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1. 发明申请

US20130137949A1 HYPERSPECTRAL IMAGING OF ANGIOGENESIS 有权
标题翻译：血管生成的高分辨成像
公开(公告)号：US20130137949A1
公开(公告)日：2013-05-30
申请号：US13678513
申请日：2012-11-15
申请人： Jenny Freeman , Svetlana Panasyuk , Michael Hopmeier , Kevin Schomacker , Derek Brand
发明人： Jenny Freeman , Svetlana Panasyuk , Michael Hopmeier , Kevin Schomacker , Derek Brand
IPC分类号： A61B5/1455
CPC分类号： A61B5/441 , A61B5/0059 , A61B5/0075 , A61B5/14551 , A61B5/412 , A61B5/445 , A61B5/742 , G01N21/314 , G01N21/359
摘要： The invention is directed to methods and systems of hyperspectral and multispectral imaging of medical tissues. In particular, the invention is directed to new devices, tools and processes for the detection and evaluation of diseases and disorders such as, but not limited to diabetes and peripheral vascular disease and cancer, that incorporate hyperspectral or multispectral imaging.
摘要翻译：本发明涉及医学组织的高光谱和多光谱成像的方法和系统。特别地，本发明涉及用于检测和评估疾病和病症（例如但不限于糖尿病和外周血管疾病和癌症）的新装置，工具和方法，其包括高光谱或多光谱成像。

2. 发明申请

US20070038042A1 Hyperspectral technology for assessing and treating diabetic foot and tissue disease 有权
标题翻译：高光谱技术用于评估和治疗糖尿病足和组织疾病
公开(公告)号：US20070038042A1
公开(公告)日：2007-02-15
申请号：US11507043
申请日：2006-08-21
申请人： Jenny Freeman , Svetlana Panasyuk , Michael Hopmeier , Derek Brand , Kevin Schomacker
发明人： Jenny Freeman , Svetlana Panasyuk , Michael Hopmeier , Derek Brand , Kevin Schomacker
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/1036 , A61B5/0075 , A61B5/0261 , A61B5/14551 , A61B5/14552 , A61B5/412 , A61B5/445 , A61B5/447 , A61B5/4884 , A61B5/7275 , A61B2562/0233 , A61B2562/046 , G01N21/31 , G01N21/359 , G01N21/474 , G01N21/4795 , G01N21/49 , G01N2021/3144 , G01N2021/4709 , G06F19/00
摘要： This invention relates generally to an index map comprising both pressure and perfusion information from a diabetic patient foot for the purpose of treatment. The index map may also be a map of perfusion and/or metabolism of the tissue (reflecting oxygen delivery and oxygen extraction, obtained by thermal imaging, hyperspectral imaging, or duplex ultrasound, MRA, CT or laser Doppler imaging. This information aids treatment in prevention of diabetic foot ulceration and amputation and in treatment of tissue compromise to prevent tissue loss in other body regions.
摘要翻译：本发明一般涉及包括来自糖尿病患者足部的压力和灌注信息以用于治疗的指标图。索引图还可以是组织的灌注和/或代谢的图（反射氧输送和氧提取，通过热成像，高光谱成像或双相超声，MRA，CT或激光多普勒成像获得），该信息有助于治疗预防糖尿病足溃疡和截肢并治疗组织妥协，以防止其他身体区域的组织损失。

3. 发明申请

US20120158100A1 Driving Microneedle Arrays into Skin and Delivering RF Energy 审中-公开
标题翻译：将微针阵列驱动到皮肤中并提供射频能量
公开(公告)号：US20120158100A1
公开(公告)日：2012-06-21
申请号：US13165675
申请日：2011-06-21
申请人： Kevin Schomacker
发明人： Kevin Schomacker
IPC分类号： A61N1/18
CPC分类号： A61B18/1477 , A61B2017/00088 , A61B2017/00092 , A61B2017/00398 , A61B2018/00005 , A61B2018/00011 , A61B2018/0016 , A61B2018/00291 , A61B2018/00452 , A61B2018/00791 , A61B2018/00815 , A61B2018/00821 , A61B2018/00827 , A61B2018/00875 , A61B2018/00892 , A61B2018/126 , A61B2018/143 , A61B2018/1472 , A61B2018/1475 , A61B2218/002 , A61B2218/007
摘要： A skin treatment includes applying vacuum to draw skin into contact with a plate defining a plurality of holes, inserting a plurality of needles through the plurality of holes into the skin, and delivering RF energy via the plurality of needles to treat the skin.
摘要翻译：皮肤处理包括施加真空以将皮肤与限定多个孔的板接触，将多个针穿过多个孔插入皮肤中，以及通过多个针输送RF能量以治疗皮肤。

