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1. 发明授权

US09464129B2 Neuronal exocytosis inhibiting peptides 有权
标题翻译：神经元胞吐作用抑制肽
公开(公告)号：US09464129B2
公开(公告)日：2016-10-11
申请号：US12447136
申请日：2007-10-24
申请人： Cristina Carreño Serraïma , Berta Ponsati Obiols , Wim Van Den Nest , Jimena Fernandez Carneado , Antonio Ferrer Montiel , Juan Cebrian Puche , Nuria Almiñana Domenech
发明人： Cristina Carreño Serraïma , Berta Ponsati Obiols , Wim Van Den Nest , Jimena Fernandez Carneado , Antonio Ferrer Montiel , Juan Cebrian Puche , Nuria Almiñana Domenech
IPC分类号： A61K38/00 , C07K14/705 , A61K8/14 , A61K8/64 , A61Q19/00 , A61Q19/10 , A61Q19/08
CPC分类号： C07K14/705 , A61K8/14 , A61K8/64 , A61K38/00 , A61Q19/00 , A61Q19/08 , A61Q19/10
摘要： The invention relates to peptides of general formula (I): R1-AA-R2 (I) which can regulate neuronal exocytosis, their stereoisomers and racemic or non-racemic mixtures thereof, and the cosmetically or pharmaceutically acceptable salts thereof, wherein AA is a sequence of 3 to 40 adjacent amino acids contained in the amino acid sequence of the SNAP-25 protein, R1 is selected from the group consisting of H or alkyl, aryl, aralkyl or acyl group; and R2 is selected from the group consisting of amino, hydroxyl or thiol, substituted or non-substituted with aliphatic or cyclic groups, with the condition that when R1 is H or acetyl, R2 is not non-substituted amino, hydroxyl or thiol. The invention also relates to a method of obtaining such peptides, cosmetic or pharmaceutical compositions containing them and their use to treat those conditions requiring neuronal exocytosis regulation, preferably for treating the skin.

2. 发明申请

US20090036363A1 Peptides as cell penetrating carriers 审中-公开
标题翻译：肽作为细胞穿透载体
公开(公告)号：US20090036363A1
公开(公告)日：2009-02-05
申请号：US10591355
申请日：2005-03-07
申请人： Ernest Giralt Lledo , Jimena Fernandez Carneado
发明人： Ernest Giralt Lledo , Jimena Fernandez Carneado
IPC分类号： C07K7/06 , A61K38/16 , A61K38/10 , A61K38/08 , A61K8/64 , C07K16/46 , C07K14/00 , C07K7/08
CPC分类号： A61K47/42 , A61K38/00 , C07K7/06 , C07K7/08
摘要： Compounds of formula (I) or their pharmaceutically or biologically acceptable salts are useful as cell penetrating carriers. According to formula (I), below, Val is L-Val or D-Val; Arg is L-Arg, D-Arg or L-(N-methyl)Arg; Pro is L-Pro or D-Pro; Leu is L-Leu or D-Leu; x is an integer from 1 to 20, preferably 3; L1 and L2 are chemical linkers; M1 and M2 are pharmacologically and/or biologically active moieties; and the bond between L1 and M1 and the bond between L2 and M2 are of the known chemical natures, including covalent and ionic. Compared with other previously described carrier peptides, this new family presents several advantages including its non-viral origin, its amphipathic character, its solubility in water and the absence of a cytotoxic effect at high concentrations. M1-L1-(Val-Arg-Leu-Pro-Pro-Pro)x-L2-M2 (I)
摘要翻译：式（I）化合物或其药学上或生物可接受的盐可用作细胞穿透载体。根据下式（I），Val是L-Val或D-Val; Arg是L-Arg，D-Arg或L-（N-甲基）Arg; Pro是L-Pro或D-Pro; Leu是L-Leu或D-Leu; x是1至20的整数，优选3; L1和L2是化学接头; M1和M2是药理学和/或生物活性部分; L1和M1之间的键和L2和M2之间的键是具有已知的化学性质，包括共价键和离子键。与其他先前描述的载体肽相比，该新家族具有几个优点，包括其非病毒来源，其两亲性特征，其在水中的溶解度和在高浓度下不存在细胞毒性作用。 M1-L1-（Val-Arg-Leu-Pro-Pro-Pro）x-L2-M2（I）<β在线上公式描述=“In-line formula”end =“lead” -line-formula description =“内联公式”end =“tail”？>

