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1. 发明授权

US06410505B1 Dimeric non-azo naphthalimides and uses for the same 有权
标题翻译：二聚非偶氮萘二酮和用途相同
公开(公告)号：US06410505B1
公开(公告)日：2002-06-25
申请号：US09438306
申请日：1999-06-28
申请人： David E. Lewis , Ronald E. Utecht , Millard M. Judy , J. Lester Matthews
发明人： David E. Lewis , Ronald E. Utecht , Millard M. Judy , J. Lester Matthews
IPC分类号： A61K31695
CPC分类号： C07D221/14
摘要： A class of predominantly hydrophilic 1,8-naphthalimide dyes. The dye contains at least two 1,8-naphthalimide ring systems, joined by a spacer moiety. Each of the 1,8-naphthalimide ring system has a ring nitrogen atom and bears, at the 4 position, an amino nitrogen atom, carrying a hydrogen. The remaining unsatisfied valences, if present, of the ring nitrogen atoms or the amino nitrogen atoms, or all, are occupied by one or more alkyl substituents. Each of the 1,8-naphthalimide ring system is free of an azo substituent and is also free of a nucleofuge. Upon activation by an activating agent in an environment independent of the presence or absence of oxygen, these compounds generate activated species. The activated species can cause structural changes in lipid and any associated proteins and polypeptides, extra- or intra-cellular or transmembrane, leading to polymerization and crosslinking.
摘要翻译：一类主要亲水的1,8-萘二甲酰亚胺染料。该染料含有至少两个由间隔部分连接的1,8-萘二甲酰亚胺环体系。每个1,8-萘二甲酰亚胺环系具有环氮原子，并且在4位具有携带氢的氨基氮原子。环状氮原子或氨基氮原子或全部的剩余不饱和化合价如果存在，则被一个或多个烷基取代基占据。每个1,8-萘二甲酰亚胺环系均不含偶氮取代基，也不含核离子。在独立于氧的存在或不存在的环境中通过活化剂活化时，这些化合物产生活化物质。活化的物质可以引起脂质和任何相关的蛋白质和多肽，细胞外或细胞内或跨膜的结构变化，导致聚合和交联。

2. 发明授权

US5917045A Dimeric non-azo naphthalimides and uses for same 失效
公开(公告)号：US5917045A
公开(公告)日：1999-06-29
申请号：US472139
申请日：1995-06-07
申请人： David E. Lewis , Ronald E. Utecht , Millard M. Judy , J. Lester Matthews
发明人： David E. Lewis , Ronald E. Utecht , Millard M. Judy , J. Lester Matthews
IPC分类号： C07D221/14 , C07D471/00 , C07F5/02 , C07F7/02 , C07F9/28
CPC分类号： C07D221/14
摘要： A class of predominantly hydrophilic 1,8-naphthalimide dyes. The dye contains at least two 1,8-naphthalimide ring systems, joined by a spacer moiety. Each of the 1,8-naphthalimide ring system has a ring nitrogen atom and bears, at the 4 position, an amino nitrogen atom, carrying a hydrogen. The remaining unsatisfied valences, if present, of the ring nitrogen atoms or the amino nitrogen atoms, or all, are occupied by one or more alkyl substituents. Each of the 1,8-naphthalimide ring system is free of an azo substituent and is also free of a nucleofuge. Upon activation by an activating agent in an environment independent of the presence or absence of oxygen, these compounds generate activated species. The activated species can cause structural changes in lipid and any associated proteins and polypeptides, extra- or intra-cellular or transmembrane, leading to polymerization and crosslinking.

