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1. 发明申请

US20210300433A1 SYSTEMS AND METHODS FOR DEFENDING AGAINST PHYSICAL ATTACKS ON IMAGE CLASSIFICATION 有权
公开(公告)号：US20210300433A1
公开(公告)日：2021-09-30
申请号：US17214071
申请日：2021-03-26
申请人： Yevgeniy Vorobeychik , Tong Wu , Liang Tong
发明人： Yevgeniy Vorobeychik , Tong Wu , Liang Tong
IPC分类号： B60W60/00 , G06N3/08 , G06K9/62
摘要： An image classification system defends against physically realizable attacks. A training dataset of input images is retrieved and an adversarial image is generated based on one of the input images that is selected. The adversarial image is created by occluding a portion of the selected image by superimposing a predetermined shape (e.g., a rectangle) containing noise on the selected image. A defense against occlusion attacks (DOA) classifier is trained using the training dataset and the adversarial image. The DOA classifier is utilized to classify captured images of items (e.g., street signs) that may have been attacked (e.g., sticker placement, vandalism).

2. 发明申请

US20090215627A1 Crystal Structure of Biotin Carboxylase (Bc) Domain of Acetyl-Coenzyme a Carboxylase and Methods of Use Thereof 审中-公开
标题翻译：乙酰辅酶a羧酸酶的生物素羧化酶（Bc）结构域的晶体结构及其使用方法
公开(公告)号：US20090215627A1
公开(公告)日：2009-08-27
申请号：US11573217
申请日：2005-08-03
申请人： Yang Shen , Sandra L. Volrath , Stephanie C. Weatherly , Tedd D. Elich , Richard Anderson , Liang Tong
发明人： Yang Shen , Sandra L. Volrath , Stephanie C. Weatherly , Tedd D. Elich , Richard Anderson , Liang Tong
IPC分类号： A01N43/60 , C12N9/00 , A61K31/5513 , A01P13/00 , A61P3/10 , G06G7/48 , C07D243/08
CPC分类号： C12N9/93 , C07K2299/00
摘要： A crystal comprising a biotin carboxylase domain of acetyl-CoA carboxylase is described, along with a computer-based method for identifying compounds that modulates activity of acetyl-CoA carboxylase, a computer-based method for rationally designing a compound that modulates activity of acetyl-CoA carboxylase, along with compounds produced by such methods, as well as compositions and methods of use thereof.
摘要翻译：描述了包含乙酰-CoA羧化酶的生物素羧化酶结构域的晶体，以及用于鉴定调节乙酰辅酶A羧化酶活性的化合物的基于计算机的方法，用于合理设计调节乙酰辅酶A羧化酶活性的化合物的基于计算机的方法， CoA羧化酶，以及通过这些方法制备的化合物，以及其组合物和使用方法。

3. 发明申请

US20080020413A1 CRYSTALLINE VISFATIN AND METHODS THEREFOR 审中-公开
标题翻译：晶体结构及其方法
公开(公告)号：US20080020413A1
公开(公告)日：2008-01-24
申请号：US11693536
申请日：2007-03-29
申请人： Liang Tong , Xiao Tao , Javed Khan
发明人： Liang Tong , Xiao Tao , Javed Khan
IPC分类号： C12N9/98 , C12N9/96 , C12Q1/48 , G06G7/58
CPC分类号： C12N9/1077
摘要： Crystals of nicotinamide phosphoribosyltransferase, methods of making the crystals, and methods of using the crystals are disclosed. The three-dimensional structures of NMPRTases are also disclosed. Also disclosed are methods for utilizing a crystal structure of an NMPRTase for identifying, designing, selecting, or testing molecules which affect NMPRTase activity, which can be used therapeutically in the treatment of diseases and disorders such as cancer and diabetes.
摘要翻译：公开了烟酰胺磷酸核糖基转移酶的晶体，制备晶体的方法和使用晶体的方法。还公开了NMPRTase的三维结构。还公开了利用NMPRTase的晶体结构鉴定，设计，选择或测试影响NMPRTase活性的分子的方法，其可用于治疗疾病和病症如癌症和糖尿病的治疗。

