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1. 发明授权

US09107717B2 Craniospinal fusion method and apparatus 有权
标题翻译：颅内融合方法及装置
公开(公告)号：US09107717B2
公开(公告)日：2015-08-18
申请号：US13335248
申请日：2011-12-22
申请人： Fraser Cummins Henderson, Sr. , John W. Newman
发明人： Fraser Cummins Henderson, Sr. , John W. Newman
IPC分类号： A61B17/80 , A61B17/70 , A61B17/88 , A61B17/00
CPC分类号： A61B17/8071 , A61B17/7055 , A61B17/80 , A61B17/8085 , A61B17/8891 , A61B2017/00004 , Y10S606/902 , Y10S606/903
摘要： A method for effecting reduction, stabilization and enhancement of fusion of the human cranio-cervical junction, which may be performed in order to relieve mechanical stresses imparted to the spinal cord and brainstem as a result of an abnormal clivo-axial angle, includes steps of achieving the correct craniocervical relationship, of effecting a fusion of a first portion of a bone forming material based structural member to a human cranium, and effecting fusion of a second portion of the bone forming material based structural member to a least one portion of a human cervical spine. Fusion of the bone forming material based structural member to the human cranium may be promoted through the use of plate member that is shaped to define a graft accommodation space between the plate member and the cranium.
摘要翻译：包括以下步骤：用于减轻，稳定和增强人类颅颈交界处融合的方法，所述方法可以执行以减轻由于异常的轴向角度而施加给脊髓和脑干的机械应力实现正确的颅颈关系，实现基于骨形成材料的结构构件的第一部分与人颅骨的融合，并且将骨形成材料基结构构件的第二部分熔化到人的至少一部分颈椎。可以通过使用成形为在板构件和颅骨之间限定移植物容纳空间的板构件来促进基于骨形成材料的结构构件与人颅骨的融合。

2. 发明授权

US08858470B2 Method for treating a neurological disorder 有权
标题翻译：治疗神经障碍的方法
公开(公告)号：US08858470B2
公开(公告)日：2014-10-14
申请号：US13163650
申请日：2011-06-17
申请人： Fraser Cummins Henderson , John W. Newman
发明人： Fraser Cummins Henderson , John W. Newman
IPC分类号： A61B5/103 , A61B5/117 , A61B17/70 , A61B17/80
CPC分类号： A61B17/7055 , A61B17/7011 , A61B17/7043 , A61B17/7044 , A61B17/7049 , A61B17/7052 , A61B17/8061
摘要： A therapeutic method for treating a neurological disease by accessing a neuraxial deformity and abnormal neuraxial stress. The method involves calculating a neuraxial stress, determining whether the neurological disorder is attributed at least in part to the neuraxial stress; and treating the neurological disorder by normalizing the neuraxial stress.
摘要翻译：一种通过进入神经轴畸形和异常神经轴应力来治疗神经疾病的治疗方法。该方法包括计算神经轴应力，确定神经系统疾病是否至少部分归因于神经轴应力; 并通过正常化神经轴应力来治疗神经障碍。

3. 发明授权

US08476043B2 Inhibitors for the soluble epoxide hydrolase 有权
标题翻译：可溶性环氧化物水解酶的抑制剂
公开(公告)号：US08476043B2
公开(公告)日：2013-07-02
申请号：US12631577
申请日：2009-12-04
申请人： Bruce D. Hammock , In-Hae Kim , Christophe Morisseau , Takaho Watanabe , John W. Newman
发明人： Bruce D. Hammock , In-Hae Kim , Christophe Morisseau , Takaho Watanabe , John W. Newman
IPC分类号： C12P19/48 , C07C211/16 , C12Q1/34
CPC分类号： C07D295/088 , C07C233/06 , C07C233/08 , C07C235/14 , C07C275/26 , C07C311/04 , C07C311/05 , C07C311/18 , C07C311/41 , C07C311/51 , C07C323/44 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2601/20 , C07C2603/18 , C07C2603/74 , C07D209/18 , C07D213/04 , C07D233/61 , C07D233/64 , C07D279/12 , C07D295/13 , C07D295/32 , C07D403/06 , C07K5/0205
摘要： Inhibitors of the soluble epoxide hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases.
摘要翻译：提供了可溶性环氧化物水解酶（sEH）的抑制剂，其包含多个药效团并且可用于治疗疾病。

