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    • 2. 发明授权
    • Small molecular compounds capable of accelerating proliferation of stem cells and use thereof
    • 能够促进干细胞增殖的小分子化合物及其用途
    • US08618145B2
    • 2013-12-31
    • US13320203
    • 2009-05-12
    • Mei HanYan FengYuanyuan Sun
    • Mei HanYan FengYuanyuan Sun
    • A61K31/4245C07D271/113
    • C07D271/07
    • The invention provides small molecule compounds capable of accelerating proliferation of stem cells and uses thereof. The compounds play an important role in the research of stem cell proliferation mechanism. The invention further relates to the uses of the compounds and relevant compounds thereof in the preparation of stem cell proliferation accelerators and the preparation of medicines accelerating stem cell proliferation. The invention also relates to the uses of the compounds in the preparation of medicines for the treatment of various diseases arising from functional cells loss or damage. The diseases arising from stem cell trauma comprise diseases related to the degeneration or damage of nervous system cells, blood system diseases, diseases related to the loss or damage of cardiovascular cells, skin burn and the like.
    • 本发明提供能够促进干细胞增殖的小分子化合物及其用途。 该化合物在干细胞增殖机制研究中起着重要作用。 本发明还涉及化合物及其相关化合物在制备干细胞增殖促进剂中的用途以及加速干细胞增殖的药物的制备。 本发明还涉及该化合物在制备用于治疗由功能性细胞损失或损伤引起的各种疾病的药物中的用途。 由干细胞创伤引起的疾病包括与神经系统细胞的退化或损伤相关的疾病,血液系统疾病,与心血管细胞的损失或损伤有关的疾病,皮肤灼伤等。
    • 3. 发明授权
    • Content-aware video resizing using discontinuous seam carving
    • 使用不连续缝合雕刻的内容感知视频调整大小
    • US07873211B1
    • 2011-01-18
    • US12355484
    • 2009-01-16
    • Matthias GrundmannVivek KwatraMei Han
    • Matthias GrundmannVivek KwatraMei Han
    • G06K9/00G06K15/16
    • G06T3/0012
    • A video is resized while preserving salient regions within the video. The dimensions of the video are reduced by selectively removing unimportant, or less salient, pixels from the video in a manner that diminishes any resulting spatial and temporal artifacts. More specifically, “seams” of pixels are selectively removed from frames of the video, where a “seam” is a horizontal or vertical chain of pixels through a frame. A seam can be selected from among all possible pixels in a row or column, thereby allowing discontinuous seams. Seams are selected using a technique that encourages the seam to pass through less-salient regions of the frame, and that reduces spatial artifacts when the video is played.
    • 调整视频大小,同时保留视频内的显着区域。 通过以减少任何导致的空间和时间假象的方式从视频中选择性地去除不重要或较不显着的像素来减小视频的尺寸。 更具体地,从视频的帧中选择性地移除像素的“接缝”,其中“接缝”是通过帧的水平或垂直的像素链。 可以从行或列中的所有可能像素中选择接缝,从而允许不连续的接缝。 使用鼓励接缝穿过框架的较不显着的区域的技术来选择接缝,并且当播放视频时减少空间伪影。
    • 4. 发明授权
    • Method for fast measurement of the saturation and the resistivity of a porous medium
    • 用于快速测量多孔介质的饱和度和电阻率的方法
    • US07642774B2
    • 2010-01-05
    • US12204932
    • 2008-09-05
    • Marc FleuryMei Han
    • Marc FleuryMei Han
    • G01V3/00
    • G01N33/241G01N27/041G01V3/14
    • A method for measuring the conducting fluid saturation and the resistivity of a porous medium have application to development of underground geological formations. A solid sample is extracted from the medium and placed in a centrifugation cell, beside a second sample for limiting the capillary end effect in the first sample. The two samples are partly desaturated by subjecting them to centrifugation. The resistivity of the sample is measured by placing it in a radial-electrode resistivity measurement cell. The saturation of the sample is then determined by measuring its nuclear magnetization by means of an NMR device. Repeating this procedure for different centrifugation velocities provides resistivity and saturation pairs allowing a relationship between saturation and resistivity to be estimated.
    • 用于测量导电流体饱和度和多孔介质电阻率的方法可用于开发地下地质构造。 将固体样品从培养基中提取并置于离心细胞中,除了第二个样品外,用于限制第一个样品中的毛细血管末端作用。 两个样品通过使其离心而部分去饱和。 通过将样品放置在径向电极电阻率测量单元中来测量样品的电阻率。 然后通过NMR装置测量其核磁化强度来确定样品的饱和度。 对于不同的离心速度重复此过程提供电阻率和饱和度对,可以估计饱和度和电阻率之间的关系。
    • 5. 发明申请
    • METHOD OF EXPANDING DOUBLE NEGATIVE T CELLS
    • 扩展双重负性T细胞的方法
    • US20090098095A1
    • 2009-04-16
    • US12093492
    • 2006-11-20
    • Li ZhangMei HanPouneh Dokouhaki
    • Li ZhangMei HanPouneh Dokouhaki
    • A61K35/12C12N5/06C12N5/08
    • A61K35/17C12N5/0636C12N2501/23C12N2501/2302C12N2501/2304C12N2501/515
    • A method of expanding double negative T cells in culture is described. The method comprises (a) providing a starting sample comprising DN T cells or precursors thereof; (b) substantially depleting CD8+ and CD4+ T cells from the starting sample; (c) culturing the sample from step (b) with an immobilized T cell mitogen in a culture medium comprising an agent that can stimulate DN T cell growth; (d) washing the cells obtained in step (c) and resuspending in a culture medium comprising the agent without the T cell mitogen; and (e) washing the cells obtained in step (d) and resuspending in a culture medium comprising the agent and a soluble T cell mitogen. The DN T cells obtained by the method are useful in a variety of applications including the treatment of cancer, infectious diseases, graft versus host disease and autoimmune disease.
