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1. 发明授权

US09206206B2 Oxidized lipid compounds and uses thereof 有权
标题翻译：氧化脂质化合物及其用途
公开(公告)号：US09206206B2
公开(公告)日：2015-12-08
申请号：US13127717
申请日：2009-11-05
申请人： Eti Kovalevski-Ishai , Zeev Ziniuk , Gideon Halperin , Itzhak Mendel , Erez Feige , Niva Yacov , Eyal Breitbart
发明人： Eti Kovalevski-Ishai , Zeev Ziniuk , Gideon Halperin , Itzhak Mendel , Erez Feige , Niva Yacov , Eyal Breitbart
IPC分类号： C07C59/125 , C07C59/10 , A61K31/685 , A61K31/683 , A61K31/66 , C07F9/09 , C07F9/10
CPC分类号： C07F9/091 , C07C59/125 , C07F9/106
摘要： Novel oxidized lipids are provided herein, as well as methods for producing same, and uses thereof in treating or preventing an inflammation associated with endogenous oxidized lipids and related conditions.
摘要翻译：本文提供了新的氧化脂质，以及其生产方法及其在治疗或预防与内源性氧化脂质和相关病症相关的炎症中的用途。

2. 发明授权

US08563534B2 Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis 有权
公开(公告)号：US08563534B2
公开(公告)日：2013-10-22
申请号：US13431262
申请日：2012-03-27
申请人： Dror Harats , Jacob George , Gideon Halperin , Niva Yacov , Eti Kovalevski-Ishai
发明人： Dror Harats , Jacob George , Gideon Halperin , Niva Yacov , Eti Kovalevski-Ishai
IPC分类号： A61K31/66
CPC分类号： C07F9/106 , A61K31/075 , A61K31/08 , A61K31/11 , A61K31/19 , A61K31/20 , A61K31/215 , A61K31/225 , A61K31/24 , A61K31/685 , C07C43/13 , C07C43/1785 , C07C43/1787 , C07F9/10 , Y02A50/411 , Y02A50/414
摘要： Novel synthetic forms of etherified oxidized phospholipids and methods of utilizing same for preventing and treating atherosclerosis and other related disorders, as well as inflammatory disorders, immune mediated diseases, autoimmune diseases and proliferative disorders, are provided. In addition, methods of synthesizing etherified and esterified oxidized phospholipids and of using same for preventing and treating atherosclerosis and other related disorders are also provided.

3. 发明申请

US20130079540A1 High-Purity Phospholipids 有权
标题翻译：高纯磷脂
公开(公告)号：US20130079540A1
公开(公告)日：2013-03-28
申请号：US13672811
申请日：2012-11-09
申请人： Gideon HALPERIN , Eti Kovalevski-Ishai
发明人： Gideon HALPERIN , Eti Kovalevski-Ishai
IPC分类号： C07F9/09
CPC分类号： C07F9/106 , C07F9/103
摘要： Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorus-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby. Further disclosed is substantially pure 1-hexadecyl-2-(4′-carboxy)butyl-sn-glycero-3-phosphocholine (CI-201).
摘要翻译：公开了高度适用于治疗有益的氧化磷脂的工业制备的新型合成路线。特别地，公开了用于有效制备具有连接到甘油主链上的甘油主链和一个或多个氧化部分的化合物的新方法，其没有进行柱层析。进一步公开的是将含磷部分如磷酸酯部分引入具有甘油主链的化合物和由此形成的中间体的新方法。进一步公开的是基本上纯的1-十六烷基-2-（4'-羧基）丁基-sn-甘油基-3-磷酸胆碱（CI-201）。

4. 发明授权

US08158611B2 Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis 有权
标题翻译：使用含有限定氧化磷脂的组合物用于预防和治疗动脉粥样硬化
公开(公告)号：US08158611B2
公开(公告)日：2012-04-17
申请号：US12985365
申请日：2011-01-06
申请人： Dror Harats , Jacob George , Gideon Halperin , Niva Yacov , Eti Kovalevski-Ishai
发明人： Dror Harats , Jacob George , Gideon Halperin , Niva Yacov , Eti Kovalevski-Ishai
IPC分类号： A61K31/66 , C07C229/00
CPC分类号： C07F9/106 , A61K31/075 , A61K31/08 , A61K31/11 , A61K31/19 , A61K31/20 , A61K31/215 , A61K31/225 , A61K31/24 , A61K31/685 , C07C43/13 , C07C43/1785 , C07C43/1787 , C07F9/10 , Y02A50/411 , Y02A50/414
摘要： Novel synthetic forms of etherified oxidized phospholipids and methods of utilizing same for preventing and treating atherosclerosis and other related disorders, as well as inflammatory disorders, immune mediated diseases, autoimmune diseases and proliferative disorders, are provided. In addition, methods of synthesizing etherified and esterified oxidized phospholipids and of using same for preventing and treating atherosclerosis and other related disorders are also provided.
摘要翻译：提供了醚化氧化磷脂的新型合成形式及其用于预防和治疗动脉粥样硬化和其它相关病症的方法，以及炎性疾病，免疫介导的疾病，自身免疫性疾病和增殖性疾病。此外，还提供了合成醚化和酯化的氧化磷脂的方法以及用于预防和治疗动脉粥样硬化等相关疾病的方法。

