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1. 发明授权

US10207069B2 System and method for determining ventilator leakage during stable periods within a breath 有权
公开(公告)号：US10207069B2
公开(公告)日：2019-02-19
申请号：US13059711
申请日：2009-03-30
申请人： Mehdi M. Jafari , Rhomere S. Jimenez , Jeffrey K. Aviano , Gail F. Upham
发明人： Mehdi M. Jafari , Rhomere S. Jimenez , Jeffrey K. Aviano , Gail F. Upham
IPC分类号： A61M16/00
摘要： Systems and methods for compensating for leaks in a ventilation system based on data obtained during periods within a breath in which the patient is neither inhaling nor exhaling. The methods and systems described herein more accurately and quickly identify changes in leakage. This information is then to estimate leakage later in the same breath or in subsequent breaths to calculate a more accurate estimate of instantaneous leakage based on current conditions. The estimated leakage is then used to compensate for the leak flow rates, reduce the patient's work of breathing and increase the patient's comfort (patient-ventilator breath phase transition synchrony).

2. 发明授权

US09364624B2 Methods and systems for adaptive base flow 有权
标题翻译：适应基流的方法和系统
公开(公告)号：US09364624B2
公开(公告)日：2016-06-14
申请号：US13313128
申请日：2011-12-07
申请人： Mehdi M. Jafari , Milenko Masic , Rhomere S. Jimenez , Jeffrey K. Aviano , Edward R. McCoy
发明人： Mehdi M. Jafari , Milenko Masic , Rhomere S. Jimenez , Jeffrey K. Aviano , Edward R. McCoy
IPC分类号： A61M16/00
CPC分类号： A61M16/0057 , A61M16/00 , A61M16/0063 , A61M16/026 , A61M16/04 , A61M16/06 , A61M16/0833 , A61M16/0875 , A61M2016/0015 , A61M2016/0021 , A61M2016/0027 , A61M2016/0039 , A61M2016/0042 , A61M2205/15 , A61M2205/3334 , A61M2205/50 , A61M2205/505 , A61M2230/40
摘要： This disclosure describes systems and methods for providing novel adaptive base flow scheduling during ventilation of a patient to optimize the accuracy of estimated exhaled tidal volume. Further, this disclosure describes systems and methods for providing novel adaptive inspiratory trigger threshold scheduling during the novel adaptive base flow scheduling.
摘要翻译：本公开描述了用于在患者通气期间提供新的适应性基流调度以优化估计的呼出潮气量的准确度的系统和方法。此外，本公开描述了在新型自适应基本流调度期间提供新颖的自适应吸气触发阈值调度的系统和方法。

3. 发明申请

US20130255682A1 METHODS AND SYSTEMS FOR COMPENSATION OF TUBING RELATED LOSS EFFECTS 有权
标题翻译：用于补偿管道相关损失效应的方法和系统
公开(公告)号：US20130255682A1
公开(公告)日：2013-10-03
申请号：US13435717
申请日：2012-03-30
申请人： Mehdi M. Jafari , Rhomere S. Jimenez , Jeffrey K. Aviano
发明人： Mehdi M. Jafari , Rhomere S. Jimenez , Jeffrey K. Aviano
IPC分类号： A61M16/00
CPC分类号： A61M16/0051 , A61M16/0063 , A61M16/026 , A61M16/0833 , A61M2016/0027 , A61M2016/0033 , A61M2205/702 , A61M2230/46
摘要： A method for ventilating a patient with a ventilator includes consecutively delivering a plurality of substantially equal volume amounts into a closed ventilator circuit during a ventilator self-test, receiving a pressure measurement for each volume delivery, calculating a change in pressure for each volume delivery, consecutively releasing a plurality of substantially equal volume amounts from the closed ventilator circuit during the ventilator self-test, calculating a change in pressure for each volume release, fitting the calculated change in pressure data for volume delivery and volume release to an inhalation non-linear model equation and an exhalation non-linear model equation, respectively, deriving one or more inhalation tubing compliance compensation coefficients from the inhalation non-linear model equation, and deriving one or more exhalation tubing compliance compensation coefficients from the exhalation non-linear model equation.
摘要翻译：用于通气机的患者通气的方法包括在呼吸机自检期间连续地将多个基本相等的体积量输送到封闭的呼吸机回路中，接收每个体积输送的压力测量值，计算每次体积输送的压力变化，在通气机自检期间连续地从闭合的呼吸机回路释放多个基本相等的体积量，计算每个体积释放的压力变化，将计算出的体积传递和体积释放的压力数据变化拟合到吸入非线性模型方程和呼气非线性模型方程，分别从吸入非线性模型方程得出一个或多个吸入管顺应性补偿系数，并从呼气非线性模型方程推导出一个或多个呼气管顺从补偿系数。

