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1. 发明申请

US20120071334A1 Methods And Marker Combinations For Screening For Predisposition To Lung Cancer 审中-公开
标题翻译：方法和标记组合筛查肺癌的倾向
公开(公告)号：US20120071334A1
公开(公告)日：2012-03-22
申请号：US12667069
申请日：2008-06-27
申请人： Tracey Colpitts , Eric L. Russell , Stephen Frost , Javier Ramirez , Bhawani Singh , John C. Russell
发明人： Tracey Colpitts , Eric L. Russell , Stephen Frost , Javier Ramirez , Bhawani Singh , John C. Russell
IPC分类号： C40B30/04 , G01N33/566 , G01N33/53 , C07K14/435 , C07K7/08
CPC分类号： G01N33/57423 , C07K14/4738 , G01N2333/47 , G01N2333/4703 , G01N2333/4725 , G01N2333/4739 , G01N2333/4742 , G01N2333/4748 , G01N2333/705 , G01N2333/70596 , G01N2333/775 , G01N2333/8125 , G01N2333/91205
摘要： The present invention relates to rapid, sensitive methods for determining whether a subject has or is at risk of developing lung cancer based on certain combinations of biomarkers, or biomarkers and biometric parameters. The methods consist of: a) quantifying in a test sample obtained from a subject, the amount of two or more biomarkers in a panel, the panel comprising at least one antibody and at least one antigen: b) comparing the amount of each biomarker quantified in the panel to a predetermined cutoff for said biomarker and assigning a score for each biomarker based on said comparison: c) combining the assigned score for each biomarker quantified in step b to obtain a total score for said subject: d) comparing the total score in step c with a predetermined total score and e) determining whether said subject has a risk of lung cancer based on the comparison in step d.
摘要翻译：本发明涉及用于基于生物标志物或生物标志物和生物测定参数的某些组合来确定受试者是否具有或具有发展肺癌的风险的快速，敏感的方法。所述方法包括：a）定量在受试者获得的测试样品中，面板中两个或多个生物标志物的量，所述面板包含至少一种抗体和至少一种抗原：b）比较每个生物标记物的量在所述面板中，对于所述生物标志物的预定截留值，并且基于所述比较分配每个生物标志物的得分：c）组合在步骤b中定量的每个生物标志物的指定得分以获得所述受试者的总分数：d）比较总分数在步骤c中具有预定的总分，以及e）基于步骤d中的比较来确定所述受试者是否具有肺癌的风险。

2. 发明申请

US20080160546A1 Methods and Marker Combinations for Screening For Predisposition to Lung Cancer 有权
标题翻译：筛选肺癌易感性的方法和标记物组合
公开(公告)号：US20080160546A1
公开(公告)日：2008-07-03
申请号：US11771727
申请日：2007-06-29
申请人： Tracey Colpitts , Eric L. Russell , Stephen Frost , Javier Ramirez , Bhawani Singh , John C. Russell
发明人： Tracey Colpitts , Eric L. Russell , Stephen Frost , Javier Ramirez , Bhawani Singh , John C. Russell
IPC分类号： G01N33/574 , C07K14/00
CPC分类号： G01N33/57423 , C07K14/4738 , G01N2333/47 , G01N2333/4703 , G01N2333/4725 , G01N2333/4739 , G01N2333/4742 , G01N2333/4748 , G01N2333/705 , G01N2333/70596 , G01N2333/775 , G01N2333/8125 , G01N2333/91205
摘要： The present invention relates to rapid, sensitive methods for determining whether a subject is at risk of developing lung cancer or has lung cancer based on certain combinations or biomarkers or biomarkers and biometric parameters.
摘要翻译：本发明涉及用于确定受试者是否处于基于某些组合或生物标志物或生物标志物和生物测定参数发展为肺癌或具有肺癌的风险的快速，敏感的方法。

