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1. 发明授权

US09353217B2 Biodegradable particles, vascular occlusion material, and method for producing biodegradable particles 有权
标题翻译：可生物降解颗粒，血管闭塞材料和生产可生物降解颗粒的方法
公开(公告)号：US09353217B2
公开(公告)日：2016-05-31
申请号：US13991495
申请日：2011-12-09
申请人： Kazuhiro Tanahashi , Megumi Nakanishi , Yasufumi Yamamura , Masaki Fujita
发明人： Kazuhiro Tanahashi , Megumi Nakanishi , Yasufumi Yamamura , Masaki Fujita
IPC分类号： C08G65/332 , C08G65/00 , A61L31/14 , C08J3/12 , C08J3/24 , A61L24/00 , A61L24/04
CPC分类号： C08G65/00 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L31/14 , A61L31/148 , A61L2300/60 , A61L2430/36 , C08G65/332 , C08G65/3322 , C08G2650/30 , C08J3/12 , C08J3/24 , C08J2300/16
摘要： Spherical biodegradable particles have improved flexibility, cause less aggregation among particles, and have improved particle shape-recovering ability after passing through a catheter or the like. The biodegradable particles include a synthetic polymer chemically cross-linked to a polyvalent carboxylic acid, the biodegradable particles having a water content of 20 to 90% in a water-saturated state.
摘要翻译：球形可生物降解的颗粒具有改善的柔性，导致颗粒之间的聚集较少，并且在通过导管等之后具有改善的颗粒形状恢复能力。可生物降解的颗粒包括与多价羧酸化学交联的合成聚合物，在水饱和状态下，生物降解性颗粒的水含量为20-90％。

2. 发明申请

US20130220912A1 CARRIER FOR BLOOD COMPONENT ADSORPTION AND BLOOD COMPONENT ADSORPTION COLUMN 有权
标题翻译：血液组分吸附载体和血液成分吸附柱
公开(公告)号：US20130220912A1
公开(公告)日：2013-08-29
申请号：US13881172
申请日：2011-10-26
申请人： Naotoshi Tomita , Yoshiyuki Ueno , Kazuhiro Tanahashi
发明人： Naotoshi Tomita , Yoshiyuki Ueno , Kazuhiro Tanahashi
IPC分类号： B01J20/28
CPC分类号： B01J20/28016 , A61K35/14 , A61M1/3679 , A61M2202/0439 , B01J20/28004 , B01J20/28023 , B01J20/28038 , B01J20/28054 , B01J20/3251 , B01J20/3285 , Y10T428/298 , Y10T428/2982
摘要： A carrier for blood component adsorption includes a water-insoluble carrier composed of a fiber or particle, the water-insoluble carrier having a surface to which a functional group(s) is/are introduced, the functional group(s) containing an acidic functional group selected from the group consisting of the sulfate group, sulfite group and sulfonate group; and containing an amino group; the fiber having a fiber diameter of, or the particle having a particle diameter of, 0.5 to 20 μm.
摘要翻译：用于血液成分吸附的载体包括由纤维或颗粒组成的水不溶性载体，具有引入官能团的表面的水不溶性载体，含有酸性官能团的官能团选自硫酸基，亚硫酸酯基和磺酸酯基的基团; 并含有氨基; 纤维的纤维直径为或者粒径为0.5〜20μm的颗粒。

3. 发明申请

US20120271010A1 HYDROPHILIC POLYMER COMPOUND HAVING ANTICOAGULATION EFFECT 审中-公开
标题翻译：具有抗凝效果的亲水聚合物化合物
公开(公告)号：US20120271010A1
公开(公告)日：2012-10-25
申请号：US13517175
申请日：2010-12-22
申请人： Hirokazu Sakaguchi , Yuka Sakaguchi , Kazuhiro Tanahashi
发明人： Hirokazu Sakaguchi , Yuka Sakaguchi , Kazuhiro Tanahashi
IPC分类号： C08G77/392
CPC分类号： C08G85/004 , A61L33/0011 , A61L2400/18
摘要： A hydrophilic polymer compound includes a polymer compound which inhibits platelet adhesion, and a compound that inhibits blood coagulation reaction, bound to the polymer compound.
摘要翻译：亲水性高分子化合物包括抑制血小板粘附的高分子化合物和与高分子化合物结合的抑制凝血反应的化合物。