4. 发明授权

US08418691B2 Leak-compensated pressure regulated volume control ventilation 有权
公开(公告)号：US08418691B2
公开(公告)日：2013-04-16
申请号：US12408414
申请日：2009-03-20
申请人： Mehdi M. Jafari , Rhomere S. Jimenez , Gail F. Upham , Jeffrey K. Aviano
发明人： Mehdi M. Jafari , Rhomere S. Jimenez , Gail F. Upham , Jeffrey K. Aviano
IPC分类号： F16K31/02
CPC分类号： A61M16/0057 , A61M16/0051 , A61M16/0063 , A61M16/026 , A61M16/04 , A61M16/0666 , A61M16/0875 , A61M2016/0027 , A61M2016/0033 , A61M2205/15 , A61M2205/502 , A61M2230/46
摘要： This disclosure describes systems and methods for compensating for leakage when during delivery of gas to a patient from a medical ventilator in a pressure regulated volume control (PRVC) ventilation mode. The technology described herein includes systems and methods that compensate the delivery of PRVC ventilation for leakage in the patient circuit by using leak-compensated lung flows as well as respiratory mechanics (lung compliance and lung resistance) estimated in a manner that compensates for elastic and inelastic leaks from the ventilation system.

5. 发明申请

US20130006133A1 METHODS AND SYSTEMS FOR MONITORING VOLUMETRIC CARBON DIOXIDE 审中-公开
公开(公告)号：US20130006133A1
公开(公告)日：2013-01-03
申请号：US13174130
申请日：2011-06-30
申请人： Peter R. Doyle , Gardner Kimm , Mehdi M. Jafari
发明人： Peter R. Doyle , Gardner Kimm , Mehdi M. Jafari
IPC分类号： A61B5/08
CPC分类号： A61B5/0836 , A61B5/087 , A61M16/0063 , A61M16/026 , A61M16/0833 , A61M2016/0027 , A61M2016/0036 , A61M2016/103 , A61M2205/502 , A61M2230/432
摘要： This disclosure describes novel systems and methods for monitoring volumetric CO2 during ventilation of a patient being ventilated by a medical ventilator. The disclosure describes more accurate, more cost effective, and/or less burdensome non-invasive methods and systems for calculating volumetric CO2 than previously utilized methods and systems. The disclosure describes estimating a flow rate in a breathing circuit to calculate a volumetric CO2. Further, the disclosure describes synchronizing the estimated flow rate with a measured CO2 to calculate a volumetric CO2. Additionally, the disclosure describes synchronizing a measured flow rate from within the breathing circuit with a measured CO2 to calculate a volumetric CO2.

6. 发明申请

US20100218767A1 LEAK-COMPENSATED RESPIRATORY MECHANICS ESTIMATION IN MEDICAL VENTILATORS 有权
标题翻译：医疗通风机中泄漏的呼吸呼吸机械估计
公开(公告)号：US20100218767A1
公开(公告)日：2010-09-02
申请号：US12395332
申请日：2009-02-27
申请人： Mehdi M. Jafari , Rhomere S. Jimenez , Gail F. Upham , Jeffrey K. Aviano
发明人： Mehdi M. Jafari , Rhomere S. Jimenez , Gail F. Upham , Jeffrey K. Aviano
IPC分类号： A61M16/00
CPC分类号： A61M16/026 , A61M16/0063 , A61M2016/0021 , A61M2016/0027 , A61M2016/0033 , A61M2205/15 , A61M2205/502 , A61M2205/52 , A61M2230/46
摘要： This disclosure describes systems and methods for compensating for leakage when determining the respiratory mechanics of a patient during delivery of gas from a medical ventilator to a patient. The systems and methods include monitoring an instantaneous flow in the ventilation system based on one or more measurements of pressure and flow in ventilation system. The leakage is modeled using a predetermined leakage model. A leak-compensated instantaneous lung flow of gas inhaled or exhaled by the patient is estimated. Using the leak-compensated lung flow and a predetermined respiratory mechanics model, the respiratory mechanics of a patient may be estimated including at least one of a leak-compensated lung compliance and a leak-compensated lung resistance. The method may include using a dynamic respiratory mechanics model or a static respiratory mechanics model that requires use of a pause maneuver to collect the necessary data.
摘要翻译：本公开描述了在从医用呼吸机向患者输送气体时确定患者的呼吸力学时补偿泄漏的系统和方法。系统和方法包括基于通风系统中的一个或多个压力和流量测量来监测通风系统中的瞬时流量。使用预定的泄漏模型建立泄漏。估计由患者吸入或呼出的气体的泄漏补偿的瞬时肺流。使用泄漏补偿肺流和预定的呼吸力学模型，可以估计患者的呼吸力学，包括泄漏补偿的肺顺应性和泄漏补偿的肺阻力中的至少一种。该方法可以包括使用动态呼吸力学模型或需要使用暂停操作来收集必要数据的静态呼吸力学模型。