3. 发明授权

US5489590A Method of treating with therapeutic composition comprising photoactive compound 失效
标题翻译：用包含光敏化合物的治疗组合物治疗的方法
公开(公告)号：US5489590A
公开(公告)日：1996-02-06
申请号：US829933
申请日：1992-02-03
申请人： Kirpal S. Gulliya , Shazib Pervaiz , J. Lester Matthews , Robert M. Dowben , Jospeh T. Newman , Edward Forest
发明人： Kirpal S. Gulliya , Shazib Pervaiz , J. Lester Matthews , Robert M. Dowben , Jospeh T. Newman , Edward Forest
IPC分类号： A61K41/00 , A61L2/00 , A61K31/47 , A61K31/535 , A61K31/54
CPC分类号： A61K41/0057 , A61K41/0071 , A61L2/0011
摘要： A therapeutic composition derived from a pre-activated photoactive compound and a conveyor for destroying tumor or other pathogenic biological contaminants infecting animal body tissues. The conveyor can either be a matrix support or an antibody. The activation of the photoactive compound to produce the pre-activated photoactive compound is carried out by the use of an activating agent. The pre-activated photoactive compound retains its therapeutic activity subsequent to activation. A method for preparing such a therapeutic composition is disclosed. Methods for treating animal body tissue, either outside the body or inside the body, infected with tumors or other pathogenic biological contaminants are disclosed.
摘要翻译：衍生自预活化光活性化合物的治疗组合物和用于破坏感染动物体组织的肿瘤或其它致病生物污染物的输送机。输送机可以是基质载体或抗体。光活性化合物的活化以产生预活化的光活性化合物通过使用活化剂进行。预活化的光活性化合物在活化后保留其治疗活性。公开了制备这种治疗组合物的方法。公开了用于治疗感染了肿瘤或其他致病生物污染物的体内或身体内部的动物体组织的方法。

4. 发明授权

US5235045A Non-azo naphthalimide dyes 失效
标题翻译：非偶氮萘酰亚胺染料
公开(公告)号：US5235045A
公开(公告)日：1993-08-10
申请号：US854416
申请日：1992-03-19
申请人： David E. Lewis , Ronald E. Utecht , Millard M. Judy , J. Lester Matthews
发明人： David E. Lewis , Ronald E. Utecht , Millard M. Judy , J. Lester Matthews
IPC分类号： A61K39/00 , A61L2/00 , C07D221/14 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D417/12 , C07D473/00 , C09B57/08
CPC分类号： C07D221/14 , A61L2/0011 , A61L2/0082 , C09B57/08 , Y10S514/885
摘要： A class of predominantly hydrophobic non-azo N-substituted 1,8-naphthalimide compounds, each bearing, at its 3-position, a nucleofuge and, at its 4-position, a heteroatomic electron-releasing group. The heteroatomic electron-releasing group is being characterized as having a heteroatom directly linked to the 4-position of the ring, and having at least one hydrogen directly attached to the heteroatom. Upon activation by an activating agent in an environment independent of the presence or absence of oxygen, these compounds generate activated species. The activated species initiate chemical changes in lipid bilayer membranes of viruses and other target cells. These changes can eradicate viruses and other target cells. The activated species can also cause structural changes in lipid and any associated proteins and polypeptides at a level beneath the surface of the membrane, leading to polymerization and crosslinking.
摘要翻译：一类主要疏水性的非偶氮N-取代的1,8-萘二甲酰亚胺化合物，各自在其3位具有核离子和在其4位上具有杂原子电子释放基团。杂原子电子释放基团的特征在于具有直接连接到环的4-位的杂原子，并且具有至少一个氢直接连接到杂原子上。在独立于氧的存在或不存在的环境中通过活化剂活化时，这些化合物产生活化物质。活化物质引发病毒和其他靶细胞脂质双层膜的化学变化。这些变化可以根除病毒和其他靶细胞。活化的物质还可以在膜的表面下方的水平下引起脂质和任何相关蛋白质和多肽的结构变化，导致聚合和交联。

