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1. 发明申请

US20060226310A1 Method of supporting tools and supplies upon a sloped surface 审中-公开
标题翻译：在倾斜表面上支撑工具和用品的方法
公开(公告)号：US20060226310A1
公开(公告)日：2006-10-12
申请号：US11435960
申请日：2006-05-17
申请人： Peter Hall , John Lampe
发明人： Peter Hall , John Lampe
IPC分类号： A47G23/02
CPC分类号： B44D3/14 , E04D15/02
摘要： The invention is a method of supporting tools and supplies atop a sloped roof. The method includes (a) obtaining a caddy with a base and a shelf pivotally connected to one another, (b) placing the base of the caddy into supportive contact with a sloped roof, (c) pivoting the shelf of the caddy relative to the base about a laterally extending axis until the shelf is substantially horizontal, (d) supporting the shelf at the substantially horizontal position with a support member, and (e) placing a plurality of individual tools or supplies upon the substantially horizontal shelf.
摘要翻译：本发明是一种在倾斜屋顶上支撑工具和用品的方法。该方法包括（a）获得具有彼此枢转连接的基座和搁板的球童，（b）将球童的基座放置成与倾斜的屋顶支撑接触，（c）使球童的架子相对于（d）通过支撑构件将搁架支撑在基本水平的位置，以及（e）将多个单独的工具或供应物放置在基本上水平的搁架上。

2. 发明申请

US20080076735A1 CYTOSKELETAL ACTIVE COMPOUNDS, COMPOSITION AND USE 失效
标题翻译： CYTOSKELETAL活性化合物，组合物和用途
公开(公告)号：US20080076735A1
公开(公告)日：2008-03-27
申请号：US11950327
申请日：2007-12-04
申请人： John Lampe , Robert Plourde , Jin She , Jason Vittitow , Paul Watson , Michael Crimmins , David Slade
发明人： John Lampe , Robert Plourde , Jin She , Jason Vittitow , Paul Watson , Michael Crimmins , David Slade
IPC分类号： A61K31/695 , A61K31/19 , A61K31/215 , C07C229/00 , C07D277/02 , C07F7/02 , C07C69/00 , A61P27/00 , A61K31/426
CPC分类号： C07D491/08 , C07D277/06 , C07D277/14 , C07D277/16 , C07D277/34 , C07D277/56 , C07D417/04 , C07D493/08 , C07D497/18
摘要： The present invention is directed to synthetic cytoskeletal active compounds that are related to natural Latrunculin A or Latrunculin B. The present invention is also directed to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier. The invention is additionally directed to a method of preventing or treating diseases or conditions associated with actin polymerization. In one embodiment of the invention, the method treats increased intraocular pressure, such as primary open-angle glaucoma. The method comprises administering to a subject a therapeutically effective amount of a cytoskeletal active compound of Formula I or II, wherein said amount is effective to influence the cytoskeleton, for example by inhibiting actin polymerization.
摘要翻译：本发明涉及与天然的秋水仙素A或梭菌素B相关的合成细胞骨架活性化合物。本发明还涉及包含这些化合物和药学上可接受的载体的药物组合物。本发明另外涉及预防或治疗与肌动蛋白聚合相关的疾病或病症的方法。在本发明的一个实施方案中，该方法治疗增加的眼内压，例如原发性开角型青光眼。该方法包括向受试者施用治疗有效量的式I或II的细胞骨架活性化合物，其中所述量有效影响细胞骨架，例如通过抑制肌动蛋白聚合。

3. 发明申请

US20060217427A1 Cytoskeletal active compounds, compositions and use 失效
标题翻译：细胞骨架活性化合物，组合物和用途
公开(公告)号：US20060217427A1
公开(公告)日：2006-09-28
申请号：US11389665
申请日：2006-03-23
申请人： John Lampe , Robert Plourde , Jin She , Jason Vittitow , Paul Watson , Michael Crimmins , David Slade
发明人： John Lampe , Robert Plourde , Jin She , Jason Vittitow , Paul Watson , Michael Crimmins , David Slade
IPC分类号： A61K31/426 , A61K31/422 , A61K31/4178 , C07D413/02 , C07D417/02 , C07D405/02
CPC分类号： C07D491/08 , C07D277/06 , C07D277/14 , C07D277/16 , C07D277/34 , C07D277/56 , C07D417/04 , C07D493/08 , C07D497/18
摘要： The present invention is directed to synthetic cytoskeletal active compounds that are related to natural Latrunculin A or Latrunculin B. The present invention is also directed to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier. The invention is additionally directed to a method of preventing or treating diseases or conditions associated with actin polymerization. In one embodiment of the invention, the method treats increased intraocular pressure, such as primary open-angle glaucoma. The method comprises administering to a subject a therapeutically effective amount of a cytoskeletal active compound of Formula I or II, wherein said amount is effective to influence the cytoskeleton, for example by inhibiting actin polymerization.
摘要翻译：本发明涉及与天然的秋水仙素A或梭菌素B相关的合成细胞骨架活性化合物。本发明还涉及包含这些化合物和药学上可接受的载体的药物组合物。本发明另外涉及预防或治疗与肌动蛋白聚合相关的疾病或病症的方法。在本发明的一个实施方案中，该方法治疗增加的眼内压，例如原发性开角型青光眼。该方法包括向受试者施用治疗有效量的式I或II的细胞骨架活性化合物，其中所述量有效影响细胞骨架，例如通过抑制肌动蛋白聚合。

