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1. 发明授权

US08445528B2 Dendrimer conjugates 有权
公开(公告)号：US08445528B2
公开(公告)日：2013-05-21
申请号：US13547929
申请日：2012-07-12
申请人： James R. Baker, Jr. , Xue-min Cheng , Thommey P. Thomas , Baohua Mark Huang
发明人： James R. Baker, Jr. , Xue-min Cheng , Thommey P. Thomas , Baohua Mark Huang
IPC分类号： A61K31/403 , A61K31/485 , C07D209/12 , C07D471/04
CPC分类号： C07D305/08
摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.

2. 发明授权

US08396839B1 Representing de-duplicated file data 有权
标题翻译：表示取消复制的文件数据
公开(公告)号：US08396839B1
公开(公告)日：2013-03-12
申请号：US12803393
申请日：2010-06-25
申请人： Mark Huang
发明人： Mark Huang
IPC分类号： G06F17/30
CPC分类号： G06F17/30156
摘要： A subset of de-duplicated is outputted. In some embodiments, the output includes a subset of data stored in de-duplicated form in a plurality of containers each including a plurality of data segments comprising the data. For each container that includes one or more data segments comprising the subset, a corresponding container data is included in the output. Each container may include one or more segments not included in the subset. For each container the corresponding container data of which is included in the output, a corresponding value in a data structure including for each container stored on the de-duplicated storage system a data value indicating whether or not the corresponding container data has been included in the output is updated.
摘要翻译：输出一个去重复的子集。在一些实施例中，输出包括在多个容器中以重复形式存储的数据子集，每个容器包括包括数据的多个数据段。对于包括包括该子集的一个或多个数据段的每个容器，相应的容器数据被包括在输出中。每个容器可以包括不包括在子集中的一个或多个段。对于包含在输出中的对应的容器数据的每个容器，在数据结构中包括对存储在去重复存储系统上的每个容器的相应值，指示对应的容器数据是否已被包括在数据结构中的数据值输出更新。

3. 发明授权

US08252834B2 Dendrimer conjugates 有权
标题翻译：树枝状结合物
公开(公告)号：US08252834B2
公开(公告)日：2012-08-28
申请号：US12403179
申请日：2009-03-12
申请人： James R. Baker, Jr. , Xue-min Cheng , Thommey P. Thomas , Baohua Mark Huang
发明人： James R. Baker, Jr. , Xue-min Cheng , Thommey P. Thomas , Baohua Mark Huang
IPC分类号： A61K31/403 , A61K31/485 , C07D209/12 , C07D471/04
CPC分类号： C07D305/08
摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.
摘要翻译：本发明涉及新的治疗和诊断树枝状大分子。特别地，本发明涉及树枝状大分子 - 连接体缀合物，其合成方法，包含缀合物的组合物，以及利用缀合物的系统和方法（例如，在诊断和/或治疗设置（例如，用于递送治疗，成像和/或靶向剂（例如，在疾病（例如癌症）诊断和/或治疗，疼痛治疗等中））。因此，本发明的树枝状大分子 - 接头缀合物还可包含一种或多种用于靶向，成像，感测和/或提供治疗或诊断材料和/或监测治疗反应的组分。

4. 发明申请

US20100125553A1 Delta compression after identity deduplication 有权
标题翻译：身份重复数据删除后的增量压缩
公开(公告)号：US20100125553A1
公开(公告)日：2010-05-20
申请号：US12291998
申请日：2008-11-14
申请人： Mark Huang , Edward K. Lee , Kai Li , Philip Shilane , Grant Wallace , Ming Benjamin Zhu
发明人： Mark Huang , Edward K. Lee , Kai Li , Philip Shilane , Grant Wallace , Ming Benjamin Zhu
IPC分类号： G06F17/30
CPC分类号： G06F11/1453 , G06F11/1464 , H03M7/30 , H03M7/3091
摘要： Delta compression after identity deduplication is disclosed. A first data segment is determined to be identical to a first previous data segment. A second data segment, not determined to be identical to a second previous data segment, is then determined to be similar to a third previous data segment.
摘要翻译：披露了身份重复数据删除后的增量压缩。第一数据段被确定为与先前的第一数据段相同。然后确定未被确定为与第二先前数据段相同的第二数据段以类似于第三先前数据段。

