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1. 发明授权

US09834620B2 Modified conjugated diene-based polymer, preparation method therefor, and rubber composition containing same 有权
公开(公告)号：US09834620B2
公开(公告)日：2017-12-05
申请号：US15121848
申请日：2015-12-11
申请人： LG Chem, Ltd.
发明人： He-Seung Lee , No-Ma Kim , Hae-Sung Sohn
IPC分类号： C08C19/25 , C08C19/22 , C07D241/00 , C07F7/18 , B60C1/00 , C08F36/04 , C08C19/26 , C08L15/00 , C08C19/44 , C08F236/06 , C08K3/04 , C08K3/36
CPC分类号： C08C19/25 , B60C1/00 , B60C1/0016 , C07D241/00 , C07F7/1804 , C08C19/22 , C08C19/26 , C08C19/44 , C08F36/04 , C08F236/06 , C08F2500/04 , C08F2500/17 , C08F2800/20 , C08K3/04 , C08K3/36 , C08L15/00
摘要： Disclosed are a modified conjugated diene-based polymer represented by specific Chemical Formula, a method of preparing the same, and a rubber composition including the same.

2. 发明授权

US09079900B2 Methods of synthesis and purification of heteroaryl compounds 有权
标题翻译：杂芳基化合物的合成和纯化方法
公开(公告)号：US09079900B2
公开(公告)日：2015-07-14
申请号：US14174896
申请日：2014-02-07
申请人： SIGNAL PHARMACEUTICALS, LLC
发明人： Roy L. Harris , John Sapienza , Graziella Shevlin , Patrick Papa , Branden Gingsee Lee , Garrick Packard , Jingjing Zhao , Patrick Anthony Jokiel , Deborah Mortensen , Jennifer Riggs , Juan Antonio Gamboa , Marie Georges Beauchamps , Matthew Michael Kreilein , Mohit Atul Kothare , Sophie Perrin-Ninkovic , Philip Pye , William Wei-Hwa Leong , Jan Elsner , Anusuya Choudhury
IPC分类号： A61K31/497 , C07D241/00 , C07D471/04 , C07D487/04 , C07D498/14 , C07D519/00
CPC分类号： C07D471/04 , C07D241/20 , C07D487/04 , C07D498/14 , C07D519/00
摘要： Provided herein are methods to prepare Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein. The Heteroaryl compounds are useful for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions.
摘要翻译：本文提供了制备具有以下结构的杂芳基化合物的方法：其中R 1 -R 4如本文所定义。杂芳基化合物可用于治疗或预防癌症，炎症状况，免疫学条件，神经变性疾病，糖尿病，肥胖症，神经障碍，年龄相关疾病或心血管疾病。

3. 发明授权

US08618296B2 Arylethynyl derivatives 有权
公开(公告)号：US08618296B2
公开(公告)日：2013-12-31
申请号：US13914336
申请日：2013-06-10
申请人： Hoffmann-La Roche Inc.
发明人： Luke Green , Wolfgang Guba , Georg Jaeschke , Synese Jolidon , Lothar Lindemann , Antonio Ricci , Daniel Rueher , Heinz Stadler , Eric Vieira
IPC分类号： A61K31/50 , A61K31/501 , A61K31/4965 , C07D239/42 , C07D401/04 , A61K31/44 , C07D237/00 , C07D239/00 , C07D241/00 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D239/02 , C07D241/02 , C07D211/00 , C07D213/00 , C07D215/00 , C07D217/00 , C07D219/00 , C07D221/00
CPC分类号： C07D471/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D413/04 , C07D413/14 , C07D491/107 , C07D498/04
摘要： The present invention relates to ethynyl compounds of formula I wherein R1, R2, R2′, R3, R3′, R4, R4′, U, V, W, Y, m, and n are as defined herein and to a pharmaceutically acceptable acid addition salts, to a racemic mixtures, or to its corresponding enantiomers and/or optical isomers and/or stereoisomers thereof. Compounds of formula I are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).