4. 发明申请

US20070249913A1 Hyperspectral Imaging of Angiogenesis 有权
标题翻译：血管生成的高光谱成像
公开(公告)号：US20070249913A1
公开(公告)日：2007-10-25
申请号：US11692131
申请日：2007-03-27
申请人： Jenny Freeman , Svetlana Panasyuk , Michael Hopmeier , Kevin Schomacker , Derek Brand
发明人： Jenny Freeman , Svetlana Panasyuk , Michael Hopmeier , Kevin Schomacker , Derek Brand
IPC分类号： A61B5/00
CPC分类号： A61B5/441 , A61B5/0059 , A61B5/0075 , A61B5/14551 , A61B5/412 , A61B5/445 , A61B5/742 , G01N21/314 , G01N21/359
摘要： The invention is directed to methods and systems of hyperspectral and multispectral imaging of medical tissues. In particular, the invention is directed to new devices, tools and processes for the detection and evaluation of diseases and disorders such as, but not limited to diabetes and peripheral vascular disease and cancer, that incorporate hyperspectral or multispectral imaging.
摘要翻译：本发明涉及医学组织的高光谱和多光谱成像的方法和系统。特别地，本发明涉及用于检测和评估疾病和病症（例如但不限于糖尿病和外周血管疾病和癌症）的新装置，工具和方法，其包括高光谱或多光谱成像。

5. 发明申请

US20140257113A1 OXYVU-1 HYPERSPECTRAL TISSUE OXYGENATION (HTO) MEASUREMENT SYSTEM 有权
标题翻译： OXYVU-1超高分子组织氧化（HTO）测量系统
公开(公告)号：US20140257113A1
公开(公告)日：2014-09-11
申请号：US14164110
申请日：2014-01-24
申请人： Svetlana Panasyuk , Jenny Freeman , Kevin Schomacker , Richard Lifsitz
发明人： Svetlana Panasyuk , Jenny Freeman , Kevin Schomacker , Richard Lifsitz
IPC分类号： A61B5/00
CPC分类号： A61B5/0075 , A61B5/14551 , G01J3/0224 , G01J3/0264 , G01J3/0289 , G01J3/28 , G01J3/2823 , G01J3/32 , G01J2003/2826
摘要： The invention is directed to a hyperspectral/multispectral system referred to as the OxyVu-1 system. The hyperspectral imaging technology performs spectral analysis at each point in a two-dimensional scanned area producing an image displaying information derived from the analysis. For the OxyVu-1 system, the spectral analytical methods determined in superficial tissues approximate values of oxygen saturation (HT-Sat), oxyhemoglobin levels (HT-Oxy), and deoxyhemoglobin levels (HT-Deoxy). The OxyVu-1 system displays the tissue oxygenation in a two-dimensional, color-coded image.The system contains a system console, a cart, system electronics, CPU, monitor, keyboard, pointing device and printer. The hyperspectral instrument head with support arm contains broadband illuminator, camera and spectral filter for collecting hyperspectral imaging cube. The single use OxyVu Check Pads and Targets are used to perform an instrument check prior to patient measurements. The OxyVu Target is placed within the intended field of view and is used as a fiduciary mark for image registration and for focusing.
摘要翻译：本发明涉及一种称为OxyVu-1系统的高光谱/多光谱系统。高光谱成像技术在二维扫描区域的每个点进行光谱分析，产生显示从分析得到的信息的图像。对于OxyVu-1系统，在表面组织中测定的光谱分析方法近似氧饱和度（HT-Sat），氧合血红蛋白水平（HT-Oxy）和脱氧血红蛋白水平（HT-脱氧）。 OxyVu-1系统在二维彩色图像中显示组织氧合。该系统包含系统控制台，购物车，系统电子设备，CPU，显示器，键盘，指点设备和打印机。具有支撑臂的高光谱仪器头包含用于收集高光谱成像立方体的宽带照明器，照相机和光谱过滤器。在使用OxyVu Check Pads和Targets之前，您可以在进行患者测量之前进行仪器检查。 OxyVu目标被放置在预期的视野内，并被用作图像配准和聚焦的受信标记。