3. 发明授权

US06627414B2 Reagents useful for detecting diseases of the gastrointestinal tract 失效
标题翻译：用于检测胃肠道疾病的试剂
公开(公告)号：US06627414B2
公开(公告)日：2003-09-30
申请号：US09050516
申请日：1998-03-30
申请人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Julian Gordon , Edward N. Granados , Mark A. Hayden , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Stephen D. Stroupe
发明人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Julian Gordon , Edward N. Granados , Mark A. Hayden , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Stephen D. Stroupe
IPC分类号： C12P2106
CPC分类号： G01N33/6893 , C07K14/47 , C07K16/3046 , C12Q1/6886 , C12Q2600/136 , G01N2800/06 , Y10S435/81 , Y10S530/828
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS 198 and transcribed from GI tract tissue, is described. These sequences are useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS 198-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS 198 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.
摘要翻译：描述了一组连续的和部分重叠的cDNA序列和由此编码的多肽，命名为CS 198并从胃肠道组织转录。这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对胃肠道疾病和病症（例如胃肠道癌）的倾向。还提供了特异性结合CS 198编码的多肽或蛋白质的抗体以及预防组织特异性CS 198多肽的作用的激动剂或抑制剂，该分子可用于治疗GI道疾病，肿瘤或转移瘤的治疗。

4. 发明授权

US06232456B1 Serine protease reagents and methods useful for detecting and treating diseases of the prostate 失效
标题翻译：丝氨酸蛋白酶试剂和用于检测和治疗前列腺疾病的方法
公开(公告)号：US06232456B1
公开(公告)日：2001-05-15
申请号：US08944483
申请日：1997-10-06
申请人： Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Edward Granados , Michael R. Klass , John C. Russell , Kent D. Stewart , Stephen D. Stroupe
发明人： Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Edward Granados , Michael R. Klass , John C. Russell , Kent D. Stewart , Stephen D. Stroupe
IPC分类号： C12N1557
CPC分类号： C12N9/6424
摘要： A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS133 and transcribed from prostate tissue is described. One polypeptide of the present invention is a member of the human serine protease family. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS133-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS133 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.
摘要翻译：描述了一组连续和部分重叠的RNA序列和由此编码的多肽，命名为PS133并从前列腺组织转录。本发明的一种多肽是人丝氨酸蛋白酶家族的成员。这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对前列腺疾病和病症如前列腺癌的倾向。还提供了特异性结合PS133编码的多肽或蛋白质的抗体，以及预防组织特异性PS133多肽的作用的激动剂或抑制剂，该分子可用于治疗前列腺疾病，肿瘤或转移瘤。

