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1. 发明授权

US08649585B2 Method and system for retrospective image combination under minimal total deformation constrain for free-breathing cardiac magnetic resonance imaging with motion correction 有权
标题翻译：用于自动呼吸心脏磁共振成像运动修正的最小总变形约束下回顾性图像组合的方法和系统
公开(公告)号：US08649585B2
公开(公告)日：2014-02-11
申请号：US13295416
申请日：2011-11-14
申请人： Hui Xue , Saurabh Shah , Christoph Guetter , Marie-Pierre Jolly , Sven Zuehlsdorff , Jens Guehring
发明人： Hui Xue , Saurabh Shah , Christoph Guetter , Marie-Pierre Jolly , Sven Zuehlsdorff , Jens Guehring
IPC分类号： G06K9/00
CPC分类号： G06T5/50 , G06T5/002 , G06T2207/10016 , G06T2207/10088 , G06T2207/20221 , G06T2207/30048
摘要： A method and system for retrospective image combination for free-breathing magnetic resonance (MR) images is disclose. A free-breathing cardiac MR image acquisition including a plurality of frames is received. A key frame is selected of the plurality of frames. A deformation field for each frame to register each frame with the key frame. A weight is determined for each pixel in each frame based on the deformation field for each frame under a minimum total deformation constraint. A combination image is then generated as a weighted average of the frames using the weight determined for each pixel in each frame.
摘要翻译：公开了用于自由呼吸磁共振（MR）图像的回顾性图像组合的方法和系统。接收包括多个帧的自由呼吸心脏MR图像采集。选择多个帧中的关键帧。每个帧的变形场用关键帧来记录每个帧。基于每个帧在最小总变形约束下的变形场，为每个帧中的每个像素确定权重。然后，使用为每个帧中的每个像素确定的权重，生成组合图像作为帧的加权平均。

2. 发明申请

US20130259337A1 Cardiac Chamber Volume Computation from Contours and Base Plane in Cardiac MR Cine Images 有权
标题翻译：心脏MR电影图像中的轮廓和基础平面的心室容量计算
公开(公告)号：US20130259337A1
公开(公告)日：2013-10-03
申请号：US13246002
申请日：2011-09-27
申请人： Jens Gühring , Marie-Pierre Jolly , Christoph Guetter , Xiaoguang Lu , Carmel Hayes , Peter Speier , Davide Piccini
发明人： Jens Gühring , Marie-Pierre Jolly , Christoph Guetter , Xiaoguang Lu , Carmel Hayes , Peter Speier , Davide Piccini
IPC分类号： G06T7/60 , G06T7/00
CPC分类号： G06T7/602 , G06T7/0012 , G06T7/62 , G06T2200/04 , G06T2207/10076 , G06T2207/30048
摘要： A system receives cardiac cine MR images consists of multiple slices of the heart over time. A series of short axis images slices are received. Long axis images are also received by the system, wherein a base plane defined by landmark points is detected. An intersection of the base plane with a contour of a heart chamber is determined for a plurality of slices in the short axis image. A volume for each of the contour slices covering the heart chamber, including for contours that are limited by base plane intersections, is evaluated. All slice volumes are summed to determine a total volume of the chamber. In one embodiment the chamber is a left ventricle and the landmark is a mitral valve. An ejection factor is determined.
摘要翻译：一个系统接收心脏电影MR图像由心脏的多个切片随时间组成。接收一系列短轴图像切片。长轴图像也由系统接收，其中检测由地标点定义的基本平面。针对短轴图像中的多个切片确定基面与心室的轮廓的交点。评估覆盖心室的每个轮廓切片的体积，包括对于由基面交点进行限制的轮廓。将所有切片体积相加以确定腔室的总体积。在一个实施例中，腔室是左心室，并且地标是二尖瓣。确定射血因子。

