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1. 发明申请

US20200166511A1 BETARETROVIRUS EPITOPES AND RELATED METHODS OF USE 审中-公开
公开(公告)号：US20200166511A1
公开(公告)日：2020-05-28
申请号：US16681494
申请日：2019-11-12
申请人： Andrew L. Mason , Mandana Rahbari , Guangzhi Zhang
发明人： Andrew L. Mason , Mandana Rahbari , Guangzhi Zhang
IPC分类号： G01N33/574 , G01N33/68 , A61K35/17 , C07K14/195
摘要： Methods for determination of risk, previous history and/or presence of a betaretrovirus infection in a subject are described herein. Said methods may comprise incubating a biological sample from the subject, the biological sample comprising immune effector-producing cells, with one or more betaretrovirus-specific epitopes, the betaretrovirus-specific epitopes comprising at least 7 contiguous amino acids according to any one of SEQ ID Nos. 1-36, and measuring the production of immune effectors by the immune effector-producing cells, wherein production of the immune effectors by the immune effector-producing cells determines risk and/or presence of betaretrovirus infection in the subject. Isolated peptides and kits for carrying out the methods are also described.

2. 发明申请

US20070127539A1 Narrow band laser with wavelength stability 审中-公开
标题翻译：窄带激光器具有波长稳定性
公开(公告)号：US20070127539A1
公开(公告)日：2007-06-07
申请号：US11238337
申请日：2005-09-28
申请人： Weizhi Wang , Guangzhi Zhang , Lam Le
发明人： Weizhi Wang , Guangzhi Zhang , Lam Le
IPC分类号： H01S3/08
CPC分类号： H01S5/141 , H01S3/08059 , H01S3/1062 , H01S5/02208 , H01S5/02248 , H01S5/02415 , H01S5/02438 , H01S5/06837
摘要： An external cavity diode laser system includes a thin film filter. The output facet of the laser diode is coated with a partial reflection coating and the cavity side facet is coated with an anti-reflection coating. A roof-top prism or corner cube retroreflector serves as the laser cavity end reflector and provides stability of the wavelength of the output over time. The laser cavity lies between the partial reflective coated facet of the laser diode and retroreflector. A collimating lens and a thin film filter are located between the end reflector and the laser diode cavity side facet. The lasing wavelength can be adjusted during either manufacture or operation by tilting the filter. Also included is thermal compensation in the mounting for the retroreflector to compensate for thermal movement of the laser system cavity.
摘要翻译：外腔二极管激光系统包括薄膜滤光片。激光二极管的输出面涂覆有部分反射涂层，腔体侧面涂有抗反射涂层。屋顶棱镜或角立方后视反射器用作激光腔端反射器，并且随时间提供输出波长的稳定性。激光腔位于激光二极管的部分反射涂层面和反射镜之间。准直透镜和薄膜滤光器位于端反射器和激光二极管腔侧面之间。激光波长可以在制造过程中通过倾斜过滤器进行操作。还包括用于后向反射器的安装中的热补偿以补偿激光系统腔的热运动。

3. 发明申请

US20050243875A1 Piezoelectric-tuned external cavity laser 有权
标题翻译：压电调谐外腔激光器
公开(公告)号：US20050243875A1
公开(公告)日：2005-11-03
申请号：US11011461
申请日：2004-12-13
申请人： Lam Le , Wade Tang , Guangzhi Zhang
发明人： Lam Le , Wade Tang , Guangzhi Zhang
IPC分类号： H01S3/10 , H01S5/02 , H01S5/022
CPC分类号： H01S5/143 , H01S5/02248
摘要： A tunable laser comprising: a foundation including a first side and an oppositely facing second side and including a hole extending from the first side to the second side; a tuning assembly including a base, a fine tuning arm and a rotational flex bearing disposed adjacent the first side of the foundation; wherein the base is disposed adjacent to the first side of the foundation; wherein one end of the flex bearing is secured to the base; wherein the other end of the flex bearing is secured to the fine tuning arm; wherein a portion of the fine tuning arm extends at least partially into the hole; an external cavity laser including a gain medium, a dispersion medium and a reflective member disposed adjacent to the second side of the foundation; wherein the gain medium and the dispersion medium grating are secured in a fixed relation relative to the each other; wherein the reflective member is secured to the portion of the arm extending into the hole; and a piezoelectric device with one end secured to the base and another end secured to the arm.
摘要翻译： 1.一种可调激光器，包括：基座，包括第一侧面和相对面对的第二侧面，并且包括从所述第一侧向所述第二侧面延伸的孔; 调谐组件，包括基座，微调臂和邻近基座的第一侧设置的旋转柔性轴承; 其中所述基座邻近所述基础的第一侧设置; 其中所述挠性轴承的一端固定到所述基座; 其中所述柔性轴承的另一端固定到所述微调臂; 其中所述微调臂的一部分至少部分地延伸到所述孔中; 包括增益介质的外腔激光器，分散介质和邻近所述基底的第二侧设置的反射构件; 其中所述增益介质和所述分散介质光栅相对于彼此以固定关系固定; 其中所述反射构件固定到延伸到所述孔中的所述臂的所述部分; 以及压电装置，其一端固定到基座，另一端固定到臂上。

4. 发明授权

US11635434B2 Betaretrovirus epitopes and related methods of use 有权
公开(公告)号：US11635434B2
公开(公告)日：2023-04-25
申请号：US16681494
申请日：2019-11-12
申请人： Andrew L. Mason , Mandana Rahbari , Guangzhi Zhang
发明人： Andrew L. Mason , Mandana Rahbari , Guangzhi Zhang
IPC分类号： G01N33/574 , A61K35/17 , G01N33/68 , A61K45/06 , C07K14/195 , A61K38/00
摘要： Methods for determination of risk, previous history and/or presence of a betaretrovirus infection in a subject are described herein. Said methods may comprise incubating a biological sample from the subject, the biological sample comprising immune effector-producing cells, with one or more betaretrovirus-specific epitopes, the betaretrovirus-specific epitopes comprising at least 7 contiguous amino acids according to any one of SEQ ID Nos. 1-36, and measuring the production of immune effectors by the immune effector-producing cells, wherein production of the immune effectors by the immune effector-producing cells determines risk and/or presence of betaretrovirus infection in the subject. Isolated peptides and kits for carrying out the methods are also described.

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