4. 发明授权

US08431607B2 Compounds and compositions as inhibitors of cannabinoid receptor 1 activity 失效
标题翻译：化合物和组合物作为大麻素受体1活性的抑制剂
公开(公告)号：US08431607B2
公开(公告)日：2013-04-30
申请号：US12519147
申请日：2007-12-12
申请人： Hong Liu , Xiaohui He , Dean Phillips , Xuefeng Zhu , Kunyong Yang , Thomas Lau , Baogen Wu , Yongping Xie , Truc Ngoc Nguyen , Xing Wang
发明人： Hong Liu , Xiaohui He , Dean Phillips , Xuefeng Zhu , Kunyong Yang , Thomas Lau , Baogen Wu , Yongping Xie , Truc Ngoc Nguyen , Xing Wang
IPC分类号： A01N43/50 , A61K31/415 , A61K31/50 , A61K31/501 , A61K31/497 , C07D401/00 , C07D233/00 , C07D233/02 , C07D241/00 , C07D241/02
CPC分类号： C07D265/32 , C07D207/26 , C07D207/40 , C07D233/12 , C07D233/16 , C07D233/32 , C07D233/38 , C07D233/42 , C07D233/46 , C07D233/50 , C07D233/52 , C07D233/74 , C07D263/20 , C07D263/22 , C07D285/06 , C07D403/04 , C07D403/06 , C07D403/14 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07F7/1804
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).
摘要翻译：本发明提供化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与大麻素受体1（CB1）的活性相关的疾病或病症的方法。

5. 发明授权

US08389533B2 Gem-disubstituted and spirocyclic amino pyridines/pyrimidines as cell cycle inhibitors 有权
标题翻译：双 - 二取代和螺环氨基吡啶/嘧啶作为细胞周期抑制剂
公开(公告)号：US08389533B2
公开(公告)日：2013-03-05
申请号：US12936725
申请日：2009-04-06
申请人： Richard V. Connors , Kang Dai , John Eksterowicz , Pingchen Fan , Benjamin Fisher , Jiasheng Fu , Kexue Li , Zhihong Li , Lawrence R. McGee , Rajiv Sharma , Xiaodong Wang
发明人： Richard V. Connors , Kang Dai , John Eksterowicz , Pingchen Fan , Benjamin Fisher , Jiasheng Fu , Kexue Li , Zhihong Li , Lawrence R. McGee , Rajiv Sharma , Xiaodong Wang
IPC分类号： A01N43/54 , A61K31/505 , C07D237/00 , C07D239/00 , C07D241/00
CPC分类号： C07D471/04 , C07D239/70 , C07D401/12 , C07D471/10 , C07D487/10 , C07D491/10 , C07D491/107 , C07D491/20
摘要： Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are gem-disubstituted or spirocyclic pyridine, pyrimidine and triazine derivatives.
摘要翻译：提供了可用于治疗CDK4介导的疾病如癌症的化合物，药物组合物和方法。主题化合物是偕二取代或螺环吡啶，嘧啶和三嗪衍生物。

6. 发明授权

US08367672B2 Pyridazine compounds, compositions and methods 有权
标题翻译：哒嗪化合物，组合物和方法
公开(公告)号：US08367672B2
公开(公告)日：2013-02-05
申请号：US11666803
申请日：2005-11-02
申请人： D. Martin Watterson , Linda J. Van Eldik , Jacques Haiech , Marcel Hibert , Jean-Jacques Bourguignon , Anastasia Velentza , Wenhui Hu , Magdalena Zasadzki
发明人： D. Martin Watterson , Linda J. Van Eldik , Jacques Haiech , Marcel Hibert , Jean-Jacques Bourguignon , Anastasia Velentza , Wenhui Hu , Magdalena Zasadzki
IPC分类号： C07D241/00 , A61K31/497
CPC分类号： C07D401/12 , A61K31/502 , C07D237/20 , C07D237/24 , C07D237/34 , C07D401/04 , C07D403/12 , C07D413/12 , C07D413/14 , C07D487/04 , C07H19/16
摘要： The invention relates to novel chemical compounds and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.
摘要翻译：本发明涉及新化合物及其制备和使用方法。特别地，本发明提供哒嗪化合物和/或相关的杂环衍生物，包含其的组合物，以及使用哒嗪化合物和/或相关杂环衍生物的方法及其组合物，用于调节细胞途径（例如，信号转导途径），用于治疗或预防炎性疾病（如阿尔茨海默病），用于研究，药物筛选和治疗应用。

