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1. 发明申请

US20080275097A1 Non-nucleoside reverse transcriptase inhibitors 有权
标题翻译：非核苷逆转录酶抑制剂
公开(公告)号：US20080275097A1
公开(公告)日：2008-11-06
申请号：US11999686
申请日：2007-12-06
申请人： Neville J. Anthony , Robert Gomez , Samson M. Jolly , Dai-Shi Su , John Lim
发明人： Neville J. Anthony , Robert Gomez , Samson M. Jolly , Dai-Shi Su , John Lim
IPC分类号： A61K31/41 , A61P31/18 , C07D231/54 , C07D235/04 , A61K31/4164 , C07D255/04 , A61K31/415
CPC分类号： C07D471/04 , C07D231/54 , C07D249/18
摘要： Compounds of Formula I: are HIV reverse transcriptase inhibitors, wherein V, W, X, Y, Z, R1, R2, R4, R5, R6, ring A, ring B, j and k are defined herein. The compounds of Formula I, and the pharmaceutically acceptable salts and prodrugs thereof, are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
摘要翻译：式I化合物是HIV逆转录酶抑制剂，其中V，W，X，Y，Z，R 1，R 2，R 4， R 5，R 6，环A，环B，j和k如本文所定义。式I化合物及其药学上可接受的盐和前药可用于抑制HIV逆转录酶，预防和治疗HIV感染以及预防，延缓发病或进展以及AIDS治疗。化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。

2. 发明申请

US20080162497A1 SYSTEM AND METHOD FOR CONVEYING PERSONAL INFORMATION THROUGH CELLULAR TEXT MESSAGING SERVICES 有权
标题翻译：通过细胞文本消息传送服务传送个人信息的系统和方法
公开(公告)号：US20080162497A1
公开(公告)日：2008-07-03
申请号：US11966419
申请日：2007-12-28
申请人： John Lim
发明人： John Lim
IPC分类号： G06F17/30 , G06F15/16
CPC分类号： H04W4/14 , G06F17/30477 , G06F17/30554 , G06F17/30864 , H04W4/12
摘要： The present invention provides a system and method for sending a cellular text message to a system server through a data network, including an identification of a requested database record and a forward address. The system server then performs a database lookup or related search and sends an enhanced message or a file to the forward address, which could be a cellular phone, e-mail address, server, computer, mobile device, or any hardware or device associated with the intended recipient that is communicatively coupled to the system server.
摘要翻译：本发明提供一种用于通过数据网络向系统服务器发送蜂窝文本消息的系统和方法，包括所请求的数据库记录和转发地址的标识。然后，系统服务器执行数据库查找或相关搜索，并将增强的消息或文件发送到转发地址，该转发地址可以是蜂窝电话，电子邮件地址，服务器，计算机，移动设备或与其相关联的任何硬件或设备通信耦合到系统服务器的预期接收者。

3. 发明申请

US20070293485A1 DRUG ADMINISTRATION METHODS 审中-公开
标题翻译：药物管理方法
公开(公告)号：US20070293485A1
公开(公告)日：2007-12-20
申请号：US11757273
申请日：2007-06-01
申请人： John Lim , Jeffrey Whitten
发明人： John Lim , Jeffrey Whitten
IPC分类号： A61K31/5383
CPC分类号： A61K31/538 , A61K9/0019 , A61K31/485 , A61K31/522 , A61K47/02 , A61K47/10 , A61K47/26 , A61K2300/00
摘要： Provided herein are methods for administering an efficacious amount of a compound of Formula I that reduce the severity of a potential adverse effect or obviate a potential adverse effect.
摘要翻译：本文提供了施用有效量的式I化合物的方法，其降低潜在副作用的严重性或消除潜在的不良反应。

4. 发明授权

US4206085A Balanced alumina matrix in zeolite containing catalyst 失效
标题翻译：含沸石催化剂中的平衡氧化铝基质
公开(公告)号：US4206085A
公开(公告)日：1980-06-03
申请号：US003407
申请日：1979-01-15
申请人： John Lim , Dennis Stamires , Michael Brady
发明人： John Lim , Dennis Stamires , Michael Brady
IPC分类号： B01J29/08 , C01F7/02 , B01J29/04
CPC分类号： C01F7/021 , B01J29/08 , C01P2006/11 , C01P2006/12 , C01P2006/14 , C01P2006/21
摘要： This invention relates to an improvement in the abrasion resistance of catalysts formulated from a mixture of an exchanged zeolite of the faujasite type, hydrated alumina and ammonium polysilicate or silica sol.
摘要翻译：本发明涉及由八面沸石型，水合氧化铝和聚硅酸铵或硅溶胶的交换的沸石的混合物配制的催化剂的耐磨性的改进。

