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1. 发明授权

US11633739B2 Droplet-based assay system 有权
公开(公告)号：US11633739B2
公开(公告)日：2023-04-25
申请号：US17137274
申请日：2020-12-29
申请人： Bio-Rad Laboratories, Inc.
发明人： Kevin D. Ness , Donald A. Masquelier , Billy W. Colston, Jr. , Benjamin J. Hindson
IPC分类号： B01L3/00 , B01L3/02 , B01L7/00 , G01N21/3563 , B01F23/41 , B01F33/3011 , B01F35/10 , C12Q1/686 , G01N21/64 , B29C45/00 , G01N21/49 , B01F101/23 , B29L31/00
摘要： System for performing a flow-based assay. The system may comprise a droplet generator to produce an emulsion including droplets in a carrier fluid. The system also may comprise a thermocycler including two or more temperature-controlled zones and also including a channel connected to the droplet generator for receiving the emulsion. The channel may form a single-pass continuous fluid route traversing the temperature-controlled zones multiple times, such that droplets passing through the channel are thermally cycled. The system further may comprise a detection station downstream from the thermocycler and configured to detect a signal from the droplets after such droplets have been thermally cycled by passing through the channel.

2. 发明申请

US20220412883A1 Method and Apparatus for Non-Invasively Measuring Blood Circulatory Hemoglobin 有权
公开(公告)号：US20220412883A1
公开(公告)日：2022-12-29
申请号：US17821126
申请日：2022-08-19
申请人： Edwards Lifesciences Corporation
发明人： Paul B. Benni
IPC分类号： G01N21/359 , A61B5/145 , A61B5/1455 , A61B5/00 , G01N21/49
摘要： A method and apparatus of non-invasively determining a blood circulatory hemoglobin value for a subject using a near-infrared spectrophotometric (NIRS) sensing device is provided. The method includes: a) non-invasively sensing tissue of the subject using the NIRS sensing device at about a time T1, and determining at least one NIRS tissue totalHb value; b) acquiring at least one circulatory blood sample from the subject at about the time T1; c) determining at least one blood circulatory THb value; d) calibrating the NIRS sensing device using the at least one blood circulatory THb value and the at least one MRS tissue TotalHb value; and e) determining at least one blood circulatory hemoglobin value using the calibrated NIRS sensing device and the at least one NIRS tissue totalHb value.

3. 发明申请

US20220364048A1 SCATTER LABELED IMAGING OF MICROVASCULATURE IN EXCISED TISSUE (SLIME) 有权
公开(公告)号：US20220364048A1
公开(公告)日：2022-11-17
申请号：US17878438
申请日：2022-08-01
申请人： Case Western Reserve University , UNIVERSITY HOSPITALS CLEVELAND MEDICAL CENTER
发明人： Michael W. JENKINS , Yehe LIU
IPC分类号： C12N5/00 , G06T7/136 , G06T7/11 , C12N5/071 , G01N21/47 , G01N21/49 , G01N33/483 , G06T5/00 , G06T5/20 , G06T5/50 , G06T7/00
摘要： The present disclosure relates to a simple, fast, and low cost method for 3D microvascular imaging, termed “scatter labeled imaging of microvasculature in excised tissue” (SLIME). The method can include perfusing a contrast agent through vasculature of a tissue sample. The contrast agent can include colloids and a dispersant. After the contrast agent is perfused through the vasculature, the vasculature of the tissue sample can be treated with a molecule that cross links with at least a portion of the dispersant to form a sticky, non-Newtonian polymer that prevents leakage of the contrast agent out of the vasculature of the tissue sample. The tissue sample can then be immersed in a solution comprising a clearing agent and subsequently imaged.

