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1. 发明申请

US20070132516A1 Control unit 失效
公开(公告)号：US20070132516A1
公开(公告)日：2007-06-14
申请号：US10575314
申请日：2004-07-22
申请人： Bernhard Mattes , Siegfried Malicki , Holger Lange , Klaus Ott
发明人： Bernhard Mattes , Siegfried Malicki , Holger Lange , Klaus Ott
IPC分类号： H03L7/00
CPC分类号： G05B19/0428 , G05B2219/24047 , G05B2219/24125 , G05B2219/2637
摘要： A control unit having an oscillator for a processor is described, the control unit storing a temporary absence of oscillation of the oscillator in a first error memory, if oscillation begins again after the absence.

2. 发明申请

US20120083386A1 DRIVE ARRANGEMENT FOR A HYBRID VEHICLE AND METHOD FOR OPERATING AN ELECTRIC ENGINE IN A HYBRID VEHICLE 审中-公开
标题翻译：混合动力车辆的驱动装置和混合动力汽车的电动发动机的运行方法
公开(公告)号：US20120083386A1
公开(公告)日：2012-04-05
申请号：US13250022
申请日：2011-09-30
申请人： HENNING VOGT , HOLGER LANGE , GEORG-FRIEDRICH LÜHRS , SASCHA LAUTERBACH , HARALD DECKER
发明人： HENNING VOGT , HOLGER LANGE , GEORG-FRIEDRICH LÜHRS , SASCHA LAUTERBACH , HARALD DECKER
IPC分类号： B60W20/00 , F16D13/58 , F16F15/30
CPC分类号： B60W20/15 , B60K6/40 , B60K6/48 , B60K2006/4825 , B60W20/00 , B60W30/20 , B60W2510/088 , Y02T10/6221 , Y02T10/6252 , Y10T477/26
摘要： A hybrid vehicle has an internal combustion engine and an electric engine. A drive arrangement for the vehicle has a crankshaft-side clutch part rigidly connected to a crankshaft of the internal combustion engine, and the crankshaft-side clutch part may be coupled to a drive train shaft-side clutch part via a clutch. The clutch part on the drive train shaft side is mechanically connected to a drive train shaft via at least one element for torsional vibration isolation. The drive train shaft is configured at least partially as a rotor of the electric engine. The crankshaft-side clutch part, the clutch and the drive train shaft-side clutch part form at least one part of the primary mass of a dual-mass flywheel. The drive train shaft forms at least one part of the secondary mass of the dual-mass flywheel.
摘要翻译：混合动力车辆具有内燃机和电动发动机。用于车辆的驱动装置具有刚性地连接到内燃机的曲轴的曲轴侧离合器部分，并且曲轴侧离合器部分可以经由离合器联接到传动系轴侧离合器部分。传动系轴侧的离合器部分经由用于扭转隔振的至少一个元件机械连接到传动系轴。传动系轴至少部分地配置为电动发动机的转子。曲轴侧离合器部分，离合器和传动系轴侧离合器部分形成双质量飞轮的主质量的至少一部分。传动系轴形成双质量飞轮的次级质量的至少一部分。