6. 发明授权

US08374682B2 Hyperspectral imaging in diabetes and peripheral vascular disease 有权
标题翻译：糖尿病和外周血管疾病中的高光谱成像
公开(公告)号：US08374682B2
公开(公告)日：2013-02-12
申请号：US11396941
申请日：2006-04-04
申请人： Jenny E. Freeman , Svetlana V. Panasyuk , Michael J. Hopmeier , Kevin Schomacker , Derek Brand
发明人： Jenny E. Freeman , Svetlana V. Panasyuk , Michael J. Hopmeier , Kevin Schomacker , Derek Brand
IPC分类号： A61B6/00
CPC分类号： A61B5/743 , A61B5/0059 , A61B5/145 , A61B5/14551 , A61B5/14552 , A61B5/412 , A61B5/444 , A61B5/445 , A61B5/7275 , G01J3/02 , G01J3/0224 , G01J3/0272 , G01J3/0283 , G01J3/10 , G01J3/12 , G01J3/2823 , G06F19/00 , G06T7/0012
摘要： The invention is directed to methods and systems of hyperspectral and multispectral imaging of medical tissues. In particular, the invention is directed to new devices, tools and processes for the detection and evaluation of diseases and disorders such as, but not limited to diabetes and peripheral vascular disease, that incorporate hyperspectral or multispectral imaging.
摘要翻译：本发明涉及医学组织的高光谱和多光谱成像的方法和系统。特别地，本发明涉及用于检测和评估诸如但不限于糖尿病和外周血管疾病的结合高光谱或多光谱成像的疾病和病症的新装置，工具和方法。

7. 发明授权

US08224425B2 Hyperspectral imaging in diabetes and peripheral vascular disease 有权
标题翻译：糖尿病和外周血管疾病中的高光谱成像
公开(公告)号：US08224425B2
公开(公告)日：2012-07-17
申请号：US11689783
申请日：2007-03-22
申请人： Jenny Freeman , Svetlana Panasyuk , Michael Hopmeier , Kevin Schomacker , Derek Brand
发明人： Jenny Freeman , Svetlana Panasyuk , Michael Hopmeier , Kevin Schomacker , Derek Brand
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/14551 , A61B5/412 , A61B5/445 , A61B2560/0228
摘要： The invention is directed to methods and systems of hyperspectral and multispectral imaging of medical tissues. In particular, the invention is directed to new devices, tools and processes for the detection and evaluation of diseases and disorders such as, but not limited to diabetes and peripheral vascular disease, that incorporate hyperspectral or multispectral imaging.
摘要翻译：本发明涉及医学组织的高光谱和多光谱成像的方法和系统。特别地，本发明涉及用于检测和评估诸如但不限于糖尿病和外周血管疾病的结合高光谱或多光谱成像的疾病和病症的新装置，工具和方法。

8. 发明申请

US20050033145A1 Wearable tissue viability diagnostic unit 审中-公开
标题翻译：可穿戴组织活力诊断单元
公开(公告)号：US20050033145A1
公开(公告)日：2005-02-10
申请号：US10882310
申请日：2004-07-02
申请人： John Graham , Dominic Bua , Kevin Schomacker
发明人： John Graham , Dominic Bua , Kevin Schomacker
IPC分类号： A61B20060101 , A61B5/05 , A61B5/103 , A61B6/00
CPC分类号： A61B5/445 , A61B5/0071 , A61B5/444
摘要： A device for gathering image information about a region of tissue that has been exposed to a contrast agent and methods of use thereof. The device preferably includes night vision goggles, and an excitation source that generates light of a wavelength to activate the contrast agent. The excitation source preferably is attached to the night vision goggles and is capable of directing light to a target. A filter preferably is attached to the night vision goggles, wherein the filter passes light sufficient to form an image of the region of tissue, and wherein the image may be assessed to determine the viability of the region of tissue.
摘要翻译：用于收集关于暴露于造影剂的组织区域的图像信息的装置及其使用方法。该装置优选地包括夜视镜和产生波长的光以激活造影剂的激发源。激发源优选地附接到夜视镜，并且能够将光引导到目标。过滤器优选地附接到夜视护目镜，其中过滤器通过足以形成组织区域的图像的光，并且其中可以评估图像以确定组织区域的存活力。