4. 发明申请

US20120116455A1 CRANIOSPINAL FUSION METHOD AND APPARATUS 有权
标题翻译： CRANIOSPINAL FUSION方法和装置
公开(公告)号：US20120116455A1
公开(公告)日：2012-05-10
申请号：US13335248
申请日：2011-12-22
申请人： Fraser Cummins Henderson, Sr. , John W. Newman
发明人： Fraser Cummins Henderson, Sr. , John W. Newman
IPC分类号： A61B17/70 , A61B17/88
CPC分类号： A61B17/8071 , A61B17/7055 , A61B17/80 , A61B17/8085 , A61B17/8891 , A61B2017/00004 , Y10S606/902 , Y10S606/903
摘要： A method for effecting reduction, stabilization and enhancement of fusion of the human cranio-cervical junction, which may be performed in order to relieve mechanical stresses imparted to the spinal cord and brainstem as a result of an abnormal clivo-axial angle, includes steps of achieving the correct craniocervical relationship, of effecting a fusion of a first portion of a bone forming material based structural member to a human cranium, and effecting fusion of a second portion of the bone forming material based structural member to a least one portion of a human cervical spine. Fusion of the bone forming material based structural member to the human cranium may be promoted through the use of plate member that is shaped to define a graft accommodation space between the plate member and the cranium.
摘要翻译：包括以下步骤：用于减轻，稳定和增强人类颅颈交界处融合的方法，所述方法可以执行以减轻由于异常的轴向角度而施加给脊髓和脑干的机械应力实现正确的颅颈关系，实现基于骨形成材料的结构构件的第一部分与人颅骨的融合，并且将骨形成材料基结构构件的第二部分熔化到人的至少一部分颈椎。可以通过使用成形为在板构件和颅骨之间限定移植物容纳空间的板构件来促进基于骨形成材料的结构构件与人颅骨的融合。

5. 发明授权

US08043342B2 Craniospinal fusion method and apparatus 有权
标题翻译：颅内融合方法及装置
公开(公告)号：US08043342B2
公开(公告)日：2011-10-25
申请号：US11832643
申请日：2007-08-01
申请人： Fraser Cummins Henderson, Sr. , John W. Newman
发明人： Fraser Cummins Henderson, Sr. , John W. Newman
IPC分类号： A61B17/70
CPC分类号： A61B17/8071 , A61B17/7055 , A61B17/80 , A61B17/8085 , A61B17/8891 , A61B2017/00004 , Y10S606/902 , Y10S606/903
摘要： A method for effecting reduction, stabilization and enhancement of fusion of the human cranio-cervical junction, which may be performed in order to relieve mechanical stresses imparted to the spinal cord and brainstem as a result of an abnormal clivo-axial angle, includes steps of achieving the correct craniocervical relationship, of effecting a fusion of a first portion of a bone forming material based structural member to a human cranium, and effecting fusion of a second portion of the bone forming material based structural member to a least one portion of a human cervical spine. Fusion of the bone forming material based structural member to the human cranium may be promoted through the use of plate member that is shaped to define a graft accommodation space between the plate member and the cranium.
摘要翻译：包括以下步骤：用于减轻，稳定和增强人类颅颈交界处融合的方法，所述方法可以执行以减轻由于异常的轴向角度而施加给脊髓和脑干的机械应力实现正确的颅颈关系，实现基于骨形成材料的结构构件的第一部分与人颅骨的融合，并且将骨形成材料基结构构件的第二部分熔化到人的至少一部分颈椎。可以通过使用成形为在板构件和颅骨之间限定移植物容纳空间的板构件来促进基于骨形成材料的结构构件与人颅骨的融合。