5. 发明授权

US5843634A Genetically engineered enzymes and their conjugates for diagnostic assays 失效
标题翻译：基因工程酶及其缀合物用于诊断测定
公开(公告)号：US5843634A
公开(公告)日：1998-12-01
申请号：US657392
申请日：1996-06-04
申请人： Elaine M Brate , Catherine A. Brennan , Dominique P. Bridon , Keeve D. Jaffe , Grant A. Krafft , Wlodzimierz Mandecki , Steven C. March , John C. Russell , Vincent T. Yue
发明人： Elaine M Brate , Catherine A. Brennan , Dominique P. Bridon , Keeve D. Jaffe , Grant A. Krafft , Wlodzimierz Mandecki , Steven C. March , John C. Russell , Vincent T. Yue
IPC分类号： G01N33/566 , C07K14/59 , C12N9/00 , C12N9/16 , C12N15/09 , C12N15/55 , C12Q1/00 , C12Q1/42 , C12R1/19 , C07K19/00 , C12Q1/44
CPC分类号： C07K14/59 , C12N9/16 , C12Q1/42 , C07K2319/40
摘要： This invention relates to genetically engineered enzymes, their ligand conjugates, their manufacture, and their use in qualitative or quantitative assays. A hybrid enzyme, such as an AP-epitope, has a foreign amino acid moiety (an epitope) inserted near the active site of the starting AP enzyme. The foreign amino acid moiety binds with an analyte, and, as a consequence of this binding, the enzymatic activity of the hybrid enzyme, AP-epitope, is modified. The changes in the enzymatic activity are dependent upon the presence, or the amount, of the analyte. In another embodiment, the hybrid enzyme consists of a cysteine introduced near the active site of an AP to give a hybrid enzyme. The cysteine on the hybrid enzyme serves as a point of conjugation of a ligand, such as theophylline, ferritin, thyroxine, or digoxigenin, to form the hybrid enzyme-ligand conjugate. The ligand binds with an antibody, an analyte or a binding molecule to an analyte and as a result of this binding, the enzymatic activity of the hybrid enzyme-ligand conjugate is modified or modulated.
摘要翻译：本发明涉及基因工程改造的酶，其配体缀合物，其制备及其在定性或定量测定中的用途。诸如AP-表位的杂交酶在起始AP酶的活性位点附近插入外源氨基酸部分（表位）。外来氨基酸部分与分析物结合，并且作为该结合的结果，修饰了杂合酶AP-表位的酶活性。酶活性的变化取决于分析物的存在或数量。在另一个实施方案中，杂交酶由在AP的活性位点附近引入的半胱氨酸组成以产生杂交酶。杂交酶上的半胱氨酸用作配体如茶碱，铁蛋白，甲状腺素或地高辛的缀合点，以形成杂交酶 - 配体缀合物。配体与分析物结合抗体，分析物或结合分子，作为该结合的结果，修饰或调节杂交酶 - 配体结合物的酶活性。

6. 发明授权

US5683383A Internal ring release erection device 失效
标题翻译：内环释放架设装置
公开(公告)号：US5683383A
公开(公告)日：1997-11-04
申请号：US511792
申请日：1995-08-07
申请人： John C. Russell , Jack H. Philbrick, Jr.
发明人： John C. Russell , Jack H. Philbrick, Jr.
IPC分类号： A61F5/41 , A61F5/00
CPC分类号： A61F5/41
摘要： An expanded elastic ring is supported in an annular groove within a ring outer cylinder for use in vacuum therapy of a dysfunctional penis. The cylinder has an open end for initial placement against a user's body with the penis contained within the cylinder. The cylinder further comprises a cap on a closed end into which a vacuum pump is integrated. The elastic ring expanded around an inner cylinder into an annular groove is remotely released within a vacuum drawn within the cylinder. In a first embodiment, the vacuum effects the release as the inner cylinder is withdrawn into an outer cylinder until the ring falls off of the inner cylinder end. In a second embodiment, push rods extending into the annular groove push the ring past a stationary inner cylinder, effected by rotation of the cap on the cylinder. An inclined face on the cap bottom surface engages the rod, pushing the rod into the annular groove.
摘要翻译：膨胀的弹性环支撑在环外筒内的环形槽中，用于功能障碍性阴茎的真空治疗。圆柱体具有开口端，用于初始放置在使用者的身体，阴茎包含在气缸内。气缸还包括在封闭端上的盖，真空泵被整合到其中。在内筒内扩展成环形槽的弹性环在气缸内抽吸的真空内被远程释放。在第一实施例中，当内筒被抽出到外筒中时，真空将释放，直到环脱离内筒端。在第二实施例中，延伸进入环形槽的推杆通过盖在气缸上的旋转而使环超过静止内筒。盖底表面上的倾斜面与杆接合，将杆推入环形槽。

