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1. 发明授权

US09234294B2 Property modulated materials and methods of making the same 有权
标题翻译：财产调控材料和制作方法
公开(公告)号：US09234294B2
公开(公告)日：2016-01-12
申请号：US13003275
申请日：2009-07-07
申请人： John Whitaker , Zhi Liang Bao
发明人： John Whitaker , Zhi Liang Bao
IPC分类号： C25D5/10 , C25D5/18 , C25D5/16
CPC分类号： C25D5/10 , C25D3/20 , C25D3/665 , C25D5/16 , C25D5/18 , C25D17/10
摘要： A method of making property modulated composite materials includes depositing a first layer of material having a first microstructure/nanostructure on a substrate followed by depositing a second layer of material having a second microstructure/nanostructure that differs from the first layer. Multiple first and second layers can be deposited to form a composite material that includes a plurality of adjacent first and second layers. By controlling the microstructure/nanostructure of the layers, the material properties of the composite material formed by this method can be tailored for a specific use. The microstructures/nanostructures of the composite materials may be defined by one or more of grain size, grain boundary geometry, crystal orientation, and a defect density.
摘要翻译：制备特性调制复合材料的方法包括在衬底上沉积具有第一微结构/纳米结构的第一材料层，然后沉积具有不同于第一层的第二微结构/纳米结构的第二材料层。可以沉积多个第一和第二层以形成包括多个相邻的第一和第二层的复合材料。通过控制层的显微组织/纳米结构，通过该方法形成的复合材料的材料性质可以针对特定用途进行调整。复合材料的微结构/纳米结构可以由晶粒尺寸，晶界几何形状，晶体取向和缺陷密度中的一种或多种来限定。

2. 发明申请

US20120094980A1 PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING 审中-公开
标题翻译：吡格列酮信号肽的吡啶类抑制剂
公开(公告)号：US20120094980A1
公开(公告)日：2012-04-19
申请号：US13273945
申请日：2011-10-14
申请人： Janet L. Gunzner , Daniel P. Sutherlin , Mark S. Stanley , Liang Bao , Georgette Castanedo , Rebecca Lalonde , Shumei Wang , Mark E. Reynolds , Scott J. Savage , Kimberly Malesky , Michael S. Dina , Michael F.T. Koehler
发明人： Janet L. Gunzner , Daniel P. Sutherlin , Mark S. Stanley , Liang Bao , Georgette Castanedo , Rebecca Lalonde , Shumei Wang , Mark E. Reynolds , Scott J. Savage , Kimberly Malesky , Michael S. Dina , Michael F.T. Koehler
IPC分类号： A61K31/551 , A61K31/5377 , C07D401/14 , A61K31/444 , C07D213/56 , A61K31/44 , C07D409/12 , A61K31/4436 , C07D413/12 , A61K31/4439 , C07D403/14 , A61K31/496 , C07D401/12 , A61K31/506 , C07D417/12 , A61K31/541 , A61K31/4545 , C12N5/07 , A61P35/00 , A61P9/00 , C07D413/14
CPC分类号： C07D213/16 , C07D213/06 , C07D213/56 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07F9/58
摘要： The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.
摘要翻译：本发明提供了可用作治疗恶性肿瘤的治疗剂的刺猬蛋白信号传导的新型抑制剂，其中化合物具有通式I：其中A，X，Y R1，R2，R3，R4，m和n如本文所述。

3. 发明授权

US07855216B2 Aza-indolyl compounds and methods of use 有权
标题翻译：氮杂 - 吲哚基化合物及其使用方法
公开(公告)号：US07855216B2
公开(公告)日：2010-12-21
申请号：US11947656
申请日：2007-11-29
申请人： Simon Charles Goodacre , Karen Williams , Stephen Price , Hazel Joan Dyke , John Gary Montana , Mark S. Stanley , Liang Bao , Wendy Lee
发明人： Simon Charles Goodacre , Karen Williams , Stephen Price , Hazel Joan Dyke , John Gary Montana , Mark S. Stanley , Liang Bao , Wendy Lee
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00 , A61P35/00 , C07D487/04 , A61K31/519 , A61K31/5025
CPC分类号： C07D471/04 , C07D487/04
摘要： The invention relates to azaindolyl compounds of Formula I with anti-cancer and/or anti-inflammatory activity and more specifically to azaindolyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
摘要翻译：本发明涉及具有抗癌和/或抗炎活性的具有式I的唑烷基化合物，更具体地涉及抑制MEK激酶活性的唑烷基化合物。本发明提供了可用于抑制异常细胞生长或治疗过度增殖性疾病或治疗哺乳动物炎性疾病的组合物和方法。本发明还涉及将化合物用于体外，原位和体内诊断或治疗哺乳动物细胞或相关病理状况的方法。

