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1. 发明授权

US07664300B2 Uterine cervical cancer computer-aided-diagnosis (CAD) 失效
标题翻译：子宫颈癌计算机辅助诊断（CAD）
公开(公告)号：US07664300B2
公开(公告)日：2010-02-16
申请号：US11184046
申请日：2005-02-03
申请人： Holger Lange , Rolf Holger Wolters
发明人： Holger Lange , Rolf Holger Wolters
IPC分类号： G06K9/00 , A61F6/14 , A61F6/06
CPC分类号： A61B5/0059 , A61B5/053 , A61B5/7264 , G06F19/00 , G06F19/321 , G06F19/324 , G06F19/3481 , G06T7/0012 , G06T7/30 , G06T2207/10016 , G06T2207/10024 , G06T2207/30004
摘要： Uterine cervical cancer Computer-Aided-Diagnosis (CAD) according to this invention consists of a core processing system that automatically analyses data acquired from the uterine cervix and provides tissue and patient diagnosis, as well as adequacy of the examination. The data can include, but is not limited to, color still images or video, reflectance and fluorescence multi-spectral or hyper-spectral imagery, coherent optical tomography imagery, and impedance measurements, taken with and without the use of contrast agents like 3-5% acetic acid, Lugol's iodine, or 5-aminolevulinic acid. The core processing system is based on an open, modular, and feature-based architecture, designed for multi-data, multi-sensor, and multi-feature fusion. The core processing system can be embedded in different CAD system realizations. For example: A CAD system for cervical cancer screening could in a very simple version consist of a hand-held device that only acquires one digital RGB image of the uterine cervix after application of 3-5% acetic acid and provides automatically a patient diagnosis. A CAD system used as a colposcopy adjunct could provide all functions that are related to colposcopy and that can be provided by a computer, from automation of the clinical workflow to automated patient diagnosis and treatment recommendation.
摘要翻译：根据本发明的子宫颈癌计算机辅助诊断（CAD）包括一个核心处理系统，其自动分析从子宫颈获得的数据，并提供组织和患者诊断以及检查的充分性。数据可以包括但不限于彩色静止图像或视频，反射率和荧光多光谱或超光谱图像，相干光学断层摄影图像和阻抗测量，在使用和不使用造影剂如3- 5％乙酸，Lugol碘或5-氨基乙酰丙酸。核心处理系统基于开放，模块化和基于特征的架构，专为多数据，多传感器和多功能融合而设计。核心处理系统可以嵌入到不同的CAD系统实现中。例如：用于宫颈癌筛查的CAD系统可以在非常简单的版本中由手持装置组成，其仅在施加3-5％乙酸后才获得子宫颈的一个数字RGB图像，并自动提供患者诊断。用作阴道镜附件的CAD系统可以提供与阴道镜相关的所有功能，并且可以由计算机提供从临床工作流程自动化到自动化患者诊断和治疗推荐的所有功能。

2. 发明申请

US20090034824A1 Computerized image analysis for acetic acid induced Cervical Intraepithelial Neoplasia 失效
标题翻译：乙酸诱导宫颈上皮内瘤变的电脑图像分析
公开(公告)号：US20090034824A1
公开(公告)日：2009-02-05
申请号：US12221645
申请日：2008-08-04
申请人： Wenjing Li , Rolf Holger Wolters
发明人： Wenjing Li , Rolf Holger Wolters
IPC分类号： G06K9/00
CPC分类号： G06K9/4652 , G06T7/0012 , G06T7/11 , G06T7/174 , G06T2207/10024 , G06T2207/20041 , G06T2207/30096
摘要： A method for differentiating cancerous lesions from surrounding tissue, which includes extracting an opacity parameter from acetowhite regions of pre acetic acid and post acetic acid images of a cervix.
摘要翻译：一种用于将癌变病变与周围组织分离的方法，其包括从乙酸的乙酸钠区域和子宫颈的后乙酸图像中提取不透明度参数。

