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1. 发明授权

US09498589B2 Methods and systems for adaptive base flow and leak compensation 有权
标题翻译：自适应基流和泄漏补偿的方法和系统
公开(公告)号：US09498589B2
公开(公告)日：2016-11-22
申请号：US13341957
申请日：2011-12-31
申请人： Mehdi M. Jafari , Milenko Masic , Rhomere S. Jimenez , Jeffrey K. Aviano , Edward R. McCoy
发明人： Mehdi M. Jafari , Milenko Masic , Rhomere S. Jimenez , Jeffrey K. Aviano , Edward R. McCoy
IPC分类号： A61M16/00
CPC分类号： A61M16/0003 , A61M16/00 , A61M16/0051 , A61M16/0063 , A61M16/026 , A61M16/0833 , A61M16/0875 , A61M2016/0018 , A61M2016/0021 , A61M2016/0027 , A61M2016/0033 , A61M2016/0036 , A61M2016/0039 , A61M2016/0042 , A61M2205/15 , A61M2205/505 , A61M2205/583 , A61M2230/40
摘要： This disclosure describes systems and methods for providing adaptive base flow scheduling during ventilation of a patient to optimize patient-machine synchrony and accuracy of estimated exhaled as well as inhaled tidal volumes. Further, this disclosure describes systems and methods for providing adaptive inspiratory trigger threshold scheduling during the adaptive base flow scheduling. Further still, this disclosure describes systems and methods for determining an estimated leak flow and adjusting the adaptive base flow scheduling and the adaptive inspiratory trigger threshold scheduling based on the estimated leak flow. Moreover, this disclosure describes systems and methods for determining a change in the estimated leak flow and adjusting the adaptive base flow scheduling and the adaptive inspiratory trigger threshold scheduling based on the change in the estimated leak flow.
摘要翻译：本公开描述了用于在患者通气期间提供适应性基本流程调度以优化患者机器同步和估计的呼出以及吸入潮气量的准确性的系统和方法。此外，本公开描述了在自适应基本流调度期间提供自适应吸气触发阈值调度的系统和方法。此外，本公开内容描述了用于基于估计的泄漏流量来确定估计泄漏流量并调整自适应基本流程调度和自适应吸气触发阈值调度的系统和方法。此外，本公开描述了基于估计的泄漏流的变化来确定估计的泄漏流量的变化并调整自适应基本流程调度和自适应吸气触发阈值调度的系统和方法。

2. 发明申请

US20130255685A1 METHODS AND SYSTEMS FOR TRIGGERING WITH UNKNOWN BASE FLOW 有权
标题翻译：用于触发未知基底流的方法和系统
公开(公告)号：US20130255685A1
公开(公告)日：2013-10-03
申请号：US13435968
申请日：2012-03-30
申请人： Mehdi M. Jafari , Rhomere S. Jimenez , Jeffrey K. Aviano
发明人： Mehdi M. Jafari , Rhomere S. Jimenez , Jeffrey K. Aviano
IPC分类号： A61M16/00
CPC分类号： A61M16/0003 , A61M16/0051 , A61M16/0063 , A61M16/026 , A61M16/0833 , A61M16/204 , A61M16/205 , A61M2016/0021 , A61M2016/0036 , A61M2016/0039 , A61M2016/0042 , A61M2205/16 , A61M2205/505 , A61M2205/70
摘要： This disclosure describes systems and methods for providing novel back-up ventilation that allows the patient to trigger or initiate the delivery of breath. Further, this disclosure describes systems and methods for triggering ventilation when base flow is unknown or undeterminable by the ventilator.
摘要翻译：本公开描述了用于提供新颖的备用通气的系统和方法，其允许患者触发或开始呼气。此外，本公开描述了当基础流未知或不能由呼吸机确定时触发通气的系统和方法。