5. 发明授权

US5177073A Therapeutic compositions derived from photoactive compounds 失效
标题翻译：衍生自光活性化合物的治疗组合物
公开(公告)号：US5177073A
公开(公告)日：1993-01-05
申请号：US509036
申请日：1990-04-13
申请人： Kirpal S. Gulliya , Shazib Pervaiz , J. Lester Matthews , Robert M. Dowben , Joseph T. Newman , Edward Forest
发明人： Kirpal S. Gulliya , Shazib Pervaiz , J. Lester Matthews , Robert M. Dowben , Joseph T. Newman , Edward Forest
IPC分类号： A61K41/00 , A61L2/00
CPC分类号： A61K41/0057 , A61K41/0071 , A61L2/0011
摘要： A therapeutic composition derived from a pre-activated photoactive compound and a conveyor for destroying tumor or other pathogenic biological contaminants infecting animal body tissues. The conveyor can either be a matrix support or an antibody. The activation of the photoactive compound to produce the pre-activated photoactive compound is carried out by the use of an activating agent. The pre-activated photoactive compound retains its therapeutic activity subsequent to activation. A method for preparing such a therapeutic composition is disclosed. Methods for treating animal body tissue, either outside the body or inside the body, infected with tumors or other pathogenic biological contaminants are disclosed.
摘要翻译：衍生自预活化光活性化合物的治疗组合物和用于破坏感染动物体组织的肿瘤或其它致病生物污染物的输送机。输送机可以是基质载体或抗体。光活性化合物的活化以产生预活化的光活性化合物通过使用活化剂进行。预活化的光活性化合物在活化后保留其治疗活性。公开了制备这种治疗组合物的方法。公开了用于治疗感染了肿瘤或其他致病生物污染物的体内或身体内部的动物体组织的方法。

6. 发明授权

US4492577A Surgical implants with solid interiors and porous surfaces 失效
标题翻译：手术植入物具有坚实的内部和多孔表面
公开(公告)号：US4492577A
公开(公告)日：1985-01-08
申请号：US436618
申请日：1982-10-25
申请人： Edward T. Farris , J. Lester Matthews
发明人： Edward T. Farris , J. Lester Matthews
IPC分类号： A61C8/00 , A61F2/30
CPC分类号： A61F2/30767 , A61C8/0012 , A61C8/0018 , A61C8/0036 , A61C8/0043 , A61C2008/0046
摘要： A device is disclosed which has a solid interior and at least one surface which is porous. The porous surface has several desired characteristics, including: (1) the majority of pores have dimensions within a size range that encourages the migration of cells into said pores, such as about 50 to about 500 micron diameters, and (2) the pores have a controlled depth, such as about 300 microns or less. Such devices may be created by several methods, such as injecting casting material into a mold which is fitted with a shell of porous material having the desired shape and characteristics. Such devices are useful as artificial teeth and orthopedic appliances.
摘要翻译：公开了一种具有固体内部和至少一个多孔的表面的装置。多孔表面具有几个期望的特征，包括：（1）大多数孔具有在促进细胞迁移到所述孔中的尺寸范围内的尺寸，例如约50至约500微米直径，和（2）孔具有受控深度，例如约300微米或更小。这样的装置可以通过几种方法来产生，例如将铸造材料注射到装配有具有期望形状和特性的多孔材料壳的模具中。这样的装置可用作人造牙齿和矫形器具。

