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1. 发明授权

US5121750A Apparatus for locating a catheter adjacent to a pacemaker node of the heart 失效
标题翻译：用于定位邻近心脏起搏器节点的导管的装置
公开(公告)号：US5121750A
公开(公告)日：1992-06-16
申请号：US724818
申请日：1991-07-02
申请人： Jefferson Katims
发明人： Jefferson Katims
IPC分类号： A61B5/042 , A61B5/06
CPC分类号： A61B5/042 , A61B5/06
摘要： A method and apparatus for locating a catheter adjacent to a pacemaker node of the heart. The placement of a catheter tip just before SA heart pacemaker node is a common and desired procedure in medicine, with the most serious complication being its accidental advancement of the beyond this point placing its tip into the heart, with often fatal complications. The catheter tip location just before SA heart pacemaker node is desired because is most often the safest and optimal location. The catheter described in the present invention is placed by a physician within a patient's body circulatory vessel and advanced towards the heart SA pacemaker node, using traditional medical procedures. From the distal tip of the catheter the endogenous electrical activity from the SA pacemaker node of the heart is monitored and transmitted via at least one insulated transmission line located within the catheter to an electronic catheter monitoring system located outside the body. As the catheter is advanced its tip moves within the patient's circulatory vessel. Simultaneously, the electronic catheter monitoring system monitors the natural pacemaker node potentials, obtained at the tip of the catheter, which increase as the node is approached and decrease as the node is passed. The electronic catheter monitoring system display indicates these monitored changes to the physician advancing the catheter. The information provided by the electronic catheter monitoring system is used by the physician to guide catheter placement and confirm its location at the desired location outside the heart before the SA node.
摘要翻译：一种用于定位邻近心脏起搏器节点的导管的方法和装置。导管尖端在SA心脏起搏器节点之前的放置是医学中常见且期望的程序，其中最严重的并发症是超出这一点将其尖端置于心脏中的意外进展，并且常常是致命的并发症。导管尖端位置恰好在SA心脏起搏器节点之前，因为最常见的是最安全和最佳的位置。本发明中描述的导管由医师放置在患者的身体循环血管内，并使用传统医疗程序前进到心脏起搏器节点。从导管的远端，通过位于导管内的至少一个绝缘传输线监测并传送来自心脏起搏器节点的内源性电活动到位于身体外部的电子导管监测系统。当导管进行时，其尖端在患者的循环血管内移动。同时，电子导管监测系统监测在导管末端获得的自然起搏器节点电位，随着节点接近而增加，并随着节点通过而减小。电子导管监测系统显示器指示医师推进导管的这些监测的变化。电子导管监测系统提供的信息由医师使用以引导导管放置并且在SA节点之前确认其位于心脏外部期望位置处的位置。

2. 发明申请

US20050192567A1 Nervous tissue stimulation device and method 有权
标题翻译：神经组织刺激装置及方法
公开(公告)号：US20050192567A1
公开(公告)日：2005-09-01
申请号：US10788271
申请日：2004-03-01
申请人： Jefferson Katims
发明人： Jefferson Katims
IPC分类号： A61B5/0484 , A61B5/05 , A61N1/18 , A61N1/20 , A61N1/22 , A61N1/36
CPC分类号： A61B5/0484 , A61B5/05 , A61B5/4041 , A61N1/36021
摘要： A method using a precisely controlled, computer programmable stimulus for neuroselective tissue stimulation that does not leave a sufficient voltage or electrical artifact on the tissue being stimulated that would interfere or prevent a monitoring system from recording the physiological response is utilized to evaluate the physiological conduction of the tissue being studied. A computer controls both the waveform, duration and intensity of the stimulus. An output trigger to the nerve response recording component controls the timing of its operation. A neuroselective nervous tissue response latency and amplitude may be determined. The computer controlled stimulus may also be administered for therapeutic purposes.
摘要翻译：使用精确控制的计算机可编程刺激用于神经选择性组织刺激的方法，其不会在干扰或阻止监测系统记录生理反应的被刺激的组织上留下足够的电压或电赝像以评估生理传导正在研究的组织。计算机控制刺激的波形，持续时间和强度。神经反应记录组件的输出触发器控制其操作的时间。可以确定神经选择性神经组织应答潜伏期和幅度。计算机控制的刺激物也可以用于治疗目的。