4. 发明授权

US07629388B2 Synthesis and characterization of biodegradable cationic poly(propylene fumarate-co-ethylene glycol) copolymer hydrogels modified with agmatine for enhanced cell adhesion 有权
标题翻译：用丁胺改性的可生物降解阳离子聚（丙烯富马酸酯 - 共 - 乙二醇）共聚物水凝胶的合成和表征，增强细胞粘附
公开(公告)号：US07629388B2
公开(公告)日：2009-12-08
申请号：US10300202
申请日：2002-11-20
申请人： Antonios G. Mikos , Kazuhiro Tanahashi
发明人： Antonios G. Mikos , Kazuhiro Tanahashi
IPC分类号： A67K47/00 , A01N25/00
CPC分类号： A61K47/60
摘要： A cross-linkable monomer comprises a fumaric acid functional group having a first end and a second end, a first spacer group affixed to said first end and comprising at least repeating unit, a first terminal group affixed to said first spacer group, a second spacer group affixed to said second end and comprising at least one ethylene glycol repeating unit, and a second terminal group affixed to said second spacer group. A hydrogel formed by cross-linking the present monomer and a method for making the monomer. A method for forming a hydrogel, comprises the steps of a) synthesizing a copolymer of poly(propylene fumarate) (PPF) and poly(ethylene glycol (PEG) so as to produce P(PF-co-EG), b) synthesizing a PEG-tethered fumarate (PEGF), c) coupling agmatine sulfate to the PEGF to produce PEGF modified with agmatine (Agm-PEGF), and d) cross-linking the P(PF-co-EG) from step a) with Agm-PEGF from step c).
摘要翻译：可交联单体包括具有第一末端和第二末端的富马酸官能团，第一间隔基团固定在所述第一末端并且包含至少重复单元，固定到所述第一间隔基团的第一末端基团，第二间隔基团固定在所述第二端并且包含至少一个乙二醇重复单元的基团和固定到所述第二间隔基团上的第二末端基团。通过交联本发明单体形成的水凝胶和制备该单体的方法。一种形成水凝胶的方法，包括以下步骤：a）合成聚（丙烯酸富马酸酯）（PPF）和聚（乙二醇（PEG））以产生P（PF-co-EG）的共聚物，b） PEG连接的富马酸酯（PEGF），c）将硫酸胍加到PEGF上以产生用胍丁胺（Agm-PEGF）修饰的PEGF，和d）将来自步骤a）的P（PF-co-EG）与Agm- 来自步骤c）的PEGF。

5. 发明授权

US09802178B2 Carrier for blood component adsorption and blood component adsorption column 有权
公开(公告)号：US09802178B2
公开(公告)日：2017-10-31
申请号：US13881172
申请日：2011-10-26
申请人： Naotoshi Tomita , Yoshiyuki Ueno , Kazuhiro Tanahashi
发明人： Naotoshi Tomita , Yoshiyuki Ueno , Kazuhiro Tanahashi
IPC分类号： B01J20/00 , A61K35/14 , B01J20/28 , A61M1/36 , B01J20/32
CPC分类号： B01J20/28016 , A61K35/14 , A61M1/3679 , A61M2202/0439 , B01J20/28004 , B01J20/28023 , B01J20/28038 , B01J20/28054 , B01J20/3251 , B01J20/3285 , Y10T428/298 , Y10T428/2982
摘要： A carrier for blood component adsorption includes a water-insoluble carrier composed of a fiber or particle, the water-insoluble carrier having a surface to which a functional group(s) is/are introduced, the functional group(s) containing an acidic functional group selected from the group consisting of the sulfate group, sulfite group and sulfonate group; and containing an amino group; the fiber having a fiber diameter of, or the particle having a particle diameter of, 0.5 to 20 μm.

