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2. 发明授权

US07884189B2 Carboxyltransferase domain of acetyl-CoA carboxylase 有权
标题翻译：乙酰辅酶A羧化酶的羧基转移酶结构域
公开(公告)号：US07884189B2
公开(公告)日：2011-02-08
申请号：US10754687
申请日：2004-01-09
申请人： Liang Tong , Hailong Zhang , Zhiru Yang
发明人： Liang Tong , Hailong Zhang , Zhiru Yang
IPC分类号： C07K14/00 , C08H1/00 , A61K38/43
CPC分类号： C12N9/93 , C07K2299/00 , C12Y604/01002
摘要： The present invention provides compositions and crystals of the carboxyltransferase (CT) domain (the C-terminal ˜90 kDa fragment) of various acetyl-CoA carboxylase (ACC) proteins, including yeast, mouse and human ACCs. Further, the present invention provides methods for identifying and designing compounds that can modulate ACC activity. These methods are based, in part, on the X-ray crystallographic structures of the CT domain of yeast ACC, either alone or bound to acetyl-CoA or a CT inhibitor, such as haloxyfop or diclofop or CP-640186. Thus, the present invention relates to the crystal structures of the carboxyltransferase (“CT”) domain of acetyl-CoA carboxylase (“ACC”), and to the use of these structures in the design of anti-obesity compounds, anti-diabetes compounds, antibiotic compounds, herbicide compounds, and in the design of herbicide resistant plants.
摘要翻译：本发明提供各种乙酰辅酶A羧化酶（ACC）蛋白质的羧基转移酶（CT）结构域（C末端〜90kDa片段）的组合物和晶体，包括酵母，小鼠和人类ACC。此外，本发明提供了鉴定和设计可调节ACC活性的化合物的方法。这些方法部分地基于酵母ACC的CT结构域的X射线晶体结构，单独或结合到乙酰辅酶A或CT抑制剂，如卤氧op op或双氯芬酸或CP-640186。因此，本发明涉及乙酰辅酶A羧化酶（“ACC”）的羧基转移酶（“CT”）结构域的结构，以及这些结构在抗肥胖化合物，抗糖尿病化合物的设计中的应用，抗生素化合物，除草剂化合物，以及设计抗除草剂植物。

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