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1. 发明授权

US09034329B2 Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof 有权
标题翻译：制备抗体或抗体片段靶向免疫脂质体用于全身给药治疗剂或诊断剂及其用途
公开(公告)号：US09034329B2
公开(公告)日：2015-05-19
申请号：US11520796
申请日：2006-09-14
申请人： Esther H. Chang , Kathleen F. Pirollo
发明人： Esther H. Chang , Kathleen F. Pirollo
IPC分类号： A61K39/395 , A61K9/127 , C12P21/08 , C12N15/11 , C07K16/28 , G01N33/53
CPC分类号： C12N15/1138 , A61K9/1271 , A61K9/1272 , C07K16/2881 , C07K2317/622 , C12N2310/14
摘要： The present invention provides methods of preparing an antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex comprising (a) preparing an antibody or antibody fragment; (b) mixing said antibody or antibody fragment with a cationic liposome to form a cationic immunoliposome or with a cationic polymer to form a polyplex; and (c) mixing said cationic immunoliposome or said polyplex with a therapeutic or diagnostic agent to form said antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex. The present invention also provides cationic immunoliposome or polymer complexes produced by such methods and compositions comprising such complexes. The present invention also provides methods for treating various diseases and disorders, including cancers, by administering the complexes and compositions of the invention to a patient.
摘要翻译：本发明提供制备抗体或抗体片段靶向阳离子免疫脂质体或聚合物复合物的方法，其包括（a）制备抗体或抗体片段; （b）将所述抗体或抗体片段与阳离子脂质体混合以形成阳离子免疫脂质体或用阳离子聚合物形成聚合物; 和（c）将所述阳离子免疫脂质体或所述多聚体与治疗剂或诊断剂混合以形成所述抗体或抗体片段靶向阳离子免疫脂质体或聚合物复合物。本发明还提供了由包含这种复合物的方法和组合物制备的阳离子免疫脂质体或聚合物复合物。本发明还提供了通过将本发明的复合物和组合物给予患者来治疗各种疾病和病症（包括癌症）的方法。

2. 发明授权

US6027892A Compositions and methods for reducing radiation and drug resistance in cells 失效
标题翻译：减少细胞辐射和耐药性的组合物和方法
公开(公告)号：US6027892A
公开(公告)日：2000-02-22
申请号：US991830
申请日：1997-12-16
申请人： Esther H. Chang , Kathleen F. Pirollo
发明人： Esther H. Chang , Kathleen F. Pirollo
IPC分类号： A61K38/00 , C12N15/113 , C12Q1/68 , C07H21/04 , C12N9/00 , C12N15/85
CPC分类号： C12N15/1135 , C12N15/1137 , C12N15/1138 , A61K38/00 , C12N2310/315
摘要： Provided are antisense oligonucleotides directed against the raf-1 gene, Ha-ras gene and HER-2 gene, components of a signal transduction pathway involving oncogenes and their normal counterparts and leading to the phenotype of cellular radioresistance. Administration of these antisense oligonucleotides is shown to reverse the radioresistance phenotype in cells overexpressing HER-2 or a mutant form of Ha-ras. Methods and compositions for reversing radiation resistance among other conditions involving these genes are disclosed.
摘要翻译：提供了针对raf-1基因，Ha-ras基因和HER-2基因的反义寡核苷酸，涉及致癌基因及其正常对应物的信号转导途径的组分，并导致细胞放射抗性的表型。显示这些反义寡核苷酸的施用可以逆转过表达HER-2或突变形式的Ha-ras的细胞中的放射抗性表型。公开了在涉及这些基因的其它条件下逆转耐辐射性的方法和组合物。

3. 发明申请

US20100329981A1 SIMPLIFIED AND IMPROVED METHOD FOR PREPARING AN ANTIBODY OR AN ANTIBODY FRAGMENT TARGETED IMMUNOLIPOSOME FOR SYSTEMIC ADMINISTRATION OF A THERAPEUTIC OR DIAGNOSTIC AGENT 有权
标题翻译：用于制备抗生素或抗体片段靶向免疫球蛋白的简化和改进的方法用于治疗或诊断代谢物的系统管理
公开(公告)号：US20100329981A1
公开(公告)日：2010-12-30
申请号：US12820800
申请日：2010-06-22
申请人： Esther H. CHANG , Kathleen F. Pirollo
发明人： Esther H. CHANG , Kathleen F. Pirollo
IPC分类号： A61K49/00 , A61K9/127 , A61K39/395 , A61P35/00 , A61N5/10 , A61M37/00
CPC分类号： A61K9/1272 , C12N15/88 , C12N2810/40
摘要： A method of preparing an antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex comprises the steps of (a) preparing an antibody or antibody fragment; (b) mixing said antibody or antibody fragment with a cationic liposome to form a cationic immunoliposome or with a cationic polymer to form a polyplex; and (c) mixing said cationic immunoliposome or said polyplex with a therapeutic or diagnostic agent to form said antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex.
摘要翻译：制备抗体或抗体片段靶向阳离子免疫脂质体或聚合物复合物的方法包括以下步骤：（a）制备抗体或抗体片段; （b）将所述抗体或抗体片段与阳离子脂质体混合以形成阳离子免疫脂质体或用阳离子聚合物形成聚合物; 和（c）将所述阳离子免疫脂质体或所述多聚体与治疗剂或诊断剂混合以形成所述抗体或抗体片段靶向阳离子免疫脂质体或聚合物复合物。