4. 发明申请

US20060206047A1 Bandage with splint 审中-公开
标题翻译：绷带夹板
公开(公告)号：US20060206047A1
公开(公告)日：2006-09-14
申请号：US11374248
申请日：2006-03-13
申请人： John Lampe , William Heegaard , Roger Heegaard
发明人： John Lampe , William Heegaard , Roger Heegaard
IPC分类号： A61F15/00 , A61F13/00
CPC分类号： A61F13/064 , A61F13/04 , A61F13/068 , A61F13/10 , A61F13/104 , A61F13/105 , A61F13/12
摘要： A bandage with (i) a supple backing layer having first and second major surfaces, and (ii) a longitudinally elongated elastic splint adhesively secured to the first major surface of the backing.
摘要翻译：绷带，其具有（i）具有第一和第二主表面的柔顺背衬层，和（ii）沿着所述背衬的第一主表面粘附的纵向伸长的弹性夹板。

5. 发明授权

US09169260B2 Amidopyrazole inhibitors of interleukin receptor-associated kinases 有权
标题翻译：白介素受体相关激酶的吡咯唑抑制剂
公开(公告)号：US09169260B2
公开(公告)日：2015-10-27
申请号：US14006565
申请日：2012-03-21
申请人： William T. McElroy , Guoqing Li , Ginny Dai Ho , Zheng Tan , Sunil Paliwal , William Michael Seganish , Deen Tulshian , John Lampe , Joey L. Methot , Hua Zhou , Michael D. Altman , Liang Zhu
发明人： William T. McElroy , Guoqing Li , Ginny Dai Ho , Zheng Tan , Sunil Paliwal , William Michael Seganish , Deen Tulshian , John Lampe , Joey L. Methot , Hua Zhou , Michael D. Altman , Liang Zhu
IPC分类号： C07D487/04 , A61K31/519 , A61K31/4162
CPC分类号： C07D487/04 , A61K31/4162
摘要： This invention relates to amidopyrazole compounds that are inhibitors of Interleukin receptor-associated kinases, in particular IRAK-4, and are useful in the treatment of cellular proliferative diseases, for example, cancer, hyperplasia, restenosis, cardiac hypertrophy, immune disorders and inflammation.
摘要翻译：本发明涉及作为白介素受体相关激酶抑制剂，特别是IRAK-4的氨基吡唑化合物，可用于治疗细胞增殖性疾病，例如癌症，增生，再狭窄，心脏肥大，免疫疾病和炎症。

6. 发明申请

US20060191812A1 Beverage container receptacle with active display 审中-公开
标题翻译：饮料容器容器，带主动显示
公开(公告)号：US20060191812A1
公开(公告)日：2006-08-31
申请号：US11338041
申请日：2006-01-24
申请人： Douglas Oudekerk , John Lampe
发明人： Douglas Oudekerk , John Lampe
IPC分类号： B65D85/00
CPC分类号： B65D25/20 , B65D2203/12
摘要： The invention takes the form of various embodiments including: first, a receptacle for a beverage container with a temperature gauge affixed to the receptacle that takes and displays a temperature reading of the container in the receptacle; second, a receptacle for receiving a beverage container with a gauge affixed to the receptacle that registers movement of the beverage container within the receptacle; third, a receptacle for receiving a beverage container with an electrically powered device attached to the receptacle; and, fourth, a receptacle for receiving a beverage container with a gauge affixed to the receptacle that indicates whether the receptacle is level with a plane.
摘要翻译：本发明采取各种实施例的形式，包括：首先，用于饮料容器的容器，其具有固定在容器上的温度计，其接收和显示容器在容器中的温度读数; 第二，用于容纳饮料容器的容器，该饮料容器具有固定到所述容器的表，所述容器将饮料容器的运动记录在容器内; 第三，用于接收具有附接到容器的电动装置的饮料容器的容器; 以及第四，用于容纳饮料容器的容器，该容器具有固定到容器的表，该容器指示容器是否与平面平齐。

