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1. 发明申请

US20130202984A1 METHOD FOR THE PRODUCTION OF AN ELECTROCHEMICAL CELL 有权
标题翻译：生产电化学细胞的方法
公开(公告)号：US20130202984A1
公开(公告)日：2013-08-08
申请号：US13702766
申请日：2011-06-08
申请人： Todd Snelson , Raymond Puffer , Daniel Walczyk , Jake Pyzza , Lakshmi Krishnan
发明人： Todd Snelson , Raymond Puffer , Daniel Walczyk , Jake Pyzza , Lakshmi Krishnan
IPC分类号： H01M8/10
CPC分类号： H01M8/0273 , C25B9/10 , H01M4/8807 , H01M4/881 , H01M4/8896 , H01M8/0258 , H01M8/0297 , H01M8/1004 , H01M8/103 , H01M2300/0082 , Y02E60/521 , Y02P70/56 , Y10T156/10
摘要： The present invention relates to a new method for the production of electrochemical cells, in particular individual cells for fuel cells and stacks, in which the individual components of a membrane electrode assembly are compressed and bonded by use of ultrasonic waves and the absence of any further additional heating. The method according to the invention allows faster cycles during the lamination of the membrane electrode assemblies.
摘要翻译：本发明涉及用于生产电化学电池，特别是用于燃料电池和电池堆的单个电池的新方法，其中膜电极组件的各个部件通过使用超声波被压缩和粘合，并且没有任何进一步的额外加热。根据本发明的方法允许在膜电极组件的层叠期间更快的循环。

2. 发明申请

US20080248094A1 VACCINE ADJUVANT PROPERTIES OF LIPSOMES FORMED AT ELEVATED TEMPERATURES FROM THE POLAR CHLOROFORM EXTRACTABLE LIPIDS FROM MYCOBACTERIUM BOVIS 审中-公开
标题翻译：来自阳离子氯化钠的可食用脂肪酸在高温条件下形成的烟草的吸入性质
公开(公告)号：US20080248094A1
公开(公告)日：2008-10-09
申请号：US11940858
申请日：2007-11-15
申请人： G. Dennis SPROTT , Lakshmi KRISHNAN , Subash SAD
发明人： G. Dennis SPROTT , Lakshmi KRISHNAN , Subash SAD
IPC分类号： A61K9/127 , A61K39/00 , A61P37/00
CPC分类号： A61K39/39 , A61K2039/55555 , A61K2039/55594
摘要： The invention relates to a liposome comprising a chloroform soluble and extractable total polar lipid of Mycobacterium spp, particularly a chloroform soluble extractable total polar lipid of Mycobacterium bovis BCG. The chloroform soluble and extractable polar lipid may comprise at least one of phosphatidylinositol (PI), phosphatidylinositol mannoside (PIM1), phosphatidylinositol dimannoside (PIM2), mono and dipalmitoylated forms of PIM1 and PIM2, phospholipid of 899 m/z, phosphatidylethanolamine and cardiolipid. The liposome may be prepared by drying chloroform soluble and extractable lipid and then hydrating said dried lipid at a temperature of 65 to 75° C. in water or phosphate buffered saline (PBS). The liposome may be used, for example, to activate dendritic cells to secrete cytokines and modulate an immune response in a mammal, or to direct an immune response to confer protection against a pathogen or a cancer.
摘要翻译：本发明涉及包含分枝杆菌属的可溶于氯仿和可提取的总极性脂质的脂质体，特别是牛分枝杆菌BCG的氯仿可溶性可提取的总极性脂质。氯仿可溶性和可萃取的极性脂质可以包含磷脂酰肌醇（PI），磷脂酰肌醇甘露糖苷（PIM 1 SUB），磷脂酰肌醇二甘草苷（PIM 2 N 2），单和二棕榈酰化形式的PIM 1和PIM 2 2，磷脂899m / z，磷脂酰乙醇胺和心磷脂。脂质体可以通过干燥氯仿可溶性和可提取的脂质，然后在65至75℃的温度下在水或磷酸盐缓冲盐水（PBS）中水合所述干燥的脂质来制备。脂质体可以用于例如激活树突细胞以分泌细胞因子并调节哺乳动物的免疫应答，或引导免疫应答以赋予对病原体或癌症的保护。

3. 发明申请

US20130156809A1 Recombinant Bacterium and Uses Thereof 审中-公开
公开(公告)号：US20130156809A1
公开(公告)日：2013-06-20
申请号：US13811690
申请日：2011-07-28
申请人： Subash Sad , Lakshmi Krishnan , Valeria Alcon , Kevin G. Young , Fanny Tzelepis
发明人： Subash Sad , Lakshmi Krishnan , Valeria Alcon , Kevin G. Young , Fanny Tzelepis
IPC分类号： A61K39/12 , A61K39/00
CPC分类号： C07K14/77 , A61K39/0005 , A61K39/0011 , A61K39/12 , A61K2039/522 , A61K2039/523 , C07K14/195 , C07K14/4713 , C07K14/4748 , C07K14/70596 , C07K14/71 , C07K2319/036 , C07K2319/35 , C12N1/20 , C12N9/0059 , C12N9/2462 , C12N9/6494 , C12N2760/10034 , C12Y110/03001 , C12Y304/24011 , Y02A50/41
摘要： The present invention relates to a recombinant bacterium expressing an antigen that is translocated to the cytosol of a host organism, and uses thereof. To this end, the present invention provides a recombinant bacterium comprising a nucleic acid encoding an antigen that is translocated to the cytosol of a host cell utilizing Type III secretion system. The recombinant bacterium is generally chosen from intracellular pathogens that reside in the phagosome and fail to induce rapid T cell activation. The translocated antigen may be a viral antigen, a bacterial antigen, or a tumour antigen. Methods of imparting immunity using the recombinant bacterium are also provided.