7. 发明授权

US5223627A Fluorescence polarization method for monitoring fetal lung maturity 失效
标题翻译：荧光偏振法监测胎儿肺成熟度
公开(公告)号：US5223627A
公开(公告)日：1993-06-29
申请号：US603871
申请日：1990-10-24
申请人： John C. Russell
发明人： John C. Russell
IPC分类号： C07D271/12 , C07F9/6506 , G01N33/542 , G01N33/68 , G01N33/92
CPC分类号： C07D271/12 , C07F9/65068 , G01N33/542 , G01N33/68 , G01N33/6884 , G01N33/92
摘要： The present invention is directed to a fluorescence polarization method for monitoring fetal lung maturity, to various components needed for preparing and carrying out such monitoring, and to methods of making these components.
摘要翻译：本发明涉及用于监测胎儿肺成熟度的荧光偏振方法，用于制备和进行这种监测所需的各种组分以及制备这些组分的方法。

8. 发明授权

US07282207B1 Reagents and methods useful for detecting diseases of the reproductive tissues 失效
标题翻译：用于检测生殖组织疾病的试剂和方法
公开(公告)号：US07282207B1
公开(公告)日：2007-10-16
申请号：US09549342
申请日：2000-04-13
申请人： Tracey L. Colpitts , John C. Russell
发明人： Tracey L. Colpitts , John C. Russell
IPC分类号： A61K39/00 , A61K39/385 , A61K38/00 , G01N33/53 , C07K2/00
CPC分类号： G01N33/57442
摘要： This invention relates generally to a multimeric polypeptide complex/antigen which may be utilized in detecting or diagnosing diseases of the uterus such as uterine cancer. Furthermore, the invention relates to methods and kits, for example, which utilize this antigen or an antibody thereto. The complex itself comprises at least one EU250 polypeptide and at least one polypeptide which may be a BU101 polypeptide and/or a TU104 polypeptide. The complex may further comprise other, as yet unknown, polypeptide sequences.
摘要翻译：本发明一般涉及可用于检测或诊断子宫疾病如子宫癌的多聚体多肽复合物/抗原。此外，本发明涉及例如利用该抗原或其抗体的方法和试剂盒。复合物本身包含至少一种EU250多肽和至少一种可以是BU101多肽和/或TU104多肽的多肽。复合物还可以包含其他尚未知的多肽序列。

9. 发明授权

US07122653B2 Reagents and methods useful for detecting diseases of the prostate 失效
公开(公告)号：US07122653B2
公开(公告)日：2006-10-17
申请号：US10082659
申请日：2002-02-25
申请人： Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Edward N. Granados , Michael R. Klass , John C. Russell , Stephen D. Stroupe
发明人： Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Edward N. Granados , Michael R. Klass , John C. Russell , Stephen D. Stroupe
IPC分类号： C07H21/04 , C07H1/00 , C07H5/04 , C07H5/06 , C07H19/00
CPC分类号： G01N33/57434
摘要： A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS190 and transcribed from prostate tissue is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS190-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS190 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.

10. 发明授权

US07087393B2 Methods for detecting CS198 antigen 失效
标题翻译：检测CS198抗原的方法
公开(公告)号：US07087393B2
公开(公告)日：2006-08-08
申请号：US10646873
申请日：2003-08-22
申请人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Julian Gordon , Edward N. Granados , Mark A. Hayden , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Stephen D. Stroupe
发明人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Julian Gordon , Edward N. Granados , Mark A. Hayden , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Stephen D. Stroupe
IPC分类号： G01N33/53 , C07K14/00
CPC分类号： G01N33/6893 , C07K14/47 , C07K16/3046 , C12Q1/6886 , C12Q2600/136 , G01N2800/06 , Y10S435/81 , Y10S530/828
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS198 and transcribed from GI tract tissue, is described. These sequences are useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS198-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS198 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.
摘要翻译：描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为CS198并从胃肠道组织转录。这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对胃肠道疾病和病症（例如胃肠道癌）的倾向。还提供了特异性结合CS198编码的多肽或蛋白质的抗体，以及预防组织特异性CS198多肽的作用的激动剂或抑制剂，该分子可用于胃肠道疾病，肿瘤或转移瘤的治疗性治疗。

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