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1. 发明授权

US08467974B2 System, method, and computer software for the presentation and storage of analysis results 有权
标题翻译：系统，方法和计算机软件，用于演示和存储分析结果
公开(公告)号：US08467974B2
公开(公告)日：2013-06-18
申请号：US13161150
申请日：2011-06-15
申请人： Shantanu V. Kaushikkar , Teresa A. Webster , Rui Mei , Linda McAllister
发明人： Shantanu V. Kaushikkar , Teresa A. Webster , Rui Mei , Linda McAllister
IPC分类号： G06F7/00
CPC分类号： G06F19/20 , B01J2219/007 , G01N2035/00158 , G06F19/18 , G06F19/26 , Y10S707/99943
摘要： A computer program product, and related systems and methods, are described that processes emission intensity data corresponding to probes of a biological probe array. The computer program includes a genotype and statistical analysis manager that determines absolute or relative expression values based, at least in part, on a statistical measure of the emission intensity data and at least one user-selectable statistical parameter. The analysis manager may also determine genotype calls for one or more probes based, at least in part, on the emission intensity data. The analysis manager may further display the absolute or relative expression values based, at least in part, on at least one user-selectable display parameter and/or a measure of normalized change between genotype calls. The measure of normalized change may be based, at least in part, on a comparison of genotype calls and a reference value.
摘要翻译：描述了计算机程序产品以及相关系统和方法，其处理对应于生物探针阵列的探针的发射强度数据。所述计算机程序包括基因型和统计分析管理器，所述基因型和统计分析管理器至少部分地基于所述发射强度数据和至少一个用户可选择的统计参数的统计测量来确定绝对或相对表达值。至少部分地基于发射强度数据，分析管理器还可以确定对一个或多个探针的基因型呼叫。至少部分地基于至少一个用户可选显示参数和/或基因型呼叫之间的归一化变化的量度，分析管理器可进一步显示绝对或相对表达值。归一化变化的度量可以至少部分地基于基因型呼叫和参考值的比较。

2. 发明申请

US20120258890A1 NS1-NP Diagnostics of Influenza Virus Infection 审中-公开
标题翻译： NS1-NP流感病毒感染诊断
公开(公告)号：US20120258890A1
公开(公告)日：2012-10-11
申请号：US13439697
申请日：2012-04-04
申请人： PETER S. LU , MICHAEL P. BELMARES , CAROL TAN , LINDA MCALLISTER
发明人： PETER S. LU , MICHAEL P. BELMARES , CAROL TAN , LINDA MCALLISTER
IPC分类号： C40B40/10
CPC分类号： G01N33/56983 , C12Q1/701 , G01N2333/11
摘要： The present application describes methods for assessing influenza infection, including prognosis. An assay that determines the amount of the NS1 and NP proteins of influenza virus shows enhanced sensitivity and reliability compared to either antigen alone. Many formats employ pan-specific antibodies (i.e., that react with all or at least with multiple strains within an influenza type).
摘要翻译：本申请描述了用于评估流感感染的方法，包括预后。与单独的抗原相比，确定流感病毒的NS1和NP蛋白的量的测定显示增强的灵敏度和可靠性。许多形式使用泛特异性抗体（即，与全部或至少与流感类型内的多种菌株反应）。

3. 发明授权

US07991560B2 System, method, and computer software for the presentation and storage of analysis results 有权
公开(公告)号：US07991560B2
公开(公告)日：2011-08-02
申请号：US11352008
申请日：2006-02-10
申请人： Shantanu V. Kaushikkar , Teresa Webster , Rui Mei , Linda McAllister
发明人： Shantanu V. Kaushikkar , Teresa Webster , Rui Mei , Linda McAllister
IPC分类号： G06F7/00
CPC分类号： G06F19/20 , B01J2219/007 , G01N2035/00158 , G06F19/18 , G06F19/26 , Y10S707/99943
摘要： A computer program product, and related systems and methods, are described that processes emission intensity data corresponding to probes of a biological probe array. The computer program includes a genotype and statistical analysis manager that determines absolute or relative expression values based, at least in part, on a statistical measure of the emission intensity data and at least one user-selectable statistical parameter. The analysis manager may also determine genotype calls for one or more probes based, at least in part, on the emission intensity data. The analysis manager may further display the absolute or relative expression values based, at least in part, on at least one user-selectable display parameter and/or a measure of normalized change between genotype calls. The measure of normalized change may be based, at least in part, on a comparison of genotype calls and a reference value.