4. 发明授权

US09034330B2 Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof 有权
标题翻译：制备抗体或抗体片段靶向免疫脂质体用于全身给药治疗剂或诊断剂及其用途
公开(公告)号：US09034330B2
公开(公告)日：2015-05-19
申请号：US11798296
申请日：2007-05-11
申请人： Esther H. Chang , Kathleen F. Pirollo
发明人： Esther H. Chang , Kathleen F. Pirollo
IPC分类号： A61K39/395 , A61K9/127 , C12P21/08 , A61K39/00 , A61K9/00 , A61K41/00 , A61K47/48 , A61K49/18 , G01N33/53
CPC分类号： A61K47/42 , A61K9/0019 , A61K9/127 , A61K9/1272 , A61K31/4025 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K39/39558 , A61K41/0038 , A61K47/6843 , A61K47/6913 , A61K49/1812 , A61K2039/505 , A61K2300/00
摘要： A method of preparing an antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex comprises the steps of (a) preparing an antibody or antibody fragment; (b) mixing said antibody or antibody fragment with a cationic liposome to form a cationic immunoliposome or with a cationic polymer to form a polyplex; and (c) mixing said cationic immunoliposome or said polyplex with a therapeutic or diagnostic agent to form said antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex.
摘要翻译：制备抗体或抗体片段靶向阳离子免疫脂质体或聚合物复合物的方法包括以下步骤：（a）制备抗体或抗体片段; （b）将所述抗体或抗体片段与阳离子脂质体混合以形成阳离子免疫脂质体或用阳离子聚合物形成聚合物; 和（c）将所述阳离子免疫脂质体或所述多聚体与治疗剂或诊断剂混合以形成所述抗体或抗体片段靶向阳离子免疫脂质体或聚合物复合物。

5. 发明授权

US08865127B2 Simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome for systemic administration of a therapeutic or diagnostic agent 有权
标题翻译：用于制备用于全身施用治疗剂或诊断剂的抗体或抗体片段靶向免疫脂质体的简化和改进的方法
公开(公告)号：US08865127B2
公开(公告)日：2014-10-21
申请号：US12820800
申请日：2010-06-22
申请人： Esther H. Chang , Kathleen F. Pirollo
发明人： Esther H. Chang , Kathleen F. Pirollo
IPC分类号： A61K49/00 , A61K9/127 , A61K39/00 , A61K39/385 , C12N15/88 , C07H21/04
CPC分类号： A61K9/1272 , C12N15/88 , C12N2810/40
摘要： Provided herein is an antibody- or antibody fragment-targeted cationic immunoliposome complex prepared by a method comprising the steps of (a) preparing an antibody or antibody fragment; (b) mixing the antibody or antibody fragment with a cationic liposome and to form a cationic immunoliposome wherein the antibody or antibody fragment is complexed with the cationic liposome, but is not chemically conjugated to the cationic liposome and wherein said antibody or antibody fragment does not comprise a lipid tag; and (c) mixing the cationic immunoliposome with a therapeutic or diagnostic agent to form the antibody- or antibody fragment-targeted cationic immunoliposome. Also provided is an antibody- or antibody fragment-targeted cationic immunoliposome comprising an antibody or antibody fragment; a cationic liposome, wherein the antibody or antibody fragment is complexed with the cationic liposome, but is not chemically conjugated to the cationic liposome and wherein said antibody or antibody fragment does not comprise a lipid tag and a therapeutic or diagnostic agent.
摘要翻译：本文提供了通过包括以下步骤的方法制备的抗体或抗体片段靶向阳离子免疫脂质体复合物：（a）制备抗体或抗体片段; （b）将抗体或抗体片段与阳离子脂质体混合并形成阳离子免疫脂质体，其中抗体或抗体片段与阳离子脂质体络合，但不与阳离子脂质体化学偶联，并且其中所述抗体或抗体片段不包括脂质标签; 和（c）将阳离子免疫脂质体与治疗剂或诊断剂混合以形成抗体或抗体片段靶向的阳离子免疫脂质体。还提供了包含抗体或抗体片段的抗体或抗体片段靶向阳离子免疫脂质体; 阳离子脂质体，其中抗体或抗体片段与阳离子脂质体络合，但不与阳离子脂质体化学偶联，并且其中所述抗体或抗体片段不包含脂质标签和治疗或诊断剂。