3. 发明授权

US08358822B2 Automatic determination of field of view in cardiac MRI 有权
标题翻译：自动确定心脏MRI中的视野
公开(公告)号：US08358822B2
公开(公告)日：2013-01-22
申请号：US12393236
申请日：2009-02-26
申请人： Ying Sun , Jens Gühring , Peter Speier , Michaela Schmidt , Jordin D. Green , Christine H. Lorenz , Marie-Pierre Jolly
发明人： Ying Sun , Jens Gühring , Peter Speier , Michaela Schmidt , Jordin D. Green , Christine H. Lorenz , Marie-Pierre Jolly
IPC分类号： G06K9/00
CPC分类号： A61B5/055
摘要： A method for automatically determining a field of view for performing a subsequent medical imaging study includes acquiring one or more preliminary images. A body mask is generated by thresholding the preliminary images and identifying a largest connected component. A boundary mask is obtained from the boundary of the generated body mask. A rectangular bounding box is fit to the obtained boundary mask. The rectangular bounding box is used as a field of view for performing a subsequent medical imaging study.
摘要翻译：用于自动确定用于执行后续医学成像研究的视野的方法包括获取一个或多个预备图像。通过对初步图像进行阈值处理并识别最大的连接分量来生成身体掩模。从生成的身体掩模的边界获得边界掩模。矩形边框适合所获得的边界掩模。矩形边界盒用作进行后续医学成像研究的视野。

4. 发明申请

US20120235679A1 MOTION COMPENSATED MAGNETIC RESONANCE RECONSTRUCTION IN REAL-TIME IMAGING 有权
标题翻译：运动补偿磁共振重建实时成像
公开(公告)号：US20120235679A1
公开(公告)日：2012-09-20
申请号：US13413812
申请日：2012-03-07
申请人： Hui Xue , Christoph Guetter , Yu Ding , Marie-Pierre Jolly , Orlando P. Simonetti , Jens Guehring , Sven Zuehlsdorff , Arne Littmann
发明人： Hui Xue , Christoph Guetter , Yu Ding , Marie-Pierre Jolly , Orlando P. Simonetti , Jens Guehring , Sven Zuehlsdorff , Arne Littmann
IPC分类号： G01R33/44
CPC分类号： G01R33/56509 , G01R33/5611 , G01R33/56325
摘要： Magnetic resonance reconstruction includes motion compensation. Inverse-consistent non-rigid registration is used to determine motion between shots. The motion is incorporated into reconstruction. The incorporation compensates for the motion resulting from the period over which the MR data is acquired.
摘要翻译：磁共振重建包括运动补偿。反向一致的非刚性配准用于确定镜头之间的运动。动议被纳入重建。该并入补偿了获取MR数据的期间产生的运动。

5. 发明申请

US20120189183A1 Automatic Registration of Image Series with Varying Contrast Based on Synthetic Images Derived from Intensity Behavior Model 有权
标题翻译：基于强度行为模型合成图像的图像系列自动对准
公开(公告)号：US20120189183A1
公开(公告)日：2012-07-26
申请号：US13237198
申请日：2011-09-20
申请人： Hui Xue , Saurabh Shah , Jens Gühring , Andreas Greiser , Christophe Chefd'hotel , Christoph Guetter , Marie-Pierre Jolly , Sven Zuehlsdorff
发明人： Hui Xue , Saurabh Shah , Jens Gühring , Andreas Greiser , Christophe Chefd'hotel , Christoph Guetter , Marie-Pierre Jolly , Sven Zuehlsdorff
IPC分类号： G06K9/40 , G06K9/00
CPC分类号： G06T5/50 , G01R33/448 , G01R33/56509 , G06T7/30 , G06T2207/10088 , G06T2207/20201 , G06T2207/30048
摘要： A method for performing motion compensation in a series of magnetic resonance (MR) images includes acquiring a set of MR image frames spanning different points along an MR recovery curve. A motion-free synthetic image is generated for each of the acquired MR image frames using prior knowledge pertaining to an MR recovery curve. Each of the acquired MR images is registered to its corresponding generated synthetic images. Motion within each of the acquired MR image is corrected based on its corresponding generated synthetic image that has been registered thereto.
摘要翻译：用于在一系列磁共振（MR）图像中执行运动补偿的方法包括获取沿着MR恢复曲线横跨不同点的一组MR图像帧。使用与MR恢复曲线相关的先前知识，为每个所获取的MR图像帧生成无运动合成图像。所获取的MR图像中的每一个被注册到其对应的生成的合成图像。基于其对应的生成的已经被注册的合成图像来校正所获取的MR图像的每一个内的运动。

