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1. 发明授权

US09381222B2 Compositions for preventing and treating obesity, hyperlipidemia, atherosclerosis, fatty liver, diabetes or metabolic syndrome containing extracts of glycine max leaves or fractions isolated from the same as an active ingredient 有权
$Compositions for preventing and treating obesity, hyperlipidemia, atherosclerosis, fatty liver, diabetes or metabolic syndrome containing extracts of glycine max leaves or fractions isolated from the same as an active ingredient$
标题翻译：用于预防和治疗肥胖症，高脂血症，动脉粥样硬化，脂肪肝，糖尿病或代谢综合征的组合物，其含有甘氨酸最多叶提取物或其作为活性成分从其分离的级分
公开(公告)号：US09381222B2
公开(公告)日：2016-07-05
申请号：US12615602
申请日：2009-11-10
申请人： Tae-Sook Jeong , Woo Song Lee , Ki Hun Park , Myung-Sook Choi , Ho Yong Park , Jong-Min Han , Hyung-Jae Jeong
发明人： Tae-Sook Jeong , Woo Song Lee , Ki Hun Park , Myung-Sook Choi , Ho Yong Park , Jong-Min Han , Hyung-Jae Jeong
IPC分类号： A61K36/48
CPC分类号： A61K36/48
摘要： The present invention relates to compositions for preventing and treating obesity, hyperlipidemia, atherosclerosis, fatty liver, diabetes or metabolic syndrome containing extracts of Glycine max leaves or fractions isolated from the same.
摘要翻译：本发明涉及用于预防和治疗肥胖，高脂血症，动脉粥样硬化，脂肪肝，糖尿病或代谢综合征的组合物，其含有从其分离的大豆叶提取物或其中的级分。

2. 发明申请

US20130178533A1 COMPOSITION FOR DIAGNOSING, TREATING, AND PREVENTING LIVER DISEASE 有权
标题翻译：用于诊断，治疗和预防肝病的组合物
公开(公告)号：US20130178533A1
公开(公告)日：2013-07-11
申请号：US13813135
申请日：2011-07-22
申请人： Jung Weon Lee , Ki Hun Park , Min Kyung Kang
发明人： Jung Weon Lee , Ki Hun Park , Min Kyung Kang
IPC分类号： G01N33/68
CPC分类号： G01N33/563 , A61K31/18 , G01N33/5067 , G01N33/6893 , G01N2800/085
摘要： The present invention relates to a composition for diagnosing, treating, and preventing liver disease, more particularly a composition for diagnosing liver disease comprising a material for measuring the grade of TM4SF5 (transmembrane 4 L six family member 5 or four-transmembrane L6 superfamily member 5) protein, a kit for diagnosing liver disease comprising the said composition, a method for providing information necessary for diagnosing liver disease composed of the following steps; measuring the level of TM4SF5 protein and the expressions and phosphorylations of TM4SF5 expression related signaling proteins; and comparing the measured levels with those of the normal control, a method for screening a material for treating liver disease, and a composition for treating or preventing liver disease comprising a material inhibiting TM4SF5 protein expression or the expressions and phosphorylations of TM4SF5 expression related signaling proteins.
摘要翻译：本发明涉及用于诊断，治疗和预防肝病的组合物，更具体地，涉及用于诊断肝病的组合物，其包括用于测量TM4SF5等级的材料（跨膜4L六族成员5或四跨膜L6超家族成员5 ）蛋白，用于诊断肝病的试剂盒，其包含所述组合物，提供用于诊断由以下步骤组成的肝病所需的信息的方法; 测量TM4SF5蛋白的水平以及TM4SF5表达相关信号蛋白的表达和磷酸化; 将所测量的水平与正常对照组相比较，筛选用于治疗肝病的材料的方法，以及用于治疗或预防肝病的组合物，其包括抑制TM4SF5蛋白表达的物质或TM4SF5表达相关信号蛋白的表达和磷酸化。