3. 发明授权

US07664300B2 Uterine cervical cancer computer-aided-diagnosis (CAD) 失效
标题翻译：子宫颈癌计算机辅助诊断（CAD）
公开(公告)号：US07664300B2
公开(公告)日：2010-02-16
申请号：US11184046
申请日：2005-02-03
申请人： Holger Lange , Rolf Holger Wolters
发明人： Holger Lange , Rolf Holger Wolters
IPC分类号： G06K9/00 , A61F6/14 , A61F6/06
CPC分类号： A61B5/0059 , A61B5/053 , A61B5/7264 , G06F19/00 , G06F19/321 , G06F19/324 , G06F19/3481 , G06T7/0012 , G06T7/30 , G06T2207/10016 , G06T2207/10024 , G06T2207/30004
摘要： Uterine cervical cancer Computer-Aided-Diagnosis (CAD) according to this invention consists of a core processing system that automatically analyses data acquired from the uterine cervix and provides tissue and patient diagnosis, as well as adequacy of the examination. The data can include, but is not limited to, color still images or video, reflectance and fluorescence multi-spectral or hyper-spectral imagery, coherent optical tomography imagery, and impedance measurements, taken with and without the use of contrast agents like 3-5% acetic acid, Lugol's iodine, or 5-aminolevulinic acid. The core processing system is based on an open, modular, and feature-based architecture, designed for multi-data, multi-sensor, and multi-feature fusion. The core processing system can be embedded in different CAD system realizations. For example: A CAD system for cervical cancer screening could in a very simple version consist of a hand-held device that only acquires one digital RGB image of the uterine cervix after application of 3-5% acetic acid and provides automatically a patient diagnosis. A CAD system used as a colposcopy adjunct could provide all functions that are related to colposcopy and that can be provided by a computer, from automation of the clinical workflow to automated patient diagnosis and treatment recommendation.
摘要翻译：根据本发明的子宫颈癌计算机辅助诊断（CAD）包括一个核心处理系统，其自动分析从子宫颈获得的数据，并提供组织和患者诊断以及检查的充分性。数据可以包括但不限于彩色静止图像或视频，反射率和荧光多光谱或超光谱图像，相干光学断层摄影图像和阻抗测量，在使用和不使用造影剂如3- 5％乙酸，Lugol碘或5-氨基乙酰丙酸。核心处理系统基于开放，模块化和基于特征的架构，专为多数据，多传感器和多功能融合而设计。核心处理系统可以嵌入到不同的CAD系统实现中。例如：用于宫颈癌筛查的CAD系统可以在非常简单的版本中由手持装置组成，其仅在施加3-5％乙酸后才获得子宫颈的一个数字RGB图像，并自动提供患者诊断。用作阴道镜附件的CAD系统可以提供与阴道镜相关的所有功能，并且可以由计算机提供从临床工作流程自动化到自动化患者诊断和治疗推荐的所有功能。

4. 发明申请

US20080240558A1 Method of automated image color calibration 失效
标题翻译：自动图像色彩校准方法
公开(公告)号：US20080240558A1
公开(公告)日：2008-10-02
申请号：US12077659
申请日：2008-03-19
申请人： Wenjing Li , Marcelo Soto-Thompson , Ulf Gustafsson , Holger Lange
发明人： Wenjing Li , Marcelo Soto-Thompson , Ulf Gustafsson , Holger Lange
IPC分类号： G06K9/00
CPC分类号： H04N1/6033 , H04N1/00045 , H04N1/401 , H04N1/6086
摘要： A method of automated image calibration that corrects for non-uniform illumination and calibrates color that is simple, fast, automated, accurate and reliable. A gray balance algorithm is applied to correct for non-uniform illumination and a color calibration algorithm is then applied to calibrate the human subject data. The system has been applied in multiple clinical sites with different instruments.
摘要翻译：一种自动图像校准方法，用于校正不均匀照明并校准简单，快速，自动，准确和可靠的颜色。应用灰度平衡算法来校正不均匀照明，然后应用颜色校准算法来校准人类受试者数据。该系统已应用于具有不同仪器的多个临床部位。