4. 发明授权

US11467338B2 Method of making a distributed optical fiber sensor having enhanced Rayleigh scattering and enhanced temperature stability, and monitoring systems employing same 有权
公开(公告)号：US11467338B2
公开(公告)日：2022-10-11
申请号：US16807232
申请日：2020-03-03
申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education
发明人： Peng Kevin Chen , Aidong Yan , Michael P. Buric , Paul R. Ohodnicki , Sheng Huang
IPC分类号： G02B6/02 , H01M8/04007 , G01N21/49 , G02B6/293 , G01M11/00 , H01M8/12
摘要： A method of making an optical fiber sensor device for distributed sensing includes generating a laser beam comprising a plurality of ultrafast pulses, and focusing the laser beam into a core of an optical fiber to form a nanograting structure within the core, wherein the nanograting structure includes a plurality of spaced nanograting elements each extending substantially parallel to a longitudinal axis of optical fiber. Also, an optical fiber sensor device for distributed sensing includes an optical fiber having a longitudinal axis, a core, and a nanograting structure within the core, wherein the nanograting structure includes a plurality of spaced nanograting elements each extending substantially parallel to the longitudinal axis of the optical fiber. Also, a distributed sensing method and system and an energy production system that employs such an optical fiber sensor device.

5. 发明授权

US11137347B2 Optically ascertaining the sun protection factor of sunscreens or other radiation protection agents 有权
公开(公告)号：US11137347B2
公开(公告)日：2021-10-05
申请号：US15769892
申请日：2016-10-20
申请人： Courage + Khazaka Electronic GmbH
发明人： Jürgen Helfmann , Ingo Gersonde
IPC分类号： G01N21/33 , A61B5/00 , G01N21/49 , G01N21/47
摘要： The invention is used to ascertain a sun protection factor for light, for example for cosmetics and sunscreens for which a sun protection factor (SPF) is specified. Two measurements of the light backscattering on the skin surface are carried out in vivo or in vitro or on skin models (animal skin models or artificial skin models) before and after applying the radiation protection means onto the skin, and the sun protection factor is ascertained therefrom. In contrast to standard methods used until now, the distance between the lighting surface and the detection surface on the skin is ascertained for the irradiation path of the measurement method. The skin lighting dose used during the measurement lies below harmful limits. The sun protection factor can be ascertained according to previous standards or for additional wavelengths or wavelength ranges (e.g. UVA, VIS, NIR, IR).

6. 发明授权

US11137339B2 Method for performing a blood count and determining the morphology of a blood smear 有权
公开(公告)号：US11137339B2
公开(公告)日：2021-10-05
申请号：US16657691
申请日：2019-10-18
申请人： Abbott Laboratories
发明人： Richard G. Kendall , John W. Roche
IPC分类号： G01N1/28 , G01N15/14 , G01N33/72 , G01N21/59 , G01N21/27 , G01N21/49 , G01N15/00
摘要： A method for counting blood cells in a sample of whole blood. The method comprises the steps of: (a) providing a sample of whole blood; (b) depositing the sample of whole blood onto a slide, e.g., a microscope slide; (c) employing a spreader to create a blood smear; (d) allowing the blood smear to dry on the slide; (e) measuring absorption or reflectance of light attributable to the hemoglobin in the red blood cells in the blood smear on the slide; (f) recording a magnified two-dimensional digital image of the area of analysis identified by the measurement in step (e) as being of suitable thickness for analysis; and (g) collecting, analyzing, and storing data from the magnified two-dimensional digital image. Optionally, steps of fixing and staining of blood cells on the slide can be employed in the method.

7. 发明授权

US11079541B2 Optical deflection device and LIDAR apparatus 有权
公开(公告)号：US11079541B2
公开(公告)日：2021-08-03
申请号：US16071895
申请日：2017-01-11
申请人： National University Corporation Yokohama National University
发明人： Toshihiko Baba , Fumio Koyama
IPC分类号： G01C3/08 , G02B6/122 , G02B6/124 , G02B6/34 , G02F1/295 , G02B6/125 , G01N21/49 , G01S7/481 , G02B6/12
摘要： An optical deflection device that achieve both high beam quality and wide angular range of deflection and compatibility with an optical integration technology of silicon photonics. The optical deflection device is a silicon photonics device including a periodic structure of a refractive index. The optical deflection device includes two configurations, which are (1) a configuration in which an optical propagation part where light propagates is a microstructure formed on silicon, and (2) a configuration in which the microstructure constituting the optical propagation part includes a periodic structure that generates slow light and a periodic structure that radiates light. The microstructure formed on the silicon of (1) makes it possible to employ the optical integration technology of silicon photonics and form the optical deflection device. The two periodic structures of (2) make it possible to form a light beam with high beam quality and a wide angular range of deflection.