6. 发明申请

US20080213223A1 Systemic viral/ligand gene delivery system and gene therapy 审中-公开
标题翻译：系统病毒/配体基因传递系统和基因治疗
公开(公告)号：US20080213223A1
公开(公告)日：2008-09-04
申请号：US11980791
申请日：2007-10-31
申请人： Esther H. Chang , Kathleen F. Pirollo , Liang Xu , William Alexander
发明人： Esther H. Chang , Kathleen F. Pirollo , Liang Xu , William Alexander
IPC分类号： A61K48/00 , C12N15/861 , A61P35/00
CPC分类号： C12N15/86 , A61K38/1709 , A61K47/6901 , A61K48/00 , C12N15/87 , C12N2710/10343 , C12N2710/10345 , A61K2300/00
摘要： The present invention relates to gene transfer and gene therapy technology. More specifically, the invention provides compositions and methods for targeted virus delivery. The method utilizes a method of mixing the virus, which may be a recombinant virus which will express a protein of interest or a nucleic acid of interest, with a cell-targeting ligand, e.g., transferrin. The virus and ligand are mixed without crosslinkers or agents which would covalently bond the virus and ligand. This simple mixing causes less inactivation than chemically linking the ligand to the virus and therefore results in a more active therapeutic composition than obtained by methods which utilize crosslinking agents.
摘要翻译：本发明涉及基因转移和基因治疗技术。更具体地，本发明提供了靶向病毒递送的组合物和方法。该方法利用将病毒（其可以表达感兴趣的蛋白质或感兴趣的核酸）的重组病毒与细胞靶向配体例如转铁蛋白混合的方法。将病毒和配体混合而不会共价结合病毒和配体的交联剂或试剂。这种简单的混合导致比化学连接配体与病毒更少的失活，因此导致比通过利用交联剂的方法获得的更有效的治疗组合物。

7. 发明授权

US08617514B2 Tumor-targeted nanodelivery systems to improve early MRI detection of cancer 有权
标题翻译：肿瘤靶向纳米递送系统，以改善癌症的早期MRI检测
公开(公告)号：US08617514B2
公开(公告)日：2013-12-31
申请号：US11583708
申请日：2006-10-20
申请人： Esther H. Chang , Kathleen F. Pirollo
发明人： Esther H. Chang , Kathleen F. Pirollo
IPC分类号： A61K51/12 , A61K49/04 , A61K49/06 , A61K49/18 , A61K39/00 , A61K9/127 , A61K35/00 , A61K35/04 , A61B5/055 , A61B8/00 , C07K16/00
CPC分类号： A61K49/1812 , A61K9/1272 , A61K49/0002 , A61K49/0466 , A61K51/1234
摘要： The present invention is in the fields of drug delivery, cancer treatment and diagnosis and pharmaceuticals. This invention provides a method of making antibody- or antibody fragment-targeted immunoliposomes for the systemic delivery of molecules to treat and image diseases, including cancerous tumors. The invention also provides immunoliposomes and compositions, as well as methods of imaging various tissues. The liposome complexes are useful for encapsulation of imaging agents, for example, for use in magnetic resonance imaging. The specificity of the delivery system is derived from the targeting antibodies or antibody fragments.
摘要翻译：本发明涉及药物递送，癌症治疗和诊断以及药物领域。本发明提供了制备抗体或抗体片段靶向免疫脂质体用于系统递送分子以治疗和成像疾病（包括癌性肿瘤）的方法。本发明还提供免疫脂质体和组合物，以及成像各种组织的方法。脂质体复合物可用于包封成像剂，例如用于磁共振成像。递送系统的特异性来自靶向抗体或抗体片段。