4. 发明申请

US20060094100A1 Structural models of carnitine acyltransferases and uses thereof 审中-公开
标题翻译：肉碱酰基转移酶的结构模型及其用途
公开(公告)号：US20060094100A1
公开(公告)日：2006-05-04
申请号：US11146700
申请日：2005-06-07
申请人： Liang Tong , Gerwald Jogl
发明人： Liang Tong , Gerwald Jogl
IPC分类号： G06F19/00 , C12N9/10
CPC分类号： C12N9/1029 , C07K2299/00 , C12Y203/01007 , G16B15/00 , G16B20/00
摘要： The present invention relates to structural models of carnitine acyltransferases, and, in particular, to models of the reactive sites of these enzymes. It is based, at least in part, on the X-ray crystallographic structures of murine carnitine acetyltransferase (“mCRAT”), both in pure form and in complex with its substrates carnitine and coenzyme A (“CoA”). The structural information provides a basis for designing modulators of the activity of CRAT and related enzymes.
摘要翻译：本发明涉及肉碱酰基转移酶的结构模型，特别涉及这些酶的反应位点的模型。它基于至少部分基于鼠类肉碱乙酰转移酶（“mCRAT”）的X射线晶体学结构，两者都是纯形式，并与其底物肉碱和辅酶A（“CoA”）复合。结构信息为设计CRAT和相关酶活性的调节剂提供了基础。

5. 发明申请

US20130243512A1 PRINTER WITH LABEL SELF-STRIPPING MECHANISM 审中-公开
标题翻译：打标机带标签自动剥离机构
公开(公告)号：US20130243512A1
公开(公告)日：2013-09-19
申请号：US13421027
申请日：2012-03-15
申请人： TER LIANG TONG , HUAT LAI CHEAH
发明人： TER LIANG TONG , HUAT LAI CHEAH
IPC分类号： B41J13/00
CPC分类号： B41J3/4075
摘要： A printer is described herein that is equipped to internally remove the backings off of self-adhesive label paper, exposing an adhesive layer when ejected from the printer. A user desiring to print some sort of indicia on the self-adhesive paper need only initiate printing, and a label with exposed adhesive is ejected from the printer. A print side of the paper is split from a backing inside the printer pulling preceding print sides and backings at certain tensions, thereby creating a particularly effective separation angle. A ribbon break shaft and one or more rollers create the correct tension in the print sides, while a platen roller and cantilever leaf spring create the correct tension in the backings. In some embodiments, the optimal separation angle lies between 19 and 25 degrees.
摘要翻译：本文描述了一种打印机，其被配备为从自粘标签纸内部去除背衬，当从打印机弹出时暴露粘合剂层。希望在自粘纸上打印某种标记的用户只需要开始打印，并且从打印机弹出带有暴露的粘合剂的标签。纸张的打印面从打印机内部的背衬中分离，以一定张力拉出前面的打印面和背衬，从而产生特别有效的分离角度。带状断裂轴和一个或多个辊在印刷侧产生正确的张力，而压辊和悬臂板簧在背衬中产生正确的张力。在一些实施例中，最佳分离角位于19和25度之间。

