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1. 发明授权

US06410505B1 Dimeric non-azo naphthalimides and uses for the same 有权
标题翻译：二聚非偶氮萘二酮和用途相同
公开(公告)号：US06410505B1
公开(公告)日：2002-06-25
申请号：US09438306
申请日：1999-06-28
申请人： David E. Lewis , Ronald E. Utecht , Millard M. Judy , J. Lester Matthews
发明人： David E. Lewis , Ronald E. Utecht , Millard M. Judy , J. Lester Matthews
IPC分类号： A61K31695
CPC分类号： C07D221/14
摘要： A class of predominantly hydrophilic 1,8-naphthalimide dyes. The dye contains at least two 1,8-naphthalimide ring systems, joined by a spacer moiety. Each of the 1,8-naphthalimide ring system has a ring nitrogen atom and bears, at the 4 position, an amino nitrogen atom, carrying a hydrogen. The remaining unsatisfied valences, if present, of the ring nitrogen atoms or the amino nitrogen atoms, or all, are occupied by one or more alkyl substituents. Each of the 1,8-naphthalimide ring system is free of an azo substituent and is also free of a nucleofuge. Upon activation by an activating agent in an environment independent of the presence or absence of oxygen, these compounds generate activated species. The activated species can cause structural changes in lipid and any associated proteins and polypeptides, extra- or intra-cellular or transmembrane, leading to polymerization and crosslinking.
摘要翻译：一类主要亲水的1,8-萘二甲酰亚胺染料。该染料含有至少两个由间隔部分连接的1,8-萘二甲酰亚胺环体系。每个1,8-萘二甲酰亚胺环系具有环氮原子，并且在4位具有携带氢的氨基氮原子。环状氮原子或氨基氮原子或全部的剩余不饱和化合价如果存在，则被一个或多个烷基取代基占据。每个1,8-萘二甲酰亚胺环系均不含偶氮取代基，也不含核离子。在独立于氧的存在或不存在的环境中通过活化剂活化时，这些化合物产生活化物质。活化的物质可以引起脂质和任何相关的蛋白质和多肽，细胞外或细胞内或跨膜的结构变化，导致聚合和交联。

2. 发明授权

US5917045A Dimeric non-azo naphthalimides and uses for same 失效
公开(公告)号：US5917045A
公开(公告)日：1999-06-29
申请号：US472139
申请日：1995-06-07
申请人： David E. Lewis , Ronald E. Utecht , Millard M. Judy , J. Lester Matthews
发明人： David E. Lewis , Ronald E. Utecht , Millard M. Judy , J. Lester Matthews
IPC分类号： C07D221/14 , C07D471/00 , C07F5/02 , C07F7/02 , C07F9/28
CPC分类号： C07D221/14
摘要： A class of predominantly hydrophilic 1,8-naphthalimide dyes. The dye contains at least two 1,8-naphthalimide ring systems, joined by a spacer moiety. Each of the 1,8-naphthalimide ring system has a ring nitrogen atom and bears, at the 4 position, an amino nitrogen atom, carrying a hydrogen. The remaining unsatisfied valences, if present, of the ring nitrogen atoms or the amino nitrogen atoms, or all, are occupied by one or more alkyl substituents. Each of the 1,8-naphthalimide ring system is free of an azo substituent and is also free of a nucleofuge. Upon activation by an activating agent in an environment independent of the presence or absence of oxygen, these compounds generate activated species. The activated species can cause structural changes in lipid and any associated proteins and polypeptides, extra- or intra-cellular or transmembrane, leading to polymerization and crosslinking.

3. 发明授权

US5235045A Non-azo naphthalimide dyes 失效
标题翻译：非偶氮萘酰亚胺染料
公开(公告)号：US5235045A
公开(公告)日：1993-08-10
申请号：US854416
申请日：1992-03-19
申请人： David E. Lewis , Ronald E. Utecht , Millard M. Judy , J. Lester Matthews
发明人： David E. Lewis , Ronald E. Utecht , Millard M. Judy , J. Lester Matthews
IPC分类号： A61K39/00 , A61L2/00 , C07D221/14 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D417/12 , C07D473/00 , C09B57/08
CPC分类号： C07D221/14 , A61L2/0011 , A61L2/0082 , C09B57/08 , Y10S514/885
摘要： A class of predominantly hydrophobic non-azo N-substituted 1,8-naphthalimide compounds, each bearing, at its 3-position, a nucleofuge and, at its 4-position, a heteroatomic electron-releasing group. The heteroatomic electron-releasing group is being characterized as having a heteroatom directly linked to the 4-position of the ring, and having at least one hydrogen directly attached to the heteroatom. Upon activation by an activating agent in an environment independent of the presence or absence of oxygen, these compounds generate activated species. The activated species initiate chemical changes in lipid bilayer membranes of viruses and other target cells. These changes can eradicate viruses and other target cells. The activated species can also cause structural changes in lipid and any associated proteins and polypeptides at a level beneath the surface of the membrane, leading to polymerization and crosslinking.
摘要翻译：一类主要疏水性的非偶氮N-取代的1,8-萘二甲酰亚胺化合物，各自在其3位具有核离子和在其4位上具有杂原子电子释放基团。杂原子电子释放基团的特征在于具有直接连接到环的4-位的杂原子，并且具有至少一个氢直接连接到杂原子上。在独立于氧的存在或不存在的环境中通过活化剂活化时，这些化合物产生活化物质。活化物质引发病毒和其他靶细胞脂质双层膜的化学变化。这些变化可以根除病毒和其他靶细胞。活化的物质还可以在膜的表面下方的水平下引起脂质和任何相关蛋白质和多肽的结构变化，导致聚合和交联。