5. 发明申请

US20050111758A1 Systems and methods for registering reflectance and fluorescence hyperspectral imagery 失效
标题翻译：用于记录反射率和荧光高光谱图像的系统和方法
公开(公告)号：US20050111758A1
公开(公告)日：2005-05-26
申请号：US10895440
申请日：2003-08-15
申请人： Holger Lange , Ulf Gustafsson
发明人： Holger Lange , Ulf Gustafsson
IPC分类号： G06K9/00 , G06K9/32 , G06T7/00
CPC分类号： G06T7/33 , G06T2207/30004
摘要： The image registration systems and methods according to this invention register reflectance and fluorescence hyperspectral imagery and provide the spatial image transformation between the reflectance and fluorescence hyperspectral imagery. A reflectance image is embedded into the fluorescence hyperspectral imagery and thereby resolves the resemblance problem of reflectance and fluorescence hyperspectral imagery. The reflectance image is embedded into the fluorescence hyperspectral imagery using (1) light from a narrow-band source embedded in Ultraviolet (UV) excitation light, (2) second order diffracted light, and/or (3) Ultraviolet (UV) excitation light reflectance. Resembling reflectance images are calculated from the reflectance hyperspectral imagery and the embedded reflectance image in the fluorescence hyperspectral imagery. The two respective reflectance images are pre-processed to maximize the resemblance between them. Image registration algorithms use the two pre-processed reflectance images and calculate the spatial image transformation that allows to map the spatial coordinates from the reflectance to the fluorescence hyperspectral imagery (and vice versa).
摘要翻译：根据本发明的图像配准系统和方法记录反射率和荧光高光谱图像，并提供反射率和荧光高光谱图像之间的空间图像转换。反射图像被嵌入到荧光高光谱图像中，从而解决了反射和荧光高光谱图像的相似问题。使用（1）来自嵌入紫外（UV）激发光的窄带光源，（2）二次衍射光和/或（3）紫外（UV）激发光）的光，将反射率图像嵌入到荧光高光谱图像中反射率。从反射高光谱图和荧光高光谱图像中嵌入的反射率图像计算反射率图像。两个相应的反射率图像被预处理以最大化它们之间的相似性。图像配准算法使用两个预处理的反射图像，并计算允许将反射率的空间坐标映射到荧光高光谱图像（反之亦然）的空间图像变换。

6. 发明申请

US20150004630A1 CELL-BASED TISSUE ANALYSIS 有权
标题翻译：基于细胞的组织分析
公开(公告)号：US20150004630A1
公开(公告)日：2015-01-01
申请号：US13934237
申请日：2013-07-03
申请人： Holger Lange , Josheph Krueger , George Young D. , Trevor Johnson , Frank Voelker , Steven Potts
发明人： Holger Lange , Josheph Krueger , George Young D. , Trevor Johnson , Frank Voelker , Steven Potts
IPC分类号： G01N33/50
CPC分类号： G01N33/5005 , G01N15/1463 , G01N2015/1006 , G01N2035/00138 , G06K9/0014 , G06K9/00147 , G06T7/0012 , G06T2207/30024
摘要： Methods for cell-based tissue analysis utilize modern trends in digital microscopy to obtain, process, calibrate, and analyze digital images of tissue sections to quantify cell-based data for improved histological analysis. Using data from multiple images of a common tissue section, or data from images of multiple tissue sections, additional degrees of freedom are realized and the resulting analysis provides added depth to histological analysis of tissue samples. With computerized analytical methods, speed and accuracy of histological analysis is greatly improved.
摘要翻译：基于细胞的组织分析的方法利用数字显微镜中的现代趋势来获得，处理，校准和分析组织切片的数字图像，以量化基于细胞的数据以改善组织学分析。使用来自多个组织部分的多个图像的数据或来自多个组织切片图像的数据，实现了附加的自由度，并且所得到的分析为组织样本的组织学分析提供了附加的深度。采用电脑化分析方法，大大提高了组织学分析的速度和准确性。

7. 发明授权

US08027533B2 Method of automated image color calibration 失效
标题翻译：自动图像色彩校准方法
公开(公告)号：US08027533B2
公开(公告)日：2011-09-27
申请号：US12077659
申请日：2008-03-19
申请人： Wenjing Li , Marcelo Soto-Thompson , Ulf Gustafsson , Holger Lange
发明人： Wenjing Li , Marcelo Soto-Thompson , Ulf Gustafsson , Holger Lange
IPC分类号： G06K9/00
CPC分类号： H04N1/6033 , H04N1/00045 , H04N1/401 , H04N1/6086
摘要： A method of automated image calibration that corrects for non-uniform illumination and calibrates color that is simple, fast, automated, accurate and reliable. A gray balance algorithm is applied to correct for non-uniform illumination and a color calibration algorithm is then applied to calibrate the human subject data. The system has been applied in multiple clinical sites with different instruments.
摘要翻译：一种自动图像校准方法，用于校正不均匀照明并校准简单，快速，自动，准确和可靠的颜色。应用灰度平衡算法来校正不均匀照明，然后应用颜色校准算法来校准人类受试者数据。该系统已应用于具有不同仪器的多个临床部位。