3. 发明申请

US20110166071A1 METHOD FOR SYNTHESIZING THYMOSINS 审中-公开
标题翻译：合成丝氨酸的方法
公开(公告)号：US20110166071A1
公开(公告)日：2011-07-07
申请号：US12300193
申请日：2007-04-25
申请人： Jimena Fernandez Carneado , Berta Ponsati Obiols , Javier Clemente Rodriguez , Raimon Rubires Ferrer , Sergi Pavon Fernandez
发明人： Jimena Fernandez Carneado , Berta Ponsati Obiols , Javier Clemente Rodriguez , Raimon Rubires Ferrer , Sergi Pavon Fernandez
IPC分类号： A61K38/22 , C07K14/575 , A61P37/04
CPC分类号： C07K1/065 , A61K38/00 , C07K14/57581
摘要： The invention relates to a method for obtaining thymosins and/or the pharmaceutically acceptable salts thereof by means of solid-phase synthesis on polymeric supports, which comprises the steps of linearly synthesizing the thymus-derived peptides in solid phase, incorporating at least one Thr or Ser in the sequence, in pseudoproline dipeptide form, obtaining the thymosins by treating the peptidyl resin with trifluoroacetic acid, and purifying the thymosins by RP-HPLC. The present invention also protects the isolated and/or purified compound obtained by means of said method and also the use thereof in the preparation of a medicinal product.
摘要翻译：本发明涉及通过固相合成在聚合物载体上获得胸腺素和/或其药学上可接受的盐的方法，该方法包括以下步骤：在固相中线性合成来自胸腺的肽，并入至少一种Thr或以脯氨酸二肽形式顺序序列，通过用三氟乙酸处理肽基树脂获得胸腺素，并通过RP-HPLC纯化胸腺素。本发明还保护通过所述方法获得的分离和/或纯化的化合物以及其在制备药物中的用途。

4. 发明申请

US20120122781A1 PEPTIDE LIGANDS OF SOMATOSTATIN RECEPTORS 有权
标题翻译：肽受体的肽配体
公开(公告)号：US20120122781A1
公开(公告)日：2012-05-17
申请号：US13319285
申请日：2010-05-06
申请人： Antonio Parente Duena , Berta Ponsati Obiols , Jimena Fernandez Carneado , Marc Gomez Caminals , Ribera Jordana I Lluch
发明人： Antonio Parente Duena , Berta Ponsati Obiols , Jimena Fernandez Carneado , Marc Gomez Caminals , Ribera Jordana I Lluch
IPC分类号： A61K38/31 , A61P35/00 , A61P1/12 , A61P25/28 , A61P17/06 , A61P37/00 , A61P1/18 , A61P19/02 , A61P37/08 , A61P19/08 , C07K7/56 , A61P27/02
CPC分类号： G01N33/74 , A61K38/00 , C07K14/655 , G01N2333/655
摘要： Peptide derivatives, their stereoisomers, mixtures thereof and/or their pharmaceutically acceptable salts, a method of obtaining them, pharmaceutical compositions containing them and the use thereof for the treatment, prevention and/or diagnosis of those conditions, disorders and/or pathologies in which the sstr1, sstr2, sstr3, sstr4 and/or sstr5 somatostatin receptors are expressed.
摘要翻译：肽衍生物，其立体异构体，其混合物和/或其药学上可接受的盐，获得它们的方法，含有它们的药物组合物及其用于治疗，预防和/或诊断这些病症，病症和/或病症的用途，其中表达sstr1，sstr2，sstr3，sstr4和/或sstr5生长抑素受体。