9. 发明授权

US09308046B2 Reduction of pain through lower fluence rates and longer treatment times 有权
标题翻译：通过较低的通量率和更长的治疗时间减少疼痛
公开(公告)号：US09308046B2
公开(公告)日：2016-04-12
申请号：US13110850
申请日：2011-05-18
申请人： Kevin Schomacker , James C. Hsia
发明人： Kevin Schomacker , James C. Hsia
IPC分类号： A61B18/18 , A61B18/20 , A61B18/00
CPC分类号： A61B18/203 , A61B2018/00023 , A61B2018/00029 , A61B2018/00464 , A61B2018/1807
摘要： A method of treating a subcutaneous fat region is provided. The method includes generating electromagnetic radiation having a wavelength of about 1,200 nm to about 1,230 nm and delivering an average power density of less than or equal to about 2.3 W/cm2 of the electromagnetic radiation to the subcutaneous fat region for at least 300 seconds. The method also includes cooling an epidermal region and at least a portion of a dermal region overlying the subcutaneous fat region for at least a portion of the at least 300 seconds. The method further includes causing necrosis of at least one fat cell in the subcutaneous fat region.
摘要翻译：提供了一种治疗皮下脂肪区域的方法。该方法包括产生波长为约1,200nm至约1,230nm的电磁辐射，并将电磁辐射的平均功率密度小于或等于约2.3W / cm 2递送至皮下脂肪区域至少300秒。该方法还包括在至少300秒的至少一部分内冷却表皮区域和覆盖皮下脂肪区域的皮肤区域的至少一部分。该方法还包括引起皮下脂肪区域中的至少一种脂肪细胞的坏死。

10. 发明授权

US08971984B2 Hyperspectral technology for assessing and treating diabetic foot and tissue disease 有权
标题翻译：高光谱技术用于评估和治疗糖尿病足和组织疾病
公开(公告)号：US08971984B2
公开(公告)日：2015-03-03
申请号：US11507043
申请日：2006-08-21
申请人： Jenny E. Freeman , Svetlana V. Panasyuk , Michael J. Hopmeier , Derek Brand , Kevin Schomacker
发明人： Jenny E. Freeman , Svetlana V. Panasyuk , Michael J. Hopmeier , Derek Brand , Kevin Schomacker
IPC分类号： A61B5/00 , G01N21/47 , A61B5/103 , A61B5/1455 , G01N21/31 , G01N21/49 , A61B5/026 , G01N21/359
CPC分类号： A61B5/1036 , A61B5/0075 , A61B5/0261 , A61B5/14551 , A61B5/14552 , A61B5/412 , A61B5/445 , A61B5/447 , A61B5/4884 , A61B5/7275 , A61B2562/0233 , A61B2562/046 , G01N21/31 , G01N21/359 , G01N21/474 , G01N21/4795 , G01N21/49 , G01N2021/3144 , G01N2021/4709 , G06F19/00
摘要： This invention relates generally to an index map comprising both pressure and perfusion information from a diabetic patient foot for the purpose of treatment. The index map may also be a map of perfusion and/or metabolism of the tissue (reflecting oxygen delivery and oxygen extraction), obtained by thermal imaging, hyperspectral imaging, or duplex ultrasound, MRA, CT or laser Doppler imaging. This information aids treatment in prevention of diabetic foot ulceration and amputation and in treatment of tissue compromise to prevent tissue loss in other body regions.
摘要翻译：本发明一般涉及包括来自糖尿病患者足部的压力和灌注信息以用于治疗的指标图。索引图还可以是通过热成像，高光谱成像或双相超声，MRA，CT或激光多普勒成像获得的组织的灌注和/或代谢的组合（反射氧气输送和氧气提取）的图。该信息有助于预防糖尿病足部溃疡和截肢并治疗组织妥协以预防其他身体区域的组织损失。

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