7. 发明授权

US5092864A Method and apparatus for improved laser surgery 失效
标题翻译：改善激光手术的方法和装置
公开(公告)号：US5092864A
公开(公告)日：1992-03-03
申请号：US516661
申请日：1990-04-30
申请人： Donald J. Hayes , J. Lester Matthews , Millard M. Judy
发明人： Donald J. Hayes , J. Lester Matthews , Millard M. Judy
IPC分类号： A61B17/22 , A61B18/20 , A61M3/02 , A61N5/06
CPC分类号： A61B18/20 , A61B2017/22085 , A61B2018/2025 , A61M3/0279 , A61N5/062
摘要： A method and apparatus for providing greater precision placement and control of the delivery of laser energy during laser surgery is disclosed and includes a pulse-controlled dye delivery system which may be coordinated with the delivery of laser energy to predetermined tissue. The pulse-controlled dye delivery system comprises at least one ejection head capable of ejecting drops of liquid dye with the diameter of each drop being less than two hundred microns. The dye is responsive to the wavelength of energy delivered by the laser performing the surgery to convert the laser energy from the surgical laser to tissue thermal energy. Circuitry is provided for precisely activating the dye delivery system and the laser energy source such that optimal conditions for successful outcome of the surgery may be achieved. Because of the small amount of dye deposited on the tissue and the very short time the dye is on the tissue before the laser energy arrives, the dye does not spread from the desired spot and concentrates the laser energy at the desired spot.
摘要翻译：公开了一种用于在激光手术期间提供更高精度放置和控制激光能量传递的方法和装置，并且包括脉冲控制的染料输送系统，其可以将激光能量传送到预定的组织。脉冲控制的染料输送系统包括至少一个能够喷射液滴的液滴的喷射头，每个液滴的直径小于二百微米。染料响应于由执行手术的激光器传送的能量的波长，以将来自外科激光的激光能量转换成组织热能。提供了用于精确激活染料输送系统和激光能量源的电路，使得可以实现手术成功结果的最佳条件。由于染料沉积在组织上的量少，染料在激光能量到达之前在组织上非常短的时间内，所以染料不会从所需的光点扩散，并将激光能量集中在所需的位置。

8. 发明授权

US5565551A Non-azo naphthalimide dyes and uses for same 失效
标题翻译：非偶氮萘酰胺染料及其用途相同
公开(公告)号：US5565551A
公开(公告)日：1996-10-15
申请号：US433092
申请日：1995-05-03
申请人： David E. Lewis , Ronald E. Utecht , Millard M. Judy , J. Lester Matthews
发明人： David E. Lewis , Ronald E. Utecht , Millard M. Judy , J. Lester Matthews
IPC分类号： A61K39/00 , A61L2/00 , C07D221/14 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D417/12 , C07D473/00 , C09B57/08 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00 , C08H1/00
CPC分类号： C07D221/14 , A61L2/0011 , A61L2/0082 , C09B57/08 , Y10S514/885
摘要： A class of predominantly hydrophobic non-azo N-substituted 1,8-naphthalimide compounds, each bearing, at its 3-position, a nucleofuge and, at its 4-position, a heteroatomic electron-releasing group. The heteroatomic electron-releasing group is being characterized as having a heteroatom directly linked to the 4-position of the ring, and having at least one hydrogen directly attached to the heteroatom. Upon activation by an activating agent in an environment independent of the presence or absence of oxygen, these compounds generate activated species. The activated species initiate chemical changes in lipid bilayer membranes of viruses and other target cells. These changes can eradicate viruses and other target cells. The activated species can also cause structural changes in lipid and any associated proteins and polypeptides at a level beneath the surface of the membrane, leading to polymerization and crosslinking.
摘要翻译：一类主要疏水性的非偶氮N-取代的1,8-萘二甲酰亚胺化合物，各自在其3位具有核离子和在其4位上具有杂原子电子释放基团。杂原子电子释放基团的特征在于具有直接连接到环的4-位的杂原子，并且具有至少一个氢直接连接到杂原子上。在独立于氧的存在或不存在的环境中通过活化剂活化时，这些化合物产生活化的物质。活化物质引发病毒和其他靶细胞脂质双层膜的化学变化。这些变化可以根除病毒和其他靶细胞。活化的物质还可以在膜的表面下方的水平下引起脂质和任何相关蛋白质和多肽的结构变化，导致聚合和交联。

