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1. 发明申请

US20200166511A1 BETARETROVIRUS EPITOPES AND RELATED METHODS OF USE 审中-公开
公开(公告)号：US20200166511A1
公开(公告)日：2020-05-28
申请号：US16681494
申请日：2019-11-12
申请人： Andrew L. Mason , Mandana Rahbari , Guangzhi Zhang
发明人： Andrew L. Mason , Mandana Rahbari , Guangzhi Zhang
IPC分类号： G01N33/574 , G01N33/68 , A61K35/17 , C07K14/195
摘要： Methods for determination of risk, previous history and/or presence of a betaretrovirus infection in a subject are described herein. Said methods may comprise incubating a biological sample from the subject, the biological sample comprising immune effector-producing cells, with one or more betaretrovirus-specific epitopes, the betaretrovirus-specific epitopes comprising at least 7 contiguous amino acids according to any one of SEQ ID Nos. 1-36, and measuring the production of immune effectors by the immune effector-producing cells, wherein production of the immune effectors by the immune effector-producing cells determines risk and/or presence of betaretrovirus infection in the subject. Isolated peptides and kits for carrying out the methods are also described.

2. 发明授权

US11635434B2 Betaretrovirus epitopes and related methods of use 有权
公开(公告)号：US11635434B2
公开(公告)日：2023-04-25
申请号：US16681494
申请日：2019-11-12
申请人： Andrew L. Mason , Mandana Rahbari , Guangzhi Zhang
发明人： Andrew L. Mason , Mandana Rahbari , Guangzhi Zhang
IPC分类号： G01N33/574 , A61K35/17 , G01N33/68 , A61K45/06 , C07K14/195 , A61K38/00
摘要： Methods for determination of risk, previous history and/or presence of a betaretrovirus infection in a subject are described herein. Said methods may comprise incubating a biological sample from the subject, the biological sample comprising immune effector-producing cells, with one or more betaretrovirus-specific epitopes, the betaretrovirus-specific epitopes comprising at least 7 contiguous amino acids according to any one of SEQ ID Nos. 1-36, and measuring the production of immune effectors by the immune effector-producing cells, wherein production of the immune effectors by the immune effector-producing cells determines risk and/or presence of betaretrovirus infection in the subject. Isolated peptides and kits for carrying out the methods are also described.

3. 发明授权

US06787303B1 Identification of a novel retrovirus associated with primary sclerosing cholangitis and autoimmune hepatitis 失效
标题翻译：鉴定与原发性硬化性胆管炎和自身免疫性肝炎相关的新型逆转录病毒
公开(公告)号：US06787303B1
公开(公告)日：2004-09-07
申请号：US09536552
申请日：2000-03-28
申请人： Andrew L. Mason , Lizhe Xu , Linsheng Guo
发明人： Andrew L. Mason , Lizhe Xu , Linsheng Guo
IPC分类号： C12Q170
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/13022 , C12Q1/702
摘要： The present invention relates first, to the identification of a retrovirus and the novel nucleotide sequences encoding a retroviral polymerase gene (POL nucleotides) associated with the existence of primary sclerosing cholangitis (PSC), autoimmune hepatitis (AIH) Crohn's disease and ulcerative colitis. The present invention further relates to methods for using the PSC associated retroviral nucleotides for the detection of PSC, AIH, Crohn's disease and ulcerative colitis in patient samples. The present invention also relates to methods for using and targeting the PSC associated retroviral POL nucleotides in gene therapy protocols for the treatment of PSC, AIH, Crohn's disease or ulcerative disease in patients in need of such treatment. The present invention further relates to diagnostic protocols and kits for the detection of PSC, AIH, Crohn's disease and ulcerative colitis in tissue samples.
摘要翻译：本发明首先涉及逆转录病毒的鉴定和编码与原发性硬化性胆管炎（PSC），自身免疫性肝炎（AIH）克罗恩病和溃疡性结肠炎存在相关的逆转录病毒聚合酶基因（POL核苷酸）的新型核苷酸序列。本发明还涉及在患者样品中使用PSC相关逆转录病毒核苷酸检测PSC，AIH，克罗恩病和溃疡性结肠炎的方法。本发明还涉及在需要这种治疗的患者中用于治疗PSC，AIH，克罗恩病或溃疡性疾病的基因治疗方案中使用和靶向PSC相关逆转录病毒POL核苷酸的方法。本发明还涉及组织样品中用于检测PSC，AIH，克罗恩病和溃疡性结肠炎的诊断方案和试剂盒。

4. 发明授权

US06468737B1 Identification of a novel retrovirus associated with primary biliary cirrhosis and autoimmune disorders 有权
标题翻译：鉴定与原发性胆汁性肝硬化和自身免疫性疾病相关的新型逆转录病毒
公开(公告)号：US06468737B1
公开(公告)日：2002-10-22
申请号：US09585651
申请日：2000-06-01
申请人： Andrew L. Mason , Lizhe Xu , James Neuberger
发明人： Andrew L. Mason , Lizhe Xu , James Neuberger
IPC分类号： C12Q170
CPC分类号： C07K14/005 , A61K39/00 , C12N7/00 , C12N2740/10022 , C12N2740/12021 , C12N2740/12022 , C12Q1/702
摘要： The present invention relates, first, to the discovery, identification, and characterization of novel nucleic acid molecules, that are associated with PBC, Sjögren's syndrome, scleroderma, SLE, autoimmune thyroiditis and various other connective tissue disorders. The novel nucleotide sequences of the present invention are retroviral in origin and are indicative of a PBC retrovirus which bears a strong correlation with PBC. The present invention is based, in part, on the Applicant's data which is the first evidence to suggest that PBC patient's tissue may harbor a transmissible agent. The association of a retroviral infectious agent with PBC was first demonstrated by Applicants in vitro by co-culture of periportal lymph nodes derived from patients at time of transplantation and healthy biliary epithelium cells. The Applicant's discoveries as described herein, report the characterization of PBC-associated infectious agent as retroviral as demonstrated by electron microscopy and immunoblot reactivity. In addition, Applicants have characterized novel nucleotide sequences which are associated with the PBC-associated retrovirus.
摘要翻译：本发明首先涉及与PBC，Sjögren综合征，硬皮病，SLE，自身免疫性甲状腺炎和各种其他结缔组织疾病相关的新型核酸分子的发现，鉴定和表征。本发明的新型核苷酸序列是来源于逆转录病毒的病毒，表示与PBC具有强相关性的PBC逆转录病毒。本发明部分地基于申请人的数据，该数据是建议PBC患者组织可能携带可传染药剂的第一证据。逆转录病毒感染剂与PBC的关联首先由申请人通过在移植时和患有健康胆道上皮细胞的患者的门静脉淋巴结共培养体外证明。如本文所述的申请人的发现报告了PBC相关传染原的表征作为逆转录病毒，如通过电子显微镜和免疫印迹反应性所证明的。此外，申请人已经表征了与PBC相关逆转录病毒相关的新型核苷酸序列。

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