4. 发明申请

US20090281089A1 PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING 审中-公开
标题翻译：吡格列酮信号肽的吡啶类抑制剂
公开(公告)号：US20090281089A1
公开(公告)日：2009-11-12
申请号：US12420746
申请日：2009-04-08
申请人： Janet L. Gunzner , Daniel P. Sutherlin , Mark S. Stanley , Liang Bao , Georgette Castanedo , Rebecca L. LaLonde , Shumei Wang , Mark E. Reynolds , Scott J. Savage , Kimberly Malesky , Michael S. Dina
发明人： Janet L. Gunzner , Daniel P. Sutherlin , Mark S. Stanley , Liang Bao , Georgette Castanedo , Rebecca L. LaLonde , Shumei Wang , Mark E. Reynolds , Scott J. Savage , Kimberly Malesky , Michael S. Dina
IPC分类号： A61K31/444 , C07D413/14 , C07D401/14 , C07D213/56 , C07D417/12 , C07D413/12 , C07D401/12 , A61P35/00 , A61K31/5377 , A61K31/4402 , A61K31/496 , A61K31/541 , A61K31/4439 , A61K31/506 , A61K31/551
CPC分类号： C07D213/16 , C07D213/06 , C07D213/56 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07F9/58
摘要： The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.
摘要翻译：本发明提供了可用作治疗恶性肿瘤的治疗剂的刺猬蛋白信号传导的新型抑制剂，其中化合物具有通式I：其中A，X，Y R1，R2，R3，R4，m和n如本文所述。

5. 发明申请

US20080085886A1 Aza-benzofuranyl compounds and methods of use 审中-公开
标题翻译：氮杂 - 苯并呋喃基化合物及其使用方法
公开(公告)号：US20080085886A1
公开(公告)日：2008-04-10
申请号：US11894506
申请日：2007-08-20
申请人： Pascal Savy , Stephen Price , Hazel Dyke , John Montana , Karen Williams , Mark Stanley , Liang Bao
发明人： Pascal Savy , Stephen Price , Hazel Dyke , John Montana , Karen Williams , Mark Stanley , Liang Bao
IPC分类号： A61K31/44 , A61K31/00 , A61K31/535 , A61P43/00 , C07D413/00 , C07D471/02
CPC分类号： C07D491/048
摘要： The invention relates to azabenzofuranyl compounds of Formula I with anti-cancer and/or anti-inflammatory activity and more specifically to azabenzofuranyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
摘要翻译：本发明涉及具有抗癌和/或抗炎活性的式I的氮杂苯并呋喃基化合物，更具体地涉及抑制MEK激酶活性的氮杂苯并呋喃基化合物。本发明提供了可用于抑制异常细胞生长或治疗过度增殖性疾病或治疗哺乳动物炎性疾病的组合物和方法。本发明还涉及将化合物用于体外，原位和体内诊断或治疗哺乳动物细胞或相关病理状况的方法。

6. 发明授权

US09278961B2 Pyridyl inhibitors of hedgehog signalling 有权
公开(公告)号：US09278961B2
公开(公告)日：2016-03-08
申请号：US12960609
申请日：2010-12-06
申请人： Janet L. Gunzner , Daniel Sutherlin , Mark S. Stanley , Liang Bao , Georgette M. Castanedo , Rebecca L. Lalonde , Shumei Wang , Mark E. Reynolds , Scott J. Savage , Kimberly Malesky , Michael S. Dina , Michael F. T. Koehler
发明人： Janet L. Gunzner , Daniel Sutherlin , Mark S. Stanley , Liang Bao , Georgette M. Castanedo , Rebecca L. Lalonde , Shumei Wang , Mark E. Reynolds , Scott J. Savage , Kimberly Malesky , Michael S. Dina , Michael F. T. Koehler
IPC分类号： C07D213/38 , C07D417/12 , C07D401/14 , A61K31/44 , C07D213/40 , C07D213/56 , C07D213/70 , C07D213/75 , C07D213/81 , C07D213/82 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/04 , C07F9/58
CPC分类号： C07D213/16 , C07D213/38 , C07D213/40 , C07D213/56 , C07D213/70 , C07D213/75 , C07D213/81 , C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07F9/58
摘要： The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.

7. 发明授权

US08202592B2 Housing and method of manufacturing thereof 有权
标题翻译：住房及其制造方法
公开(公告)号：US08202592B2
公开(公告)日：2012-06-19
申请号：US12503799
申请日：2009-07-15
申请人： Jen-Hong Hsu , He-Xing Fu , Hai-Peng Yan , Yong Yang , Liang-Bao Tao , Chang-Shuang Zhu , Yu-Guo Zhang , Hai-Lin Chen
发明人： Jen-Hong Hsu , He-Xing Fu , Hai-Peng Yan , Yong Yang , Liang-Bao Tao , Chang-Shuang Zhu , Yu-Guo Zhang , Hai-Lin Chen
IPC分类号： B29D22/00 , B29D23/00 , B32B1/08
CPC分类号： B44F9/10 , H05K5/0243 , Y10T428/1352 , Y10T428/1355 , Y10T428/1359
摘要： A housing includes a plastic substrate, a supporting layer, a hair line layer, a decorative layer, and a transparent protection layer. The supporting layer, the hair line layer, the decorative layer, and the transparent protection layer are formed on the substrate in that order.
摘要翻译：壳体包括塑料基板，支撑层，发线层，装饰层和透明保护层。支撑层，发线层，装饰层和透明保护层依次形成在基板上。

