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1. 发明申请

US20100028362A1 MODULATION OF T HELPER CELL-MEDIATED IMMUNE RESPONSES 有权
标题翻译： T细胞介导的免疫应答的调节
公开(公告)号：US20100028362A1
公开(公告)日：2010-02-04
申请号：US12298275
申请日：2007-04-27
申请人： Tue Gia Nguyen , Jonathan M. Morris , Eileen D.M. Gallery , Sharon McCracken
发明人： Tue Gia Nguyen , Jonathan M. Morris , Eileen D.M. Gallery , Sharon McCracken
IPC分类号： A61K39/395 , G01N33/53 , C07K16/18 , A61P37/02
CPC分类号： C07K16/4283 , A61K2039/505 , C07K2317/76 , G01N33/6854 , G01N33/6863 , G01N2800/24 , G01N2800/52 , Y02A50/412 , Y02A50/58
摘要： Provided herein are methods for modulating one or more of a T-helper cell or monocyte lineage cell-mediated immune response in a subject, the method comprises administering to the subject an effective amount of a compound which binds to surface membrane immunoglobulin D (smIgD). Also provided are methods of diagnosis of one or more of a T-helper cell or monocyte lineage cell-mediated immune disease, and compositions and kits for use in such methods.
摘要翻译：本文提供了调节受试者中T辅助细胞或单核细胞谱系细胞介导的免疫应答中的一种或多种的方法，所述方法包括向受试者施用有效量的结合表面膜免疫球蛋白D（smIgD）的化合物，。还提供了诊断T辅助细胞或单核细胞谱系细胞介导的免疫疾病中的一种或多种的方法，以及用于这些方法的组合物和试剂盒。

2. 发明授权

US09471969B2 Methods for differential image quality enhancement for a multiple detector system, systems and use thereof 有权
标题翻译：用于多检测器系统的差分图像质量增强的方法，系统及其用途
公开(公告)号：US09471969B2
公开(公告)日：2016-10-18
申请号：US14727518
申请日：2015-06-01
申请人： Yousheng Zeng , Jonathan M. Morris , Hazem M. Abdelmoati
发明人： Yousheng Zeng , Jonathan M. Morris , Hazem M. Abdelmoati
IPC分类号： G06K9/34 , G06T5/40 , G06T5/50 , G06T7/00 , G01M3/38 , G01N21/3504 , G08B21/12 , G06T5/00 , G01N21/31 , H04N1/60 , H04N5/235
CPC分类号： G06T5/40 , G01M3/38 , G01N21/314 , G01N21/3504 , G01N2021/3513 , G01N2201/06113 , G06T5/007 , G06T5/50 , G06T7/0004 , G06T2207/10016 , G06T2207/10048 , G08B21/12 , H04N1/6077 , H04N5/235
摘要： Methods for differential image quality enhancement for a detection system including multiple electromagnetic radiation detectors which include obtaining an image from a chemical band electromagnetic radiation detector and an image from a reference band electromagnetic radiation detector. Each of the images includes a plurality of pixels, each pixel having an associated intensity value. One or more intensity values of a plurality of pixels from the reference band image are adjusted based on one or more intensity value parameters of the chemical band image.
摘要翻译：一种用于包括多个电磁辐射检测器的检测系统的差分图像质量增强方法，包括从化学带电磁辐射检测器获取图像和来自参考频带电磁辐射检测器的图像。每个图像包括多个像素，每个像素具有相关联的强度值。基于化学带图像的一个或多个强度值参数来调整来自参考带图像的多个像素的一个或多个强度值。