4. 发明授权

US09537166B2 Method for the production of an electrochemical cell 有权
标题翻译：生产电化学电池的方法
公开(公告)号：US09537166B2
公开(公告)日：2017-01-03
申请号：US13702766
申请日：2011-06-08
申请人： Todd Snelson , Raymond Puffer , Daniel Walczyk , Jake Pyzza , Lakshmi Krishnan
发明人： Todd Snelson , Raymond Puffer , Daniel Walczyk , Jake Pyzza , Lakshmi Krishnan
IPC分类号： H01M4/88 , H01M8/10 , C25B9/10 , H01M8/02
CPC分类号： H01M8/0273 , C25B9/10 , H01M4/8807 , H01M4/881 , H01M4/8896 , H01M8/0258 , H01M8/0297 , H01M8/1004 , H01M8/103 , H01M2300/0082 , Y02E60/521 , Y02P70/56 , Y10T156/10
摘要： The present invention relates to a new method for the production of electrochemical cells, in particular individual cells for fuel cells and stacks, in which the individual components of a membrane electrode assembly are compressed and bonded by use of ultrasonic waves and the absence of any further additional heating. The method according to the invention allows faster cycles during the lamination of the membrane electrode assemblies.
摘要翻译：本发明涉及用于生产电化学电池，特别是用于燃料电池和电池堆的单个电池的新方法，其中膜电极组件的各个部件通过使用超声波被压缩和粘合，并且没有任何进一步的额外加热。根据本发明的方法允许在膜电极组件的层叠期间更快的循环。

5. 发明授权

US08936793B2 Synthetic archaeal glycolipid adjuvants 有权
标题翻译：合成古细糖糖脂佐剂
公开(公告)号：US08936793B2
公开(公告)日：2015-01-20
申请号：US12225381
申请日：2007-03-30
申请人： Dennis Sprott , Dennis M. Whitfield , Lakshmi Krishnan
发明人： Dennis Sprott , Dennis M. Whitfield , Lakshmi Krishnan
IPC分类号： A61K39/395 , A61K9/127 , A61K39/39 , C07H15/06 , A61K39/00
CPC分类号： A61K9/1272 , A61K39/39 , A61K2039/55583 , A61K2039/55594 , C07H15/06
摘要： Archaeal lipid adjuvants are synthesized by chemically coupling various carbohydrates or anionic polar groups to the free hydroxyl(s) of archaeal lipid cores. Chemically stable lipid cores such as saturated archaeol and caldarchaeol are obtained from appropriate Archaea. Archaeosome lipid vesicles are formulated from the synthetic lipids selected to serve as antigen carriers that target antigen-presenting cells and promote an appropriate immune response to the antigen.
摘要翻译：通过将各种碳水化合物或阴离子极性基团与古细菌脂质核心的游离羟基化学偶联来合成古菌脂质佐剂。化学稳定的脂质核，如饱和的古生物和钙质石是从适当的古菌获得的。从选择用作靶向抗原呈递细胞并促进对抗原的适当免疫应答的抗原载体的合成脂质配制考古细胞脂质囊泡。

6. 发明申请

US20100316657A1 Synthetic Archaeal Glycolipid Adjuvants 有权
标题翻译：合成古菌糖脂佐剂
公开(公告)号：US20100316657A1
公开(公告)日：2010-12-16
申请号：US12225381
申请日：2007-03-30
申请人： Dennis Sprott , Dennis M. Whitfield , Lakshmi Krishnan
发明人： Dennis Sprott , Dennis M. Whitfield , Lakshmi Krishnan
IPC分类号： A61K39/00 , C07H15/00 , A61K47/44 , C07H1/06 , A61P35/00
CPC分类号： A61K9/1272 , A61K39/39 , A61K2039/55583 , A61K2039/55594 , C07H15/06
摘要： Archaeal lipid adjuvants are synthesized by chemically coupling various carbohydrates or anionic polar groups to the free hydroxyl(s) of archaeal lipid cores. Chemically stable lipid cores such as saturated archaeol and caldarchaeol are obtained from appropriate Archaea. Archaeosome lipid vesicles are formulated from the synthetic lipids selected to serve as antigen carriers that target antigen-presenting cells and promote an appropriate immune response to the antigen.
摘要翻译：通过将各种碳水化合物或阴离子极性基团与古细菌脂质核心的游离羟基化学偶联来合成古菌脂质佐剂。化学稳定的脂质核，如饱和的古生物和钙质石是从适当的古菌获得的。从选择用作靶向抗原呈递细胞并促进对抗原的适当免疫应答的抗原载体的合成脂质配制考古细胞脂质囊泡。

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