7. 发明授权

US08329903B2 Light-emitting element including organometallic complex including pyrazine derivative 有权
标题翻译：发光元件包括有机金属络合物，包括吡嗪衍生物
公开(公告)号：US08329903B2
公开(公告)日：2012-12-11
申请号：US13353829
申请日：2012-01-19
申请人： Hideko Inoue , Satoshi Seo
发明人： Hideko Inoue , Satoshi Seo
IPC分类号： C07D241/00 , C01G55/00
CPC分类号： C07F15/0033
摘要： An organometallic complex is provided by which favorable red-color light emission can be obtained. Further, an organometallic complex having a peak of light emission at about 620 nm is provided because the wavelength of light which is perceived as excellent red-color light is about 620 nm. Furthermore, an organometallic complex is provided by which red-color light emission with high luminous efficiency (cd/A) can be obtained. An organometallic complex represented by the following general formula (G2) and a light-emitting element, a light-emitting device, and an electronic device including the organometallic complex represented by the following general formula (G2) are provided.
摘要翻译：提供了可以获得有利的红色发光的有机金属络合物。此外，由于感觉为优异的红色光的光的波长为约620nm，因此提供了在约620nm具有发光峰值的有机金属络合物。此外，提供了可以获得具有高发光效率（cd / A）的红色发光的有机金属络合物。提供了由以下通式（G2）表示的有机金属配合物和发光元件，发光装置和包含由以下通式（G2）表示的有机金属配合物的电子器件。

8. 发明授权

US08163905B2 Compounds and their uses 708 有权
标题翻译：化合物及其用途708
公开(公告)号：US08163905B2
公开(公告)日：2012-04-24
申请号：US12147132
申请日：2008-06-26
申请人： Stephen Brough , Richard Evans , Timothy Jon Luker , Piotr Raubo
发明人： Stephen Brough , Richard Evans , Timothy Jon Luker , Piotr Raubo
IPC分类号： C07D241/00
CPC分类号： C07D491/113 , C07D241/08 , C07D241/20 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/04 , C07D413/12 , C07D471/10
摘要： The present invention relates to pyrazinone derivatives of formula (I): wherein R1, R2, R3, R4, R5, R6 and R7 are as herein defined; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：本发明涉及式（I）的吡嗪酮衍生物：其中R1，R2，R3，R4，R5，R6和R7如本文所定义; 其制备方法，含有它们的药物组合物及其在治疗中的用途。

9. 发明授权

US08134146B2 Heterocyclic radical or diradical, the dimers, oligomers, polymers, dispiro compounds and polycycles thereof, the use thereof, organic semiconductive material and electronic or optoelectronic component 有权
标题翻译：二环，二聚体，低聚物，聚合物，二恶烷化合物及其多环，其用途，有机半导体材料和电子或光电子组件
公开(公告)号：US08134146B2
公开(公告)日：2012-03-13
申请号：US11688777
申请日：2007-03-20
申请人： Michael Limmert , Olaf Zeika , Martin Ammann , Horst Hartmann , Ansgar Werner
发明人： Michael Limmert , Olaf Zeika , Martin Ammann , Horst Hartmann , Ansgar Werner
IPC分类号： H01L51/00 , C07D207/00 , C07D209/56 , C07D221/00 , C07D239/00 , C07D241/00 , C07D245/00 , C07D307/00 , C07D333/00
CPC分类号： H01L51/0051 , C07D235/02 , C08G61/00 , H01L51/002 , H01L51/0067 , H01L51/0071 , H01L51/0081 , H01L51/5076 , Y02E10/549
摘要： The present invention relates to heterocyclic radicals or diradicals, the dimers, oligomers, polymers, dispiro compounds and polycycles thereof, to the use thereof to organic semiconductive materials and to electronic and optoelectronic components.
摘要翻译：本发明涉及其用于有机半导体材料和电子和光电子组分的杂环基团或双基，其二聚体，低聚物，聚合物，二氢化合物和多环体。