5. 发明授权

US06838452B2 Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis 有权
公开(公告)号：US06838452B2
公开(公告)日：2005-01-04
申请号：US10445347
申请日：2003-05-27
申请人： Dror Harats , Jacob George , Gideon Halperin
发明人： Dror Harats , Jacob George , Gideon Halperin
IPC分类号： A61K31/075 , A61K31/08 , A61K31/11 , A61K31/19 , A61K31/20 , A61K31/215 , A61K31/225 , A61K31/24 , A61K31/685 , A61P9/00 , C07C43/13 , C07C43/178 , C07F9/10 , A61K31/66 , C07F9/02
CPC分类号： C07F9/106 , A61K31/075 , A61K31/08 , A61K31/11 , A61K31/19 , A61K31/20 , A61K31/215 , A61K31/225 , A61K31/24 , A61K31/685 , C07C43/13 , C07C43/1785 , C07C43/1787 , C07F9/10 , Y02A50/411 , Y02A50/414
摘要： Novel synthetic forms of etherified oxidized phospholipids and methods of utilizing same for preventing and treating atherosclerosis and other related disorders, as well as inflammatory disorders, immune mediated diseases, autoimmune diseases and proliferative disorders, are provided. In addition, methods of synthesizing etherified and esterified oxidized phospholipids and of using same for preventing and treating atherosclerosis and other related disorders are also provided.

6. 发明授权

US08999960B2 Oxidized thiophospholipid compounds and uses thereof 有权
标题翻译：氧化硫代磷脂化合物及其用途
公开(公告)号：US08999960B2
公开(公告)日：2015-04-07
申请号：US13122766
申请日：2009-10-01
申请人： Eyal Breitbart , Eti Kovalevski-Ishai , Erez Feige , Itzhak Mendel , Zeev Ziniuk , Gideon Halperin
发明人： Eyal Breitbart , Eti Kovalevski-Ishai , Erez Feige , Itzhak Mendel , Zeev Ziniuk , Gideon Halperin
IPC分类号： C07F9/10 , C07F9/165 , A61K31/661 , A61P37/06
CPC分类号： C07F9/10
摘要： Novel oxidized thiophospholipids are provided herein, as well as methods for producing same, and uses thereof in treating or preventing an inflammation associated with endogenous oxidized lipids and related conditions. Exemplary oxidized thiophospholipid according to embodiments described herein have the formula: wherein X1, X2, A1, A2, B′, B″, D′ and D″ are as described herein.
摘要翻译：本文提供了新的氧化型硫代磷脂，以及其生产方法及其用于治疗或预防与内源性氧化脂质和相关病症相关的炎症的用途。根据本文所述实施方案的示例性氧化硫磷脂具有下式：其中X1，X2，A1，A2，B'，B“，D'和D”如本文所述。

7. 发明申请

US20110195937A1 OXIDIZED THIOPHOSPHOLIPID COMPOUNDS AND USES THEREOF 有权
标题翻译：氧化的硫代磷脂化合物及其用途
公开(公告)号：US20110195937A1
公开(公告)日：2011-08-11
申请号：US13122766
申请日：2009-10-01
申请人： Eyal Breitbar , Eti Kovalevski-Ishai , Erez Feige , Itzhak Mendel , Zeev Ziniuk , Gideon Halperin
发明人： Eyal Breitbar , Eti Kovalevski-Ishai , Erez Feige , Itzhak Mendel , Zeev Ziniuk , Gideon Halperin
IPC分类号： A61K31/661 , C07F9/165 , A61P37/06
CPC分类号： C07F9/10
摘要： Novel oxidized thiophospholipids are provided herein, as well as methods for producing same, and uses thereof in treating or preventing an inflammation associated with endogenous oxidized lipids and related conditions. Exemplary oxidized thiophospholipid according to embodiments described herein have the formula: wherein X1, X2, A1, A2, B′, B″, D′ and D″ are as described herein.
摘要翻译：本文提供了新的氧化型硫代磷脂，以及其生产方法及其用于治疗或预防与内源性氧化脂质和相关病症相关的炎症的用途。根据本文所述实施方案的示例性氧化硫磷脂具有下式：其中X1，X2，A1，A2，B'，B“，D'和D”如本文所述。