5. 发明申请

US20110206752A1 COMPOSITIONS FOR THE TREATMENT OF PAIN AND/OR INFLAMATION 审中-公开
标题翻译：治疗疼痛和/或炎症的组合物
公开(公告)号：US20110206752A1
公开(公告)日：2011-08-25
申请号：US13055598
申请日：2009-07-24
申请人： Cristina Carreno Serraima , Wim Van Den Nest , Antonio Ferrer Montiel , Maria Camprubi Robes , Jimena Fernandez Carneado , Berta Ponsati Obliols
发明人： Cristina Carreno Serraima , Wim Van Den Nest , Antonio Ferrer Montiel , Maria Camprubi Robes , Jimena Fernandez Carneado , Berta Ponsati Obliols
IPC分类号： A61K38/08 , A61K9/14 , A61K9/00 , A61K9/127 , A61K38/16 , A61K38/10 , A61K38/07 , A61K38/06 , A61P29/00
CPC分类号： A61L15/44 , A61K8/64 , A61K38/00 , A61L2300/25 , A61L2300/402 , A61L2300/41 , A61Q19/00 , C07K14/705
摘要： Compositions for the treatment of pain and/or inflammation comprising at least one peptide with the general formula (I) R1-AA-R2, its stereoisomers, mixtures thereof, and its cosmetically and pharmaceutically acceptable salts. Peptide with general formula (I), its stereoisomers, mixtures thereof, and its cosmetically and pharmaceutically acceptable salts for the treatment of pain and/or inflammation.
摘要翻译：用于治疗疼痛和/或炎症的组合物，其包含至少一种具有通式（I）的化合物R1-AA-R2，其立体异构体，其混合物及其化妆品和药学上可接受的盐。具有通式（I）的肽，其立体异构体，其混合物及其用于治疗疼痛和/或炎症的美容和药学上可接受的盐。

6. 发明申请

US20100021510A1 NEURONAL EXOCYTOSIS INHIBITING PEPTIDES 有权
标题翻译：神经外植体抑制肽
公开(公告)号：US20100021510A1
公开(公告)日：2010-01-28
申请号：US12447136
申请日：2007-10-24
申请人： Cristina Carreno Serraïma , Berta Ponsati Obiols , Wim Van Den Nest , Jimena Fernandez Carneado , Antonio Ferrer Montiel , Juan Cebrian Puche , Nuria Almiñana Domenech
发明人： Cristina Carreno Serraïma , Berta Ponsati Obiols , Wim Van Den Nest , Jimena Fernandez Carneado , Antonio Ferrer Montiel , Juan Cebrian Puche , Nuria Almiñana Domenech
IPC分类号： A61K8/64 , C07K5/10 , C07K7/06 , C07K7/08 , C07K14/00 , A61K38/07 , A61K38/08 , A61K38/10 , A61K38/16 , A61K9/127 , A61K8/14 , A61K9/14 , A61P17/00 , A61Q1/00 , A61Q19/00
CPC分类号： C07K14/705 , A61K8/14 , A61K8/64 , A61K38/00 , A61Q19/00 , A61Q19/08 , A61Q19/10
摘要： The invention relates to peptides of general formula (I): R1-AA-R2 (I) which can regulate neuronal exocytosis, their stereoisomers and racemic or non-racemic mixtures thereof, and the cosmetically or pharmaceutically acceptable salts thereof, wherein AA is a sequence of 3 to 40 adjacent amino acids contained in the amino acid sequence of the SNAP-25 protein, R1 is selected from the group consisting of H or alkyl, aryl, aralkyl or acyl group; and R2 is selected from the group consisting of amino, hydroxyl or thiol, substituted or non-substituted with aliphatic or cyclic groups, with the condition that when R1 is H or acetyl, R2 is not non-substituted amino, hydroxyl or thiol. The invention also relates to a method of obtaining such peptides, cosmetic or pharmaceutical compositions containing them and their use to treat those conditions requiring neuronal exocytosis regulation, preferably for treating the skin.
摘要翻译：本发明涉及通式（I）的肽：可以调节神经元胞吐作用的R1-AA-R2（I），其立体异构体和外消旋或非外消旋混合物，以及其化妆品或药学上可接受的盐，其中AA为 SNAP-25蛋白的氨基酸序列中含有3〜40个相邻氨基酸的序列，R1选自H或烷基，芳基，芳烷基或酰基; R 2选自氨基，羟基或硫醇，被脂肪族或环状基团取代或未取代，条件是当R 1为H或乙酰基时，R 2不为未取代的氨基，羟基或硫醇。本发明还涉及获得这样的肽的方法，含有它们的化妆品或药物组合物及其用于治疗需要神经元胞吐作用调节的条件，优选用于治疗皮肤。

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