3. 发明申请

US20090252694A1 Novel Chalcone Derivatives, Pharmaceutically Acceptable Salt, Method for Preparation and Uses Thereof 有权
标题翻译：新型查耳酮衍生物，药学上可接受的盐，其制备方法及用途
公开(公告)号：US20090252694A1
公开(公告)日：2009-10-08
申请号：US12295669
申请日：2006-04-03
申请人： Ki Hun Park , Jin Hyo Kim , Woo Duck Seo , Young Bae Ryu , Hyung Won Ryu , Woo Song Lee , Sang Wan Gal
发明人： Ki Hun Park , Jin Hyo Kim , Woo Duck Seo , Young Bae Ryu , Hyung Won Ryu , Woo Song Lee , Sang Wan Gal
IPC分类号： A61K8/35 , C07C211/27 , A61K31/137 , A61P3/10 , A61P3/04 , A61P35/00 , A61P31/12 , A61P31/18 , A61P31/14 , A61P31/20 , A61Q19/02 , C07C49/796 , A61K31/12
CPC分类号： C07C49/796 , C07C45/74 , C07C49/835 , C07C225/22 , C07C311/08 , C07C311/21
摘要： Disclosed relates to a novel chalcone derivative, pharmaceutically acceptable salt thereof, a method for preparing the same and uses thereof, the chalcone derivative being readily obtained through the steps of: reacting aminoacetophenone with sulfonylchloride under the presence of an appropriate salt; and reacting the compound prepared in the above step with hydroxybenzaldehide under the presence of an appropriate catalyst. The chalcone derivative of formula 1 in accordance with the present invention having strong enzyme inhibitory activities for glycosidase can be effectively used in preventing and treating various diseases induced by glycosidase, and the chalcone derivative of the invention having tyrosinase and melanin synthesis inhibitory activities can be effectively used as a skin-whitening compound.
摘要翻译：本发明涉及一种新型查耳酮衍生物，其药学上可接受的盐，其制备方法及其用途，所述查耳酮衍生物通过以下步骤容易地获得：在适当的盐存在下使氨基苯乙酮与磺酰氯反应; 并在合适的催化剂存在下使上述步骤制备的化合物与羟基苯甲醛反应。具有强糖酶抑制活性的本发明式1的查耳酮衍生物可有效地用于预防和治疗由糖苷酶诱导的各种疾病，具有酪氨酸酶和黑色素合成抑制活性的本发明查耳酮衍生物可以有效地用作皮肤美白化合物。

4. 发明授权

US09057725B2 Composition for diagnosing, treating, and preventing liver disease 有权
标题翻译：用于诊断，治疗和预防肝脏疾病的组合物
公开(公告)号：US09057725B2
公开(公告)日：2015-06-16
申请号：US13813135
申请日：2011-07-22
申请人： Jung Weon Lee , Ki Hun Park , Min Kyung Kang
发明人： Jung Weon Lee , Ki Hun Park , Min Kyung Kang
IPC分类号： G01N33/563 , A61K39/395 , A61K39/00 , G01N33/68 , G01N33/50 , A61K31/18
CPC分类号： G01N33/563 , A61K31/18 , G01N33/5067 , G01N33/6893 , G01N2800/085
摘要： A composition for diagnosing, treating, and preventing liver disease, more particularly a composition for diagnosing liver disease comprising a material for measuring the grade of TM4SF5 (transmembrane 4 L six family member 5 or four-transmembrane L6 superfamily member 5) protein, a kit for diagnosing liver disease comprising the composition, a method for providing information necessary for diagnosing liver disease composed of the following steps: measuring the level of TM4SF5 protein and the expressions and phosphorylations of TM4SF5 expression related signaling proteins; and comparing the measured levels with those of the normal control, a method for screening a material for treating liver disease, and a composition for treating or preventing liver disease comprising a material inhibiting TM4SF5 protein expression or the expressions and phosphorylations of TM4SF5 expression related signaling proteins.
摘要翻译：一种用于诊断，治疗和预防肝病的组合物，更具体地，用于诊断肝病的组合物，包括用于测量TM4SF5等级的材料（跨膜4L六族成员5或四跨膜L6超家族成员5）蛋白质，试剂盒用于诊断包括该组合物的肝病的方法，提供诊断肝病所必需的信息的方法，其包括以下步骤：测量TM4SF5蛋白的水平以及TM4SF5表达相关信号蛋白的表达和磷酸化; 将所测量的水平与正常对照组相比较，筛选用于治疗肝病的材料的方法，以及用于治疗或预防肝病的组合物，其包括抑制TM4SF5蛋白表达的物质或TM4SF5表达相关信号蛋白的表达和磷酸化。