4. 发明授权

US5565551A Non-azo naphthalimide dyes and uses for same 失效
标题翻译：非偶氮萘酰胺染料及其用途相同
公开(公告)号：US5565551A
公开(公告)日：1996-10-15
申请号：US433092
申请日：1995-05-03
申请人： David E. Lewis , Ronald E. Utecht , Millard M. Judy , J. Lester Matthews
发明人： David E. Lewis , Ronald E. Utecht , Millard M. Judy , J. Lester Matthews
IPC分类号： A61K39/00 , A61L2/00 , C07D221/14 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D417/12 , C07D473/00 , C09B57/08 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00 , C08H1/00
CPC分类号： C07D221/14 , A61L2/0011 , A61L2/0082 , C09B57/08 , Y10S514/885
摘要： A class of predominantly hydrophobic non-azo N-substituted 1,8-naphthalimide compounds, each bearing, at its 3-position, a nucleofuge and, at its 4-position, a heteroatomic electron-releasing group. The heteroatomic electron-releasing group is being characterized as having a heteroatom directly linked to the 4-position of the ring, and having at least one hydrogen directly attached to the heteroatom. Upon activation by an activating agent in an environment independent of the presence or absence of oxygen, these compounds generate activated species. The activated species initiate chemical changes in lipid bilayer membranes of viruses and other target cells. These changes can eradicate viruses and other target cells. The activated species can also cause structural changes in lipid and any associated proteins and polypeptides at a level beneath the surface of the membrane, leading to polymerization and crosslinking.
摘要翻译：一类主要疏水性的非偶氮N-取代的1,8-萘二甲酰亚胺化合物，各自在其3位具有核离子和在其4位上具有杂原子电子释放基团。杂原子电子释放基团的特征在于具有直接连接到环的4-位的杂原子，并且具有至少一个氢直接连接到杂原子上。在独立于氧的存在或不存在的环境中通过活化剂活化时，这些化合物产生活化的物质。活化物质引发病毒和其他靶细胞脂质双层膜的化学变化。这些变化可以根除病毒和其他靶细胞。活化的物质还可以在膜的表面下方的水平下引起脂质和任何相关蛋白质和多肽的结构变化，导致聚合和交联。

5. 发明授权

US5766600A Non-azo naphtalimide dyes and uses for same 失效
公开(公告)号：US5766600A
公开(公告)日：1998-06-16
申请号：US433093
申请日：1995-05-03
申请人： David E. Lewis , Ronald E. Utecht , Millard M. Judy , J. Lester Matthews
发明人： David E. Lewis , Ronald E. Utecht , Millard M. Judy , J. Lester Matthews
IPC分类号： A61K39/12 , A61L2/00 , A61K39/02
CPC分类号： A61L2/0082 , A61L2/0011
摘要： A class of predominantly hydrophobic non-azo N-substituted 1,8-naphthalimide compounds, each bearing, at its 3-position, a nucleofuge and, at its 4-position, a heteroatomic electron-releasing group. The heteroatomic electron-releasing group is being characterized as having a heteroatom directly linked to the 4-position of the ring, and having at least one hydrogen directly attached to the heteroatom. Upon activation by an activating agent in an environment independent of the presence or absence of oxygen, these compounds generate activated species. The activated species initiate chemical changes in lipid bilayer membranes of viruses and other target cells. These changes can eradicate viruses and other target cells. The activated species can also cause structural changes in lipid and any associated proteins and polypeptides at a level beneath the surface of the membrane, leading to polymerization and crosslinking.