9. 发明授权

US5091385A Pre-activated therapeutic agents derived from photoactive compounds 失效
标题翻译：从光化合物衍生的预活化治疗药物
公开(公告)号：US5091385A
公开(公告)日：1992-02-25
申请号：US252256
申请日：1988-09-30
申请人： Kirpal S. Gulliya , Shazib Pervaiz , J. Lester Matthews , Robert M. Dowben , Joseph T. Newman , Edward Forest
发明人： Kirpal S. Gulliya , Shazib Pervaiz , J. Lester Matthews , Robert M. Dowben , Joseph T. Newman , Edward Forest
IPC分类号： A61K41/00 , A61L2/00 , A61P31/12 , A61P33/00 , A61P35/00
CPC分类号： A61K41/0057 , A61K41/0071 , A61L2/0011
摘要： A pre-activated therapeutic agent derived from a photoactive compound for destroying tumor or other pathogenic biological contaminants infecting animal body tissues. The activation of the photoactive compound is carried out prior to the photoactive compound is being brought into contact with the tissue to be treated. The resultant pre-activated therapeutic agent, or mixture, retains its therapeutic activity subsequent to activation. A method for preparing such a pre-activated therapeutic agent is disclosed. Methods for treating animal body tissue, either outside the body or inside the body, infected with tumors or other pathogenic biological contaminants are disclosed.
摘要翻译：衍生自光活性化合物的预活化治疗剂，用于破坏感染动物体组织的肿瘤或其它致病性生物污染物。光活性化合物的活化在使光敏化合物与待处理的组织接触之前进行。所得预活化治疗剂或混合物在活化后保留其治疗活性。公开了一种制备这种预激活治疗剂的方法。公开了用于治疗感染了肿瘤或其他致病生物污染物的体内或身体内部的动物体组织的方法。

10. 发明授权

US5041078A Photodynamic viral deactivation with sapphyrins 失效
标题翻译：光动力病毒与莽草素的失活
公开(公告)号：US5041078A
公开(公告)日：1991-08-20
申请号：US454300
申请日：1989-12-21
申请人： J. Lester Matthews , Millard M. Judy , Joseph T. Newman , Frank Sogandares-Bernal , Jonathan L. Sessler , Anthony Harriman , Bhaskar G. Maiya
发明人： J. Lester Matthews , Millard M. Judy , Joseph T. Newman , Frank Sogandares-Bernal , Jonathan L. Sessler , Anthony Harriman , Bhaskar G. Maiya
IPC分类号： A61K41/00 , A61L2/00 , C07D487/22
CPC分类号： A61K41/0038 , A61K41/0076 , A61K47/48069 , A61L2/0011 , A61L2/0088 , C07D487/22
摘要： The present invention demonstrates a method of photodynamic inactivation of viruses having a membranous envelope, such as Herpes simplex type 1 and Human immunodeficiency type 1 viruses. The method uses substituted sapphyrin compounds to effect viral deactivation during radiation with light at or near the absorption wavelength of the sapphyrin compound. A highly reactive species selectively toxic to infectious agents is produced.One particular sapphyrin compound useful for the practice of the invention is 8,17-bis(carboxymethyl)-3,12,13,22-tetraethyl-2,7,18,23-tetramethylsapphyrin (Sapphyrin 2). The most preferred sapphyrin sapphyrin compound for the practice of the invention is 3,8,12,13,17,22-hexaethyl-2,7,18,23-tetramethylsapphyrin (Sapphyrin 1).The method is particularly suitable for inactivation of viruses in blood and blood products.
摘要翻译：本发明示出了具有膜包膜的病毒的光动力灭活方法，例如1型单纯疱疹病毒和1型人类免疫缺陷病毒。该方法使用取代的莽草素化合物在辐射期间在卟啉化合物的吸收波长处或附近的光下实现病毒失活。产生对感染性试剂有选择性毒性的高度活性的物质。可用于实施本发明的一种特定的莽草素化合物是8,17-双（羧甲基）-3,12,13,22-四乙基-2,7,18,23-四甲基ap啶（Sapphyrin 2）。用于实施本发明的最优选的鲑鱼卟吩化合物是3,8,12,13,17,22-六乙基-2,7,18,23-四甲基卟啉（Sapphyrin 1）。该方法特别适合灭活血液和血液制品中的病毒。

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