fragments), and the use of such antibodies (or fragments), for example, to treat diseases and conditions associated with aberrant levels of S1P.
摘要翻译：本发明涉及与S1P特异性反应的抗S1P试剂，特别是人源化单克隆抗体（及其抗原结合片段），含有此类抗体（或片段）的组合物，以及使用这种抗体（或片段），例如治疗与S1P异常水平相关的疾病和病症。

7. 发明申请

US20080145360A1 Immune-Derived Moieties Reactive Against Lysophosphatidic Acid 有权
标题翻译：对溶血磷脂酸反应的免疫衍生部分
公开(公告)号：US20080145360A1
公开(公告)日：2008-06-19
申请号：US11755721
申请日：2007-05-30
申请人： Roger A. SABBADINI , William A. Garland , Genevieve Hansen
发明人： Roger A. SABBADINI , William A. Garland , Genevieve Hansen
IPC分类号： A61K39/00 , C07K16/00 , A61K39/395
CPC分类号： G01N33/92 , A61K47/544 , A61K47/60 , A61K47/643 , A61K47/646 , A61K2039/505 , C07K16/18 , C07K16/30 , C07K2317/24 , C07K2317/56 , C07K2317/73 , C07K2317/74
摘要： Compositions and methods for producing monoclonal antibodies and their derivatives reactive against bioactive lipid targets are described. These compositions include derivatized lipids, each of which comprises a bioactive lipid that having a polar head group and at least one hydrocarbon chain (e.g., a lysolipid such as lysophosphatidic acid or sphingosine-1-phosphate) in which a carbon atom has been derivatized with a pendant reactive group; immunogens made by linking a derivatized lipid to a carrier moiety (e.g., a carrier protein, polyethylene glycol, colloidal gold, alginate, or a silicone bead); monoclonal antibodies and derivatives produced by immunizing an animal with such an immunogen; and therapeutic and diagnostic compositions containing such antibodies and antibody derivatives. Methods for making such derivatized lipids, immunogens, and monoclonal antibodies and derivatives, methods for detecting such antibodies once generated, and therapeutic and diagnostic methods for using such antibodies and derivatives, are also described.
摘要翻译：描述了用于产生针对生物活性脂质靶标的反应性的单克隆抗体及其衍生物的组合物和方法。这些组合物包括衍生的脂质，其各自包含具有极性头基团和至少一个烃链的生物活性脂质（例如溶血磷脂酸或鞘氨醇-1-磷酸酯等溶血磷脂酸或鞘氨醇-1-磷酸酯），其中碳原子已被衍生化，吊坠反应组; 通过将衍生的脂质与载体部分（例如载体蛋白，聚乙二醇，胶体金，藻酸盐或硅酮珠）连接而制备的免疫原; 通过用这种免疫原免疫动物产生的单克隆抗体和衍生物; 以及含有此类抗体和抗体衍生物的治疗和诊断组合物。还描述了制备这种衍生化脂质，免疫原和单克隆抗体及其衍生物的方法，一旦产生的检测此类抗体的方法，以及使用这些抗体和衍生物的治疗和诊断方法。

8. 发明申请

US20070286871A1 VACCINES 有权
标题翻译：疫苗
公开(公告)号：US20070286871A1
公开(公告)日：2007-12-13
申请号：US11696131
申请日：2007-04-03
申请人： Leslie Hickle , Abraham Anderson , Robert Brown , Paul Budworth , Gordana Djordjevic , Scott Kroken , Peter Luginbuhl , Toby Richardson , Genevieve Hansen
发明人： Leslie Hickle , Abraham Anderson , Robert Brown , Paul Budworth , Gordana Djordjevic , Scott Kroken , Peter Luginbuhl , Toby Richardson , Genevieve Hansen
IPC分类号： A61K39/295 , A61K39/116 , C07H21/04
CPC分类号： A61K39/385 , A61K39/012 , A61K39/08 , A61K2039/552 , A61K2039/55516 , A61K2039/6037 , A61K2039/6075 , C07K2319/55 , C12N2720/10034 , C12N2760/18434 , C12N2770/20034 , Y02A50/489
摘要： The present invention relates to compositions for inducing immune responses, including an antigen and a promiscuous T-cell epitope. Also provided are methods of inducing immune responses in hosts, comprising administering compositions comprising antigens and promiscuous T-cell epitopes to the host.
摘要翻译：本发明涉及用于诱导免疫应答的组合物，包括抗原和混杂T细胞表位。还提供了在宿主中诱导免疫应答的方法，包括向宿主施用包含抗原和混杂的T细胞表位的组合物。