3. 发明申请

US20130025596A1 METHODS AND SYSTEMS FOR MODEL-BASED TRANSFORMED PROPORTIONAL ASSIST VENTILATION 审中-公开
标题翻译：基于模型变换比例辅助通气的方法和系统
公开(公告)号：US20130025596A1
公开(公告)日：2013-01-31
申请号：US13191709
申请日：2011-07-27
申请人： Mehdi M. Jafari , Peter R. Doyle , Rhomere S. Jimenez , Jeffrey K. Aviano , Edward R. McCoy , Gail F. Upham
发明人： Mehdi M. Jafari , Peter R. Doyle , Rhomere S. Jimenez , Jeffrey K. Aviano , Edward R. McCoy , Gail F. Upham
IPC分类号： A61M16/00
CPC分类号： A61M16/0051 , A61M16/0063 , A61M16/026 , A61M16/0833 , A61M2016/0021 , A61M2016/0027 , A61M2016/003 , A61M2205/50 , A61M2205/505
摘要： This disclosure describes systems and methods for providing a model-based transformed proportional assist breath type during ventilation of a patient. The disclosure describes a novel breath type that delivers a target pressure calculated based on a predetermined trajectory and a support setting to a triggering patient.
摘要翻译：本公开描述了在患者通气期间提供基于模型的变换比例辅助呼吸类型的系统和方法。本公开描述了一种新颖的呼吸类型，其将基于预定轨迹计算的目标压力和支撑设置传递给触发患者。

4. 发明授权

US08272379B2 Leak-compensated flow triggering and cycling in medical ventilators 有权
标题翻译：泄漏补偿流量触发和医疗呼吸机循环
公开(公告)号：US08272379B2
公开(公告)日：2012-09-25
申请号：US12242741
申请日：2008-09-30
申请人： Mehdi M. Jafari , Jeffrey K. Aviano , Rhomere S. Jimenez , Gail F. Upham
发明人： Mehdi M. Jafari , Jeffrey K. Aviano , Rhomere S. Jimenez , Gail F. Upham
IPC分类号： A61M11/00
CPC分类号： A61M16/0057 , A61M16/0051 , A61M16/0063 , A61M16/026 , A61M16/04 , A61M16/06 , A61M16/0666 , A61M16/0875 , A61M2016/0021 , A61M2016/0027 , A61M2016/0033 , A61M2205/15 , A61M2205/502 , A61M2205/52 , A61M2230/46
摘要： This disclosure describes systems and methods for compensating for inelastic and elastic leaks in a ventilation system. The disclosure describes a model-based enhancement to conventional flow triggering and cycling methodologies that improves the timing and patient work of flow-based triggering and cycling performance. The methods and systems described herein compensate for the leak condition and minimize additional effort a patient has to exert to generate the same patient synchrony and comfort level compared to no leak condition. One method described includes calculating an elastic leakage and an inelastic leakage based on current measurements of pressure and flow in the ventilation system and then estimating a leak-compensated lung flow using the inelastic and elastic leaks and pneumatic attributes of the patient-ventilator system.
摘要翻译：本公开描述了用于补偿通气系统中的非弹性和弹性泄漏的系统和方法。本公开描述了对常规流量触发和循环方法的基于模型的增强，其改进了基于流的触发和循环性能的时间和患者工作。本文所述的方法和系统补偿了泄漏状况，并且尽可能减少病人与无泄漏状况相比产生相同患者同步和舒适度的额外努力。所描述的一种方法包括基于通气系统中的压力和流量的当前测量值来计算弹性泄漏和非弹性泄漏，然后使用患者 - 呼吸机系统的非弹性和弹性泄漏和气动属性来估计泄漏补偿肺流。

5. 发明申请

US20120216810A1 Methods And Systems For Transitory Ventilation Support 有权
标题翻译：过渡性通气支持方法与系统
公开(公告)号：US20120216810A1
公开(公告)日：2012-08-30
申请号：US13035977
申请日：2011-02-27
申请人： Mehdi M. Jafari , Peter R. Doyle , Rhomere S. Jimenez , Jeffrey K. Aviano
发明人： Mehdi M. Jafari , Peter R. Doyle , Rhomere S. Jimenez , Jeffrey K. Aviano
IPC分类号： A61M16/00
CPC分类号： A61M16/0063 , A61M16/0051 , A61M16/024 , A61M16/0833 , A61M2016/0021 , A61M2016/0027 , A61M2016/0039 , A61M2205/505 , A61M2230/46 , A61M2230/60
摘要： This disclosure describes systems and methods for providing a transitory ventilation support breath type during ventilation of a patient. The disclosure describes a novel breath type that provides for a beneficial transition between an assist breath type and an effort-based breath type and/or a breath type that is beneficial for weak patients.
摘要翻译：本公开描述了用于在患者通气期间提供短暂通气支持呼吸型的系统和方法。本公开描述了一种新颖的呼吸类型，其提供辅助呼吸类型和基于努力的呼吸类型和/或有利于弱病人的呼吸类型之间的有益过渡。

