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1. 发明申请

US20120077863A1 GUANIDINO-SUBSTITUTED BI-AND POLYPHENYLS AS SMALL MOLECULE CARRIERS 审中-公开
标题翻译：作为小分子载体的甘氨酸取代的双 - 聚双环
公开(公告)号：US20120077863A1
公开(公告)日：2012-03-29
申请号：US13203667
申请日：2010-03-01
申请人： David Selwood , Roberta Worthington , Anne-Sophie Rebstock , Michela Simone , Matt Gooding , Henry Dube , Kai Stoeber , Slavica Tudzarova , Christoffer Boshoff , Gareth Williams , Sarah Kingsbury , Dimitrios Lagos , Juan Manuel Funes Quesada
发明人： David Selwood , Roberta Worthington , Anne-Sophie Rebstock , Michela Simone , Matt Gooding , Henry Dube , Kai Stoeber , Slavica Tudzarova , Christoffer Boshoff , Gareth Williams , Sarah Kingsbury , Dimitrios Lagos , Juan Manuel Funes Quesada
IPC分类号： A61K31/713 , C12N5/071 , A61K31/155 , C07C279/08 , C07H21/02
CPC分类号： C07D277/18 , C07C279/08 , C07C279/24 , C07C323/60 , Y02P20/55
摘要： A compound of formula I, or a pharmaceutically acceptable salt thereof, wherein —X1, X2 and X3 are each independently where Y is an alkylene, alkenylene or alkynylene group, each of which may be optionally substituted with one or more substituents selected from alkyl, halo, CF3, OH, alkoxy, NH2, CN, NO2 and COOH; W is absent or is O, S or NH; R1, R2, R3 and R4 are each independently selected from H, alkyl, aryl and a protecting group Pi; R7, R8 and R9 are each independently selected from H, alkyl, halo, CF3, OH, alkoxy, CN, NO2 and COOH; —q is 1, 2, 3 or 4; q′ is 0, 1, 2 or 3, where q+q′ equals 4; p and r are each independently 1, 2, 3, 4 or 5; p′ and r′ are each independently 0, 1, 2, 3 or 4, where p+p′ and r+r′ each equal 5; and —n is 0, 1, 2, 3, 4, 5 or 6.
摘要翻译：式I化合物或其药学上可接受的盐，其中-X1，X2和X3各自独立地为Y为亚烷基，亚烯基或亚炔基，其各自可以任选地被一个或多个选自烷基，卤素，CF 3，OH，烷氧基，NH 2，CN，NO 2和COOH; W不存在或是O，S或NH; R1，R2，R3和R4各自独立地选自H，烷基，芳基和保护基团Pi; R 7，R 8和R 9各自独立地选自H，烷基，卤素，CF 3，OH，烷氧基，CN，NO 2和COOH; -q为1,2,3或4; q'为0,1,2或3，其中q + q'等于4; p和r各自独立地为1,2,3,4或5; p'和r'各自独立地为0,1,2,3或4，其中p + p'和r + r'各自等于5; 和-n是0，1，2，3，4，5或6。

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