3. 发明申请

US20170039716A1 Methods And Systems For Detecting A Chemical Species 审中-公开
标题翻译：检测化学物种的方法和系统
公开(公告)号：US20170039716A1
公开(公告)日：2017-02-09
申请号：US15298543
申请日：2016-10-20
申请人： Jonathan M. Morris , Yousheng Zeng
发明人： Jonathan M. Morris , Yousheng Zeng
IPC分类号： G06T7/00 , G02B5/20 , G06K9/62 , G01M3/04 , G01N21/3504 , G01M3/38 , G01N21/27 , G02B27/10 , G06K9/40
CPC分类号： G06T7/32 , G01J3/28 , G01J3/2803 , G01J3/36 , G01J3/42 , G01M3/04 , G01M3/38 , G01N21/274 , G01N21/314 , G01N21/3504 , G01N2021/3177 , G01N2021/3531 , G01N2201/06113 , G01N2201/068 , G01N2201/129 , G01S5/021 , G01S5/0236 , G02B5/208 , G02B27/106 , G06K9/40 , G06K9/6201 , G06K9/6289 , G06T2207/20224
摘要： Methods and systems for detecting at least one chemical species including obtaining a first image from a first electromagnetic radiation detector and obtaining a second image from a second electromagnetic radiation detector. The first image includes a first plurality of pixels and the second image includes a second plurality of pixels, each pixel having an associated intensity value. A first resultant image is generated. The first resultant image includes a plurality of resultant pixels, each pixel having an associated intensity value. One or more regions of interest are determined. The correlation between the first image, the second image, and the first resultant image is determined for the one or more regions of interest using a correlation coefficient algorithm to calculate a first correlation coefficient and a second correlation coefficient. The presence of the chemical species is determined based, at least in part, on the first correlation coefficient and the second correlation coefficient.
摘要翻译：用于检测至少一种化学物质的方法和系统，包括从第一电磁辐射检测器获得第一图像并从第二电磁辐射检测器获得第二图像。第一图像包括第一多个像素，并且第二图像包括第二多个像素，每个像素具有相关联的强度值。生成第一个合成图像。第一合成图像包括多个合成像素，每个像素具有相关联的强度值。确定感兴趣的一个或多个区域。使用相关系数算法，针对一个或多个感兴趣区域确定第一图像，第二图像和第一合成图像之间的相关性，以计算第一相关系数和第二相关系数。至少部分地基于第一相关系数和第二相关系数确定化学物质的存在。

4. 发明申请

US20150371374A1 Methods for Differential Image Quality Enhancement for a Multiple Detector System, Systems and Use Thereof 审中-公开
标题翻译：用于多检测器系统的差分图像质量增强的方法，系统和用途
公开(公告)号：US20150371374A1
公开(公告)日：2015-12-24
申请号：US14727518
申请日：2015-06-01
申请人： Yousheng Zeng , Jonathan M. Morris , Hazem M. Abdelmoati
发明人： Yousheng Zeng , Jonathan M. Morris , Hazem M. Abdelmoati
IPC分类号： G06T5/40 , G01N21/3504 , G01M3/38 , G06T5/50 , G06T7/00
CPC分类号： G06T5/40 , G01M3/38 , G01N21/314 , G01N21/3504 , G01N2021/3513 , G01N2201/06113 , G06T5/007 , G06T5/50 , G06T7/0004 , G06T2207/10016 , G06T2207/10048 , G08B21/12 , H04N1/6077 , H04N5/235
摘要： Methods for differential image quality enhancement for a detection system including multiple electromagnetic radiation detectors which include obtaining an image from a chemical band electromagnetic radiation detector and an image from a reference band electromagnetic radiation detector. Each of the images includes a plurality of pixels, each pixel having an associated intensity value. One or more intensity values of a plurality of pixels from the reference band image are adjusted based on one or more intensity value parameters of the chemical band image.
摘要翻译：一种用于包括多个电磁辐射检测器的检测系统的差分图像质量增强方法，包括从化学带电磁辐射检测器获取图像和来自参考频带电磁辐射检测器的图像。每个图像包括多个像素，每个像素具有相关联的强度值。基于化学带图像的一个或多个强度值参数来调整来自参考带图像的多个像素的一个或多个强度值。