6. 发明授权

US08585412B2 Configurable respiratory muscle pressure generator 有权
标题翻译：可配置的呼吸肌力发生器
公开(公告)号：US08585412B2
公开(公告)日：2013-11-19
申请号：US12241901
申请日：2008-09-30
申请人： Mehdi M. Jafari , Jeffrey K. Aviano , Roger S. Mecca
发明人： Mehdi M. Jafari , Jeffrey K. Aviano , Roger S. Mecca
IPC分类号： G09B23/28
CPC分类号： G09B23/288
摘要： Systems and methods are provided for etiologic-based breath simulation and/or ventilator test platforms that provide operator-configurable breathing patterns, patient respiratory muscular effort waveform characteristics and patient parameter values. According to one embodiment, multiple respiratory muscle effort waveform specifications, each of which have associated therewith one or more waveform parameters, are provided for use by a breathing effort generator. The waveform specifications include (i) a specification based upon an empirical model that approximates clinically-observed, patient-generated muscle pressures, (ii) a specification based on configurable etiology-driven templates and/or (iii) a specification based on a configurable piecewise trajectory template. A waveform engine of the breathing effort generator is configured in accordance with a selected waveform specification and corresponding waveform parameter values. Finally, the desired breathing pattern is simulated by a lung simulation system based on one or more model parameter values and a respiratory muscle effort waveform generated by the waveform engine.
摘要翻译：为基于病因的呼吸模拟和/或呼吸机测试平台提供系统和方法，其提供操作者可配置的呼吸模式，患者呼吸肌力量波形特征和患者参数值。根据一个实施例，提供了多个呼吸肌力量波形规格，每个呼吸肌力量波形规格中的每一个都与一个或多个波形参数相关联，供呼吸努力发生器使用。波形规范包括（i）基于近似于临床观察的患者产生的肌肉压力的经验模型的规范，（ii）基于可配置的病因驱动模板的规范和/或（iii）基于可配置的分段轨迹模板。根据选择的波形规格和对应的波形参数值，配置呼吸力发生器的波形引擎。最后，基于一个或多个模型参数值和由波形引擎产生的呼吸肌力量波形，通过肺模拟系统模拟所需呼吸模式。

7. 发明授权

US08528554B2 Inverse sawtooth pressure wave train purging in medical ventilators 失效
标题翻译：医用呼吸机逆锯齿波压力列车清洗
公开(公告)号：US08528554B2
公开(公告)日：2013-09-10
申请号：US12553568
申请日：2009-09-03
申请人： Medhi M. Jafari , Jeffrey K. Aviano , Daniel G. Grabol , Edward R. McCoy , Gail F. Upham
发明人： Medhi M. Jafari , Jeffrey K. Aviano , Daniel G. Grabol , Edward R. McCoy , Gail F. Upham
IPC分类号： A61M16/00
CPC分类号： A61M16/00 , A61M16/0051 , A61M16/0063 , A61M16/024 , A61M16/0833 , A61M16/085 , A61M16/0858 , A61M2016/0027
摘要： This disclosure describes systems and methods for purging narrow diameter sensor tubing, occasionally referred to as “sensor lines,” in a ventilation system. The disclosure describes a novel approach in which a series of short, periodic releases of pressurized gas through the sensor tubes are used to clear any blockages due to condensation or patient secretions.
摘要翻译：本公开描述了用于在通风系统中吹扫窄直径传感器管道的系统和方法，有时称为“传感器线路”。本公开描述了一种新颖的方法，其中通过传感器管的一系列短期定期释放的加压气体用于清除由于冷凝或患者分泌物引起的任何阻塞。

8. 发明授权

US08448641B2 Leak-compensated proportional assist ventilation 有权
公开(公告)号：US08448641B2
公开(公告)日：2013-05-28
申请号：US13565595
申请日：2012-08-02
申请人： Mehdi M. Jafari , Rhomere S. Jimenez , Gail F. Upham , Jeffrey K. Aviano
发明人： Mehdi M. Jafari , Rhomere S. Jimenez , Gail F. Upham , Jeffrey K. Aviano
IPC分类号： F16K31/02
CPC分类号： A61M16/0057 , A61M16/0051 , A61M16/0063 , A61M16/026 , A61M16/04 , A61M16/0666 , A61M16/0816 , A61M16/0875 , A61M2016/0021 , A61M2016/0027 , A61M2016/0033 , A61M2205/15 , A61M2205/505 , A61M2230/46
摘要： This disclosure describes systems and methods for compensating for leakage when during delivery of gas from a medical ventilator in a proportional assist mode to a patient. The technology described herein includes systems and methods to compensate the delivery of PA ventilation for leakage in the patient circuit by using leak-compensated lung flows as well as leak-compensated respiratory mechanics parameters (lung compliance and lung resistance) estimated in a manner that compensates for elastic and inelastic leaks from the ventilation system.