8. 发明授权

US07780882B2 Simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome for systemic administration of a therapeutic or diagnostic agent 有权
标题翻译：用于制备用于全身施用治疗剂或诊断剂的抗体或抗体片段靶向免疫脂质体的简化和改进的方法
公开(公告)号：US07780882B2
公开(公告)日：2010-08-24
申请号：US10113927
申请日：2002-04-02
申请人： Esther H. Chang , Kathleen F. Pirollo
发明人： Esther H. Chang , Kathleen F. Pirollo
IPC分类号： B01J13/02 , B01J13/04 , A61K9/127 , A61K39/00 , A61K39/395
CPC分类号： A61K9/1272 , C12N15/88 , C12N2810/40
摘要： A method of preparing an antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex comprises the steps of (a) preparing an antibody or antibody fragment; (b) mixing said antibody or antibody fragment with a cationic liposome to form a cationic immunoliposome or with a cationic polymer to form a polyplex; and (c) mixing said cationic immunoliposome or said polyplex with a therapeutic or diagnostic agent to form said antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex.
摘要翻译：制备抗体或抗体片段靶向阳离子免疫脂质体或聚合物复合物的方法包括以下步骤：（a）制备抗体或抗体片段; （b）将所述抗体或抗体片段与阳离子脂质体混合以形成阳离子免疫脂质体或用阳离子聚合物形成聚合物; 和（c）将所述阳离子免疫脂质体或所述多聚体与治疗剂或诊断剂混合以形成所述抗体或抗体片段靶向阳离子免疫脂质体或聚合物复合物。

9. 发明申请

US20090053299A1 Methods for generating immune response using cationic-liposome-mediated nucleic acid delivery 审中-公开
标题翻译：使用阳离子脂质体介导的核酸递送产生免疫反应的方法
公开(公告)号：US20090053299A1
公开(公告)日：2009-02-26
申请号：US12216715
申请日：2008-07-09
申请人： Esther H. Chang , Kathleen F. Pirollo
发明人： Esther H. Chang , Kathleen F. Pirollo
IPC分类号： A61K9/127 , A61K31/7088 , A61K39/395 , A61K38/40 , A61P31/12
CPC分类号： C12N15/88 , A61K9/1272 , A61K39/12 , A61K39/29 , A61K47/6911 , A61K47/6913 , A61K2039/53 , A61K2039/543 , A61K2039/55555 , C12N2730/10134 , C12N2740/16134 , C12N2760/16134 , C12N2770/20034 , C12N2770/24134 , C12N2810/80 , C12N2810/859
摘要： The present invention is in the fields of drug delivery, and specifically, cationic liposome-based vaccines. In embodiments, this invention provides methods of making ligand-targeted (e.g., antibody- or antibody fragment-targeted) liposomes useful for the delivery of molecules to induce immune responses against viral antigens or to treat or prevent viral diseases. The specificity of the delivery system is derived from the targeting ligands.
摘要翻译：本发明涉及药物递送领域，特别是基于阳离子脂质体的疫苗。在实施方案中，本发明提供了制备用于递送分子以诱导针对病毒抗原的免疫应答或治疗或预防病毒性疾病的配体靶向（例如，抗体或抗体片段靶向的）脂质体的方法。递送系统的特异性来源于靶向配体。

10. 发明授权

US06803360B1 Compositions and methods for reducing radiation and drug resistance in cells 有权
标题翻译：减少细胞辐射和耐药性的组合物和方法
公开(公告)号：US06803360B1
公开(公告)日：2004-10-12
申请号：US09716320
申请日：2000-11-21
申请人： Esther H. Chang , Kathleen F. Pirollo
发明人： Esther H. Chang , Kathleen F. Pirollo
IPC分类号： A01N4304
CPC分类号： C12N15/1135 , A61K9/1271 , A61K9/1272 , A61K38/00 , A61K48/0025 , C12N15/1137 , C12N15/1138 , C12N15/88 , C12N2310/315
摘要： Provided are antisense oligonucleotides directed against the raf-1 gene, Ha-ras gene and HER-2 gene, components of a signal transduction pathway involving oncogenes and their normal counterparts and leading to the phenotype of cellular radioresistance. Administration of these antisense oligonucleotides is shown to reverse the radioresistance phenotype in cells overexpressing HER-2 or a mutant form of Ha-ras. Methods and compositions for reversing radiation resisting among other conditions involving these genes are disclosed.
摘要翻译：提供了针对raf-1基因，Ha-ras基因和HER-2基因的反义寡核苷酸，涉及致癌基因及其正常对应物的信号转导途径的组分，并导致细胞放射抗性的表型。显示这些反义寡核苷酸的施用可以逆转过表达HER-2或突变形式的Ha-ras的细胞中的放射抗性表型。公开了在涉及这些基因的其他条件之间逆转耐辐射的方法和组合物。

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