6. 发明申请

US20110021448A1 Inhibitors for the Soluble Epoxide Hydrolase 有权
标题翻译：可溶性环氧化物水解酶抑制剂
公开(公告)号：US20110021448A1
公开(公告)日：2011-01-27
申请号：US12631577
申请日：2009-12-04
申请人： BRUCE D. HAMMOCK , IN-HAE KIM , CHRISTOPHE MORISSEAU , TAKAHO WATANABE , JOHN W. NEWMAN
发明人： BRUCE D. HAMMOCK , IN-HAE KIM , CHRISTOPHE MORISSEAU , TAKAHO WATANABE , JOHN W. NEWMAN
IPC分类号： A61K31/7024 , C07C69/716 , C07C69/78 , C07C275/26 , C07C233/06 , C07C233/11 , C07C255/31 , C07D233/70 , C07D271/12 , C07H15/24 , C12N9/99 , A61K31/215 , A61K31/245 , A61K31/17 , A61K31/16 , A61K31/167 , A61K31/4166 , A61K31/4245 , A61P29/00 , A61P11/00 , A61P13/12 , A61P1/16 , A61P9/12 , A61P9/08
CPC分类号： C07D295/088 , C07C233/06 , C07C233/08 , C07C235/14 , C07C275/26 , C07C311/04 , C07C311/05 , C07C311/18 , C07C311/41 , C07C311/51 , C07C323/44 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2601/20 , C07C2603/18 , C07C2603/74 , C07D209/18 , C07D213/04 , C07D233/61 , C07D233/64 , C07D279/12 , C07D295/13 , C07D295/32 , C07D403/06 , C07K5/0205
摘要： Inhibitors of the soluble epoxide hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases.
摘要翻译：提供了可溶性环氧化物水解酶（sEH）的抑制剂，其包含多个药效团并且可用于治疗疾病。

7. 发明申请

US20100179597A1 CRANIOSPINAL FUSION METHOD AND APPARATUS 有权
标题翻译： CRANIOSPINAL FUSION方法和装置
公开(公告)号：US20100179597A1
公开(公告)日：2010-07-15
申请号：US12688848
申请日：2010-01-15
申请人： FRASER CUMMINS HENDERSON , JOHN W. NEWMAN
发明人： FRASER CUMMINS HENDERSON , JOHN W. NEWMAN
IPC分类号： A61B17/70 , A61B17/88 , A61B17/56
CPC分类号： A61B17/7055 , A61B17/7011 , A61B17/7043 , A61B17/7044 , A61B17/7049 , A61B17/7052 , A61B17/8061
摘要： A spinal stabilization system that may be used to fix craniocervical junction. The system includes a cranial spinal attachment system that anchors one or more surgical instruments to a cranial surface using at least one cranial clamp and cranial fastener. The cranial spinal attachment system may be positioned along a perimeter of a cranial defect.
摘要翻译：可用于固定颅颈结的脊柱稳定系统。该系统包括颅骨附接系统，其使用至少一个颅骨夹具和颅骨紧固件将一个或多个外科器械固定到颅面。颅骨附件系统可以沿着颅骨缺损的周边定位。

8. 发明申请

US20090177230A1 OSTEOINTEGRATION APPARATUS 有权
标题翻译： OSTEOINTEGRATION装置
公开(公告)号：US20090177230A1
公开(公告)日：2009-07-09
申请号：US12350936
申请日：2009-01-08
申请人： Fraser Cummins Henderson, SR. , Rebecca M.S. Henderson , John W. Newman
发明人： Fraser Cummins Henderson, SR. , Rebecca M.S. Henderson , John W. Newman
IPC分类号： A61B17/70 , A61B17/88
CPC分类号： A61B17/7055 , A61B17/7011 , A61B17/7043 , A61B17/7044 , A61B17/7049 , A61B17/7052 , A61B17/8061
摘要： A method for effecting reduction, stabilization and enhancement of fusion of the human cranio-cervical junction, which may be performed in order to relieve mechanical stresses imparted to the spinal cord and brainstem as a result of an abnormal clivo-axial angle, includes steps of achieving the correct craniocervical relationship, of effecting a fusion of a first portion of a bone forming material based structural member to a human cranium, and effecting fusion of a second portion of the bone forming material based structural member to a least one portion of a human cervical spine. Fusion of the bone forming material based structural member to the human cranium may be promoted through the use an osteointegration apparatus that includes a porous ossomeric mesh and a frame member.
摘要翻译：包括以下步骤：用于减轻，稳定和增强人类颅颈交界处融合的方法，所述方法可以执行以减轻由于异常的轴向角度而施加给脊髓和脑干的机械应力实现正确的颅颈关系，实现基于骨形成材料的结构构件的第一部分与人颅骨的融合，并且将骨形成材料基结构构件的第二部分熔化到人的至少一部分颈椎。可以通过使用包括多孔骨架网和框架构件的骨整合装置来促进基于骨形成材料的结构构件与人颅骨的融合。

