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1. 发明申请

US20070197524A1 Fluorenes and carbazoles as ligands of the EP2 receptor 审中-公开
标题翻译：芴和咔唑作为EP2受体的配体
公开(公告)号：US20070197524A1
公开(公告)日：2007-08-23
申请号：US11642975
申请日：2006-12-21
申请人： Nico Brauer , Bernd Buchmann , Christoph Huwe , Bernhard Lindenthal , Gernot Langer , Olaf Peters , Gerd Schubert , Ulrich Bothe , Luisella Toschi , Michaele Peters-Kottig
发明人： Nico Brauer , Bernd Buchmann , Christoph Huwe , Bernhard Lindenthal , Gernot Langer , Olaf Peters , Gerd Schubert , Ulrich Bothe , Luisella Toschi , Michaele Peters-Kottig
IPC分类号： A61K31/5377 , A61K31/4709 , A61K31/428 , A61K31/4178 , A61K31/416 , A61K31/403 , C07D403/02
CPC分类号： C07D209/88
摘要： The present invention relates to carbazoles/fluorenes, to processes for their preparation and to their use for preparing pharmaceutical agents for the treatment of disorders connected to the EP2 receptor.
摘要翻译：本发明涉及咔唑/芴，其制备方法及其用于制备用于治疗与EP 2受体相关的病症的药物的用途。

2. 发明授权

US07166438B2 In Vitro screening for ligands of the estrogen receptor 失效
标题翻译：体外筛选雌激素受体配体
公开(公告)号：US07166438B2
公开(公告)日：2007-01-23
申请号：US09989952
申请日：2001-11-20
申请人： Vladimir Patchev , Youriy Mitev , Siegmund Wolf , Gernot Langer
发明人： Vladimir Patchev , Youriy Mitev , Siegmund Wolf , Gernot Langer
IPC分类号： G01N33/53
CPC分类号： G01N33/743 , G01N2500/02 , G01N2500/04 , G01N2500/10 , G01N2500/20
摘要： A method for in vitro screening a group of test substances for a ligand using two assay systems, i.e. a cellular or tissue assay system and an enzymatic assay system, is described. First, those test substances are selected which have transcriptional ER-mediated activity measured by an ER-driven reporter gene in the cellular or tissue assay system with an EC50(ER)(half-maximally effective ligand concentration) lower than or equal to 10 nmol/l. Then in an enzymatic assay system the selected test substances having the required transcriptional ER-mediated activity are tested by measuring a physical-chemical interaction (recruitment) of SRC-1 and the ER in the presence of the test substances. The selected ligand activates the ER and induces interaction with the co-present SRC-1 with an E50(ER+SRC) higher than or equal to 100 nmol/l. The ligands found by the inventive screening method are useful for treatment and prevention of neuro-degeneration in the cerebral cortex, especially of age-related cognitive disorders, affective disorders, Alzheimer's diseases and cerebral ischemia/stroke.
摘要翻译：描述了使用两个测定系统（即细胞或组织测定系统和酶测定系统）体外筛选配体的一组测试物质的方法。首先，选择在细胞或组织测定系统中通过ER驱动的报告基因测量的具有转录ER介导活性的测试物质，其具有EC 50（ER）（半最大有效配体浓度）低于或等于10nmol / l。然后在酶分析系统中，通过测量在存在测试物质的情况下测量SRC-1和ER的物理 - 化学相互作用（招募）来测试所选择的具有所需转录ER介导活性的测试物质。选择的配体激活ER并诱导与共同存在的SRC-1与高于或等于100nmol / l的E 50（ER + SRC）的相互作用。通过本发明筛选方法发现的配体可用于治疗和预防大脑皮质中的神经变性，特别是与年龄相关的认知障碍，情感障碍，阿尔茨海默病和脑缺血/卒中。

3. 发明授权

US06531459B1 Vitamin D derivatives with phosphorus atoms in the side chains 失效
标题翻译：维生素D衍生物与侧链中的磷原子
公开(公告)号：US06531459B1
公开(公告)日：2003-03-11
申请号：US09581907
申请日：2000-08-04
申请人： Andreas Steinmeyer , Günter Neef , Gerald Kirsch , Katica Schwarz , Herbert Wiesinger , Martin Haberey , Marianne Fähnrich , Gernot Langer
发明人： Andreas Steinmeyer , Günter Neef , Gerald Kirsch , Katica Schwarz , Herbert Wiesinger , Martin Haberey , Marianne Fähnrich , Gernot Langer
IPC分类号： A61K3159
CPC分类号： C07C401/00 , C07F9/383 , C07F9/386 , C07F9/4018 , C07F9/404 , C07F9/405 , C07F9/532
摘要： Described are new vitamin D derivatives such as of the formula (I) detailed in this disclosure. Also described are methods for preparing these derivatives, inter mediates used to prepare the derivatives and use of the derivatives as pharmaceutical agents.
摘要翻译：描述了新的维生素D衍生物，例如本公开中详述的式（I）。还描述了制备这些衍生物的方法，用于制备衍生物的中间体和作为药剂的衍生物的用途。