8. 发明申请

US20210196155A1 Method and Apparatus for Light-Weight, Non-Invasive, Point of Care Diabetes Screening Device 有权
公开(公告)号：US20210196155A1
公开(公告)日：2021-07-01
申请号：US17203087
申请日：2021-03-16
申请人： Rijul GUPTA
发明人： Rijul GUPTA
IPC分类号： A61B5/1455 , A61B5/145 , G01J3/00 , A61B5/00 , G01N21/31 , G01N21/47 , G01J3/28 , G01N21/49 , G01J3/02 , G01J3/10 , G01J3/427 , G01J3/457
摘要： A multi-channel measurement device for measuring properties of human tissue, may comprise a microcontroller and first and second source/sensor complexes. The first source/sensor complex may include a first housing having a first measurement portion, a first light sensor coupled to the microcontroller and exposed to the first measurement portion, and a first plurality of light sources coupled to the microcontroller and exposed to the first measurement portion. The second source/sensor complex may include a second housing having a second measurement portion, a second light sensor coupled to the microcontroller and exposed to the second measurement portion, and a second plurality of light sources coupled to the microcontroller and exposed to the second measurement portion. The first and second source/sensor complexes are coupled to each other such that the first measurement portion is opposite the second measurement portion and human tissue may be placed between the the first and second measurement portions. The microprocessor is configured with instructions stored in non-volatile memory to individually activate each of the light sources of the first and second pluralities of light sources and to record light intensity detected by the first and second light sources while an individual light source is activated. Each combination of an individually activated light source and one of the first and second light sensors provides a distinct measurement channel for measuring the absorption spectra of human blood and tissue.

9. 发明申请

US20210033805A1 Integrated Photonics Device Having Integrated Edge Outcouplers 有权
公开(公告)号：US20210033805A1
公开(公告)日：2021-02-04
申请号：US16969034
申请日：2019-02-13
申请人： Apple Inc.
发明人： Michael J. Bishop , Vijay M. Iyer , Jason S. Pelc , Mario J. Costello
IPC分类号： G02B6/42 , G01N21/49 , G01N21/47
摘要： Described herein is an integrated photonics device including a light emitter, integrated edge outcoupler(s), optics, and a detector array. The device can include a hermetically sealed enclosure. The hermetic seal can reduce the amount of moisture and/or contamination that may affect the measurement, analysis, and/or the function of the individual components within the sealed enclosure. Additionally or alternatively, the hermetic seal can be used to protect the components within the enclosure from environmental contamination induced during the manufacturing, packaging, and/or shipping process. The outcoupler(s) can be formed by creating one or more pockets in the layers of a die. Outcoupler material can be formed in the pocket and, optionally, subsequent layers can be deposited on top. The edge of the die can be polished until a targeted polish plane is achieved. Once the outcoupler is formed, the die can be flipped over and other components can be formed.

10. 发明申请

US20210003382A1 ABERRATION DIVERSE OPTICAL COHERENT TOMOGRAPHY (OCT) IMAGING TO SUPPRESS OPTICAL SCATTERING NOISE 有权
公开(公告)号：US20210003382A1
公开(公告)日：2021-01-07
申请号：US17025814
申请日：2020-09-18
申请人： Cornell University
发明人： Steven Adie , Siyang Liu , Michael Lamont
IPC分类号： G01B9/02 , G01N21/49
摘要： The technology disclosed in this patent document can be used to implement an optical coherent tomography (OCT) system that combines a control of the probe light to the target sample with different optical aberration patterns in optically probing the target sample and an OCT imaging processing to enhance the OCT imaging quality by combining image signals from in-phase contributions from the probing with different optical aberration patterns while suppressing randomly phased contributions from scattering by the target sample.

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