4. 发明申请

US20060222647A1 Methods and compositions for modulating the activity of PDE5 审中-公开
标题翻译：调节PDE5活性的方法和组合物
公开(公告)号：US20060222647A1
公开(公告)日：2006-10-05
申请号：US10352534
申请日：2003-01-28
申请人： Joseph Beavo , Jackie Corbin , Kenneth Ferguson , Sharron Francis , Ann Kadlecek , Linda McAllister-Lucas , Kate Loughney , William Sonnenburg , Melissa Thomas , Sergei Rybalkin
发明人： Joseph Beavo , Jackie Corbin , Kenneth Ferguson , Sharron Francis , Ann Kadlecek , Linda McAllister-Lucas , Kate Loughney , William Sonnenburg , Melissa Thomas , Sergei Rybalkin
IPC分类号： A61K48/00 , A61K38/54 , A61K39/395
CPC分类号： C12N9/16
摘要： The present invention provides agents such as agonists, antibodies, antagonists or inhibitors to modulate the activity of PDE5 proteins. These compositions and methods are useful for the diagnosis or treatment of conditions associated with the presence, the deficiency, altered levels, or altered activity of PDE5 proteins.
摘要翻译：本发明提供了诸如激动剂，抗体，拮抗剂或调节PDE5蛋白活性的抑制剂的药剂。这些组合物和方法可用于诊断或治疗与PDE5蛋白的存在，缺乏，改变的水平或改变的活性相关的病症。

5. 发明申请

US20060167636A1 System, method, and computer software for the presentation and storage of analysis results 有权
公开(公告)号：US20060167636A1
公开(公告)日：2006-07-27
申请号：US11352008
申请日：2006-02-10
申请人： Shantanu Kaushikkar , Teresa Webster , Rui Mei , Linda McAllister
发明人： Shantanu Kaushikkar , Teresa Webster , Rui Mei , Linda McAllister
IPC分类号： G06F19/00
CPC分类号： G06F19/20 , B01J2219/007 , G01N2035/00158 , G06F19/18 , G06F19/26 , Y10S707/99943
摘要： A computer program product, and related systems and methods, are described that processes emission intensity data corresponding to probes of a biological probe array. The computer program includes a genotype and statistical analysis manager that determines absolute or relative expression values based, at least in part, on a statistical measure of the emission intensity data and at least one user-selectable statistical parameter. The analysis manager may also determine genotype calls for one or more probes based, at least in part, on the emission intensity data. The analysis manager may further display the absolute or relative expression values based, at least in part, on at least one user-selectable display parameter and/or a measure of normalized change between genotype calls. The measure of normalized change may be based, at least in part, on a comparison of genotype calls and a reference value.

6. 发明申请

US20110246085A1 System, method, and computer software for the presentation and storage of analysis results 有权
标题翻译：系统，方法和计算机软件，用于演示和存储分析结果
公开(公告)号：US20110246085A1
公开(公告)日：2011-10-06
申请号：US13161150
申请日：2011-06-15
申请人： Shantanu Kaushikkar , Teresa Webster , Rui Mei , Linda McAllister
发明人： Shantanu Kaushikkar , Teresa Webster , Rui Mei , Linda McAllister
IPC分类号： G06F19/00
CPC分类号： G06F19/20 , B01J2219/007 , G01N2035/00158 , G06F19/18 , G06F19/26 , Y10S707/99943
摘要： A computer program product, and related systems and methods, are described that processes emission intensity data corresponding to probes of a biological probe array. The computer program includes a genotype and statistical analysis manager that determines absolute or relative expression values based, at least in part, on a statistical measure of the emission intensity data and at least one user-selectable statistical parameter. The analysis manager may also determine genotype calls for one or more probes based, at least in part, on the emission intensity data. The analysis manager may further display the absolute or relative expression values based, at least in part, on at least one user-selectable display parameter and/or a measure of normalized change between genotype calls. The measure of normalized change may be based, at least in part, on a comparison of genotype calls and a reference value.
摘要翻译：描述了计算机程序产品以及相关系统和方法，其处理对应于生物探针阵列的探针的发射强度数据。所述计算机程序包括基因型和统计分析管理器，所述基因型和统计分析管理器至少部分地基于所述发射强度数据和至少一个用户可选择的统计参数的统计测量来确定绝对或相对表达值。至少部分地基于发射强度数据，分析管理器还可以确定对一个或多个探针的基因型呼叫。至少部分地基于至少一个用户可选显示参数和/或基因型呼叫之间的归一化变化的量度，分析管理器可进一步显示绝对或相对表达值。归一化变化的度量可以至少部分地基于基因型呼叫和参考值的比较。