3. 发明申请

US20080226148A1 Method of image quality assessment to produce standardized imaging data 失效
标题翻译：图像质量评估方法来制作标准化成像数据
公开(公告)号：US20080226148A1
公开(公告)日：2008-09-18
申请号：US12075910
申请日：2008-03-14
申请人： Jia Gu , Wenjing Li , John Hargrove , Rolf Holger Wolters
发明人： Jia Gu , Wenjing Li , John Hargrove , Rolf Holger Wolters
IPC分类号： G06K9/00 , G06K9/40
CPC分类号： G06T5/40 , A61B5/0084 , G06K9/4652 , G06T5/007 , G06T5/50 , G06T7/0002 , G06T2207/10016 , G06T2207/10024 , G06T2207/10152 , G06T2207/30004 , G06T2207/30168
摘要： Automated image quality assessment methods, which include locating a region of interest, region assessment, contrast assessment, blur assessment, and contaminant detection, on video data and high-resolution imagery. Where the blur assessment is performed without a reference image by dividing the region into non-overlapping block, measuring the wavenumber frequency of the blocks and calculating the ratio of the low frequency to high frequency areas.
摘要翻译：自动图像质量评估方法，包括定位感兴趣区域，区域评估，对比度评估，模糊评估和污染物检测，对视频数据和高分辨率图像。在通过将区域划分为非重叠块来进行模糊评估而不参考图像的情况下，测量块的波数频率并计算低频到高频区域的比率。

4. 发明申请

US20120283574A1 Diagnosis Support System Providing Guidance to a User by Automated Retrieval of Similar Cancer Images with User Feedback 审中-公开
标题翻译：诊断支持系统通过用户反馈自动检索类似的癌症图像为用户提供指导
公开(公告)号：US20120283574A1
公开(公告)日：2012-11-08
申请号：US13464914
申请日：2012-05-04
申请人： Sun Young Park , Dustin Michael Sargent , Rolf Holger Wolters , Ulf Peter Gustafsson
发明人： Sun Young Park , Dustin Michael Sargent , Rolf Holger Wolters , Ulf Peter Gustafsson
IPC分类号： A61B1/303 , A61B6/00
CPC分类号： G06F19/321 , G06F16/5838 , G06K9/46 , G06K9/6215 , G06K9/6218 , G06K9/629 , G06T7/0014
摘要： The present invention is a diagnosis support system providing automated guidance to a user by automated retrieval of similar disease images and user feedback. High resolution standardized labeled and unlabeled, annotated and non-annotated images of diseased tissue in a database are clustered, preferably with expert feedback. An image retrieval application automatically computes image signatures for a query image and a representative image from each cluster, by segmenting the images into regions and extracting image features in the regions to produce feature vectors, and then comparing the feature vectors using a similarity measure. Preferably the features of the image signatures are extended beyond shape, color and texture of regions, by features specific to the disease. Optionally, the most discriminative features are used in creating the image signatures. A list of the most similar images is returned in response to a query. Keyword query is also supported.
摘要翻译：本发明是通过自动检索类似的疾病图像和用户反馈来向用户提供自动指导的诊断支持系统。数据库中患病组织的高分辨率标准化标签和未标记，注释和非注释图像聚类，最好与专家反馈。图像检索应用程序通过将图像分割成区域并提取区域中的图像特征来自动计算来自每个群集的查询图像和代表图像的图像签名，以产生特征向量，然后使用相似性度量来比较特征向量。优选地，通过特定于疾病的特征，图像特征的特征被扩展到区域的形状，颜色和纹理之外。可选地，最具有歧视性的特征用于创建图像签名。响应于查询返回最相似图像的列表。还支持关键字查询。