6. 发明申请

US20120177269A1 Detection of Landmarks and Key-frames in Cardiac Perfusion MRI Using a Joint Spatial-Temporal Context Model 有权
标题翻译：使用联合空间时空背景模型检测心脏灌注MRI中的地标和关键帧
公开(公告)号：US20120177269A1
公开(公告)日：2012-07-12
申请号：US13234694
申请日：2011-09-16
申请人： Xiaoguang Lu , Jens Gühring , Hui Xue , Marie-Pierre Jolly , Christoph Guetter , Bogdan Georgescu , Sven Zuehlsdorff , Arne Littmann
发明人： Xiaoguang Lu , Jens Gühring , Hui Xue , Marie-Pierre Jolly , Christoph Guetter , Bogdan Georgescu , Sven Zuehlsdorff , Arne Littmann
IPC分类号： G06K9/00
CPC分类号： G06K9/4609 , G06K2209/051 , G06T7/11 , G06T7/143 , G06T7/194 , G06T2207/10088 , G06T2207/20164 , G06T2207/30048
摘要： A method including receiving an image sequence, wherein the image sequence includes a plurality of two-dimensional (2D) image frames of an organ arranged in a time sequence; constructing a three-dimensional (3D) volume by stacking a plurality of the 2D image frames in time order; detecting a best bounding box for a target of interest in the 3D volume, wherein the best bounding box is specified by a plurality of parameters including spatial and temporal information contained in the 3D volume; and determining the target of interest from the best bounding box.
摘要翻译：一种包括接收图像序列的方法，其中所述图像序列包括以时间顺序排列的器官的多个二维（2D）图像帧; 通过以时间顺序堆叠多个2D图像帧来构造三维（3D）体积; 检测所述3D体积中感兴趣的目标的最佳边界框，其中所述最佳边界框由包括在所述3D体积中的空间和时间信息的多个参数指定; 并从最佳边界框确定感兴趣的目标。

7. 发明申请

US20120076380A1 SYSTEM AND METHOD FOR BACKGROUND PHASE CORRECTION FOR PHASE CONTRAST FLOW IMAGES 有权
标题翻译：用于相位对比流图像的相位校正的系统和方法
公开(公告)号：US20120076380A1
公开(公告)日：2012-03-29
申请号：US13210497
申请日：2011-08-16
申请人： Jens Gühring , Marie-Pierre Jolly , Hui Xue
发明人： Jens Gühring , Marie-Pierre Jolly , Hui Xue
IPC分类号： G06K9/00
CPC分类号： G01R33/56316 , A61B5/0263 , A61B5/055 , G01R33/5608
摘要： A method for correcting the background phase in magnetic resonance phase contrast flow images includes providing a time series of velocity encoded magnetic resonance images of a patient, where the time series of velocity encoded images comprises for each time point a phase contrast image where a pixel intensity is proportional to a flow velocity, measuring a change of intensity for each pixel over the time series of phase contrast images, identifying pixels with a low measure of temporal change as stationary pixels, and calculating a correction field for the stationary pixels, where the correction field represents a background phase to be subtracted from the phase contrast image.
摘要翻译：用于校正磁共振相位对比流图像中的背景相位的方法包括提供患者的速度编码的磁共振图像的时间序列，其中速度编码图像的时间序列包括每个时间点的像素强度与流速成比例，测量在相位对比图像的时间序列上的每个像素的强度变化，将以时间变化的低度量度的像素识别为静止像素，以及计算用于静止像素的校正场，其中校正场表示从相位差图像中减去的背景相位。

8. 发明授权

US08131076B2 Editing of pre-segmented images using seeds derived from contours 有权
标题翻译：使用源自轮廓的种子编辑预分割图像
公开(公告)号：US08131076B2
公开(公告)日：2012-03-06
申请号：US12031966
申请日：2008-02-15
申请人： Marie-Pierre Jolly , Leo Grady
发明人： Marie-Pierre Jolly , Leo Grady
IPC分类号： G06K9/34
CPC分类号： G06K9/342
摘要： A method for processing an object in image data includes the steps of drawing a contour on a pre-segmentation of an object in image data, generating at least one seed point on the pre-segmentation from an intersection of the contour and the pre-segmentation, providing a weighting factor between the seed points and the pre-segmentation, and segmenting the pre-segmentation using the seed points and the weighting factor to generate a new pre-segmentation.
摘要翻译：一种用于处理图像数据中的对象的方法包括以下步骤：对图像数据中的对象的预分割绘制轮廓，从轮廓和预分割的交点产生预分割上的至少一个种子点提供种子点和预分割之间的加权因子，以及使用种子点和加权因子分割预分割以产生新的预分割。