6. 发明授权

US07884189B2 Carboxyltransferase domain of acetyl-CoA carboxylase 有权
标题翻译：乙酰辅酶A羧化酶的羧基转移酶结构域
公开(公告)号：US07884189B2
公开(公告)日：2011-02-08
申请号：US10754687
申请日：2004-01-09
申请人： Liang Tong , Hailong Zhang , Zhiru Yang
发明人： Liang Tong , Hailong Zhang , Zhiru Yang
IPC分类号： C07K14/00 , C08H1/00 , A61K38/43
CPC分类号： C12N9/93 , C07K2299/00 , C12Y604/01002
摘要： The present invention provides compositions and crystals of the carboxyltransferase (CT) domain (the C-terminal ˜90 kDa fragment) of various acetyl-CoA carboxylase (ACC) proteins, including yeast, mouse and human ACCs. Further, the present invention provides methods for identifying and designing compounds that can modulate ACC activity. These methods are based, in part, on the X-ray crystallographic structures of the CT domain of yeast ACC, either alone or bound to acetyl-CoA or a CT inhibitor, such as haloxyfop or diclofop or CP-640186. Thus, the present invention relates to the crystal structures of the carboxyltransferase (“CT”) domain of acetyl-CoA carboxylase (“ACC”), and to the use of these structures in the design of anti-obesity compounds, anti-diabetes compounds, antibiotic compounds, herbicide compounds, and in the design of herbicide resistant plants.
摘要翻译：本发明提供各种乙酰辅酶A羧化酶（ACC）蛋白质的羧基转移酶（CT）结构域（C末端〜90kDa片段）的组合物和晶体，包括酵母，小鼠和人类ACC。此外，本发明提供了鉴定和设计可调节ACC活性的化合物的方法。这些方法部分地基于酵母ACC的CT结构域的X射线晶体结构，单独或结合到乙酰辅酶A或CT抑制剂，如卤氧op op或双氯芬酸或CP-640186。因此，本发明涉及乙酰辅酶A羧化酶（“ACC”）的羧基转移酶（“CT”）结构域的结构，以及这些结构在抗肥胖化合物，抗糖尿病化合物的设计中的应用，抗生素化合物，除草剂化合物，以及设计抗除草剂植物。

7. 发明申请

US20230072533A1 ORDINAL CLASSIFICATION THROUGH NETWORK DECOMPOSITION 有权
公开(公告)号：US20230072533A1
公开(公告)日：2023-03-09
申请号：US17896747
申请日：2022-08-26
申请人： Takehiko Mizoguchi , Liang Tong , Zhengzhang Chen , Wei Cheng , Haifeng Chen , Nauman Ahad
发明人： Takehiko Mizoguchi , Liang Tong , Zhengzhang Chen , Wei Cheng , Haifeng Chen , Nauman Ahad
IPC分类号： G06K9/62 , G06N3/08
摘要： A computer-implemented method for ordinal classification of input data is provided. The method includes learning, by an encoder neural network, compact neural representations of the input data. The method further includes freezing the encoder neural network for downstream tasks. The method also includes training, by a hardware processor, K−1 ordinal classifiers on top of the compact neural representations to obtained trained K−1 ordinal classifiers. The method additionally includes generating, by the hardware processor, a predicted ordinal label by aggregating the trained K−1 ordinal classifiers.

8. 发明申请

US20110280813A1 NEURAMINIDASE INHIBITORS AND USES THEREOF 审中-公开
标题翻译：神经酰胺糖苷酶抑制剂及其用途
公开(公告)号：US20110280813A1
公开(公告)日：2011-11-17
申请号：US13128688
申请日：2009-11-13
申请人： Alice Prince , Liang Tong
发明人： Alice Prince , Liang Tong
IPC分类号： A61K8/64 , A61K31/7105 , C40B30/02 , C07K2/00 , C07K16/40 , A61K31/4015 , A61K38/08 , A01N43/16 , A61K31/351 , A01N47/44 , A61K31/196 , A01N37/30 , A61K31/215 , A61K31/713 , A61K31/711 , A01N57/16 , A61K39/395 , A01N37/18 , A61P31/04 , A01P1/00 , A61K31/545 , A61K31/43 , A61K31/65 , A61K8/49 , A61K8/60 , A61K8/43 , A61K8/42 , A61P11/00 , A61Q11/00 , A01N43/36
CPC分类号： A61K31/4015 , A61K31/196 , A61K31/215
摘要： The invention is related to various methods for inhibiting or reducing biofilm formation, treating a biofilm production-related disorder, preventing biofilm formation, and screening for neuraminidase inhibitors.
摘要翻译：本发明涉及抑制或减少生物膜形成，治疗生物膜生产相关病症，预防生物膜形成和筛选神经氨酸酶抑制剂的各种方法。