6. 发明授权

US5472878A Fluorescent method for monitoring oil degradation 失效
标题翻译：荧光法监测油质退化
公开(公告)号：US5472878A
公开(公告)日：1995-12-05
申请号：US255416
申请日：1994-06-08
申请人： David E. Lewis , Ronald E. Utecht , Millard M. Judy , J. Lester Matthews
发明人： David E. Lewis , Ronald E. Utecht , Millard M. Judy , J. Lester Matthews
IPC分类号： C07D221/14 , C09B57/08 , G01N21/64 , G01N31/22 , G01N33/22
CPC分类号： G01N21/643 , C07D221/14 , C09B57/08 , G01N31/22
摘要： A method for the qualitative or quantitative determination of the deleterious agent in a substantially non-aqueous medium, such as an oil. The method involves using a non-azo 1,8-naphthalimide dye for the detection or quantitation of the total hydrogen ion activity in a substantially non-aqueous medium. The method includes the steps of: Mixing the dye with the substantially non-aqueous medium, which may or may not contain any hydrogen ion, to form a mixture; irradiating the mixture with a fluorescent light sufficient to cause the mixture to emit a detectable fluorescent emission spectrum; detecting the fluorescent emission spectrum of the mixture; and comparing the detected fluorescent emission spectrum with standard fluorescent emission spectra generated by reacting the dye with different known hydrogen ion activities, wherein differences between the fluorescent emission spectra compared are dependent upon the presence or levels of the hydrogen ion activity present in the mixture.
摘要翻译：用于在基本上非水介质如油中定性或定量测定有害剂的方法。该方法包括使用非偶氮1,8-萘二甲酰亚胺染料来检测或定量在基本上非水介质中的总氢离子活度。该方法包括以下步骤：将染料与基本上非水介质混合，其可以含有或不含有任何氢离子以形成混合物; 用足以使混合物发射可检测的荧光发射光谱的荧光照射混合物; 检测混合物的荧光发射光谱; 并且将检测到的荧光发射光谱与通过使染料与不同的已知氢离子活性反应产生的标准荧光发射光谱进行比较，其中所比较的荧光发射光谱之间的差异取决于混合物中存在的氢离子活性的存在或水平。

7. 发明授权

US5420136A Eradication of pathogenic biological contaminants using non-azo naphthalimide dyes 失效
标题翻译：使用非偶氮萘酰胺染料消除致病生物污染物
公开(公告)号：US5420136A
公开(公告)日：1995-05-30
申请号：US103924
申请日：1993-08-09
申请人： David E. Lewis , Ronald E. Utecht , Millard M. Judy , J. Lester Matthews
发明人： David E. Lewis , Ronald E. Utecht , Millard M. Judy , J. Lester Matthews
IPC分类号： A61K39/00 , A61L2/00 , C07D221/14 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D417/12 , C07D473/00 , C09B57/08 , A61K31/435 , A61K31/535 , A61K31/54
CPC分类号： C07D221/14 , A61L2/0011 , A61L2/0082 , C09B57/08 , Y10S514/885
摘要： A class of predominantly hydrophobic non-azo N-substituted 1,8-naphthalimide compounds, each bearing, at its 3-position, a nucleofuge and, at its 4-position, a heteroatomic electron-releasing group. The heteroatomic electron-releasing group is being characterized as having a heteroatom directly linked to the 4-position of the ring, and having at least one hydrogen directly attached to the heteroatom. Upon activation by an activating agent in an environment independent of the presence or absence of oxygen, these compounds generate activated species. The activated species initiate chemical changes in lipid bilayer membranes of viruses and other target cells. These changes can eradicate viruses and other target cells. The activated species can also cause structural changes in lipid and any associated proteins and polypeptides at a level beneath the surface of the membrane, leading to polymerization and crosslinking.
摘要翻译：一类主要疏水性的非偶氮N-取代的1,8-萘二甲酰亚胺化合物，各自在其3位具有核离子和在其4位上具有杂原子电子释放基团。杂原子电子释放基团的特征在于具有直接连接到环的4-位的杂原子，并且具有至少一个氢直接连接到杂原子上。在独立于氧的存在或不存在的环境中通过活化剂活化时，这些化合物产生活化的物质。活化物质引发病毒和其他靶细胞脂质双层膜的化学变化。这些变化可以根除病毒和其他靶细胞。活化的物质还可以在膜的表面下方的水平下引起脂质和任何相关蛋白质和多肽的结构变化，导致聚合和交联。