8. 发明申请

US20090046905A1 Uterine cervical cancer computer-aided-diagnosis (CAD) 失效
标题翻译：子宫颈癌计算机辅助诊断（CAD）
公开(公告)号：US20090046905A1
公开(公告)日：2009-02-19
申请号：US11184046
申请日：2005-02-03
申请人： Holger Lange , Rolf Holger Wolters
发明人： Holger Lange , Rolf Holger Wolters
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/053 , A61B5/7264 , G06F19/00 , G06F19/321 , G06F19/324 , G06F19/3481 , G06T7/0012 , G06T7/30 , G06T2207/10016 , G06T2207/10024 , G06T2207/30004
摘要： Uterine cervical cancer Computer-Aided-Diagnosis (CAD) according to this invention consists of a core processing system that automatically analyses data acquired from the uterine cervix and provides tissue and patient diagnosis, as well as adequacy of the examination. The data can include, but is not limited to, color still images or video, reflectance and fluorescence multi-spectral or hyper-spectral imagery, coherent optical tomography imagery, and impedance measurements, taken with and without the use of contrast agents like 3-5% acetic acid, Lugol's iodine, or 5-aminolevulinic acid. The core processing system is based on an open, modular, and feature-based architecture, designed for multi-data, multi-sensor, and multi-feature fusion. The core processing system can be embedded in different CAD system realizations. For example: A CAD system for cervical cancer screening could in a very simple version consist of a hand-held device that only acquires one digital RGB image of the uterine cervix after application of 3-5% acetic acid and provides automatically a patient diagnosis. A CAD system used as a colposcopy adjunct could provide all functions that are related to colposcopy and that can be provided by a computer, from automation of the clinical workflow to automated patient diagnosis and treatment recommendation.
摘要翻译：根据本发明的子宫颈癌计算机辅助诊断（CAD）包括一个核心处理系统，其自动分析从子宫颈获得的数据，并提供组织和患者诊断以及检查的充分性。数据可以包括但不限于彩色静止图像或视频，反射率和荧光多光谱或超光谱图像，相干光学断层摄影图像和阻抗测量，在使用和不使用造影剂如3- 5％乙酸，Lugol碘或5-氨基乙酰丙酸。核心处理系统基于开放，模块化和基于特征的架构，专为多数据，多传感器和多功能融合而设计。核心处理系统可以嵌入到不同的CAD系统实现中。例如：用于宫颈癌筛查的CAD系统可以在非常简单的版本中由手持装置组成，其仅在施加3-5％乙酸后才获得子宫颈的一个数字RGB图像，并自动提供患者诊断。用作阴道镜附件的CAD系统可以提供与阴道镜相关的所有功能，并且可以由计算机提供从临床工作流程自动化到自动化患者诊断和治疗推荐的所有功能。