7. 发明申请

US20090241962A1 VENTILATOR LEAK COMPENSATION 有权
标题翻译：通风机泄漏补偿
公开(公告)号：US20090241962A1
公开(公告)日：2009-10-01
申请号：US12414419
申请日：2009-03-30
申请人： Mehdi M. Jafari , Rhomere S. Jimenez , Edward R. McCoy , Jeffrey K. Aviano
发明人： Mehdi M. Jafari , Rhomere S. Jimenez , Edward R. McCoy , Jeffrey K. Aviano
IPC分类号： A61M16/00
CPC分类号： A61M16/0057 , A61M16/0051 , A61M16/0063 , A61M16/026 , A61M16/04 , A61M16/06 , A61M16/0666 , A61M16/0875 , A61M2016/0021 , A61M2016/0027 , A61M2016/0033 , A61M2205/15 , A61M2205/502 , A61M2205/52 , A61M2230/46
摘要： A ventilator including a pneumatic system for providing and receiving breathing gas, and a controller operatively coupled with the pneumatic system. The controller is operable to control circulation by the pneumatic system of breathing gas to and from a patient, and to adjust at least one of a volume and pressure of breathing gas delivered to the patient, such adjustment being based upon elastic properties of a component used to fluidly couple the pneumatic system to a patient.
摘要翻译：一种呼吸机，包括用于提供和接收呼吸气体的气动系统，以及与所述气动系统可操作地连接的控制器。控制器可操作以控制气动系统向患者和从患者呼吸气体的循环，并且调节输送到患者的呼吸气体的体积和压力中的至少一个，所述调整基于所使用的组件的弹性特性将气动系统流体地联接到患者身上。

8. 发明申请

US20090241955A1 LEAK-COMPENSATED FLOW TRIGGERING AND CYCLING IN MEDICAL VENTILATORS 有权
标题翻译：泄漏补偿流量触发和循环在医疗通风器
公开(公告)号：US20090241955A1
公开(公告)日：2009-10-01
申请号：US12242741
申请日：2008-09-30
申请人： Mehdi M. Jafari , Jeffrey K. Aviano , Rhomere S. Jimenez , Gail F. Upham
发明人： Mehdi M. Jafari , Jeffrey K. Aviano , Rhomere S. Jimenez , Gail F. Upham
IPC分类号： A61M16/00
CPC分类号： A61M16/0057 , A61M16/0051 , A61M16/0063 , A61M16/026 , A61M16/04 , A61M16/06 , A61M16/0666 , A61M16/0875 , A61M2016/0021 , A61M2016/0027 , A61M2016/0033 , A61M2205/15 , A61M2205/502 , A61M2205/52 , A61M2230/46
摘要： This disclosure describes systems and methods for compensating for inelastic and elastic leaks in a ventilation system. The disclosure describes a model-based enhancement to conventional flow triggering and cycling methodologies that improves the timing and patient work of flow-based triggering and cycling performance. The methods and systems described herein compensate for the leak condition and minimize additional effort a patient has to exert to generate the same patient synchrony and comfort level compared to no leak condition. One method described includes calculating an elastic leakage and an inelastic leakage based on current measurements of pressure and flow in the ventilation system and then estimating a leak-compensated lung flow using the inelastic and elastic leaks and pneumatic attributes of the patient-ventilator system.
摘要翻译：本公开描述了用于补偿通气系统中的非弹性和弹性泄漏的系统和方法。本公开描述了对常规流量触发和循环方法的基于模型的增强，其改进了基于流的触发和循环性能的时间和患者工作。本文所述的方法和系统补偿了泄漏状况，并且尽可能减少病人与无泄漏状况相比产生相同患者同步和舒适度的额外努力。所描述的一种方法包括基于通气系统中的压力和流量的当前测量值来计算弹性泄漏和非弹性泄漏，然后使用患者 - 呼吸机系统的非弹性和弹性泄漏和气动属性来估计泄漏补偿肺流。