    • 描述了在培养中扩增双重负T细胞的方法。 该方法包括(a)提供包含DN T细胞或其前体的起始样品; (b)从起始样品中大量消耗CD8 +和CD4 + T细胞; (c)在包含可刺激DN T细胞生长的试剂的培养基中培养来自步骤(b)的样品与固定的T细胞丝裂原; (d)洗涤步骤(c)中获得的细胞,并重新悬浮在包含不含T细胞丝裂原的试剂的培养基中; 和(e)洗涤步骤(d)中获得的细胞,并重新悬浮于包含该试剂和可溶性T细胞丝裂原的培养基中。 通过该方法获得的DN T细胞可用于各种应用,包括治疗癌症,感染性疾病,移植物抗宿主病和自身免疫性疾病。
    • 8. 发明申请
    • VIDEO FOREGROUND SEGMENTATION METHOD
    • 视频前缀分割方法
    • US20070116356A1
    • 2007-05-24
    • US11553043
    • 2006-10-26
    • Yihong GONGMei HANWei XU
    • Yihong GONGMei HANWei XU
    • G06K9/34
    • G06K9/38G06T7/12G06T7/181G06T7/194G06T7/215G06T7/277G06T2207/10016H04N7/141
    • A fully automatic, computationally efficient segmentation method of video employing sequential clustering of sparse image features. Both edge and corner features of a video scene are employed to capture an outline of foreground objects and the feature clustering is built on motion models which work on any type of object and moving/static camera in which two motion layers are assumed due to camera and/or foreground and the depth difference between the foreground and background. Sequential linear regression is applied to the sequences and the instantaneous replacements of image features in order to compute affine motion parameters for foreground and background layers and consider temporal smoothness simultaneously. The Foreground layer is then extracted based upon sparse feature clustering which is time efficient and refined incrementally using Kalman filtering.
    • 一种使用稀疏图像特征的顺序聚类的全自动,计算效率高的视频分割方法。 使用视频场景的边缘和角落特征来捕获前景对象的轮廓,并且特征聚类建立在对任何类型的对象和移动/静态相机工作的运动模型上,其中由于相机而假设两个运动层, /或前景和前景和背景之间的深度差。 序列线性回归应用于图像特征的序列和瞬时替换,以便计算前景和背景层的仿射运动参数,同时考虑时间平滑度。 然后基于稀疏特征聚类提取前景层,这是使用卡尔曼滤波进行时间有效和精确地提取的。
    • 10. 发明授权
    • Interactive construction of 3D models from panoramic images employing hard and soft constraint characterization and decomposing techniques
    • 使用硬和软约束表征和分解技术从全景图像中互动构建3D模型
    • US06271855B1
    • 2001-08-07
    • US09099098
    • 1998-06-18
    • Heung-Yeung ShumMei HanRichard S. Szeliski
    • Heung-Yeung ShumMei HanRichard S. Szeliski
    • G06T1510
    • G06T17/00
    • An interactive system and process for constructing a model of a 3D scene from a panoramic view of the scene. In the constructed model, the 3D scene is represented by sets of connected planes. The modeling begins by providing the user with a display of an image of the panoramic view. The user is then required to specify information concerning certain geometric features of the scene. A computer program recovers a camera orientation matrix of the panoramic view based on the features specified by the user. Plane normals and line directions for planes in the 3D scene are estimated using this matrix as well as the user-specified information. A camera translation is also recovered, as are plane distances and vertex point locations for planes in the 3D scene, using the user-supplied information, camera orientation matrix, and the estimated plane normals and line directions. The model of the 3D scene is then constructed based on the plane normal and plane distance, and/or the vertex point locations, of each plane in the set. Preferably, the plane distances and vertex point locations, and optionally the camera translation, are recovered by creating a system of equations based on the geometric constraints of the 3D scene. The constraint equation are characterized as hard is they include a user-designated parameter, otherwise they are considered soft constraints. The systems of equations is solved in a manner which gives priority to hard constraint equations. A decomposing process can also be employed prior to solving the systems of equation to ensure their solvability.
    • 一种用于从场景全景构建3D场景的模型的交互式系统和过程。 在构造的模型中,3D场景由连接平面的集合表示。 该建模开始于向用户提供全景图像的显示。 然后,用户需要指定关于场景的某些几何特征的信息。 计算机程序基于用户指定的特征来恢复全景照相机方向矩阵。 使用该矩阵以及用户指定的信息来估计3D场景中的平面的平面法线和线方向。 还可以使用用户提供的信息,照相机方向矩阵和估计的平面法线和线方向恢复相机平移以及3D场景中的平面的平面距离和顶点位置。 然后基于该组中每个平面的平面法线和平面距离和/或顶点位置来构建3D场景的模型。 优选地,通过基于3D场景的几何约束创建方程式系统来恢复平面距离和顶点位置以及可选地相机平移。 约束方程的特征是硬包括用户指定的参数,否则它们被认为是软约束。 以优先考虑硬约束方程的方式解决方程组。 在解决方程组之前也可以采用分解过程,以确保其可解性。