7. 发明申请

US20090280504A1 NS1-NP Diagnostics of Influenza Virus Infection 有权
标题翻译： NS1-NP流感病毒感染诊断
公开(公告)号：US20090280504A1
公开(公告)日：2009-11-12
申请号：US12405150
申请日：2009-03-16
申请人： PETER S. LU , MICHAEL P. BELMARES , CAROL TAN , LINDA MCALLISTER
发明人： PETER S. LU , MICHAEL P. BELMARES , CAROL TAN , LINDA MCALLISTER
IPC分类号： G01N33/53 , C12Q1/02
CPC分类号： G01N33/56983 , C12Q1/701 , G01N2333/11
摘要： The present application describes methods for assessing influenza infection, including prognosis. An assay that determines the amount of the NS1 and NP proteins of influenza virus shows enhanced sensitivity and reliability compared to either antigen alone. Many formats employ pan-specific antibodies (i.e., that react with all or at least with multiple strains within an influenza type).
摘要翻译：本申请描述了用于评估流感感染的方法，包括预后。与单独的抗原相比，确定流感病毒的NS1和NP蛋白的量的测定显示增强的灵敏度和可靠性。许多形式使用泛特异性抗体（即，与全部或至少与流感类型内的多种菌株反应）。

8. 发明授权

US07031846B2 Method, system, and computer software for the presentation and storage of analysis results 有权
公开(公告)号：US07031846B2
公开(公告)日：2006-04-18
申请号：US10219882
申请日：2002-08-15
申请人： Shantanu Kaushikkar , Teresa Webster , Rui Mei , Linda McAllister
发明人： Shantanu Kaushikkar , Teresa Webster , Rui Mei , Linda McAllister
IPC分类号： G01N33/48 , C12Q1/68 , G06F7/00
CPC分类号： G06F19/20 , B01J2219/007 , G01N2035/00158 , G06F19/18 , G06F19/26 , Y10S707/99943
摘要： A computer program product, and related systems and methods, are described that processes emission intensity data corresponding to probes of a biological probe array. The computer program includes a genotype and statistical analysis manager that determines absolute or relative expression values based, at least in part, on a statistical measure of the emission intensity data and at least one user-selectable statistical parameter. The analysis manager may also determine genotype calls for one or more probes based, at least in part, on the emission intensity data, The analysis manager may further display the absolute or relative expression values based, at least in part, on at least one user-selectable display parameter and/or a measure of normalized change between genotype calls. The measure of normalized change may be based, at least in part, on a comparison of genotype calls and a reference value.

9. 发明授权

US08163474B2 NS1-NP diagnostics of influenza virus infection 有权
标题翻译： NS1-NP诊断流感病毒感染
公开(公告)号：US08163474B2
公开(公告)日：2012-04-24
申请号：US12405150
申请日：2009-03-16
申请人： Peter S. Lu , Michael P. Belmares , Carol Tan , Linda McAllister
发明人： Peter S. Lu , Michael P. Belmares , Carol Tan , Linda McAllister
IPC分类号： C12Q1/70 , G01N33/53 , A61K39/1451
CPC分类号： G01N33/56983 , C12Q1/701 , G01N2333/11
摘要： The present application describes methods for assessing influenza infection, including prognosis. An assay that determines the amount of the NS1 and NP proteins of influenza virus shows enhanced sensitivity and reliability compared to either antigen alone. Many formats employ pan-specific antibodies (i.e., that react with all or at least with multiple strains within an influenza type).
摘要翻译：本申请描述了用于评估流感感染的方法，包括预后。与单独的抗原相比，确定流感病毒的NS1和NP蛋白的量的测定显示增强的灵敏度和可靠性。许多形式使用泛特异性抗体（即，与全部或至少与流感类型内的多种菌株反应）。

10. 发明申请

US20060216809A1 cGMP-binding, cGMP-specific phosphodiesterase materials and methods 审中-公开
标题翻译： cGMP结合，cGMP特异性磷酸二酯酶材料和方法
公开(公告)号：US20060216809A1
公开(公告)日：2006-09-28
申请号：US11315036
申请日：2005-12-21
申请人： Joseph Beavo , Jackie Corbin , Kenneth Ferguson , Sharron Francis , Ann Kadlecek , Kate Loughney , Linda McAllister-Lucas , William Sonnenburg , Melissa Thomas
发明人： Joseph Beavo , Jackie Corbin , Kenneth Ferguson , Sharron Francis , Ann Kadlecek , Kate Loughney , Linda McAllister-Lucas , William Sonnenburg , Melissa Thomas
IPC分类号： C12N9/16 , C07H21/04 , C12P21/06
CPC分类号： C12N9/16
摘要： The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
摘要翻译：本发明提供编码cGMP结合，命名为cGB-PDE的cGMP特异性磷酸二酯酶的新型纯化和分离的核苷酸序列。本发明还提供了用于重组生产cGB-PDE多肽产物的方法和材料以及用于鉴定调节cGB-PDE多肽的酶活性的化合物的方法。

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