9. 发明授权

US06410329B1 Method for achieving site specific integration of exogenous DNA delivered by non-biological means to plant cells 有权
标题翻译：通过非生物手段将植物细胞递送的外源DNA实现位点特异性整合的方法
公开(公告)号：US06410329B1
公开(公告)日：2002-06-25
申请号：US09574132
申请日：2000-05-18
申请人： Genevieve Hansen , MaryDell Chilton , Janet Louise Suttie
发明人： Genevieve Hansen , MaryDell Chilton , Janet Louise Suttie
IPC分类号： C12N1582
CPC分类号： C12N15/8201 , C12N15/8206 , C12N15/8207
摘要： The present invention provides an improved method of site directed integration of an exogenous DNA molecule by co-delivery of a gene of interest flanked by nucleotide sequences recognized by a recombinase and a mRNA encoding the homologous recombinase.
摘要翻译：本发明提供了通过共同转运由重组酶识别的核苷酸序列侧翼的感兴趣的基因和编码同源重组酶的mRNA的位点定向整合外源DNA分子的改进方法。

10. 发明授权

US09217749B2 Immune-derived moieties reactive against lysophosphatidic acid 有权
标题翻译：对溶血磷脂酸具有反应性的免疫衍生部分
公开(公告)号：US09217749B2
公开(公告)日：2015-12-22
申请号：US11755721
申请日：2007-05-30
申请人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen
发明人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen
IPC分类号： G01N33/92 , C07K16/18 , C07K16/30 , C12P21/08 , A61K47/48 , A61K39/00
CPC分类号： G01N33/92 , A61K47/544 , A61K47/60 , A61K47/643 , A61K47/646 , A61K2039/505 , C07K16/18 , C07K16/30 , C07K2317/24 , C07K2317/56 , C07K2317/73 , C07K2317/74
摘要： Compositions and methods for producing monoclonal antibodies and their derivatives reactive against bioactive lipid targets are described. These compositions include derivatized lipids, each of which comprises a bioactive lipid that having a polar head group and at least one hydrocarbon chain (e.g., a lysolipid such as lysophosphatidic acid or sphingosine-1-phosphate) in which a carbon atom has been derivatized with a pendant reactive group; immunogens made by linking a derivatized lipid to a carrier moiety (e.g., a carrier protein, polyethylene glycol, colloidal gold, alginate, or a silicone bead); monoclonal antibodies and derivatives produced by immunizing an animal with such an immunogen; and therapeutic and diagnostic compositions containing such antibodies and antibody derivatives. Methods for making such derivatized lipids, immunogens, and monoclonal antibodies and derivatives, methods for detecting such antibodies once generated, and therapeutic and diagnostic methods for using such antibodies and derivatives, are also described.
摘要翻译：描述了用于产生针对生物活性脂质靶标的反应性的单克隆抗体及其衍生物的组合物和方法。这些组合物包括衍生的脂质，其各自包含具有极性头基团和至少一个烃链的生物活性脂质（例如溶血磷脂酸或鞘氨醇-1-磷酸酯等溶血磷脂酸或鞘氨醇-1-磷酸酯），其中碳原子已被衍生化，吊坠反应组; 通过将衍生的脂质与载体部分（例如载体蛋白，聚乙二醇，胶体金，藻酸盐或硅酮珠）连接而制备的免疫原; 通过用这种免疫原免疫动物产生的单克隆抗体和衍生物; 以及含有此类抗体和抗体衍生物的治疗和诊断组合物。还描述了制备这种衍生化脂质，免疫原和单克隆抗体及其衍生物的方法，一旦产生的检测此类抗体的方法，以及使用这些抗体和衍生物的治疗和诊断方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式