9. 发明申请

US20050009163A1 Methods of using crystal structure of carboxyltransferase domain of acetyl-CoA carboxylase, modulators thereof, and computer methods 有权
标题翻译：乙酰辅酶A羧化酶羧基转移酶结构域的结构方法及其调节剂，计算机方法
公开(公告)号：US20050009163A1
公开(公告)日：2005-01-13
申请号：US10754687
申请日：2004-01-09
申请人： Liang Tong , Hailong Zhang
发明人： Liang Tong , Hailong Zhang
IPC分类号： C12N9/00 , G06F19/00 , C12N9/10 , G01N33/48 , G01N33/50
CPC分类号： C12N9/93 , C07K2299/00 , C12Y604/01002
摘要： The present invention provides compositions and crystals of the carboxyltransferase (CT) domain (the C-terminal ˜90 kDa fragment) of various acetyl-CoA carboxylase (ACC) proteins, including yeast, mouse and human ACCs. Further, the present invention provides methods for identifying and designing compounds that can modulate ACC activity. These methods are based, in part, on the X-ray crystallographic structures of the CT domain of yeast ACC, either alone or bound to acetyl-CoA or a CT inhibitor, such as haloxyfop or diclofop or CP-640186. Thus, the present invention relates to the crystal structures of the carboxyltransferase (“CT”) domain of acetyl-CoA carboxylase (“ACC”), and to the use of these structures in the design of anti-obesity compounds, anti-diabetes compounds, antibiotic compounds, herbicide compounds, and in the design of herbicide resistant plants.
摘要翻译：本发明提供各种乙酰辅酶A羧化酶（ACC）蛋白质的羧基转移酶（CT）结构域（C末端〜90kDa片段）的组合物和晶体，包括酵母，小鼠和人ACC。此外，本发明提供了鉴定和设计可调节ACC活性的化合物的方法。这些方法部分地基于酵母ACC的CT结构域的X射线晶体结构，单独或结合到乙酰辅酶A或CT抑制剂，如卤氧op op或双氯芬酸或CP-640186。因此，本发明涉及乙酰辅酶A羧化酶（“ACC”）的羧基转移酶（“CT”）结构域的结构，以及这些结构在抗肥胖化合物，抗糖尿病化合物的设计中的应用，抗生素化合物，除草剂化合物，以及设计抗除草剂植物。

10. 发明申请

US20090175805A1 Neuraminidase Inhibitors and uses thereof 审中-公开
标题翻译：神经氨酸酶抑制剂及其用途
公开(公告)号：US20090175805A1
公开(公告)日：2009-07-09
申请号：US12282759
申请日：2007-03-13
申请人： Alice Prince , Liang Tong
发明人： Alice Prince , Liang Tong
IPC分类号： A61K8/49
CPC分类号： A61K31/538 , A01N41/06 , A01N43/16 , A01N43/42 , A01N43/60 , A01N43/84 , A01N61/00 , C12N9/2402 , C12Y302/01018
摘要： The invention is related to various methods for inhibiting or reducing biofilm formation, treating a biofilm production-related disorder, preventing biofilm formation, and screening for neuraminidase inhibitors. The invention also encompasses a mutant bacterial strain with a deleted neuraminidase gene.
摘要翻译：本发明涉及抑制或减少生物膜形成，治疗生物膜生产相关病症，预防生物膜形成和筛选神经氨酸酶抑制剂的各种方法。本发明还包括具有缺失的神经氨酸酶基因的突变型细菌菌株。

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