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1. 发明授权

US08734849B2 Multiparticle pharmaceutical dosage form containing a mucoadhesively formulated peptide or protein active substances method for producing said pharmaceutical dosage form 有权
标题翻译：含有粘膜配制肽或蛋白质活性物质的多粒药物剂型用于生产所述药物剂型
公开(公告)号：US08734849B2
公开(公告)日：2014-05-27
申请号：US10564096
申请日：2004-07-15
申请人： Rosario Lízio , Hans-Ulrich Petereit , Erna Roth , Inès Andres , Michael Damm
发明人： Rosario Lízio , Hans-Ulrich Petereit , Erna Roth , Inès Andres , Michael Damm
IPC分类号： A61K9/14
CPC分类号： A61K9/5026 , A61K9/1629 , A61K9/1652 , A61K9/1676 , A61K9/5078 , A61K38/00
摘要： The invention relates to an oral, multiparticle pharmaceutical dosage form containing pellets, the size of which ranges from 50 to 2500 μm and which essentially consist of: a) an inner matrix layer containing an active substance which is a peptide or a protein, including the derivatives or conjugates thereof, and which is embedded in a matrix consisting of a polymer with mucoadhesive effect, and b) an outer film coating essentially consisting of an anionic polymer or copolymer, which can be optionally formulated with pharmaceutically conventional adjuvants, more particularly softening agents.
摘要翻译：本发明涉及含有丸粒的口服多颗粒药物剂型，其尺寸范围为50-2500μm，其基本上由以下组成：a）含有作为肽或蛋白质的活性物质的内基质层，包括衍生物或共轭物，并且其嵌入由具有粘膜粘附作用的聚合物组成的基质中，以及b）基本上由阴离子聚合物或共聚物组成的外膜包衣，其可以任选地与药学上常规的佐剂配制，更特别的是软化剂。

2. 发明授权

US08694642B2 Selective proxying in domain name systems 有权
标题翻译：域名系统中的选择性代理
公开(公告)号：US08694642B2
公开(公告)日：2014-04-08
申请号：US13279075
申请日：2011-10-21
申请人： Mathew Dempsky , David Ulevitch , Noah Treuhaft , Michael Damm
发明人： Mathew Dempsky , David Ulevitch , Noah Treuhaft , Michael Damm
IPC分类号： G06F15/16 , G06F15/173
CPC分类号： H04L61/1511 , H04L61/6013
摘要： Systems and methods for processing requests for domain name information in accordance with subscriber information are provided. A request for domain name information can be correlated with subscriber preferences to resolve the domain name information. Domain names may be flagged for blocking or proxying by one or more subscriber preferences. In response to a flagged domain name, a client device can be redirected to a web server that can function as proxy on behalf of the user for accessing the flagged domain. In one example, user preferences and/or network preferences can be used to determine whether a particular user can bypass a blocking preference and access the flagged domain using the proxy.
摘要翻译：提供了根据用户信息处理域名信息请求的系统和方法。对域名信息的请求可以与用户偏好相关联，以解决域名信息。可以通过一个或多个订阅者偏好来标记域名以阻止或代理。响应于已标记的域名，可以将客户端设备重定向到可以代表用户作为代理的Web服务器，以访问被标记的域。在一个示例中，可以使用用户偏好和/或网络偏好来确定特定用户是否可以绕过阻止偏好并且使用代理来访问被标记的域。

3. 发明申请

US20130058986A1 SOLID DOSAGE FORMS COMPRISING AN ENTERIC COATING WITH ACCELERATED DRUG RELEASE 审中-公开
标题翻译：固体药剂包含加速药物释放的肠衣
公开(公告)号：US20130058986A1
公开(公告)日：2013-03-07
申请号：US13603984
申请日：2012-09-05
申请人： Fang LIU , Abdul W. Basit , Rosario Lizio , Hans-Ulrich Petereit , Christian Meier , Michael Damm
发明人： Fang LIU , Abdul W. Basit , Rosario Lizio , Hans-Ulrich Petereit , Christian Meier , Michael Damm
IPC分类号： A61K9/00
摘要： The present invention provides a solid dosage form including an inner coating located between a core containing a pharmaceutically active ingredient and an outer enteric coating; wherein the inner coating includes a partially neutralized anionic polymeric material and at least a carboxylic acid having 2 to 16 carbon atoms, the salts thereof, or mixtures of the acid and its salt; wherein the outer coating includes an anionic polymeric material which is less neutralized than the material of the inner coating or not at all neutralized.
摘要翻译：本发明提供了一种固体剂型，其包括位于含有药物活性成分的核心和外部肠溶衣之间的内部涂层; 其中所述内涂层包括部分中和的阴离子聚合物材料和至少一种具有2至16个碳原子的羧酸，其盐，或其酸及其盐的混合物; 其中所述外涂层包括阴离子聚合物材料，所述阴离子聚合物材料比所述内涂层的材料中和程度低，或者完全不被中和。