9. 发明授权

US07734075B2 Contrast-invariant registration of cardiac and renal magnetic resonance perfusion images 有权
标题翻译：心脏和肾脏磁共振灌注图像的对比不变记录
公开(公告)号：US07734075B2
公开(公告)日：2010-06-08
申请号：US11078035
申请日：2005-03-11
申请人： Ying Sun , Marie-Pierre Jolly , Jose M. F. Moura
发明人： Ying Sun , Marie-Pierre Jolly , Jose M. F. Moura
IPC分类号： G06K9/00 , A61B5/05
CPC分类号： A61B5/055
摘要： A system and method are provided for contrast-invariant registration of images, the system including a processor, an imaging adapter or a communications adapter for receiving an image data sequence, a user interface adapter for selecting a reference frame from the image sequence or cropping a region of interest (ROI) from the reference frame, a tracking unit for tracking the ROI across the image sequence, and an estimation unit for segmenting the ROI in the reference frame or performing an affine registration for the ROI; and the method including receiving an image sequence, selecting a reference frame from the image sequence, cropping a region of interest (ROI) from the reference frame, tracking the ROI across the image sequence, segmenting the ROI in the reference frame, and performing an affine registration for the ROI.
摘要翻译：提供了用于对比度不变的图像配准的系统和方法，所述系统包括处理器，成像适配器或用于接收图像数据序列的通信适配器，用于从图像序列中选择参考帧的用户接口适配器或裁剪来自参考帧的感兴趣区域（ROI），用于跟踪跨越图像序列的ROI的跟踪单元，以及用于在参考帧中分割ROI或对ROI执行仿射注册的估计单元; 并且所述方法包括接收图像序列，从所述图像序列中选择参考帧，从所述参考帧裁剪感兴趣区域（ROI），沿所述图像序列跟踪所述ROI，在所述参考帧中分割所述ROI，以及执行 ROI的仿射注册。

10. 发明申请

US20100121175A1 Automatic Femur Segmentation And Condyle Line Detection in 3D MR Scans For Alignment Of High Resolution MR 有权
标题翻译： 3D MR扫描中自动股骨分割和髁线检测用于高分辨率MR的对准
公开(公告)号：US20100121175A1
公开(公告)日：2010-05-13
申请号：US12426323
申请日：2009-04-20
申请人： Marie-Pierre Jolly , Christopher V. Alvino , Benjamin L. Odry , Jens Gühring
发明人： Marie-Pierre Jolly , Christopher V. Alvino , Benjamin L. Odry , Jens Gühring
IPC分类号： A61B5/05
CPC分类号： A61B5/055 , A61B5/4514 , A61B5/4528 , A61B6/466 , A61B6/5223 , G01R33/543 , G01R33/546 , G01R33/5608 , G06T7/12 , G06T7/143 , G06T2207/10088 , G06T2207/20076 , G06T2207/20081 , G06T2207/20084 , G06T2207/30008
摘要： A method for automatic femur segmentation and condyle line detection. The method includes: scanning a knee of a patient with medical imaging equipment to obtain 3D imaging data with such equipment; processing the obtained 3D imaging data in a digital processor to determine two lines tangent to the bottom of the knee condyles in an axial and a coronal plane; and automatically scanning the patient in the defined plane. The processing includes: determining an approximate location of the knee; using the determined the location to define a volume of interest; segmenting the femur in the defined volume of interest; and determining a bottom point on the femur portion on a right side and a left side of the segmented femur in an axial and a coronal slice to determine the two lines.
摘要翻译：一种自动股骨段分割和髁线检测的方法。该方法包括：使用医学成像设备扫描患者的膝盖，以使用这种设备获得3D成像数据; 在数字处理器中处理获得的3D成像数据以确定在轴向和冠状平面中与膝盖底部相切的两条线; 并在定义的平面中自动扫描患者。该处理包括：确定膝盖的大致位置; 使用确定的位置来定义感兴趣的体积; 在定义的感兴趣体积中分割股骨; 并且在轴向和冠状切片中确定分割股骨的右侧和左侧的股骨部分上的底点以确定两条线。

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