5. 发明授权

US08445722B2 Method for screening anti-cancer compounds inhibiting function of TM4SF5 and anti-cancer composition containing chalcone compounds 有权
公开(公告)号：US08445722B2
公开(公告)日：2013-05-21
申请号：US12162940
申请日：2007-12-07
申请人： Ki Hun Park , Jung Weon Lee , Young Bae Ryu , Hyung Won Ryu , Sin-Ae Lee
发明人： Ki Hun Park , Jung Weon Lee , Young Bae Ryu , Hyung Won Ryu , Sin-Ae Lee
IPC分类号： G01N33/53 , C12Q1/48 , C12Q1/34 , C07C311/00 , C07C309/63
CPC分类号： A61K31/135 , C07C49/835 , C07C49/84 , C07C309/66 , C07C309/73 , C07C309/75 , C07C309/76 , C07C311/21 , C07C311/29 , C07C311/44 , G01N33/5011 , G01N2333/9121
摘要： The present invention relates to a method for screening an anticancer compound and an anticancer compound screened using the method, and more particularly, to a method for screening an anticancer compound, the method comprising: culturing cancer cells expressing the oncogenic protein transmembrane 4 L6 family member 5 (TM4SF5), expressed as the polypeptide of SEQ ID NO: 2, treating the cancer cells with an anticancer candidate, and determining that the anticancer candidate is an anticancer substance when the candidate exhibits antagonistic activity against tumor formation and metastasis based on several events through the molecular mechanism of TM4SF5. The present invention also relates to chalcone compounds screened to have anticancer activity using the method, and an anticancer composition comprising the compound as an effective ingredient.

6. 发明申请

US20100068730A1 METHOD FOR SCREENING ANTI-CANCER COMPOUNDS INHIBITING FUNCTION OF TM4SF5 AND ANTI-CANCER COMPOSITION CONTAINING CHALCONE COMPOUNDS 有权
标题翻译：用于筛选抗癌化合物抑制TM4SF5功能的方法和含有化合物的抗癌组合物
公开(公告)号：US20100068730A1
公开(公告)日：2010-03-18
申请号：US12162940
申请日：2007-12-07
申请人： Ki Hun PARK , Jung Weon LEE , Young Bae RYU , Hyung Won RYU , Sin-Ae LEE
发明人： Ki Hun PARK , Jung Weon LEE , Young Bae RYU , Hyung Won RYU , Sin-Ae LEE
IPC分类号： G01N33/53 , C12Q1/48 , C12Q1/34 , C07C311/00 , C07C309/63
CPC分类号： A61K31/135 , C07C49/835 , C07C49/84 , C07C309/66 , C07C309/73 , C07C309/75 , C07C309/76 , C07C311/21 , C07C311/29 , C07C311/44 , G01N33/5011 , G01N2333/9121
摘要： The present invention relates to a method for screening an anticancer compound and an anticancer compound screened using the method, and more particularly, to a method for screening an anticancer compound, the method comprising: culturing cancer cells expressing the oncogenic protein transmembrane 4 L6 family member 5 (TM4SF5), expressed as the polypeptide of SEQ ID NO: 2, treating the cancer cells with an anticancer candidate, and determining that the anticancer candidate is an anticancer substance when the candidate exhibits antagonistic activity against tumor formation and metastasis based on several events through the molecular mechanism of TM4SF5. The present invention also relates to chalcone compounds screened to have anticancer activity using the method, and an anticancer composition comprising the compound as an effective ingredient.
摘要翻译：本发明涉及使用该方法筛选抗癌化合物和抗癌化合物的方法，更具体地，涉及一种抗癌化合物的筛选方法，所述方法包括：培养表达致癌蛋白跨膜4L6家族成员的癌细胞 5（TM4SF5），表达为SEQ ID NO：2的多肽，用抗癌候选物治疗癌细胞，并且当候选物基于若干事件显示出对肿瘤形成和转移的拮抗活性时，确定抗癌候选物是抗癌物质通过TM4SF5的分子机制。本发明还涉及使用该方法筛选具有抗癌活性的查耳酮化合物和包含该化合物作为有效成分的抗癌组合物。