9. 发明申请

US20090241951A1 LEAK-COMPENSATED PRESSURE TRIGGERING IN MEDICAL VENTILATORS 有权
标题翻译：泄漏补偿压力在医疗通风机中的触发
公开(公告)号：US20090241951A1
公开(公告)日：2009-10-01
申请号：US12242756
申请日：2008-09-30
申请人： Mehdi M. Jafari , Jeffrey K. Aviano , Rhomere S. Jimenez , Gail F. Upham
发明人： Mehdi M. Jafari , Jeffrey K. Aviano , Rhomere S. Jimenez , Gail F. Upham
IPC分类号： A61M16/00
CPC分类号： A61M16/0057 , A61M16/0051 , A61M16/0063 , A61M16/026 , A61M16/04 , A61M16/06 , A61M16/0666 , A61M16/0875 , A61M2016/0021 , A61M2016/0027 , A61M2016/0033 , A61M2205/15 , A61M2205/502 , A61M2205/52 , A61M2230/46
摘要： This disclosure describes systems and methods for compensating for inelastic and elastic leaks in a ventilation system. The disclosure describes a model-based enhancement to conventional pressure triggering methodology that optimizes the timing and patient work of pressure triggering performance. The methods and systems described herein compensate for the additional effort a patient has to exert to generate the same amount of airway pressure drops compared to no leak condition. One method described includes calculating an elastic leakage and an inelastic leakage based on current measurements of pressure and flow in the ventilation system and then compensating a pressure threshold for the effects of the inelastic and elastic leaks in the system.
摘要翻译：本公开描述了用于补偿通气系统中的非弹性和弹性泄漏的系统和方法。本公开描述了对常规压力触发方法的基于模型的增强，其优化了压力触发性能的时间和病人工作。本文描述的方法和系统补偿了与无泄漏状况相比，患者必须施加额外的努力以产生相同量的气道压降。所描述的一种方法包括基于通气系统中的压力和流量的当前测量值计算弹性泄漏和非弹性泄漏，然后补偿系统中非弹性和弹性泄漏的影响的压力阈值。

10. 发明授权

US06823866B2 Medical ventilator triggering and cycling method and mechanism 有权
标题翻译：医用呼吸机触发和循环的方法和机制
公开(公告)号：US06823866B2
公开(公告)日：2004-11-30
申请号：US10617590
申请日：2003-07-11
申请人： Mehdi M. Jafari , Gardner J. Kimm , Karrie McGuigan
发明人： Mehdi M. Jafari , Gardner J. Kimm , Karrie McGuigan
IPC分类号： A61M1600
CPC分类号： A61M16/205 , A61M16/0051 , A61M16/0069 , A61M16/026 , A61M16/0858 , A61M16/125 , A61M2016/0021 , A61M2016/0027 , A61M2016/0039 , A61M2016/0042 , A61M2205/15
摘要： A medical ventilator system and method that triggers, cycles, or both based on patient effort, which is determined from cross-correlating patient flow and patient pressure. The medical ventilator is also controlled such that sensitivity to a patient initiated trigger increases as the expiratory phase of the breathing cycle progresses. The present invention also provides adaptive adjustment of cycling criteria to optimize the cycling operation.
摘要翻译：一种医疗呼吸机系统和方法，其基于患者的努力触发，循环或两者，其由患者流量和患者压力的相互关联确定。医疗呼吸机也受到控制，使得对呼吸循环的呼气阶段的敏感性随着呼吸循环的进行而增加。本发明还提供了循环准则的自适应调整以优化循环操作。

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