5. 发明授权

US09161182B2 System and method for conveying personal information through cellular text messaging services 有权
标题翻译：通过蜂窝短信服务传送个人信息的系统和方法
公开(公告)号：US09161182B2
公开(公告)日：2015-10-13
申请号：US11966419
申请日：2007-12-28
申请人： John Lim
发明人： John Lim
IPC分类号： G06F17/30 , H04W4/12
CPC分类号： H04W4/14 , G06F17/30477 , G06F17/30554 , G06F17/30864 , H04W4/12
摘要： The present invention provides a system and method for sending a cellular text message to a system server through a data network, including an identification of a requested database record and a forward address. The system server then performs a database lookup or related search and sends an enhanced message or a file to the forward address, which could be a cellular phone, e-mail address, server, computer, mobile device, or any hardware or device associated with the intended recipient that is communicatively coupled to the system server.
摘要翻译：本发明提供一种用于通过数据网络向系统服务器发送蜂窝文本消息的系统和方法，包括所请求的数据库记录和转发地址的标识。然后，系统服务器执行数据库查找或相关搜索，并将增强的消息或文件发送到转发地址，转发地址可以是蜂窝电话，电子邮件地址，服务器，计算机，移动设备或与其相关联的任何硬件或设备通信耦合到系统服务器的预期接收者。

6. 发明授权

US08551445B2 Preparation and use of alkylating agents 有权
标题翻译：烷基化剂的制备和使用
公开(公告)号：US08551445B2
公开(公告)日：2013-10-08
申请号：US12858238
申请日：2010-08-17
申请人： John Lim
发明人： John Lim
IPC分类号： A61K51/00 , G05B21/00
CPC分类号： C07D213/20 , C07B2200/05 , C07C67/10 , C07C213/08 , C07C227/16 , C07C269/06 , C07C319/14 , C07D453/02 , C07C69/78 , C07C69/68 , C07C323/03 , C07C323/58 , C07C215/40 , C07C229/36 , C07C271/34
摘要： Methods of alkylating target compounds are disclosed. The alkylating agent can be radiolabeled. In some instances, the alkylating agent is synthesized and then reacted with a target compound without an intervening purification step. The method comprises synthesizing an alkylating agent having the formula: X—(CR1R2)aCR3R4-LG wherein, a is 0, 1, 2 or 3, R1, R2, R3 and R4 are independently H, X or alkyl, X is a halogen or a label, with the proviso that at least one X is a halogen, LG is a leaving group; and directly reacting said alkylating agent with a target compound comprising an alkylation reactive group under conditions suitable for the alkylation of said target compound.
摘要翻译：公开了烷基化目标化合物的方法。烷基化剂可以放射性标记。在一些情况下，合成烷基化剂，然后与目标化合物反应而不需要介入纯化步骤。该方法包括合成具有下列通式的烷基化剂：X-（CR 1 R 2）a CR 3 R 4 -L-其中a为0,1,2或3，R 1，R 2，R 3和R 4独立地为H，X或烷基，X为卤素或标签，条件是至少一个X是卤素，LG是离去基团; 并在适于所述目标化合物的烷基化的条件下使所述烷基化剂与包含烷基化反应性基团的目标化合物直接反应。

7. 发明申请

US20120022045A1 BRIDGED COMPOUNDS AS HIV INTEGRASE INHIBITORS 审中-公开
标题翻译：桥联化合物作为HIV整合抑制剂
公开(公告)号：US20120022045A1
公开(公告)日：2012-01-26
申请号：US13146595
申请日：2010-01-25
申请人： Shankar Venkatraman , John S. Wai , Wayne Thompson , Boyoung Kim , Richard C.A. Isaacs , H. Marie Loughran , Dai-Shi Su , John Lim , Mark W. Embrey , Peter D. Williams
发明人： Shankar Venkatraman , John S. Wai , Wayne Thompson , Boyoung Kim , Richard C.A. Isaacs , H. Marie Loughran , Dai-Shi Su , John Lim , Mark W. Embrey , Peter D. Williams
IPC分类号： A61K31/55 , A61P31/18 , A61K31/519 , C07D471/08 , C07D487/08 , C07D491/18
CPC分类号： C07D487/18 , C07D471/18 , C07D491/18
摘要： Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: the asterisk * in Q denotes the point of attachment to the rest of the compound; and n, L1, L2, X1, X2, χ3, Y, Z, R1, R2 and R3 are defined herein. The N compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset or progression of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se (or as hydrates or solvates thereof) or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
摘要翻译：式I化合物是HIV整合酶和HIV复制抑制剂的抑制剂：Q中的星号*表示与化合物其余部分的连接点; 并且n，L1，L2，X1，X2，χ3，Y，Z，R1，R2和R3在本文中定义。 N化合物可用于预防或治疗艾滋病毒感染，预防，治疗或延迟艾滋病的发病或进展。该化合物用作抗体作为化合物本身（或其水合物或溶剂化物）或以药学上可接受的盐形式的HIV感染和AIDS。化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。