7. 发明申请

US20130303602A1 NOVEL PTEROCARPAN COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE OR COMPLICATION THEREOF, OR FOR ANTIOXIDANT CONTAINING THE SAME AS AN ACTIVE INGREDIENT 审中-公开
标题翻译：新型药物化合物或药物接受的盐和药物组合物，用于预防或治疗代谢性疾病或其代谢综合症，或将含有其作为活性成分的抗氧化剂
公开(公告)号：US20130303602A1
公开(公告)日：2013-11-14
申请号：US13895760
申请日：2013-05-16
申请人： Tae-Sook JEONG , Ho-Yong PARK , Ki Hun PARK
发明人： Tae-Sook JEONG , Ho-Yong PARK , Ki Hun PARK
IPC分类号： C07D493/04
CPC分类号： A61K31/352 , A61K31/366 , A61K36/48 , C07D493/04
摘要： The present invention relates to novel pterocarpan compound or pharmaceutically acceptable salt thereof and a composition for the prevention or treatment of metabolic disease or complications thereof comprising the same as an active ingredient. The novel pterocarpan compound of the present invention isolated from soybean leaves inhibits α-glucosidase activity and hACAT activity, and suppresses LDL-oxidation efficiently. Therefore, the compound of the present invention not only can be effectively used for the prevention or treatment of metabolic disease or complications thereof but also can be effectively used as an anti-oxidative composition owing to its excellent anti-oxidative activity.
摘要翻译：本发明涉及新颖的番茄红素化合物或其药学上可接受的盐，以及用于预防或治疗代谢疾病或其并发症的组合物，其包含其作为活性成分。从大豆叶中分离的本发明的新颖的特蓬卡班化合物抑制α-葡糖苷酶活性和hACAT活性，有效抑制低密度脂蛋白氧化。因此，本发明的化合物不仅可以有效地用于预防或治疗代谢性疾病或其并发症，还可以有效地用作抗氧化组合物，因为其具有优异的抗氧化活性。

8. 发明申请

US20100291248A1 Compositions for Preventing and Treating Obesity, Hyperlipidemia, Atherosclerosis, Fatty Liver, Diabetes or Metabolic Syndrome Containing Extracts of Glycine Max Leaves or Fractions Isolated from the Same as an Active Ingredient 有权
标题翻译：用于预防和治疗肥胖，高脂血症，动脉粥样硬化，脂肪肝，糖尿病或代谢综合征的组合物，其含有作为活性成分从其分离的甘氨酸叶或提取物的提取物
公开(公告)号：US20100291248A1
公开(公告)日：2010-11-18
申请号：US12615602
申请日：2009-11-10
申请人： Tae-Sook Jeong , Woo Song Lee , Ki Hun Park , Myung-Sook Choi , Ho Yong Park , Jong-Min Han , Hyung-Jae Jeong
发明人： Tae-Sook Jeong , Woo Song Lee , Ki Hun Park , Myung-Sook Choi , Ho Yong Park , Jong-Min Han , Hyung-Jae Jeong
IPC分类号： A61K36/00
CPC分类号： A61K36/48
摘要： The present invention relates to compositions for preventing and treating obesity, hyperlipidemia, atherosclerosis, fatty liver, diabetes or metabolic syndrome containing extracts of Glycine max leaves or fractions isolated from the same.
摘要翻译：本发明涉及用于预防和治疗肥胖，高脂血症，动脉粥样硬化，脂肪肝，糖尿病或代谢综合征的组合物，其含有从其分离的大豆叶提取物或其中的级分。