5. 发明申请

US20150369693A1 Systems for Detecting a Chemical Species and Use Thereof 审中-公开
标题翻译：检测化学物质及其用途的系统
公开(公告)号：US20150369693A1
公开(公告)日：2015-12-24
申请号：US14727524
申请日：2015-06-01
申请人： Jonathan M. Morris , Yousheng Zeng
发明人： Jonathan M. Morris , Yousheng Zeng
IPC分类号： G01M3/38 , G01N21/3504 , G02B5/20
CPC分类号： G01M3/38 , G01M3/22 , G01M3/40 , G01N21/314 , G01N21/3504 , G01N2021/3166 , G01N2021/3177 , G01N2021/3522 , G01N2021/3531 , G01N2201/06113 , G01N2201/068 , G02B5/208 , G02B27/10
摘要： Systems and methods for detecting chemical species including a lens, a beam splitter, first and second bandpass filters, and first and second electromagnetic radiation detectors. The first bandpass filter has a first transmittance window having a first width transmitting greater than 50% of the filtered first electromagnetic radiation beam within a first electromagnetic radiation wavelength range. The second bandpass filter includes a second transmittance window having a second width within a second electromagnetic radiation wavelength range. The second transmittance window has an upper limit wavelength value that is greater than an upper limit wavelength value of the first transmittance window. The second bandpass filter is configured to transmit a lesser percentage of the second electromagnetic radiation beam passing through the second transmittance window than the first bandpass filter transmits of the first electromagnetic radiation beam passing through the first transmittance window.
摘要翻译：用于检测化学物质的系统和方法，包括透镜，分束器，第一和第二带通滤光器以及第一和第二电磁辐射探测器。第一带通滤波器具有第一透射窗，其具有在第一电磁辐射波长范围内透射大于滤波的第一电磁辐射束的50％的第一宽度。第二带通滤波器包括在第二电磁辐射波长范围内具有第二宽度的第二透射窗。第二透射窗具有比第一透光率窗的上限波长值大的上限波长值。第二带通滤波器被配置为透射通过第二透射窗的第二电磁辐射束的比通过第一透射窗的第一电磁辐射束的第一带通滤波器透射的更小百分比。

6. 发明授权

US09156916B2 Modulation of T helper cell-mediated immune responses 有权
标题翻译：调节T辅助细胞介导的免疫应答
公开(公告)号：US09156916B2
公开(公告)日：2015-10-13
申请号：US12298275
申请日：2007-04-27
申请人： Tue G. Nguyen , Jonathan M. Morris , Eileen D. M. Gallery , Sharon McCracken
发明人： Tue G. Nguyen , Jonathan M. Morris , Eileen D. M. Gallery , Sharon McCracken
IPC分类号： A61K39/00 , A61K39/395 , C07K16/42 , G01N33/68
CPC分类号： C07K16/4283 , A61K2039/505 , C07K2317/76 , G01N33/6854 , G01N33/6863 , G01N2800/24 , G01N2800/52 , Y02A50/412 , Y02A50/58
摘要： Provided herein are methods for modulating one or more of a T-helper cell or monocyte lineage cell-mediated immune response in a subject, the method comprises administering to the subject an effective amount of a compound which binds to surface membrane immunoglobulin D (smIgD). Also provided are methods of diagnosis of one or more of a T-helper cell or monocyte lineage cell-mediated immune disease, and compositions and kits for use in such methods.
摘要翻译：本文提供了调节受试者中T辅助细胞或单核细胞谱系细胞介导的免疫应答中的一种或多种的方法，所述方法包括向受试者施用有效量的结合表面膜免疫球蛋白D（smIgD）的化合物，。还提供了诊断T辅助细胞或单核细胞谱系细胞介导的免疫疾病中的一种或多种的方法，以及用于这些方法的组合物和试剂盒。