5. 发明申请

US20100130868A1 Process and device for detection of precancer tissues with infrared spectroscopy 失效
标题翻译：用红外光谱检测癌前组织的方法和装置
公开(公告)号：US20100130868A1
公开(公告)日：2010-05-27
申请号：US12590790
申请日：2009-11-13
申请人： John Taylor Hargrove , Rolf Holger Wolters , Ulf Peter Gustafsson
发明人： John Taylor Hargrove , Rolf Holger Wolters , Ulf Peter Gustafsson
IPC分类号： A61B6/00
CPC分类号： A61B5/0075 , A61B5/0086 , A61B5/7264
摘要： A process for determining whether tissue is precancer, in which tests discriminating between precancer and benign tissue and between precancer and normal tissue are combined, and tissue that is classified as precancer in both tests is determined to be precancer, in which neither of the tests to be combined is the most selective. Further, a process and device in which certain optimal wavelengths of glycogen, phosphate and lipid, but not protein, discriminate between normal and precancer tissues.
摘要翻译：用于确定组织是否是癌前期的方法，其中将前瞻性组织和良性组织之间以及癌前期和正常组织之间的区别的试验结合在一起，并且在两个测试中被分类为癌前期的组织被确定为癌前期，其中两个试验组合是最有选择性的。此外，其中糖原，磷酸盐和脂质的某些最佳波长但不是蛋白质的某些最佳波长区分正常和癌前组织的过程和装置。

6. 发明申请

US20080226147A1 Method to provide automated quality feedback to imaging devices to achieve standardized imaging data 失效
标题翻译：为成像设备提供自动质量反馈以实现标准化成像数据的方法
公开(公告)号：US20080226147A1
公开(公告)日：2008-09-18
申请号：US12075890
申请日：2008-03-14
申请人： John Hargrove , Jia Gu , Wenjing Li , Rolf Holger Wolters
发明人： John Hargrove , Jia Gu , Wenjing Li , Rolf Holger Wolters
IPC分类号： G06K9/00
CPC分类号： G06T5/40 , A61B5/0084 , G06K9/4652 , G06T5/007 , G06T5/50 , G06T7/0002 , G06T2207/10016 , G06T2207/10024 , G06T2207/10152 , G06T2207/30004 , G06T2207/30168
摘要： Automated image quality assessment algorithms, which perform the functions of locating a region of interest, maximizing the image contrast, and ensuring the region of interest is properly centered in the image. Wherein the region of interest is located by spectral matching filter using a target spectrum obtained from samples of the image itself.
摘要翻译：自动图像质量评估算法，其执行定位感兴趣区域的功能，最大化图像对比度，并确保感兴趣的区域在图像中适当地居中。其中通过使用从图像本身的样本获得的目标光谱的光谱匹配滤波器来定位感兴趣区域。

7. 发明授权

US06678398B2 Dual mode real-time screening and rapid full-area, selective-spectral, remote imaging and analysis device and process 失效
标题翻译：双模式实时筛选和快速全区域，选择性光谱，远程成像和分析设备和过程
公开(公告)号：US06678398B2
公开(公告)日：2004-01-13
申请号：US10387761
申请日：2003-03-12
申请人： Rolf Holger Wolters , Joseph Allen Sweat , Michael James Deweert , Robert Benton Seiple, Jr. , David George Shibasaki Walton
发明人： Rolf Holger Wolters , Joseph Allen Sweat , Michael James Deweert , Robert Benton Seiple, Jr. , David George Shibasaki Walton
IPC分类号： G06K900
CPC分类号： A61B1/0638 , A61B1/00186 , A61B1/043 , A61B1/0653 , A61B5/0071 , A61B5/0075 , A61B5/0084
摘要： The invention provides a device and process for real-time screening of areas that can be identified as suspicious either through image segmentation utilizing image processing techniques or through treatment with an exogenous fluorescent marker that selectively localizes in abnormal areas. If screening detects a suspicious area, then the invention allows acquiring of autofluorescence images at multiple selected narrow differentiating spectral bands so that a “virtual biopsy” can be obtained to differentiate abnormal areas from normal areas based on differentiating portions of autofluorescence spectra. Full spatial information is collected, but autofluorescence data is collected only at the selected narrow spectral bands, avoiding the collection of full spectral data, so that the speed of analysis is increased.
摘要翻译：本发明提供一种用于通过图像分割利用图像处理技术或通过用选择性定位在异常区域中的外源性荧光标记物进行治疗而被识别为可疑的区域的实时筛选的装置和过程。如果筛选检测到可疑区域，则本发明允许在多个选定的窄差分光谱带上获得自发荧光图像，使得可以基于自发荧光光谱的微分部分获得“虚拟活检”以区分异常区域与正常区域。收集完整的空间信息，但仅在选定的窄光谱带收集自发荧光数据，避免收集全光谱数据，从而提高分析速度。