9. 发明授权

US07181055B2 Systems and methods for registering reflectance and fluorescence hyperspectral imagery 失效
标题翻译：用于记录反射率和荧光高光谱图像的系统和方法
公开(公告)号：US07181055B2
公开(公告)日：2007-02-20
申请号：US10895440
申请日：2003-08-15
申请人： Holger Lange , Ulf Peter Gustafsson
发明人： Holger Lange , Ulf Peter Gustafsson
IPC分类号： G06K9/00
CPC分类号： G06T7/33 , G06T2207/30004
摘要： The image registration systems and methods according to this invention register reflectance and fluorescence hyperspectral imagery and provide the spatial image transformation between the reflectance and fluorescence hyperspectral imagery. A reflectance image is embedded into the fluorescence hyperspectral imagery and thereby resolves the resemblance problem of reflectance and fluorescence hyperspectral imagery. The reflectance image is embedded into the fluorescence hyperspectral imagery using (1) light from a narrow-band source embedded in Ultraviolet (UV) excitation light, (2) second order diffracted light, and/or (3) Ultraviolet (UV) excitation light reflectance. Resembling reflectance images are calculated from the reflectance hyperspectral imagery and the embedded reflectance image in the fluorescence hyperspectral imagery. The two respective reflectance images are pre-processed to maximize the resemblance between them. Image registration algorithms use the two pre-processed reflectance images and calculate the spatial image transformation that allows to map the spatial coordinates from the reflectance to the fluorescence hyperspectral imagery (and vice versa).
摘要翻译：根据本发明的图像配准系统和方法记录反射率和荧光高光谱图像，并提供反射率和荧光高光谱图像之间的空间图像转换。反射图像被嵌入到荧光高光谱图像中，从而解决了反射和荧光高光谱图像的相似问题。使用（1）来自嵌入紫外（UV）激发光的窄带光源，（2）二次衍射光和/或（3）紫外（UV）激发光）的光，将反射率图像嵌入到荧光高光谱图像中反射率。从反射高光谱图和荧光高光谱图像中嵌入的反射率图像计算反射率图像。两个相应的反射率图像被预处理以最大化它们之间的相似性。图像配准算法使用两个预处理的反射图像，并计算允许将反射率的空间坐标映射到荧光高光谱图像（反之亦然）的空间图像变换。

10. 发明授权

US06304161B1 Electromagnetic actuator, particularly for driving an engine valve 失效
标题翻译：电磁执行器，特别是用于驱动发动机气门
公开(公告)号：US06304161B1
公开(公告)日：2001-10-16
申请号：US09507935
申请日：2000-02-22
申请人： Michael Schebitz , Ernst-Siegfried Hartmann , Jurgen Wahnschaffe , Hans Willi Goebel , Holger Lange
发明人： Michael Schebitz , Ernst-Siegfried Hartmann , Jurgen Wahnschaffe , Hans Willi Goebel , Holger Lange
IPC分类号： H01F300
CPC分类号： F01L1/46 , F01L9/04
摘要： An electromagnetic actuator for operating a driven component includes first and second electromagnets having respective first and second pole faces oriented toward one another and defining a space therebetween; an armature disposed between the electromagnets and movable back and forth between the first and second pole faces in a direction of motion; a driving component attached to the armature for moving therewith as a unitary structure; and a resetting spring unit attached solely to the driving component or the driven component and exerting forces opposing movements of the armature caused by electromagnetic forces generated by the electromagnets. The resetting spring unit is in a relaxed state when the armature is in a mid position between the first and second pole faces and is in an armed state upon movement of the armature from the mid position in either direction. A mechanism connects the driving component with the driven component for effecting a transmission of moving forces from the driving component to the driven component to cause displacements of the driven component as a function of displacements of the armature and the driving component.
摘要翻译：用于操作从动部件的电磁致动器包括第一和第二电磁体，其具有彼此朝向彼此并且在它们之间限定空间的相应的第一和第二极面; 设置在所述电磁体之间的衔铁，并且在所述第一和第二极面之间沿运动方向前后移动; 附接到所述电枢的驱动部件，用于作为整体结构移动; 以及复位弹簧单元，其单独地附接到驱动部件或从动部件，并且由电磁体产生的电磁力施加相反的电枢运动的力。当电枢处于第一和第二极面之间的中间位置时，复位弹簧单元处于松弛状态，并且当电枢从任一方向上的中间位置移动时处于悬挂状态。机构将驱动部件与被驱动部件连接起来，以实现从驱动部件到被驱动部件的移动力的传递，从而使驱动部件的位移作为衔铁和驱动部件的位移的函数。

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