7. 发明授权

US09501827B2 Methods and systems for detecting a chemical species 有权
标题翻译：检测化学物种的方法和系统
公开(公告)号：US09501827B2
公开(公告)日：2016-11-22
申请号：US14727514
申请日：2015-06-01
申请人： Yousheng Zeng , Jonathan M. Morris , Hazem M. Abdelmoati
发明人： Yousheng Zeng , Jonathan M. Morris , Hazem M. Abdelmoati
IPC分类号： G06K9/34 , G06T7/00 , G01N21/3504 , G01M3/38 , G01N21/31 , G01J3/28 , G01J3/36 , G01J3/42 , G01M3/04 , G06K9/40 , G06K9/62
CPC分类号： G06T7/32 , G01J3/28 , G01J3/2803 , G01J3/36 , G01J3/42 , G01M3/04 , G01M3/38 , G01N21/274 , G01N21/314 , G01N21/3504 , G01N2021/3177 , G01N2021/3531 , G01N2201/06113 , G01N2201/068 , G01N2201/129 , G01S5/021 , G01S5/0236 , G02B5/208 , G02B27/106 , G06K9/40 , G06K9/6201 , G06K9/6289 , G06T2207/20224
摘要： Methods and systems for detecting at least one chemical species including obtaining a first image from a first electromagnetic radiation detector and obtaining a second image from a second electromagnetic radiation detector. The first image includes a first plurality of pixels and the second image includes a second plurality of pixels, each pixel having an associated intensity value. A first resultant image is generated. The first resultant image includes a plurality of resultant pixels, each pixel having an associated intensity value. One or more regions of interest are determined. The correlation between the first image, the second image, and the first resultant image is determined for the one or more regions of interest using a correlation coefficient algorithm to calculate a first correlation coefficient and a second correlation coefficient. The presence of the chemical species is determined based, at least in part, on the first correlation coefficient and the second correlation coefficient.
摘要翻译：用于检测至少一种化学物质的方法和系统，包括从第一电磁辐射检测器获得第一图像并从第二电磁辐射检测器获得第二图像。第一图像包括第一多个像素，并且第二图像包括第二多个像素，每个像素具有相关联的强度值。生成第一个合成图像。第一合成图像包括多个合成像素，每个像素具有相关联的强度值。确定感兴趣的一个或多个区域。使用相关系数算法，针对一个或多个感兴趣区域确定第一图像，第二图像和第一合成图像之间的相关性，以计算第一相关系数和第二相关系数。至少部分地基于第一相关系数和第二相关系数确定化学物质的存在。

8. 发明授权

US09448134B2 Systems for detecting a chemical species and use thereof 有权
标题翻译：用于检测化学物质的系统及其用途
公开(公告)号：US09448134B2
公开(公告)日：2016-09-20
申请号：US14727524
申请日：2015-06-01
申请人： Jonathan M. Morris , Yousheng Zeng
发明人： Jonathan M. Morris , Yousheng Zeng
IPC分类号： G01N21/00 , G01M3/38 , G02B5/20 , G01N21/3504 , G01M3/22 , G01M3/40 , G02B27/10 , G01N21/31 , G01N21/3518
CPC分类号： G01M3/38 , G01M3/22 , G01M3/40 , G01N21/314 , G01N21/3504 , G01N2021/3166 , G01N2021/3177 , G01N2021/3522 , G01N2021/3531 , G01N2201/06113 , G01N2201/068 , G02B5/208 , G02B27/10
摘要： Systems and methods for detecting chemical species including a lens, a beam splitter, first and second bandpass filters, and first and second electromagnetic radiation detectors. The first bandpass filter has a first transmittance window having a first width transmitting greater than 50% of the filtered first electromagnetic radiation beam within a first electromagnetic radiation wavelength range. The second bandpass filter includes a second transmittance window having a second width within a second electromagnetic radiation wavelength range. The second transmittance window has an upper limit wavelength value that is greater than an upper limit wavelength value of the first transmittance window. The second bandpass filter is configured to transmit a lesser percentage of the second electromagnetic radiation beam passing through the second transmittance window than the first bandpass filter transmits of the first electromagnetic radiation beam passing through the first transmittance window.
摘要翻译：用于检测化学物质的系统和方法，包括透镜，分束器，第一和第二带通滤光器以及第一和第二电磁辐射探测器。第一带通滤波器具有第一透射窗，其具有在第一电磁辐射波长范围内透射大于滤波的第一电磁辐射束的50％的第一宽度。第二带通滤波器包括在第二电磁辐射波长范围内具有第二宽度的第二透射窗。第二透射窗具有比第一透光率窗的上限波长值大的上限波长值。第二带通滤波器被配置为透射通过第二透射窗的第二电磁辐射束的比通过第一透射窗的第一电磁辐射束的第一带通滤波器透射的更小百分比。