7. 发明申请

US20140194404A1 AMIDOPYRAZOLE INHIBITORS OF INTERLEUKIN RECEPTOR-ASSOCIATED KINASES 有权
标题翻译：白介素受体相关激酶的氨基吡唑抑制剂
公开(公告)号：US20140194404A1
公开(公告)日：2014-07-10
申请号：US14006565
申请日：2012-03-21
申请人： William T. McElroy , Guoqing Li , Ginny Dai Ho , Zheng Tan , Sunil Paliwal , William Michael Seganish , Deen Tulshian , John Lampe , Joey L. Methot , Hua Zhou , Michael D. Altman , Liang Zhu
发明人： William T. McElroy , Guoqing Li , Ginny Dai Ho , Zheng Tan , Sunil Paliwal , William Michael Seganish , Deen Tulshian , John Lampe , Joey L. Methot , Hua Zhou , Michael D. Altman , Liang Zhu
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , A61K31/4162
摘要： This invention relates to amidopyrazole compounds that are inhibitors of Interleukin receptor-associated kinases, in particular IRAK-4, and are useful in the treatment of cellular proliferative diseases, for example, cancer, hyperplasia, restenosis, cardiac hypertrophy, immune disorders and inflammation.
摘要翻译：本发明涉及作为白介素受体相关激酶抑制剂，特别是IRAK-4的氨基吡唑化合物，可用于治疗细胞增殖性疾病，例如癌症，增生，再狭窄，心脏肥大，免疫疾病和炎症。

8. 发明授权

US08550433B2 Adjustable column system and method 有权
标题翻译：可调柱系统和方法
公开(公告)号：US08550433B2
公开(公告)日：2013-10-08
申请号：US13079985
申请日：2011-04-05
申请人： John Lampe , Dominic DiPilla
发明人： John Lampe , Dominic DiPilla
IPC分类号： E21D15/44
CPC分类号： F16F9/0263 , A47C3/30 , F16F2230/0052
摘要： An apparatus includes an outer rectangular tube and an inner rectangular tube. The inner rectangular tube and the outer rectangular tube are movable in relation to each other. In some versions a gas spring is positioned within the outer rectangular tube and the inner rectangular tube. In some versions, the apparatus further comprises a pair of inner bearing blocks operable to change the coefficient of friction between the inner rectangular tube and the outer rectangular tube. In some versions, the apparatus further comprises an outer bearing block assembly operable to change the coefficient of friction between the outer bearing block assembly and the inner rectangular tube.
摘要翻译：一种装置包括外部矩形管和内部矩形管。内部矩形管和外部矩形管可相对于彼此移动。在一些形式中，气弹簧定位在外矩形管和内矩形管内。在一些形式中，该装置还包括一对内轴承座，其可操作以改变内矩形管与外矩形管之间的摩擦系数。在一些形式中，该装置还包括可操作以改变外轴承座组件和内矩形管之间的摩擦系数的外轴承座组件。

9. 发明申请

US20070215759A1 DEVICE FOR ORGANIZING SLACK IN MEDICAL TUBING 审中-公开
标题翻译：用于组织医疗管道中的滑块的装置
公开(公告)号：US20070215759A1
公开(公告)日：2007-09-20
申请号：US11688032
申请日：2007-03-19
申请人： Roger Heegaard , Ernest Ruiz , James Skakoon , John Lampe
发明人： Roger Heegaard , Ernest Ruiz , James Skakoon , John Lampe
IPC分类号： B05B15/06
CPC分类号： A61M5/1418
摘要： A device for organizing slack in a flexible line comprising a unitary element with clips formed in the top and bottom of the element for releasably retaining a flexible line at a point intermediate the ends of the line in the absence of an inwardly pinching bias. The device preferably has a saddle curved first major surface.
摘要翻译：一种用于在柔性线中组织松弛的装置，包括具有形成在元件的顶部和底部中的夹子的整体元件，用于在没有向内夹持偏压的情况下可释放地将柔性线保持在线的端部之间的点处。该装置优选地具有鞍形弯曲的第一主表面。

10. 发明申请

US20110240938A1 ADJUSTABLE COLUMN SYSTEM AND METHOD 有权
标题翻译：可调节柱系统和方法
公开(公告)号：US20110240938A1
公开(公告)日：2011-10-06
申请号：US13079985
申请日：2011-04-05
申请人： John Lampe , Dominic DiPilla
发明人： John Lampe , Dominic DiPilla
IPC分类号： B66F3/25
CPC分类号： F16F9/0263 , A47C3/30 , F16F2230/0052
摘要： An apparatus includes an outer rectangular tube and an inner rectangular tube. The inner rectangular tube and the outer rectangular tube are movable in relation to each other. In some versions a gas spring is positioned within the outer rectangular tube and the inner rectangular tube. In some versions, the apparatus further comprises a pair of inner bearing blocks operable to change the coefficient of friction between the inner rectangular tube and the outer rectangular tube. In some versions, the apparatus further comprises an outer bearing block assembly operable to change the coefficient of friction between the outer bearing block assembly and the inner rectangular tube.
摘要翻译：一种装置包括外部矩形管和内部矩形管。内部矩形管和外部矩形管可相对于彼此移动。在一些形式中，气弹簧定位在外矩形管和内矩形管内。在一些形式中，该装置还包括一对内轴承座，其可操作以改变内矩形管与外矩形管之间的摩擦系数。在一些形式中，该装置还包括可操作以改变外轴承座组件和内矩形管之间的摩擦系数的外轴承座组件。

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