8. 发明授权

US5308773A Non-azo 1,8-naphthalimide dyes for the detection and quantitation of a paramagnetic metal cation in a non-aqueous medium 失效
标题翻译：非偶氮1,8-萘二甲酰亚胺染料，用于在非水介质中检测和定量顺磁金属阳离子
公开(公告)号：US5308773A
公开(公告)日：1994-05-03
申请号：US977508
申请日：1992-11-16
申请人： David E. Lewis , Ronald E. Utecht , Millard M. Judy , J. Lester Matthews
发明人： David E. Lewis , Ronald E. Utecht , Millard M. Judy , J. Lester Matthews
IPC分类号： C07D221/14 , C09B57/08 , G01N21/64 , G01N31/22 , G01N33/20 , C07D221/06
CPC分类号： G01N21/643 , C07D221/14 , C09B57/08 , G01N31/22
摘要： The use of a class of non-azo 1,8-naphthalimide dyes for the detection and quantitation of a paramagnetic metal cation in a non-aqueous medium and some of the dyes that will complex with a paramagnetic metal cation. The concentration of the paramagnetic metal cation is determined by monitoring differences in the detected fluorescent emission spectra of the non-azo 1,8-naphthalimide dye solution when it is mixed with paramagnetic metal cations present in the non-aqueous medium. The detected fluorescent emission spectra will vary in relation to the presence or amount of the paramagnetic metal cation in the mixture.
摘要翻译：使用一类非偶氮1,8-萘二甲酰亚胺染料来检测和定量非水介质中的顺磁性金属阳离子，以及一些与顺磁性金属阳离子复合的染料。通过监测非偶氮1,8-萘二甲酰亚胺染料溶液与非水介质中存在的顺磁性金属阳离子混合时检测到的荧光发射光谱的差异来确定顺磁性金属阳离子的浓度。检测到的荧光发射光谱将相对于混合物中顺磁金属阳离子的存在或量而变化。

9. 发明申请

US20130230472A1 BONDING TISSUES AND CROSS-LINKING PROTEINS WITH NAPHTHALIMIDE COMPOUNDS 有权
公开(公告)号：US20130230472A1
公开(公告)日：2013-09-05
申请号：US13772510
申请日：2013-02-21
申请人： Ronald E. Utecht , Kaia L. Kloster , Millard M. Judy , Kevin J. Vaska , James L. Matthews
发明人： Ronald E. Utecht , Kaia L. Kloster , Millard M. Judy , Kevin J. Vaska , James L. Matthews
IPC分类号： A61K41/00 , A61K8/73 , A61Q17/04 , A61K31/722
CPC分类号： C08B37/003 , A61B17/00 , A61B17/08 , A61K8/736 , A61K31/722 , A61K41/00 , A61K41/0042 , A61K41/0057 , A61K47/61 , A61K2800/57 , A61K2800/81 , A61K2800/94 , A61L24/08 , A61N5/062 , A61N2005/0602 , A61N2005/0663 , A61Q17/04 , A61Q19/00
摘要： Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide compounds form chemically-reactive species that cross-link proteins, bond connective tissues together, and bond tissues and other biomaterials together. A naphthalimide-labeled biomolecule, such as a naphthalimide-labeled chitosan, is also capable of bonding tissues without subsequent direct illumination of the contacted tissue area. The naphthalimide compounds may be used in tissue or arterial repair, stabilization of an expanded arterial wall after angioplasty, tethering pharmaceutical agents to tissue surfaces to provide local drug delivery, and for chemically bonding skin care products, sunscreens, and cosmetics to the skin.

10. 发明申请

US20130045171A1 BONDING TISSUES AND CROSS-LINKING PROTEINS WITH NAPHTHALIMIDE COMPOUNDS 有权
公开(公告)号：US20130045171A1
公开(公告)日：2013-02-21
申请号：US13547196
申请日：2012-07-12
申请人： Ronald E. Utecht , Kaia L. Kloster , Millard M. Judy , Kevin J. Vaska , James L. Matthews
发明人： Ronald E. Utecht , Kaia L. Kloster , Millard M. Judy , Kevin J. Vaska , James L. Matthews
IPC分类号： A61K31/722 , A61M37/00 , A61P17/02 , A61M25/10 , A61K8/73 , A61Q17/04
CPC分类号： C08B37/003 , A61B17/00 , A61B17/08 , A61K8/736 , A61K31/722 , A61K41/00 , A61K41/0042 , A61K41/0057 , A61K47/61 , A61K2800/57 , A61K2800/81 , A61K2800/94 , A61L24/08 , A61N5/062 , A61N2005/0602 , A61N2005/0663 , A61Q17/04 , A61Q19/00
摘要： Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide compounds form chemically-reactive species that cross-link proteins, bond connective tissues together, and bond tissues and other biomaterials together. A naphthalimide-labeled biomolecule, such as a naphthalimide-labeled chitosan, is also capable of bonding tissues without subsequent direct illumination of the contacted tissue area. The naphthalimide compounds may be used in tissue or arterial repair, stabilization of an expanded arterial wall after angioplasty, tethering pharmaceutical agents to tissue surfaces to provide local drug delivery, and for chemically bonding skin care products, sunscreens, and cosmetics to the skin.

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