9. 发明授权

US09442011B2 Methods for calibrating a multiple detector system 有权
标题翻译：校准多重探测器系统的方法
公开(公告)号：US09442011B2
公开(公告)日：2016-09-13
申请号：US14727532
申请日：2015-06-01
申请人： Jonathan M. Morris , Yousheng Zeng
发明人： Jonathan M. Morris , Yousheng Zeng
IPC分类号： G01N21/00 , G01J3/28 , G01N21/27 , G01N21/31 , G01J3/36 , G01J3/42 , G01N21/3504
CPC分类号： G01J3/28 , G01J3/2803 , G01J3/36 , G01J3/42 , G01N21/274 , G01N21/314 , G01N21/3504 , G01N2021/3531
摘要： Methods for calibrating multiple electromagnetic radiation detectors within a detection system and methods of using such calibrated systems which include generating a calibration electromagnetic radiation beam at a first temperature. At least a portion of the calibration electromagnetic radiation beam is detected with a first electromagnetic radiation detector. An average intensity value of a plurality of pixels from the first electromagnetic radiation detector is obtained. One or more pixels of the first electromagnetic radiation detector are adjusted to decrease the difference between the intensity of an individual pixel and the average intensity value of the first electromagnetic radiation detector. Detecting at least a portion of the calibration electromagnetic radiation beam with a second electromagnetic radiation detector. One or more pixels of the second electromagnetic radiation detector are adjusted to decrease the difference between the intensity of an individual pixel and the average intensity value of the first electromagnetic radiation detector.
摘要翻译：用于在检测系统内校准多个电磁辐射检测器的方法以及使用这种校准系统的方法，其包括在第一温度下产生校准电磁辐射束。用第一电磁辐射检测器检测校准电磁辐射束的至少一部分。获得来自第一电磁辐射检测器的多个像素的平均强度值。调整第一电磁辐射检测器的一个或多个像素以减小单个像素的强度与第一电磁辐射检测器的平均强度值之间的差异。用第二电磁辐射检测器检测至少一部分校准电磁辐射束。调整第二电磁辐射检测器的一个或多个像素以减小单个像素的强度与第一电磁辐射检测器的平均强度值之间的差异。

10. 发明申请

US20150371386A1 Methods and Systems for Detecting a Chemical Species 审中-公开
标题翻译：检测化学物种的方法和系统
公开(公告)号：US20150371386A1
公开(公告)日：2015-12-24
申请号：US14727514
申请日：2015-06-01
申请人： Yousheng Zeng , Jonathan M. Morris , Hazem M. Abdelmoati
发明人： Yousheng Zeng , Jonathan M. Morris , Hazem M. Abdelmoati
IPC分类号： G06T7/00
CPC分类号： G06T7/32 , G01J3/28 , G01J3/2803 , G01J3/36 , G01J3/42 , G01M3/04 , G01M3/38 , G01N21/274 , G01N21/314 , G01N21/3504 , G01N2021/3177 , G01N2021/3531 , G01N2201/06113 , G01N2201/068 , G01N2201/129 , G01S5/021 , G01S5/0236 , G02B5/208 , G02B27/106 , G06K9/40 , G06K9/6201 , G06K9/6289 , G06T2207/20224
摘要： Methods and systems for detecting at least one chemical species including obtaining a first image from a first electromagnetic radiation detector and obtaining a second image from a second electromagnetic radiation detector. The first image includes a first plurality of pixels and the second image includes a second plurality of pixels, each pixel having an associated intensity value. A first resultant image is generated. The first resultant image includes a plurality of resultant pixels, each pixel having an associated intensity value. One or more regions of interest are determined. The correlation between the first image, the second image, and the first resultant image is determined for the one or more regions of interest using a correlation coefficient algorithm to calculate a first correlation coefficient and a second correlation coefficient. The presence of the chemical species is determined based, at least in part, on the first correlation coefficient and the second correlation coefficient.
摘要翻译：用于检测至少一种化学物质的方法和系统，包括从第一电磁辐射检测器获得第一图像并从第二电磁辐射检测器获得第二图像。第一图像包括第一多个像素，并且第二图像包括第二多个像素，每个像素具有相关联的强度值。生成第一个合成图像。第一合成图像包括多个合成像素，每个像素具有相关联的强度值。确定感兴趣的一个或多个区域。使用相关系数算法，针对一个或多个感兴趣区域确定第一图像，第二图像和第一合成图像之间的相关性，以计算第一相关系数和第二相关系数。至少部分地基于第一相关系数和第二相关系数确定化学物质的存在。

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