5. 发明申请

US20090287005A1 DENDRIMER CONJUGATES 有权
标题翻译： DENDRIMER联合
公开(公告)号：US20090287005A1
公开(公告)日：2009-11-19
申请号：US12403179
申请日：2009-03-12
申请人： James R. Baker, JR. , Xue-min Cheng , Thommey P. Thomas , Baohua Mark Huang
发明人： James R. Baker, JR. , Xue-min Cheng , Thommey P. Thomas , Baohua Mark Huang
IPC分类号： C07D305/08
CPC分类号： C07D305/08
摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.
摘要翻译：本发明涉及新的治疗和诊断树枝状大分子。特别地，本发明涉及树枝状大分子 - 连接体缀合物，其合成方法，包含缀合物的组合物，以及利用缀合物的系统和方法（例如，在诊断和/或治疗设置（例如，用于递送治疗，成像和/或靶向剂（例如，在疾病（例如癌症）诊断和/或治疗，疼痛治疗等中））。因此，本发明的树枝状大分子 - 接头缀合物还可包含一种或多种用于靶向，成像，感测和/或提供治疗或诊断材料和/或监测治疗反应的组分。

6. 发明申请

US20080103462A1 WOUND HEALING PATCH WITH INTEGRAL PASSIVE VACUUM AND ELECTROSTIMULATION 审中-公开
标题翻译：具有整体被动真空和电沉积的创伤治疗贴
公开(公告)号：US20080103462A1
公开(公告)日：2008-05-01
申请号：US11876175
申请日：2007-10-22
申请人： Stuart Wenzel , Mariam Maghribi , Mark Huang , Zara Sieh , Michael V. Williamson
发明人： Stuart Wenzel , Mariam Maghribi , Mark Huang , Zara Sieh , Michael V. Williamson
IPC分类号： A61M35/00
CPC分类号： A61M27/00 , A61F13/023 , A61F2013/00174 , A61F2013/00187 , A61F2013/0028 , A61F2013/0054 , A61F2013/00902 , A61F2013/00919 , A61F2013/00931 , A61M1/0003 , A61M1/0011 , A61M1/0088 , A61N1/205
摘要： In one example, the present invention is directed to wound-healing patche that passively or actively draw fluids from a wound using an internal, integral vacuum source. The patches may also include electrodes and electronics for electrostimulation, and bioactive compounds that promote healing, such as anti-inflammatory agents.
摘要翻译：在一个实例中，本发明涉及伤口愈合贴片，其被动地或主动地使用内部的整体式真空源从伤口吸取流体。贴剂还可以包括用于电刺激的电极和电子元件，以及促进愈合的生物活性化合物，例如抗炎剂。

7. 发明授权

US09026505B1 Storing differences between precompressed and recompressed data files 有权
标题翻译：存储预压缩和重新压缩的数据文件之间的差异
公开(公告)号：US09026505B1
公开(公告)日：2015-05-05
申请号：US13329072
申请日：2011-12-16
申请人： Mark Huang
发明人： Mark Huang
IPC分类号： G06F7/02 , G06F17/30
CPC分类号： G06F17/30153 , G06F17/30106 , G06F17/3015 , G06F17/30156 , G06F17/30162
摘要： A system comprises a processor and a memory. The processor is configured to decompress a precompressed file; recompress the decompressed file; and determine a difference file. The memory is coupled to the processor and configured to provide the processor with instructions.
摘要翻译：系统包括处理器和存储器。处理器被配置为解压缩预压缩的文件; 重新压缩解压文件; 并确定差异文件。存储器耦合到处理器并且被配置为向处理器提供指令。