6. 发明申请

US20140018505A1 BIODEGRADABLE PARTICLE, VASCULAR EMBOLIZATION MATERIAL AND METHOD FOR PRODUCING BIODEGRADABLE PARTICLES 有权
标题翻译：生物可降解颗粒，生物可降解颗粒的血管形成材料和方法
公开(公告)号：US20140018505A1
公开(公告)日：2014-01-16
申请号：US14008194
申请日：2012-03-29
申请人： Masaki Fujita , Megumi Nakanishi , Yoshitake Takahashi , Yasufumi Yamamura , Kazuhiro Tanahashi
发明人： Masaki Fujita , Megumi Nakanishi , Yoshitake Takahashi , Yasufumi Yamamura , Kazuhiro Tanahashi
IPC分类号： A61L24/04 , A61L24/00
CPC分类号： A61L24/046 , A61L24/0042 , A61L31/06 , A61L31/148 , A61L2430/36 , C08G63/08 , C08G63/664 , C08J3/28 , C08J2367/04 , C08L67/04
摘要： A biodegradable particle including a block copolymer produced by copolymerization of a biodegradable copolymer having a structure composed of hydroxycarboxylic acid a1, whose homopolymer produced by homopolymerization has a glass transition point of not less than 40° C. and hydroxycarboxylic acid a2, whose homopolymer produced by homopolymerization has a glass transition point of not more than −40° C.; a water-soluble polymer comprising a functional group selected from the group consisting of a hydroxyl group, amino group and carboxylic acid group at each of both ends; and a polyvalent compound comprising 2 or more functional groups each selected from the group consisting of a hydroxyl group, amino group and carboxylic acid group; wherein a ratio of mass of said structure composed of hydroxycarboxylic acid a2 to mass of said biodegradable copolymer is 30 to 90% by mass.
摘要翻译：包含由具有由均聚产生的均聚物的羟基羧酸a1构成的结构的生物降解性共聚物的共聚制得的嵌段共聚物的玻璃化转变温度为40℃以上的生物降解性粒子和羟基羧酸a2，其均聚物由均聚反应玻璃化转变温度不高于-40℃。在两端各自包含选自羟基，氨基和羧酸基的官能团的水溶性聚合物; 和包含2个以上选自羟基，氨基和羧酸基的官能团的多价化合物; 其中由羟基羧酸a2构成的所述结构的质量与所述生物降解性共聚物的质量之比为30〜90质量％。

7. 发明申请

US20130327698A1 CARRIER FOR BLOOD COMPONENT ADSORPTION AND BLOOD COMPONENT ADSORPTION COLUMN 有权
标题翻译：血液组分吸附载体和血液成分吸附柱
公开(公告)号：US20130327698A1
公开(公告)日：2013-12-12
申请号：US14001065
申请日：2012-02-24
申请人： Naotoshi Tomita , Yoshiyuki Ueno , Kazuhiro Tanahashi
发明人： Naotoshi Tomita , Yoshiyuki Ueno , Kazuhiro Tanahashi
IPC分类号： A61M1/36 , B01J20/22
CPC分类号： A61M1/3679 , B01J20/22 , B01J20/28004 , B01J20/28016 , B01J20/28023 , B01J20/28052 , B01J20/321 , B01J20/3219 , B01J20/3251 , B01J20/3257 , B01J20/3259 , B01J20/3293 , B01J2220/58
摘要： A carrier for blood component adsorption enables selective and efficient adsorption removal of granulocytes and monocytes and, at the same time, enables adsorption removal of inflammatory cytokines. The carrier for blood component adsorption includes a water-insoluble carrier having a surface to which a functional group(s) containing a silyl group and an amino group is/are introduced.
摘要翻译：用于血液成分吸附的载体能够选择性且有效地吸附去除粒细胞和单核细胞，并且同时能够吸附去除炎性细胞因子。用于血液成分吸附的载体包括具有引入了含有甲硅烷基和氨基的官能团的表面的水不溶性载体。

8. 发明申请

US20120156302A1 BIODEGRADABLE PARTICLE AND METHOD FOR PRODUCING THE SAME 审中-公开
标题翻译：生物可降解颗粒及其生产方法
公开(公告)号：US20120156302A1
公开(公告)日：2012-06-21
申请号：US13402851
申请日：2012-02-22
申请人： Kazuhiro TANAHASHI , Megumi Nakanishi
发明人： Kazuhiro TANAHASHI , Megumi Nakanishi
IPC分类号： A61K9/14 , A61K47/34
CPC分类号： A61L31/148 , A61K9/0019 , A61K9/14 , A61L24/0042 , A61L24/046 , A61L31/06 , A61L2430/36 , C08J3/12 , C08J2367/04 , C08L67/04 , C08L71/02 , C08L2666/22
摘要： The present invention aims to provide a biodegradable particle capable of being molded without an aggregation or cohesion of the particles, capable of being carried or injected without clogging by an aggregation in a micro diameter tube such as of a catheter, needle or syringe mainly used in pharmaceutical and medical applications of which inner diameter is smaller than the particle size or in a blood vessel and capable of being smoothly degraded in a specified period of time so that degraded component can finally be absorbed or discharged in vitro. As means for solving the problem, the present invention provides a biodegradable particle characterized in that a compressive modulus of the particle in water saturated state is 10 MPa or less.
摘要翻译：本发明的目的在于提供一种可生物降解的颗粒，其能够在没有颗粒聚集或内聚的情况下模制，能够被携带或注入，而不会在主要用于其内径小于粒径或在血管中的能够在规定时间内顺利降解的药物和医疗应用，使得降解的成分最终能够在体外被吸收或排出。作为解决问题的手段，本发明提供一种生物降解性粒子，其特征在于，水饱和状态下的粒子的压缩弹性模量为10MPa以下。