9. 发明授权

US06843107B2 System and process for detecting leaks in sealed articles 有权
标题翻译：用于检测密封物品泄漏的系统和过程
公开(公告)号：US06843107B2
公开(公告)日：2005-01-18
申请号：US10641545
申请日：2003-08-15
申请人： John W. Newman , Steve Thayer
发明人： John W. Newman , Steve Thayer
IPC分类号： G01M3/38 , G01M20060101 , G01M3/02 , G01M3/26 , G01M3/34 , G01M3/36 , G01N21/88
CPC分类号： G01M3/363 , G01N2201/0227 , G03H1/0443
摘要： A system and method for leak testing a plurality of hermetic electronic packages of the type that have an internal chamber that is isolated from ambient conditions by a seal structure is advantageously designed to be able to calculate the leak rate of each individual device in a manner that is independent of structural manufacturing variances that typically exist within a sampling of such devices. The method preferably involves positioning a plurality of the hermetic electronic packages within a test area, and then stimulating the hermetic electronic packages with a modulated input of energy, such as by varying the ambient pressure about the devices. A property such as the physical position of one portion of a lid of each of the hermetic electronic packages is then sensed. The sensed property is one that is known to change as a first function of the modulated input of energy and also as a second function of pressure conditions within the hermetically sealed internal chamber. The first and second functions are linearly independent of each other. By comparing the stimulation of the devices to the sensed property and by discriminating using the two known functions a leak rate is determined for each individual device that is substantially independent of variances, such as differences in lid thickness that may exist between the different devices. Accordingly, an accurate determination of leak rate may be made with a minimum of calibration.
摘要翻译：用于对具有通过密封结构与环境条件隔离的内部室的多个密封电子封装进行泄漏测试的系统和方法有利地设计成能够以下述方式计算每个单独设备的泄漏率：独立于通常存在于这种设备的采样内的结构制造差异。该方法优选地包括将多个密封电子封装定位在测试区域内，然后用调制的能量输入来刺激密封电子封装，例如通过改变围绕器件的环境压力。然后感测诸如每个密封电子包装件的盖子的一部分的物理位置的属性。感测的特性是已知的作为调制的能量输入的第一函数而变化的属性，并且还作为密封的内部腔室内的压力条件的第二函数。第一和第二功能彼此线性独立。通过将装置的刺激与感测到的属性进行比较，并且通过使用两个已知功能进行区分，确定每个单独装置的泄漏率基本上不依赖于方差，例如可能存在于不同装置之间的盖厚度的差异。因此，可以用最小的校准来进行泄漏率的精确确定。

10. 发明授权

US06717681B1 Portable real-time high-resolution digital phase-stepping shearography with integrated excitation mechanisms 有权
公开(公告)号：US06717681B1
公开(公告)日：2004-04-06
申请号：US09537862
申请日：2000-03-28
申请人： Benjamin A. Bard , Guowen Lu , Shudong Wu , John W. Newman
发明人： Benjamin A. Bard , Guowen Lu , Shudong Wu , John W. Newman
IPC分类号： G01B902
CPC分类号： G01B9/02054 , G01B9/02098 , G01B11/162
摘要： A portable nondestructive testing instrument uses high-speed phase-stepping shearography, and vacuum stressing, to produce images of disbonds, impact damage, or delaminations, in metal or composite structures. The invention is especially useful in the inspection of large areas where only external access is feasible, such as in large aircraft, space vehicles, boats, or civil engineered structures having multiple bond lines. The invention includes a novel combination of components and techniques, including a high-spatial-resolution CCD sensor, low-voltage piezoceramic phase stepping, rapid phase stepping, a fast phase calculation technique, a fast image smoothing technique, and an implementation of all of the above in a portable unit. Specially designed timing and control algorithms allow data acquisition, transfer, calculation, smoothing, and display at rates of up to two times per second. The invention also includes the above-described combination, in conjunction with three excitation mechanisms provided in an integrated portable package.

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