9. 发明授权

US09072698B2 Method for screening anti-cancer compounds inhibiting function of TM4SF5 and anti-cancer composition containing chalcone compounds 有权
标题翻译：用于筛选抑制TM4SF5功能的抗癌化合物的方法和含查耳酮化合物的抗癌组合物
公开(公告)号：US09072698B2
公开(公告)日：2015-07-07
申请号：US13482568
申请日：2012-05-29
申请人： Ki Hun Park , Jung Weon Lee , Young Bae Ryu , Hyung Won Ryu , Sin-Ae Lee
发明人： Ki Hun Park , Jung Weon Lee , Young Bae Ryu , Hyung Won Ryu , Sin-Ae Lee
IPC分类号： C12Q1/00 , A61K31/135 , C07C49/835 , C07C49/84 , C07C309/66 , C07C309/73 , C07C309/75 , C07C309/76 , C07C311/21 , C07C311/29 , C07C311/44 , G01N33/50
CPC分类号： A61K31/135 , C07C49/835 , C07C49/84 , C07C309/66 , C07C309/73 , C07C309/75 , C07C309/76 , C07C311/21 , C07C311/29 , C07C311/44 , G01N33/5011 , G01N2333/9121
摘要： The present invention relates to a method for screening an anticancer compound and an anticancer compound screened using the method, and more particularly, to a method for screening an anticancer compound, the method comprising: culturing cancer cells expressing the oncogenic protein transmembrane 4 L6 family member 5 (TM4SF5), expressed as the polypeptide of SEQ ID NO: 2, treating the cancer cells with an anticancer candidate, and determining that the anticancer candidate is an anticancer substance when the candidate exhibits antagonistic activity against tumor formation and metastasis based on several events through the molecular mechanism of TM4SF5. The present invention also relates to chalcone compounds screened to have anticancer activity using the method, and an anticancer composition comprising the compound as an effective ingredient.
摘要翻译：本发明涉及使用该方法筛选抗癌化合物和抗癌化合物的方法，更具体地，涉及一种抗癌化合物的筛选方法，所述方法包括：培养表达致癌蛋白跨膜4L6家族成员的癌细胞 5（TM4SF5），表达为SEQ ID NO：2的多肽，用抗癌候选物治疗癌细胞，并且当候选物基于若干事件显示出对肿瘤形成和转移的拮抗活性时，确定抗癌候选物是抗癌物质通过TM4SF5的分子机制。本发明还涉及使用该方法筛选具有抗癌活性的查耳酮化合物和包含该化合物作为有效成分的抗癌组合物。

10. 发明授权

US07851654B2 Chalcone derivatives, pharmaceutically acceptable salt, method for preparation and uses thereof 有权
标题翻译：查耳酮衍生物，药学上可接受的盐，其制备方法和用途
公开(公告)号：US07851654B2
公开(公告)日：2010-12-14
申请号：US12295669
申请日：2006-04-03
申请人： Ki Hun Park , Jin Hyo Kim , Woo Duck Seo , Young Bae Ryu , Hyung Won Ryu , Woo Song Lee , Sang Wan Gal
发明人： Ki Hun Park , Jin Hyo Kim , Woo Duck Seo , Young Bae Ryu , Hyung Won Ryu , Woo Song Lee , Sang Wan Gal
IPC分类号： C07C211/00 , A61K31/13 , A61K31/135
CPC分类号： C07C49/796 , C07C45/74 , C07C49/835 , C07C225/22 , C07C311/08 , C07C311/21
摘要： Disclosed relates to a novel chalcone derivative, pharmaceutically acceptable salt thereof, a method for preparing the same and uses thereof, the chalcone derivative being readily obtained through the steps of: reacting aminoacetophenone with sulfonylchloride under the presence of an appropriate salt; and reacting the compound prepared in the above step with hydroxybenzaldehide under the presence of an appropriate catalyst. The chalcone derivative of formula 1 in accordance with the present invention having strong enzyme inhibitory activities for glycosidase can be effectively used in preventing and treating various diseases induced by glycosidase, and the chalcone derivative of the invention having tyrosinase and melanin synthesis inhibitory activities can be effectively used as a skin-whitening compound.
摘要翻译：本发明涉及一种新型查耳酮衍生物，其药学上可接受的盐，其制备方法及其用途，所述查耳酮衍生物通过以下步骤容易地获得：在适当的盐存在下使氨基苯乙酮与磺酰氯反应; 并在合适的催化剂存在下使上述步骤制备的化合物与羟基苯甲醛反应。具有强糖酶抑制活性的本发明式1的查耳酮衍生物可有效地用于预防和治疗由糖苷酶诱导的各种疾病，具有酪氨酸酶和黑色素合成抑制活性的本发明查耳酮衍生物可以有效地用作皮肤美白化合物。

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