10. 发明申请

US20110224433A1 Process for Manufacturing Substituted 3-pyridylmethyl Ammonium Bromides 有权
标题翻译：制备取代的3-吡啶基甲基溴化铵的方法
公开(公告)号：US20110224433A1
公开(公告)日：2011-09-15
申请号：US13128787
申请日：2009-11-13
申请人： Joachim Gebhardt , Frederik Menges , Michael Rack , Michael Keil , Jochen Schroeder , Stefan Orsten , Helmut Zech , David Cortes , Robert Leicht , Tony Yegerlehner , Rodney F. Klima
发明人： Joachim Gebhardt , Frederik Menges , Michael Rack , Michael Keil , Jochen Schroeder , Stefan Orsten , Helmut Zech , David Cortes , Robert Leicht , Tony Yegerlehner , Rodney F. Klima
IPC分类号： C07D251/00 , C07D213/80 , C07D237/00 , C07D241/00 , C07D401/04
CPC分类号： C07D401/04 , C07D213/80 , C07D401/06 , C07D403/06 , C07D413/06 , C07D417/06
摘要： A process for manufacturing 5,6-disubstituted-3-pyridylmethyl ammonium bromides (I), wherein Q is a tertiary aliphatic or cyclic, saturated, partially unsaturated or aromatic amine; Z is hydrogen or halogen; Z1 is hydrogen, halogen, cyano or nitro; Y and Y1 are each independently OR1, NR1R2, or when taken together YY1 is —O—, —S— or NR3—; R1 and R2 are each independently hydrogen, C1-C4 alkyl optionally substituted with C1-C4 alkoxy or phenyl optionally substituted with one to three C1-C4 alkyl groups, C1-C4 alkoxy groups or halogen atoms, or phenyl optionally substituted with one to three C1-C4 alkyl groups, C1-C4 alkoxy groups or halogen atoms; R3 is hydrogen or C1-C4 alkyl; comprises the steps of (i) reacting a compound of formula (II), wherein the symbols have the meaning given in formula (I), with bromine in the presence of a radical initiator in a solvent mixture comprising an aqueous phase and an organic phase, where the organic phase comprises a solvent selected from 1,2-dichloroethane, chlorobenzene, 1,2-dichlorobenzene, 1,3-dichlorobenzene, 1,4-dichlorobenzene and tetrachloromethane, and where the pH-value of the aqueous phase is from 3 to
摘要翻译：制备5,6-二取代-3-吡啶基甲基溴化铵（I）的方法，其中Q是叔脂族或环状饱和的，部分不饱和的或芳族的胺; Z是氢或卤素; Z1是氢，卤素，氰基或硝基; Y和Y1各自独立地为OR 1，NR 1 R 2，或者当Y Y 1为-O - ， - S-或NR 3 - 时。 R 1和R 2各自独立地为氢，任选被C 1 -C 4烷氧基取代的C 1 -C 4烷基或任选被一至三个C 1 -C 4烷基，C 1 -C 4烷氧基或卤素原子取代的苯基，或任选被一至三个 C1-C4烷基，C1-C4烷氧基或卤原子; R3是氢或C1-C4烷基; 包括以下步骤：（i）在自由基引发剂存在下，将包含式（I）中给出的符号的式（II）化合物与溴在含水相和有机相的溶剂混合物中反应，其中有机相包含选自1,2-二氯乙烷，氯苯，1,2-二氯苯，1,3-二氯苯，1,4-二氯苯和四氯甲烷的溶剂，其中水相的pH值来自 3至<8，得到3-溴甲基-5,6-二取代的吡啶化合物（III），其中Y，Y 1，Z和Z 1具有式（I）中给出的含义，和（ⅱ）使溴化合物式（III）与叔胺碱Q在溶剂中在约0℃至100℃的温度范围内

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