9. 发明申请

US20110124009A1 COMPOSITION, KIT AND METHOD FOR ASSAYING NEUROPATHY 审中-公开
标题翻译：组合物，用于测定神经病变的试剂盒和方法
公开(公告)号：US20110124009A1
公开(公告)日：2011-05-26
申请号：US12935800
申请日：2009-03-31
申请人： Takeshi Iwata , Kiyoshi Matsuno , Kazuhiro Tanahashi
发明人： Takeshi Iwata , Kiyoshi Matsuno , Kazuhiro Tanahashi
IPC分类号： G01N33/68 , C07K16/18 , C07K16/40 , G01N33/573 , C12Q1/48 , C12Q1/34 , C12Q1/42 , B01D59/44
CPC分类号： G01N33/6893 , G01N2800/16 , G01N2800/168 , G01N2800/60
摘要： The present invention relates to a method for detecting a disease accompanied with neuropathy such as glaucoma, comprising measuring and/or detecting one or more of polypeptides shown in SEQ ID NOS: 1 to 15, mutants thereof, or fragments thereof in a biological sample from a subject, and also to a composition or kit for diagnosis of a disease accompanied with neuropathy such as glaucoma.
摘要翻译：本发明涉及一种用于检测伴有神经病如青光眼的疾病的方法，其包括在生物样品中测量和/或检测SEQ ID NO：1至15所示多肽，其突变体或其片段中的一种或多种受试者，以及用于诊断伴有神经病如青光眼的疾病的组合物或试剂盒。

10. 发明申请

US20110009503A1 FRACTIONATION APPARATUS 审中-公开
标题翻译：分类装置
公开(公告)号：US20110009503A1
公开(公告)日：2011-01-13
申请号：US12834666
申请日：2010-07-12
申请人： Kazuhiro TANAHASHI , Hiroshi Takahashi , Hiroyuki Sugaya , Shigehisa Wada
发明人： Kazuhiro TANAHASHI , Hiroshi Takahashi , Hiroyuki Sugaya , Shigehisa Wada
IPC分类号： C08J5/22 , C08J3/28
CPC分类号： C07K1/22
摘要： The present invention discloses a fractionation device used for proteins and/or peptides, which has any of the following features:1) At least one portion of a substrate surface with which proteins or the like are made in contact has an amount of adsorption of bovine serum albumin of 50 ng/cm2 or less with respect to the substrate surface, when a bovine serum albumin solution is made in contact therewith. 2) At least one portion of a substrate surface with which proteins or the like are made in contact has an amount of adsorption of human β2-microglobulin of 3 ng/cm2 or less with respect to the substrate surface, when a protein aqueous solution consisting of human β2-microglobulin and bovine serum albumin is made in contact with the substrate surface. 3) The fractionation device is provided with: a means for supplying a solution containing proteins or the like; a means for separating proteins or the like from the solution; and a means for concentrating proteins or the like in the solution, and in the fractionation device, at least one portion of the substrate surface with which proteins or the like are made in contact is subjected to a grafting process by using a hydrophilic polymer. By using the above-mentioned device, it becomes possible to reduce non-peculiar adsorption of protein onto the substrate, and consequently to easily provide a sample from which proteins having high-molecular weights have been removed, and which is advantageously used for an analysis.
摘要翻译：本发明公开了一种用于蛋白质和/或肽的分级装置，其具有以下特征：1）与蛋白质等接触的底物表面的至少一部分具有牛的吸附量当与其接触的牛血清白蛋白溶液时，相对于底物表面的血清白蛋白为50ng / cm 2以下。 2）当与蛋白质接触的基底表面的至少一部分相对于底物表面具有3ng / cm 2以下的人和2μg微球蛋白的吸附量，当蛋白质水溶液由人类和微生物组织的2-微球蛋白和牛血清白蛋白组成的溶液与底物表面接触。 3）分离装置设有：用于供给含有蛋白质等的溶液的装置; 用于从溶液中分离蛋白质等的方法; 以及用于将蛋白质等浓缩在溶液中的方法，并且在分级装置中，通过使用亲水性聚合物对与蛋白质等接触的基底表面的至少一部分进行接枝处理。通过使用上述装置，可以减少蛋白质在基质上的非特异性吸附，从而容易地提供已经除去高分子量蛋白质的样品，并且有利地用于分析。

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