8. 发明授权

US08972678B2 Efficient backup replication 有权
标题翻译：高效备份复制
公开(公告)号：US08972678B2
公开(公告)日：2015-03-03
申请号：US13332474
申请日：2011-12-21
申请人： Mark Huang
发明人： Mark Huang
IPC分类号： G06F12/16
CPC分类号： G06F11/1435 , G06F11/1451 , G06F11/1453 , G06F11/1456 , G06F11/1464 , G06F11/202 , G06F11/2094 , G06F2201/83 , G06F2201/84
摘要： A system for backup replication comprises a processor and a memory. The processor is configured to determine data present in a most recent backup not present in a previous backup; transmit an extent specification; and transmit data segment fingerprints of the one or more data segments. The memory is coupled to the processor and is configured to provide the processor with instructions.
摘要翻译：用于备份复制的系统包括处理器和存储器。处理器被配置为确定存在于先前备份中不存在的最新备份中的数据; 传输范围规范; 并发送一个或多个数据段的数据段指纹。存储器耦合到处理器并且被配置为向处理器提供指令。

9. 发明授权

US08535806B2 Medical device having bonding regions and method of making the same 有权
标题翻译：具有接合区域的医疗器械及其制造方法
公开(公告)号：US08535806B2
公开(公告)日：2013-09-17
申请号：US12888091
申请日：2010-09-22
申请人： I Mark Huang , Michael V. Williamson
发明人： I Mark Huang , Michael V. Williamson
IPC分类号： B32B9/04 , B32B27/00 , B32B15/04 , B32B15/00 , B32B9/00
CPC分类号： B32B9/04 , C04B37/00 , C09J5/02 , C09J5/06 , C09J2400/166 , Y10T156/10 , Y10T428/12979 , Y10T428/31504 , Y10T428/31544 , Y10T428/31678
摘要： Medical devices having bonded joints are disclosed. The bonded joints include two surfaces bonded by a layer of phenoxy resin therebetween. In the preferred embodiments, bonded surfaces include materials that are suitable for medical devices. Most preferably, Nitinol includes at least one bonded surface, however, other preferred materials may include, but are not limited to cobalt chromium, stainless steel, titanium, tantalum, and plastic. An intraluminal device including a plurality of locations with a phenoxy resin layer is also disclosed wherein the phenoxy resin further includes a radioopaque additive, a lubricious additive, or both radioopaque and lubricious additives. Also disclosed is an intraluminal device having contiguous heterogeneous structural elements of metallic members and non-metallic sections that are bonded together by a layer of phenoxy resin therebetween.
摘要翻译：公开了具有接合接头的医疗器械。接合接头包括两层，它们之间通过一层苯氧树脂结合。在优选实施例中，接合表面包括适合于医疗装置的材料。最优选地，镍钛诺包括至少一个键合表面，然而，其它优选的材料可以包括但不限于钴铬，不锈钢，钛，钽和塑料。还公开了一种包括具有苯氧基树脂层的多个位置的管腔内装置，其中所述苯氧基树脂还包括不透射线添加剂，润滑添加剂或放射性不透明和润滑添加剂两者。还公开了一种具有金属构件和非金属部分的连续异质结构元件的管腔内装置，其通过其间的一层苯氧基树脂结合在一起。

10. 发明授权

US08447740B1 Stream locality delta compression 有权
公开(公告)号：US08447740B1
公开(公告)日：2013-05-21
申请号：US12291989
申请日：2008-11-14
申请人： Mark Huang , Philip Shilane , Grant Wallace , Nitin Garg , Edward K. Lee , Ming Benjamin Zhu , Kai Li
发明人： Mark Huang , Philip Shilane , Grant Wallace , Nitin Garg , Edward K. Lee , Ming Benjamin Zhu , Kai Li
IPC分类号： G06F17/00
CPC分类号： G06F17/30162 , G06F17/30153 , G06F17/30156 , G06F17/30864
摘要： Stream locality delta compression is disclosed. A previous stream indicated locale of data segments is selected. A first data segment is then determined to be similar to a data segment in the stream indicated locale.

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