8. 发明申请

US20110092461A1 PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING 有权
标题翻译：吡格列酮信号肽的吡啶类抑制剂
公开(公告)号：US20110092461A1
公开(公告)日：2011-04-21
申请号：US12960609
申请日：2010-12-06
申请人： Janet L. GUNZNER , Daniel Sutherlin , Mark S. Stanley , Liang Bao , Georgette M. Castanedo , Rebecca L. Lalonde , Shumei Wang , Mark E. Reynolds , Scott J. Savage , Kimberly Malesky , Michael S. Dina
发明人： Janet L. GUNZNER , Daniel Sutherlin , Mark S. Stanley , Liang Bao , Georgette M. Castanedo , Rebecca L. Lalonde , Shumei Wang , Mark E. Reynolds , Scott J. Savage , Kimberly Malesky , Michael S. Dina
IPC分类号： A61K31/675 , C07D413/12 , C07D401/14 , C07D213/56 , C07D409/12 , C07D401/12 , C07D413/14 , C07D417/12 , A61K31/5377 , A61K31/444 , A61K31/4418 , A61K31/4436 , A61K31/4439 , A61K31/496 , A61K31/506 , A61K31/541 , A61K31/551 , C12N5/071 , A61P35/00
CPC分类号： C07D213/16 , C07D213/38 , C07D213/40 , C07D213/56 , C07D213/70 , C07D213/75 , C07D213/81 , C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07F9/58
摘要： The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.
摘要翻译：本发明提供了可用作治疗恶性肿瘤的治疗剂的刺猬蛋白信号传导的新型抑制剂，其中化合物具有通式I：其中A，X，Y R1，R2，R3，R4，m和n如本文所述。

9. 发明授权

US07893085B2 Aza-benzothiophenyl compounds and methods of use 有权
标题翻译：氮杂 - 苯并噻吩基化合物及其使用方法
公开(公告)号：US07893085B2
公开(公告)日：2011-02-22
申请号：US11894345
申请日：2007-08-20
申请人： Pascal Pierre Savy , Stephen Price , Hazel Joan Dyke , John Gary Montana , Karen Williams , Mark S. Stanley , Liang Bao
发明人： Pascal Pierre Savy , Stephen Price , Hazel Joan Dyke , John Gary Montana , Karen Williams , Mark S. Stanley , Liang Bao
IPC分类号： C07D221/00 , A61K31/4365 , A61P35/00 , A61P29/00 , C07D241/00 , C07D487/04 , A61K31/519 , A61K31/5025
CPC分类号： C07D495/04
摘要： The invention relates to azabenzothiophenyl compounds of Formula I with anti-cancer and/or anti-inflammatory activity and more specifically to azabenzothiophenyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
摘要翻译：本发明涉及具有抗癌和/或抗炎活性的式I的氮杂苯并噻吩基化合物，更具体地涉及抑制MEK激酶活性的氮杂苯并噻吩基化合物。本发明提供了可用于抑制异常细胞生长或治疗过度增殖性疾病或治疗哺乳动物炎性疾病的组合物和方法。本发明还涉及将化合物用于体外，原位和体内诊断或治疗哺乳动物细胞或相关病理状况的方法。

10. 发明申请

US20120118745A1 LOW STRESS PROPERTY MODULATED MATERIALS AND METHODS OF THEIR PREPARATION 有权
标题翻译：低应变性质调制材料及其制备方法
公开(公告)号：US20120118745A1
公开(公告)日：2012-05-17
申请号：US13003283
申请日：2009-07-07
申请人： Zhi Liang Bao
发明人： Zhi Liang Bao
IPC分类号： C25D5/00 , C25D1/00
CPC分类号： C25D5/10 , C25D3/20 , C25D3/665 , C25D5/16 , C25D5/18 , C25D17/10
摘要： The technology described herein sets forth methods of making low stress or stress free coatings and articles using electrodeposition without the use of stress reducing agents in the deposition process. The articles and coatings can be layered or nanolayered wherein in the microstructure/nanostructure and composition of individual layers can be independently modulated.
摘要翻译：本文描述的技术阐述了在沉积过程中不使用应力还原剂的情况下使用电沉积来制造低应力或无应力涂层和制品的方法。制品和涂层可以是层状或纳米层，其中在微结构/纳米结构中，各层的组成可以独立调制。

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