4. 发明申请

US20120087977A1 AQUEOUS CARBONATED MEDIUM CONTAINING AN AMINO(METH)ACRYLATE POLYMER OR COPOLYMER 有权
标题翻译：含氨基（甲基）丙烯酸酯聚合物或共聚物的水性中和体
公开(公告)号：US20120087977A1
公开(公告)日：2012-04-12
申请号：US13322530
申请日：2009-07-30
申请人： Rosario Lizio , Michael Damm , Hans-Ulrich Petereit
发明人： Rosario Lizio , Michael Damm , Hans-Ulrich Petereit
IPC分类号： A61K47/32 , C08J3/205 , A61K9/14 , B32B1/08 , A61K9/48 , A23L1/30 , A23P1/08 , A23P1/02 , C08L33/14 , A61K9/32
CPC分类号： A61K47/08 , Y10T428/13 , Y10T428/1352
摘要： The invention relates to an aqueous medium containing an amino(meth)acrylate polymer or copolymer which is not soluble in demineralised water, characterized in that the medium has a content of an aqueous phase of at least 60% by weight and a content of up to 40% by weight of solids comprising the amino(meth)acrylate polymer or copolymer, whereby the aqueous phase is charged by a sufficient amount of carbon dioxide that effects the amino(meth)acrylate polymer or copolymer to be present in solute form in the medium. The aqueous medium may be used beneficially as a coating or binding solution for the spray coating or binding of pharmaceutical compositions or nutraceutical compositions or cosmetical compositions.
摘要翻译：本发明涉及含有不溶于去离子水的氨基（甲基）丙烯酸酯聚合物或共聚物的水性介质，其特征在于所述介质的含水量至少为60重量％，含量至多 40重量％的包含氨基（甲基）丙烯酸酯聚合物或共聚物的固体，由此通过足够量的二氧化碳装入水相，使得氨基（甲基）丙烯酸酯聚合物或共聚物以溶质形式存在于介质中。有利地，水性介质可用作药物组合物或营养组合物或美容组合物的喷涂或结合的包衣或结合溶液。

5. 发明申请

US20100129446A1 SOLID DOSAGE FORMS COMPRISING AN ENTERIC COATING WITH ACCELERATED DRUG RELEASE 有权
标题翻译：固体药剂包含加速药物释放的肠衣
公开(公告)号：US20100129446A1
公开(公告)日：2010-05-27
申请号：US12598138
申请日：2007-05-07
申请人： Fang Liu , Abdul W. Basit , Rosario Lizio , Hans-Ulrich Petereit , Christian Meier , Michael Damm
发明人： Fang Liu , Abdul W. Basit , Rosario Lizio , Hans-Ulrich Petereit , Christian Meier , Michael Damm
IPC分类号： A61K9/32 , B05D3/00 , A61K31/57 , A61K31/522
CPC分类号： A61K9/5073 , A61K9/5026
摘要： The present invention refers to a solid dosage form comprising an inner coating located between a core containing a pharmaceutically active ingredient and an outer enteric coating; wherein said inner coating comprises a partially neutralized anionic polymeric material, and at least a carboxylic acid having 2 to 16 carbon atoms the salts thereof or mixtures of said acid and its salt; wherein said outer coating comprises an anionic polymeric material which is less or not at all neutralized than the material of the inner coating.
摘要翻译：本发明涉及一种固体剂型，其包含位于包含药物活性成分的核心和外部肠溶衣之间的内部涂层; 其中所述内涂层包含部分中和的阴离子聚合物材料，和至少一种具有2至16个碳原子的羧酸盐或其所述酸及其盐的混合物; 其中所述外涂层包含阴离子聚合物材料，其比内涂层的材料更少或不完全中和。

6. 发明申请

US20090142407A1 Solid peptide preparations for inhalation and their preparation 审中-公开
公开(公告)号：US20090142407A1
公开(公告)日：2009-06-04
申请号：US12156800
申请日：2008-06-04
申请人： Rosario Lizio , Michael Damm , Werner Sarlikiotis , Elisabeth Wolf-Heuss
发明人： Rosario Lizio , Michael Damm , Werner Sarlikiotis , Elisabeth Wolf-Heuss
IPC分类号： A61K9/14 , A61K38/28
CPC分类号： A61K9/0075 , A61K9/008 , A61K9/14
摘要： The invention relates to solid pharmaceutical preparations, in particular for inhalatory administration in mammals, their preparation and their use such as, for example, in powder inhalers.

7. 发明授权

US08676989B2 Robust domain name resolution 有权
标题翻译：强大的域名解析
公开(公告)号：US08676989B2
公开(公告)日：2014-03-18
申请号：US12723447
申请日：2010-03-12
申请人： Noah Treuhaft , David Ulevitch , