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1. 发明授权

US09987486B2 Method for the treatment of consciousness disorders 有权
公开(公告)号：US09987486B2
公开(公告)日：2018-06-05
申请号：US15250431
申请日：2016-08-29
申请人： Cefaly Technology Sprl
发明人： Pierre Rigaux
IPC分类号： A61N1/00 , A61N1/20 , A61N1/04 , A61N1/22 , A61N1/36 , A61N1/24
CPC分类号： A61N1/205 , A61N1/0456 , A61N1/0476 , A61N1/0484 , A61N1/22 , A61N1/24 , A61N1/36025 , A61N1/36034
摘要： The present invention provides a method for the treatment of consciousness disorder comprising the steps of positioning at least two electrodes on a patient's head such that the first electrode is positioned on the right supraorbicular cortex and the second electrode is positioned on the left dorso-lateral prefrontal cortex; connecting said electrodes to at least one source of electrical current; delivering direct current to the electrodes, and removing the electrodes from the patient's head after a time T; wherein steps a) to d) represent a treatment session and wherein at least one treatment session is is applied on the patient's head at least 2 days per week.

2. 发明授权

US09827418B2 Stimulation device and method for transcutaneous electrical stimulation 有权
公开(公告)号：US09827418B2
公开(公告)日：2017-11-28
申请号：US15027953
申请日：2014-10-10
申请人： GI THERAPIES PTY LTD
发明人： Bridget Rae Southwell , Rod Wiebenga , David Fisher
IPC分类号： A61N1/00 , A61N1/32 , A61N1/22 , A61N1/04 , A61N1/36
CPC分类号： A61N1/321 , A61N1/0452 , A61N1/0456 , A61N1/048 , A61N1/0484 , A61N1/22 , A61N1/323 , A61N1/36007 , A61N1/36014
摘要： A device for transcutaneous electrical stimulation is provided. The device comprises circuitry configured to generate transcutaneous stimulation signals. The device also comprises a first signal output component for electrically connecting to a first electrode connector to deliver generated transcutaneous stimulation signals. The first signal output component comprises a first four-pole electrical connector part. The device further comprises a second signal output component for electrically connecting to a second electrode connector to deliver generated transcutaneous stimulation signals. The second signal output component comprises a second four-pole electrical connector part. The device further comprises a controller to selectively control output of the stimulation signals to selected pairs of poles across the first and second four-pole electrical connector parts. Each selected pair of poles comprises one pole from the first four-pole electrical connector part and one pole from the second four-pole electrical connector part.

3. 发明授权

US09421367B1 Method and apparatus for performing microcurrent electrotherapy 有权
标题翻译：用于进行微电流电疗的方法和装置
公开(公告)号：US09421367B1
公开(公告)日：2016-08-23
申请号：US09656519
申请日：2000-09-07
申请人： Keith F. Wendell , David G. Estes
发明人： Keith F. Wendell , David G. Estes
IPC分类号： A61N1/22 , A61N1/36 , A61N1/32 , A61N1/04
CPC分类号： A61N1/36014 , A61N1/0408 , A61N1/0456 , A61N1/0468 , A61N1/0472 , A61N1/0484 , A61N1/32 , A61N1/321 , A61N1/326
摘要： An electrotherapy method and apparatus for healing injuries and tissue diseases to the human or animal body is disclosed. Particularly, the electrotherapy method disclosed herein comprises delivering a current under various conditions, such as, applying microcurrents ranging from 4 milliamperes to 1 femtoamperes, applying an alternating current with a frequency in the range of 0.00065 Hz to 0.00085 Hz, utilizing large surface-area electrodes to achieve low current densities of less than 5 microamperes per square inch. The apparatus of the present invention includes a plurality of electrode wraps for applying said electrotherapy method to a body. Each electrode wrap includes a first layer wrap of water absorptive material and a second layer wrap of moderately conductive material. Each electrode wrap is placed on a portion of the body, including, without limitation, arms, legs, hands, feet and torso. The method and apparatus of the present invention are useful in treating wounds, ulcerations, spinal cord injuries, amyotrophic lateral sclerosis, multiple sclerosis, nervous system abnormalities, scar tissue and age lines.
摘要翻译：公开了一种用于治疗人体或动物体的损伤和组织疾病的电疗方法和装置。特别地，本文公开的电疗方法包括在各种条件下递送电流，例如施加范围从4毫安至1毫安的微电流，施加频率在0.00065Hz至0.00085Hz范围内的交流电，利用大的表面积电极以实现小于5微安/平方英寸的低电流密度。本发明的装置包括用于将一种电疗方法应用于身体的多个电极罩。每个电极包裹物包括吸水材料的第一层包裹物和适度导电材料的第二层包裹物。每个电极包裹物放置在身体的一部分上，包括但不限于手臂，腿，手，脚和躯干。本发明的方法和装置可用于治疗伤口，溃疡，脊髓损伤，肌萎缩性侧索硬化，多发性硬化，神经系统异常，瘢痕组织和年龄线。

4. 发明授权

US09174040B2 Nerve stimulation and blocking for treatment of gastrointestinal disorders 有权
标题翻译：神经刺激和阻塞用于治疗胃肠道疾病
公开(公告)号：US09174040B2
公开(公告)日：2015-11-03
申请号：US14019126
申请日：2013-09-05
申请人： EnteroMedics Inc.
发明人： Mark B. Knudson , Richard R. Wilson , Katherine S. Tweden , Timothy R. Conrad
IPC分类号： A61N1/18 , A61N1/06 , A61N1/22 , A61N1/05 , A61N1/32 , A61N1/36
CPC分类号： A61N1/36007 , A61N1/05 , A61N1/0551 , A61N1/321 , A61N1/36053 , A61N1/3606 , A61N1/36071
摘要： At least one of a plurality of gastrointestinal disorders is treated by stimulating an enteric nervous system of a patient to enhance a functional tone of the enteric nervous system. A treatment includes electrically stimulating a vagus nerve of the patient at a stimulation site proximal to at least one site of vagal innervation of a gastrointestinal organ. The electrical stimulation includes applying a stimulation signal at the stimulation site. An optional proximal electrical blocking signal is applied to the vagus nerve at a proximal blocking site proximal to the stimulation site. The proximal blocking signal is selected to at least partially block nerve impulses at the proximal blocking site.
摘要翻译：通过刺激患者的肠神经系统来治疗多种胃肠道疾病中的至少一种，以增强肠神经系统的功能性色调。治疗包括在靠近胃肠器官的迷走神经支配的至少一个部位的刺激部位电刺激患者的迷走神经。电刺激包括在刺激部位施加刺激信号。在靠近刺激部位的近端阻塞位置，将可选的近端电阻塞信号施加到迷走神经。选择近端阻塞信号以至少部分阻断近端阻塞部位处的神经冲动。

5. 发明申请

US20050192567A1 Nervous tissue stimulation device and method 有权
标题翻译：神经组织刺激装置及方法
公开(公告)号：US20050192567A1
公开(公告)日：2005-09-01
申请号：US10788271
申请日：2004-03-01
申请人： Jefferson Katims
发明人： Jefferson Katims
IPC分类号： A61B5/0484 , A61B5/05 , A61N1/18 , A61N1/20 , A61N1/22 , A61N1/36
CPC分类号： A61B5/0484 , A61B5/05 , A61B5/4041 , A61N1/36021
摘要： A method using a precisely controlled, computer programmable stimulus for neuroselective tissue stimulation that does not leave a sufficient voltage or electrical artifact on the tissue being stimulated that would interfere or prevent a monitoring system from recording the physiological response is utilized to evaluate the physiological conduction of the tissue being studied. A computer controls both the waveform, duration and intensity of the stimulus. An output trigger to the nerve response recording component controls the timing of its operation. A neuroselective nervous tissue response latency and amplitude may be determined. The computer controlled stimulus may also be administered for therapeutic purposes.
摘要翻译：使用精确控制的计算机可编程刺激用于神经选择性组织刺激的方法，其不会在干扰或阻止监测系统记录生理反应的被刺激的组织上留下足够的电压或电赝像以评估生理传导正在研究的组织。计算机控制刺激的波形，持续时间和强度。神经反应记录组件的输出触发器控制其操作的时间。可以确定神经选择性神经组织应答潜伏期和幅度。计算机控制的刺激物也可以用于治疗目的。

6. 发明授权

US6087394A Compositions, apparatus and methods for facilitating surgical procedures 有权
标题翻译：用于促进外科手术的组合物，装置和方法
公开(公告)号：US6087394A
公开(公告)日：2000-07-11
申请号：US379381
申请日：1999-08-23
申请人： Francis G. Duhaylongsod
发明人： Francis G. Duhaylongsod
IPC分类号： A61B17/00 , A61K31/00 , A61K31/138 , A61K31/27 , A61K45/06 , A61M25/00 , A61P9/04 , A01N47/10 , A61N1/18 , A61N1/20 , A61N1/22 , A61N1/24
CPC分类号： A61K31/27 , A61K31/00 , A61K45/06 , A61M2210/125 , Y10S514/922
摘要： Methods are provided for conducting surgical procedures in a patient wherein, during the surgical procedure, autonomous ventricular electrical conductivity and escape beats are reversibly and transiently suppressed to facilitate the surgical procedure. Also provided are compositions which are capable of inducing ventricular asystole in a patient. The compositions may include an AV node blocker. In one embodiment, compositions including an atrioventricular (AV) node blocker and a .beta.-blocker are provided, wherein the .beta.-blocker is present in an amount sufficient to substantially reduce the amount of AV node blocker required to induce ventricular asystole in the patient. The compositions and methods may be used for inducing temporary ventricular asystole in a beating heart, and to facilitate the performance of a variety of surgical techniques, including minimally invasive microsurgical techniques. Methods for performing a surgical procedure on a human patient are provided wherein a composition capable of inducing transient reversible ventricular asystole is administered to the heart, for example by intracoronary injection. The heart then is electrically paced using an electrical pacing system, thereby to maintain the patient's blood circulation. The electrical pacing then is selectively intermittently stopped to allow ventricular asystole to occur, and the steps of the surgical or therapeutic procedure, such as suturing, are conducted during the time that the electrical pacing is intermittently stopped. The methods and compositions advantageously may be used in a range of different surgical procedures including cardiac, vascular and neurosurgical procedures.
摘要翻译：提供了用于在患者中进行外科手术的方法，其中在外科手术过程中，自主心室电导率和逃逸搏动是可逆的和瞬时的抑制以便于外科手术。还提供了能够诱导患者心室停搏的组合物。组合物可以包括AV结节阻断剂。在一个实施方案中，提供包括房室（AV）节段阻断剂和β-阻断剂的组合物，其中所述β-阻断剂的存在量足以基本上减少在患者体内诱导室性心动过速所需的AV结节阻断剂的量。组合物和方法可以用于在搏动的心脏中诱导临时心室停搏，并且促进各种手术技术的执行，包括微创显微外科技术。提供了对人类患者进行外科手术的方法，其中例如通过冠状动脉内注射向心脏施用能够诱发暂时的可逆性心室停搏的组合物。然后使用电起搏系统对心脏进行电动起搏，从而维持患者的血液循环。然后选择性地间歇性地停止电起搏以允许发生心室停搏，并且在电起搏间歇停止的时间期间进行手术或治疗程序的步骤，例如缝合。所述方法和组合物有利地可用于一系列不同的外科手术，包括心脏，血管和神经外科程序。

7. 发明授权

US06002965A Self applied device and method for prevention of deep vein thrombosis 失效
标题翻译：自适应装置及预防深静脉血栓形成的方法
公开(公告)号：US06002965A
公开(公告)日：1999-12-14
申请号：US94512
申请日：1998-06-10
申请人： Amiram Katz , Orly Katz
发明人： Amiram Katz , Orly Katz
IPC分类号： A61N1/32 , A61N1/24 , A61N1/18 , A61N1/22
CPC分类号： A61N1/321 , A61N1/36003 , Y10S128/15
摘要： An elongated rectangular cuff having fasteners and electrodes with an attached control unit for providing a predetermined electrical signal to the electrodes. The predetermined electrical signal is substantially a square wave with a duration of between 0.1 and 0.3 milliseconds, a frequency of between 0.1 and 0.5 Hertz, with 5 to 15 repetitions delivered every 5 to 15 minute intervals. The control unit provides a controllable intensity of between 1 to 20 milliamperes. The cuff or sleeve, when wrapped around a user's leg and positioned below the knee such that the electrodes contact the calf muscles, causes a muscle and nerve stimulation resulting in contraction of the calf muscle. Blood flow is therefore increased regardless of body position or a movement greatly decreasing the possibility of developing deep vein thrombosis or pulmonary embolism, which may be fatal. In addition it reduces ankle edema and leg discomfort associated with prolonged sitting. A predetermined applied signal is safe with little risk of harm to the user. Additionally, preferably the control unit has a single external control for controlling intensity preventing a user from applying an inappropriate signal. A simple to use, compact device and method is disclosed that can safely be used by individuals having no prior knowledge of anatomy, effectively during extended periods of sitting or immobility, such as when traveling.
摘要翻译：具有紧固件和电极的细长矩形箍，其具有附接的控制单元，用于向电极提供预定的电信号。预定的电信号基本上是持续时间在0.1和0.3毫秒之间，频率在0.1和0.5赫兹之间的方波，每5到15分钟间隔传送5到15次。控制单元提供1至20毫安之间的可控强度。袖口或袖子当缠绕在使用者的腿部并且位于膝盖下方以使得电极与小腿肌肉接触时，引起肌肉和神经刺激，导致小腿肌肉的收缩。因此，不管身体位置或运动大大降低发生深静脉血栓形成或肺栓塞的可能性，血液流动可能是致命的。此外，它减少与长期坐着相关的脚踝水肿和腿部不适。预定的应用信号是安全的，对用户几乎没有危害的风险。此外，优选地，控制单元具有用于控制防止用户施加不适当信号的强度的单个外部控制。公开了一种易于使用，紧凑的装置和方法，可以在长时间的坐着或不动时（例如旅行时）有效地安全地使用具有解剖学先验知识的个体。

8. 发明授权

US5999855A Method and apparatus for electrical activation of the expiratory muscles to restore cough 有权
标题翻译：用于激活呼气肌恢复咳嗽的方法和装置
公开(公告)号：US5999855A
公开(公告)日：1999-12-07
申请号：US224244
申请日：1998-12-30
申请人： Anthony F. DiMarco
发明人： Anthony F. DiMarco
IPC分类号： A61N1/36 , A61N1/22
CPC分类号： A61N1/3601
摘要： A method and apparatus are provided for electrical stimulation of the expiratory muscles in a human or other mammal to produce cough in patients with spinal cord injuries resulting in paralysis of their expiratory muscles. The method of electrically activating expiratory muscles of a human patient or other mammal includes positioning a first epidural electrode at a first location on the dorsal surface of a spinal cord of a patient and a second epidural electrode, if necessary, at a second location on the dorsal surface of the patient's spinal cord. The first epidural electrode is positioned on the spinal cord dorsal surface in the region of the T.sub.9 -T.sub.10 spinal root level, while the second epidural electrode is positioned in the region of the lower thoracic spinal root, at the T.sub.12 -L.sub.1 spinal cord level. Electrical stimulation pulses are selectively passed to the first and second epidural electrodes from an implanted radio-frequency receiver and stimulation pulse generator to activate expiratory muscles of the patient to produce cough. The invention provides a safe, effective, and portable means by which spinal cord injured patients are able to clear secretions more easily and thereby improve their lifestyle and reduce the morbidity and mortality due to respiratory complications.
摘要翻译：提供了一种方法和装置，用于电刺激人或其他哺乳动物中的呼气肌，以在导致其呼气肌麻痹的脊髓损伤患者中产生咳嗽。电活化人类患者或其他哺乳动物的呼吸肌的方法包括将第一硬膜外电极定位在患者脊髓的背表面上的第一位置和第二硬膜外电极上，如果需要，在第二位置上患者脊髓背表面。第一硬膜外电极位于T9-T10脊髓水平区域的脊髓背表面，而第二硬膜外电极位于下胸部脊髓根部的T12-L1脊髓水平的区域。电刺激脉冲从植入的射频接收器和刺激脉冲发生器选择性地传递到第一和第二硬膜外电极，以激活患者的呼气肌产生咳嗽。本发明提供了一种安全，有效和便携的手段，使脊髓损伤的患者能够更容易地清除分泌物，从而改善他们的生活方式，并降低由呼吸道并发症引起的发病率和死亡率。