9. 发明授权

US08424521B2 Leak-compensated respiratory mechanics estimation in medical ventilators 有权
标题翻译：医用呼吸机泄漏补偿呼吸力学估计
公开(公告)号：US08424521B2
公开(公告)日：2013-04-23
申请号：US12395332
申请日：2009-02-27
申请人： Mehdi M. Jafari , Rhomere S. Jimenez , Gail F. Upham , Jeffrey K. Aviano
发明人： Mehdi M. Jafari , Rhomere S. Jimenez , Gail F. Upham , Jeffrey K. Aviano
IPC分类号： F16K31/02
CPC分类号： A61M16/026 , A61M16/0063 , A61M2016/0021 , A61M2016/0027 , A61M2016/0033 , A61M2205/15 , A61M2205/502 , A61M2205/52 , A61M2230/46
摘要： This disclosure describes systems and methods for compensating for leakage when determining the respiratory mechanics of a patient during delivery of gas from a medical ventilator to a patient. The systems and methods include monitoring an instantaneous flow in the ventilation system based on one or more measurements of pressure and flow in ventilation system. The leakage is modeled using a predetermined leakage model. A leak-compensated instantaneous lung flow of gas inhaled or exhaled by the patient is estimated. Using the leak-compensated lung flow and a predetermined respiratory mechanics model, the respiratory mechanics of a patient may be estimated including at least one of a leak-compensated lung compliance and a leak-compensated lung resistance. The method may include using a dynamic respiratory mechanics model or a static respiratory mechanics model that requires use of a pause maneuver to collect the necessary data.
摘要翻译：本公开描述了在从医用呼吸机向患者输送气体时确定患者的呼吸力学时补偿泄漏的系统和方法。系统和方法包括基于通风系统中的一个或多个压力和流量测量来监测通风系统中的瞬时流量。使用预定的泄漏模型建立泄漏。估计由患者吸入或呼出的气体的泄漏补偿的瞬时肺流。使用泄漏补偿肺流和预定的呼吸力学模型，可以估计患者的呼吸力学，包括泄漏补偿的肺顺应性和泄漏补偿的肺阻力中的至少一种。该方法可以包括使用动态呼吸力学模型或需要使用暂停操作来收集必要数据的静态呼吸力学模型。

10. 发明授权

US08272380B2 Leak-compensated pressure triggering in medical ventilators 有权
标题翻译：泄漏补偿压力触发医疗呼吸机
公开(公告)号：US08272380B2
公开(公告)日：2012-09-25
申请号：US12242756
申请日：2008-09-30
申请人： Mehdi M. Jafari , Jeffrey K. Aviano , Rhomere S. Jimenez , Gail F. Upham
发明人： Mehdi M. Jafari , Jeffrey K. Aviano , Rhomere S. Jimenez , Gail F. Upham
IPC分类号： A61M11/00
CPC分类号： A61M16/0057 , A61M16/0051 , A61M16/0063 , A61M16/026 , A61M16/04 , A61M16/06 , A61M16/0666 , A61M16/0875 , A61M2016/0021 , A61M2016/0027 , A61M2016/0033 , A61M2205/15 , A61M2205/502 , A61M2205/52 , A61M2230/46
摘要： This disclosure describes systems and methods for compensating for inelastic and elastic leaks in a ventilation system. The disclosure describes a model-based enhancement to conventional pressure triggering methodology that optimizes the timing and patient work of pressure triggering performance. The methods and systems described herein compensate for the additional effort a patient has to exert to generate the same amount of airway pressure drops compared to no leak condition. One method described includes calculating an elastic leakage and an inelastic leakage based on current measurements of pressure and flow in the ventilation system and then compensating a pressure threshold for the effects of the inelastic and elastic leaks in the system.
摘要翻译：本公开描述了用于补偿通气系统中的非弹性和弹性泄漏的系统和方法。本公开描述了对常规压力触发方法的基于模型的增强，其优化了压力触发性能的时间和病人工作。本文描述的方法和系统补偿了与无泄漏状况相比，患者必须施加额外的努力以产生相同量的气道压降。所描述的一种方法包括基于通气系统中的压力和流量的当前测量值计算弹性泄漏和非弹性泄漏，然后补偿系统中非弹性和弹性泄漏的影响的压力阈值。

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