8. 发明授权

US08131054B2 Computerized image analysis for acetic acid induced cervical intraepithelial neoplasia 失效
标题翻译：乙酸诱导宫颈上皮内瘤变的计算机图像分析
公开(公告)号：US08131054B2
公开(公告)日：2012-03-06
申请号：US12221645
申请日：2008-08-04
申请人： Wenjing Li , Rolf Holger Wolters
发明人： Wenjing Li , Rolf Holger Wolters
IPC分类号： G06K9/00
CPC分类号： G06K9/4652 , G06T7/0012 , G06T7/11 , G06T7/174 , G06T2207/10024 , G06T2207/20041 , G06T2207/30096
摘要： A method for differentiating cancerous lesions from surrounding tissue, which includes extracting an opacity parameter from acetowhite regions of pre acetic acid and post acetic acid images of a cervix.
摘要翻译：一种用于将癌变病变与周围组织分离的方法，其包括从乙酸的乙酸钠区域和子宫颈的后乙酸图像中提取不透明度参数。

9. 发明授权

US08532750B2 Process and device for detection of precancer tissues with infrared spectroscopy 失效
标题翻译：用红外光谱检测癌前组织的方法和装置
公开(公告)号：US08532750B2
公开(公告)日：2013-09-10
申请号：US12590790
申请日：2009-11-13
申请人： John Taylor Hargrove , Rolf Holger Wolters , Ulf Peter Gustafsson
发明人： John Taylor Hargrove , Rolf Holger Wolters , Ulf Peter Gustafsson
IPC分类号： A61B6/00
CPC分类号： A61B5/0075 , A61B5/0086 , A61B5/7264
摘要： A process for determining whether tissue is precancer, in which tests discriminating between precancer and benign tissue and between precancer and normal tissue are combined, and tissue that is classified as precancer in both tests is determined to be precancer, in which neither of the tests to be combined is the most selective. Further, a process and device in which certain optimal wavelengths of glycogen, phosphate and lipid, but not protein, discriminate between normal and precancer tissues.
摘要翻译：用于确定组织是否是癌前期的方法，其中将前瞻性组织和良性组织之间以及癌前期和正常组织之间的区别的试验结合在一起，并且在两个测试中被分类为癌前期的组织被确定为癌前期，其中两个试验组合是最有选择性的。此外，其中糖原，磷酸盐和脂质的某些最佳波长但不是蛋白质的某些最佳波长区分正常和癌前组织的过程和装置。

10. 发明授权

US08401258B2 Method to provide automated quality feedback to imaging devices to achieve standardized imaging data 失效
标题翻译：为成像设备提供自动质量反馈以实现标准化成像数据的方法
公开(公告)号：US08401258B2
公开(公告)日：2013-03-19
申请号：US12075890
申请日：2008-03-14
申请人： John Hargrove , Jia Gu , Wenjing Li , Rolf Holger Wolters
发明人： John Hargrove , Jia Gu , Wenjing Li , Rolf Holger Wolters
IPC分类号： G06K9/03 , G06K9/52
CPC分类号： G06T5/40 , A61B5/0084 , G06K9/4652 , G06T5/007 , G06T5/50 , G06T7/0002 , G06T2207/10016 , G06T2207/10024 , G06T2207/10152 , G06T2207/30004 , G06T2207/30168
摘要： Automated image quality assessment algorithms, which perform the functions of locating a region of interest, maximizing the image contrast, and ensuring the region of interest is properly centered in the image. Wherein the region of interest is located by spectral matching filter using a target spectrum obtained from samples of the image itself.
摘要翻译：自动图像质量评估算法，其执行定位感兴趣区域的功能，最大化图像对比度，并确保感兴趣的区域在图像中适当地居中。其中通过使用从图像本身的样本获得的目标光谱的光谱匹配滤波器来定位感兴趣区域。

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