4. 发明申请

US20090042878A1 THIENOPYRIMIDYLAMINES AS MODULATORS OF THE EP2 RECEPTOR 审中-公开
标题翻译：作为EP2受体的调节剂的三苯甲酰亚胺
公开(公告)号：US20090042878A1
公开(公告)日：2009-02-12
申请号：US12170774
申请日：2008-07-10
申请人： Nico BRAEUER , Bernd Buchmann , Marcus Koppitz , Olaf Peters , Antonius Ter Laak , Bernhard Lindenthal , Gernot Langer , Tim Wintermantel
发明人： Nico BRAEUER , Bernd Buchmann , Marcus Koppitz , Olaf Peters , Antonius Ter Laak , Bernhard Lindenthal , Gernot Langer , Tim Wintermantel
IPC分类号： A61K31/5377 , C07D495/04 , A61K31/519 , A61P35/00
CPC分类号： C07D495/04
摘要： The present invention relates to thienopyrimidylamines of the general formula I, to processes for their preparation and to their use for production of pharmaceutical compositions for treatment of disorders and indications connected to the EP2 receptor.
摘要翻译：本发明涉及通式I的噻吩并嘧啶胺，其制备方法及其用于制备用于治疗与EP2受体相关的疾病和适应症的药物组合物。

5. 发明申请

US20070060573A1 Acyltryptophanols 审中-公开
标题翻译：酰基色氨酸
公开(公告)号：US20070060573A1
公开(公告)日：2007-03-15
申请号：US11501228
申请日：2006-08-09
申请人： Lars Wortmann , Arwed Cleve , Bernd Menzenbach , Hans-Peter Muhn , Gernot Langer , Anna Schrey , Ronald Kuehne , Marcu Koppitz , Dirk Kosemund
发明人： Lars Wortmann , Arwed Cleve , Bernd Menzenbach , Hans-Peter Muhn , Gernot Langer , Anna Schrey , Ronald Kuehne , Marcu Koppitz , Dirk Kosemund
IPC分类号： A61K31/551 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/405 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D209/16 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/14
摘要： The present patent application relates to acyltryptophanols of the general formula I, in which Q, X, Y, W, R1, R2, R3, R4, R5, R8 have the meanings stated in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.
摘要翻译：本发明涉及通式I的酰基色氨酸，其中Q，X，Y，W，R 1，R 2，R 3，R 4，R 5，R 8具有说明书中所述的含义。根据本发明的化合物是有效的FSH拮抗剂，可用于例如男性或女性的生育控制，或用于预防和/或治疗骨质疏松症。

6. 发明授权

US07071344B1 Vitamin D derivatives with cyclopropyl rings in the lateral chains, a method and intermediate products for the production thereof and the utilization thereof for producing medicaments 失效
标题翻译：在侧链中具有环丙基环的维生素D衍生物，用于制备其的方法和中间产物及其用于生产药物的用途
公开(公告)号：US07071344B1
公开(公告)日：2006-07-04
申请号：US09509934
申请日：1998-09-29
申请人： Andreas Steinmeyer , Gunter Neef , Gerald Kirsch , Katica Schwarz , Herbert Wiesinger , Martin Haberey , Marianne Fahnrich , Gernot Langer
发明人： Andreas Steinmeyer , Gunter Neef , Gerald Kirsch , Katica Schwarz , Herbert Wiesinger , Martin Haberey , Marianne Fahnrich , Gernot Langer
IPC分类号： C07J41/00 , A61K31/59
CPC分类号： C07C401/00 , A61K31/59 , A61K38/13 , A61K39/395 , A61K31/445 , A61K31/435 , A61K2300/00
摘要： The invention relates to novel vitamin D derivatives of general formula (I), a method for the production thereof, intermediate products of the method and the utilization of vitamin D derivatives for producing medicaments.
摘要翻译：本发明涉及通式（I）的新型维生素D衍生物，其制备方法，该方法的中间产物和用于生产药物的维生素D衍生物的利用。

7. 发明申请

US20080125435A1 1-(Het)aryl-3-[hetaryl-piperidin-4-yl]-thioureas as modulators of the EP2 receptor 审中-公开
标题翻译：作为EP2受体的调节剂的1-（Het）芳基-3- [叔丁基 - 哌啶-4-基] - 硫脲
公开(公告)号：US20080125435A1
公开(公告)日：2008-05-29
申请号：US11896924
申请日：2007-09-06
申请人： Nico Brauer , Bernd Buchmann , Christoph Huwe , Marcus Koppitz , Antonius Ter Laak , Gernot Langer , Bernhard Lindenthal , Olaf Peters , Tim Wintermantel
发明人： Nico Brauer , Bernd Buchmann , Christoph Huwe , Marcus Koppitz , Antonius Ter Laak , Gernot Langer , Bernhard Lindenthal , Olaf Peters , Tim Wintermantel
IPC分类号： A61K31/502 , C07D401/04 , A61K31/517 , A61P15/00 , A61P19/10 , A61P35/04 , A61P31/00 , A61K31/473
CPC分类号： C07D401/04
摘要： The present invention relates to aryl-3-[(het)aryl-piperidin-4-yl]-thioureas, processes for the production thereof and the use thereof for the production of pharmaceutical agents for the treatment of diseases and indications which are connected with the EP2 receptor.
摘要翻译：本发明涉及芳基-3 - [（het）芳基 - 哌啶-4-基] - 硫脲，其制备方法及其用于生产用于治疗与 EP2受体。