9. 发明授权

US4583547A Garment apparatus for delivering or receiving electric impulses 失效
标题翻译：用于传送或接收电脉冲的服装设备
公开(公告)号：US4583547A
公开(公告)日：1986-04-22
申请号：US517810
申请日：1983-07-27
申请人： Herman Granek , Murry Granek , John Church
发明人： Herman Granek , Murry Granek , John Church
IPC分类号： A41D1/00 , A61B5/0408 , A61N1/04 , A61N1/22 , A61B5/04
CPC分类号： A61N1/22 , A61B5/04085 , A61B5/6804 , A61N1/0452 , A61N1/0456 , A61N1/0484 , A41D1/002 , A61N1/0464
摘要： A garment containing multiple conductive paths made of conductive cloth is used to connect an external electrical apparatus to various points on the skin of the wearer. The garment can be designed for electrical monitoring of sites or electrical stimulation. Designated sites on the garment can be activated by soaking the site with conducting fluid.
摘要翻译：使用包含由导电布制成的多个导电路径的衣服将外部电气设备连接到穿着者皮肤上的各个点。服装可以设计用于电站监控或电刺激。衣服上的指定地点可以通过用导电流体浸泡场地来激活。

10. 发明授权

US4432368A Automatic electrode placement device 失效
标题翻译：自动电极放置装置
公开(公告)号：US4432368A
公开(公告)日：1984-02-21
申请号：US277940
申请日：1981-06-26
申请人： Allen S. Russek
发明人： Allen S. Russek
IPC分类号： A61B5/0478 , A61B5/04 , A61B5/0408 , A61N1/04 , A61N1/22
CPC分类号： A61N1/0484 , A61N1/22
摘要： A device for placement against a body and for loacting at least one electrode at predetermined portions of a body includes a first portion having at least one electrode thereon, said at least one electrode overlying at least two stimulation points on the body of a wearer, and electrical connectors coupled to the first portion for electrically connecting the at least one electrode to an electrical signal receiving and/or generating device. The device is removably secured to the body of a wearer with a predetermined automatic orientation relative to the body of a wearer so that the at least one electrode is properly located adjacent a body portion of the wearer to overlie said at least two stimulation points. A locating device is provided on the device for positively placing the device relative to a predetermined body portion of the wearer to insure proper electrode placement against the body.
摘要翻译：用于放置在身体上并用于在身体的预定部分处放置至少一个电极的装置包括其上具有至少一个电极的第一部分，所述至少一个电极覆盖穿戴者身体上的至少两个刺激点，以及电连接器，其耦合到第一部分，用于将至少一个电极电连接到电信号接收和/或产生装置。该装置以相对于穿着者身体的预定的自动取向可拆卸地固定到穿着者的身体，使得至少一个电极适当地位于邻近佩戴者的身体部分以覆盖所述至少两个刺激点。定位装置设置在装置上，用于相对于穿戴者的预定身体部分确定放置装置，以确保适当的电极放置在身体上。

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