8. 发明授权

US07973023B2 Oxidized lipids and uses thereof in the treatment of inflammatory diseases and disorders 有权
标题翻译：氧化脂质及其在治疗炎性疾病和病症中的用途
公开(公告)号：US07973023B2
公开(公告)日：2011-07-05
申请号：US12588371
申请日：2009-10-14
申请人： Dror Harats , Jacob George , Gideon Halperin , Itzhak Mendel , Niva Yacov , Eti Kovalevski-Ishai
发明人： Dror Harats , Jacob George , Gideon Halperin , Itzhak Mendel , Niva Yacov , Eti Kovalevski-Ishai
IPC分类号： A61K31/66
CPC分类号： C07F9/106 , A61K31/075 , A61K31/08 , A61K31/11 , A61K31/19 , A61K31/20 , A61K31/215 , A61K31/225 , A61K31/24 , A61K31/685 , C07C43/13 , C07C43/1785 , C07C43/1787 , C07F9/10 , Y02A50/411 , Y02A50/414
摘要： Novel synthetic oxidized lipids and methods utilizing oxidized lipids for treating and preventing an inflammation associated with an endogenous oxidized lipid are provided.
摘要翻译：提供新型合成氧化脂质和利用氧化脂质治疗和预防与内源性氧化脂质相关的炎症的方法。

9. 发明申请

US20110097350A1 METHODS EMPLOYING AND COMPOSITIONS CONTAINING DEFINED OXIDIZED PHOSPHOLIPIDS FOR PREVENTION AND TREATMENT OF ATHEROSCLEROSIS 有权
标题翻译：含有定义氧化磷脂的方法和组合物用于预防和治疗甲状腺功能亢进
公开(公告)号：US20110097350A1
公开(公告)日：2011-04-28
申请号：US12985365
申请日：2011-01-06
申请人： Dror HARATS , Jacob George , Gideon Halperin , Niva Yacov , Eti Kovalevski-Ishai
发明人： Dror HARATS , Jacob George , Gideon Halperin , Niva Yacov , Eti Kovalevski-Ishai
IPC分类号： A61K39/00 , C07F9/09 , A61K31/66 , A61K38/18 , A61P29/00 , A61P19/02 , A61P37/02 , A61P9/00
CPC分类号： C07F9/106 , A61K31/075 , A61K31/08 , A61K31/11 , A61K31/19 , A61K31/20 , A61K31/215 , A61K31/225 , A61K31/24 , A61K31/685 , C07C43/13 , C07C43/1785 , C07C43/1787 , C07F9/10 , Y02A50/411 , Y02A50/414
摘要： Novel synthetic forms of etherified oxidized phospholipids and methods of utilizing same for preventing and treating atherosclerosis and other related disorders, as well as inflammatory disorders, immune mediated diseases, autoimmune diseases and proliferative disorders, are provided. In addition, methods of synthesizing etherified and esterified oxidized phospholipids and of using same for preventing and treating atherosclerosis and other related disorders are also provided.
摘要翻译：提供了醚化氧化磷脂的新型合成形式及其用于预防和治疗动脉粥样硬化和其它相关病症的方法，以及炎性疾病，免疫介导的疾病，自身免疫性疾病和增殖性疾病。此外，还提供了合成醚化和酯化的氧化磷脂的方法以及用于预防和治疗动脉粥样硬化等相关疾病的方法。

10. 发明申请

US20120329757A1 Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis 有权
公开(公告)号：US20120329757A1
公开(公告)日：2012-12-27
申请号：US13431262
申请日：2012-03-27
申请人： Dror HARATS , Jacob George , Gideon Halperin , Niva Yacov , Eti Kovalevski-Ishai
发明人： Dror HARATS , Jacob George , Gideon Halperin , Niva Yacov , Eti Kovalevski-Ishai
IPC分类号： A61K31/685 , A61P9/10 , C07F9/09 , A61P35/00 , A61P1/00 , A61P29/00 , A61P19/02 , A61P9/00
CPC分类号： C07F9/106 , A61K31/075 , A61K31/08 , A61K31/11 , A61K31/19 , A61K31/20 , A61K31/215 , A61K31/225 , A61K31/24 , A61K31/685 , C07C43/13 , C07C43/1785 , C07C43/1787 , C07F9/10 , Y02A50/411 , Y02A50/414
摘要： Novel synthetic forms of etherified oxidized phospholipids and methods of utilizing same for preventing and treating atherosclerosis and other related disorders, as well as inflammatory disorders, immune mediated diseases, autoimmune diseases and proliferative disorders, are provided. In addition, methods of synthesizing etherified and esterified oxidized phospholipids and of using same for preventing and treating atherosclerosis and other related disorders are also provided.

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