8. 发明申请

US20080004268A1 INHIBITORS OF SOLUBLE ADENYLATE CYCLASE 审中-公开
标题翻译：可溶性丙烯酸环化酶的抑制剂
公开(公告)号：US20080004268A1
公开(公告)日：2008-01-03
申请号：US11835164
申请日：2007-08-07
申请人： Duy NGUYEN , Anne MENGEL , Martin FRITSCH , Gernot LANGER , Ulf BOEMER , Knut EIS , Bernd MENZENBACH , Bernd BUCHMANN , Seock-Kyu KHIM
发明人： Duy NGUYEN , Anne MENGEL , Martin FRITSCH , Gernot LANGER , Ulf BOEMER , Knut EIS , Bernd MENZENBACH , Bernd BUCHMANN , Seock-Kyu KHIM
IPC分类号： A61K31/5377 , A61K31/454 , A61K31/405 , C07D413/02 , C07D405/02 , C07D403/02
CPC分类号： C07D209/40 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D411/12 , C07D413/12 , C07D413/14
摘要： The invention relates to compounds of general formula I as well as their production and use as a medication.
摘要翻译：本发明涉及通式I的化合物及其作为药物的生产和用途。

9. 发明申请

US20050227951A1 Verification of translation 审中-公开
标题翻译：验证翻译
公开(公告)号：US20050227951A1
公开(公告)日：2005-10-13
申请号：US11141060
申请日：2005-06-01
申请人： Andreas Steinmeyer , Gunter Neef , Gerald Kirsch , Katica Schwarz , Herbert Wiesinger , Martin Haberey , Marianne Fahnrich , Gernot Langer
发明人： Andreas Steinmeyer , Gunter Neef , Gerald Kirsch , Katica Schwarz , Herbert Wiesinger , Martin Haberey , Marianne Fahnrich , Gernot Langer
IPC分类号： C07D317/20 , A61K31/59 , A61K31/593 , A61K38/13 , A61K39/395 , A61P3/02 , A61P3/10 , A61P3/14 , A61P9/10 , A61P11/06 , A61P15/16 , A61P15/18 , A61P17/04 , A61P17/14 , A61P19/02 , A61P19/08 , A61P19/10 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/04 , C07C47/293 , C07C401/00 , C07D317/26 , C07D319/06
CPC分类号： C07C401/00 , A61K31/59 , A61K38/13 , A61K39/395 , A61K31/445 , A61K31/435 , A61K2300/00
摘要： The invention relates to new vitamin D derivatives of general formula (I), process for their production, intermediate products of the process as well as the use for production of pharmaceutical agents.
摘要翻译：本发明涉及通式（I）的新维生素D衍生物，其生产方法，该方法的中间产物以及制药用途的用途。

10. 发明申请

US20100029599A1 Indolylamides as modulators of the EP2 receptor 审中-公开
标题翻译：吲哚酰胺作为EP2受体的调节剂
公开(公告)号：US20100029599A1
公开(公告)日：2010-02-04
申请号：US12511335
申请日：2009-07-29
申请人： Marcus Koppitz , Antonius Ter Laak , Tim Wintermantel , Bernhard Lindenthal , Nico Bräuer , Gernot Langer , Bernd Buchmann
发明人： Marcus Koppitz , Antonius Ter Laak , Tim Wintermantel , Bernhard Lindenthal , Nico Bräuer , Gernot Langer , Bernd Buchmann
IPC分类号： C07D209/02 , A61K31/60 , A61K31/192 , A61K31/405 , A61K31/5415 , A61K31/415 , A61K31/365 , A61P29/00 , A61K31/444 , A61P35/04 , A61P9/10 , A61P13/12 , A61P1/00 , A61P25/28 , A61P19/10 , A61P15/00
CPC分类号： C07D209/42 , C07D403/14
摘要： The present invention relates to indolylamide derivatives of the general formula (I), to processes for preparation thereof and to use thereof for production of pharmaceutical compositions for treatment of disorders and indications associated with the EP2 receptor.
摘要翻译：本发明涉及通式（I）的吲哚酰胺衍生物，其制备方法及其用于制备用于治疗与EP2受体相关的病症和适应症的药物组合物。

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