3. 发明授权

US5078678A Method and apparatus for locating a catheter adjacent to a pacemaker node of the heart 失效
标题翻译：用于定位邻近心脏起搏器节点的导管的方法和装置
公开(公告)号：US5078678A
公开(公告)日：1992-01-07
申请号：US487296
申请日：1990-03-02
申请人： Jefferson Katims
发明人： Jefferson Katims
IPC分类号： A61B5/042 , A61B5/06
CPC分类号： A61B5/042 , A61B5/06
摘要： A method and apparatus for locating a catheter adjacent to a pacemaker node of the heart. The placement of a catheter tip just before SA heart pacemaker node is a common and desired procedure in medicine, with the most serious complication being its accidental advancement of the beyond this point placing its tip into the heart, with often fatal complications. The catheter tip location just before SA heart pacemaker node is desired because is most often the safest and optimal location. The catheter described in the present invention is placed by a physician within a patients body circulatory vessel and advanced towards the heart SA pacemaker node, using traditional medical procedures. From the distal tip of the catheter the endogenous electrical activity from the SA pacemaker node of the heart is monitored and transmitted via at least one insulated transmission line located within the catheter to an electronic catheter monitoring system located outside the body. As the catheter is advanced its tip moves within the patient's circulatory vessel. Simultaneously, the electronic catheter monitoring system monitors the natural pacemaker node potentials, obtained at the tip of the catheter, which increase as the node is approached and decrease as the node is passed. The electronic catheter monitoring system display indicates these monitored changes to the physician advancing the catheter. The information provided by the electronic catheter monitoring system is used by the physician to guide catheter placement and confirm its location at the desired location outside the heart before the SA node.
摘要翻译：一种用于定位邻近心脏起搏器节点的导管的方法和装置。导管尖端在SA心脏起搏器节点之前的放置是医学中常见且期望的程序，其中最严重的并发症是超出这一点将其尖端置于心脏中的意外进展，并且常常是致命的并发症。导管尖端位置恰好在SA心脏起搏器节点之前，因为最常见的是最安全和最佳的位置。本发明中描述的导管由医师在患者体循环血管内放置，并使用传统的医疗程序前进到心脏起搏器节点。从导管的远端，通过位于导管内的至少一个绝缘传输线监测并传送来自心脏起搏器节点的内源性电活动到位于身体外部的电子导管监测系统。当导管进行时，其尖端在患者的循环血管内移动。同时，电子导管监测系统监测在导管末端获得的自然起搏器节点电位，随着节点接近而增加，并随着节点通过而减小。电子导管监测系统显示器指示医师推进导管的这些监测的变化。电子导管监测系统提供的信息由医师使用以引导导管放置并且在SA节点之前确认其位于心脏外部期望位置处的位置。

4. 发明申请

US20070032827A1 METHOD AND APPARATUS FOR PRODUCING THERAPEUTIC AND DIAGNOSTIC STIMULATION 审中-公开
标题翻译：用于生产治疗和诊断性刺激的方法和装置
公开(公告)号：US20070032827A1
公开(公告)日：2007-02-08
申请号：US11463038
申请日：2006-08-08
申请人： Jefferson Katims
发明人： Jefferson Katims
IPC分类号： A61N1/00
CPC分类号： A61N1/3787 , A61N1/06 , A61N1/36007 , A61N1/36017 , A61N1/36021 , A61N1/36067 , A61N1/36071 , A61N1/40
摘要： Advances have been made in electrical stimulation for medical, diagnostic and therapeutic uses, including cutaneous uses and non-cutaneous uses (such as medical implant devices). The novel systems are based on a modulated continuous symmetric wave-form especially at a high-frequency (1 kHz-50,000 kHz), especially devices including a FPGA or ASCI chip. Such electrical systems finally make possible safe, miniaturized medical devices small enough to be hand-held or implantable. A high-frequency symmetric waveform is used to synthesize a low-frequency sine wave.
摘要翻译：在医疗，诊断和治疗用途的电刺激中已经取得进展，包括皮肤用途和非皮肤用途（例如医疗植入装置）。新颖的系统基于调制的连续对称波形，特别是在高频（1 kHz至50,000 kHz），特别是包括FPGA或ASCI芯片的器件。这样的电气系统最终使安全的，小型化的医疗设备足够小以便被手持或可植入。高频对称波形用于合成低频正弦波。

5. 发明授权

US5078714A Method and apparatus for placement of a probe in the body and the medical procedure for guiding and locating a catheter or probe in the body 失效
标题翻译：用于将探针放置在体内的方法和装置以及用于将导管或探针引导和定位在体内的医疗程序
公开(公告)号：US5078714A
公开(公告)日：1992-01-07
申请号：US487303
申请日：1990-03-02
申请人： Jefferson Katims
发明人： Jefferson Katims
IPC分类号： A61B5/06 , A61M25/01
CPC分类号： A61M25/0105 , A61B5/06
摘要： A method and apparatus for guiding a physician in the placement of a probe in the body. The method of placement of a catheter or probe in the body through a multi-directional walled path departing from a straight line involving inserting an insulated catheter or probe with a distal uninsulated tip which is electronically connected in a circuit to an electronic catheter guidance system apparatus located outside the patients body which has a power source and a calibrated monitor. The catheter is advanced by a physician into an initial opening in said multi-directional path in a patient's body moving the tip of said catheter or probe forward along said path until the calibrated monitor displays that an obstruction has been met indicating a change in path direction. Using this information the physician halts or discontinues or slows down in the forward movement of said catheter or probe until an adjustment is made such as by twisting or turning or externally pushing the contacting wall so that forward movement of the catheter or probe may be continued without obstruction as determined by the information provided by the electronic catheter guidance system display. The physician repeats such steps as the calibrated monitor displays that the catheter tip is within the desired walled path and that the catheter may be utilized.
摘要翻译：一种用于引导医师将探针放置在体内的方法和装置。将导管或探针放置在身体内的方法是通过离开直线的多方向的围墙路径，包括将绝缘的导管或探针插入到远端未绝缘的尖端中，该远端未绝缘的尖端电路连接到电路中的电子导管系统装置位于具有电源和校准监视器的患者体外。导管由医师进入患者体内的所述多方向路径中的初始开口，使所述导管或探针的尖端沿着所述路径向前移动，直到校准的监视器显示已经满足指示路径方向改变的障碍物。使用该信息，医生在所述导管或探针的向前运动中停止或停止或减慢直到进行调整，例如通过扭转或转动或外推推动接触壁，使得导管或探针的向前运动可以在没有梗阻由电子导管引导系统显示的信息确定。医生重复这样的步骤，校准的监视器显示导管尖端在期望的围壁路径内，并且可以使用导管。

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