8. 发明申请

US20060247229A1 Sulfonyl substituted n-(biarylmethyl) aminocyclopropanecarboxamides 失效
标题翻译：磺酰基取代的正（联芳基甲基）氨基环丙烷甲酰胺
公开(公告)号：US20060247229A1
公开(公告)日：2006-11-02
申请号：US10565040
申请日：2004-08-03
申请人： Neville Anthony , Robert Gomez , Samson Jolly , John Lim , Dai-shi Su
发明人： Neville Anthony , Robert Gomez , Samson Jolly , John Lim , Dai-shi Su
IPC分类号： A61K31/54 , A61K31/505 , A61K31/18
CPC分类号： C07D213/82 , C07C307/02 , C07C309/65 , C07C309/66 , C07C309/67 , C07C309/76 , C07C311/09 , C07C311/46 , C07C2601/02 , C07D215/58 , C07D239/28 , C07D417/12
摘要： N-(Sulfonyloxybiarylmethyl)aminocyclopropanecarboxamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.
摘要翻译： N-（磺酰氧基联芳基甲基）氨基环丙烷甲酰胺衍生物是缓激肽B1拮抗剂或反激动剂，其可用于治疗或预防与缓激肽B1途径相关的疼痛和炎症等症状。

9. 发明授权

US5667798A Transdermal drug delivery system 失效
标题翻译：透皮给药系统
公开(公告)号：US5667798A
公开(公告)日：1997-09-16
申请号：US477914
申请日：1995-06-07
申请人： Robert B. Royds , John Lim , Joel D. Rosen
发明人： Robert B. Royds , John Lim , Joel D. Rosen
IPC分类号： A61K9/70 , A61F13/00
CPC分类号： A61K9/7084 , A61K9/703 , A61K9/7092 , A61M35/006
摘要： In a transdermal drug delivery system, encapsulation material used to coat drug granules controls the release of an active ingredient. The active ingredient is released into a water retaining matrix, which acts as a reservoir, and transdermal drug penetration is driven by the resulting concentration gradient. The delivery system is enclosed in a patch comprising a composite shell, which acts as an occlusive covering when attached to skin, thus enhancing the hydration of the skin area and fostering absorption of the drug. Visible change indicators incorporated into the system provide indicators at significant "landmarks" in the lifetime of the patch. Microcapsules used for the indicator may be formulated so that the penetration of moisture effects a color change at a time when the active ingredient is almost exhausted. This feature alerts to the user to the need for application of a replacement patch.
摘要翻译：在透皮药物递送系统中，用于包衣药物颗粒的包封材料控制活性成分的释放。将活性成分释放到作为储存器的保水基质中，透皮药物穿透由所得浓度梯度驱动。递送系统被封装在包括复合壳的贴片中，该复合壳当附着于皮肤时用作闭塞性覆盖物，从而增强皮肤区域的水合并促进药物的吸收。纳入系统的可见变化指标提供了补丁生命周期中重要“地标”的指标。用于指示剂的微胶囊可以配制成使得当活性成分几乎耗尽时，水分的渗透会影响颜色变化。此功能可以提醒用户需要应用更换补丁。

10. 发明授权

US4325845A Zeolite catalysts and method of producing the same 失效
标题翻译：沸石催化剂及其制备方法
公开(公告)号：US4325845A
公开(公告)日：1982-04-20
申请号：US92722
申请日：1979-11-09
申请人： John Lim , Michael Brady
发明人： John Lim , Michael Brady
IPC分类号： B01J29/08 , C10G11/05
CPC分类号： B01J29/08 , C10G11/05
摘要： This invention relates to a method of producing a zeolite containing cracking catalyst by employing a sodium silicate derived silica gel in combination with clay to form a catalyst having a good attrition resistance, low carbon, and hydrogen forming properties.
摘要翻译：本发明涉及通过使用硅酸钠衍生的硅胶与粘土组合制备含沸石的裂化催化剂的方法，以形成具有良好耐磨性，低碳和氢形成性能的催化剂。

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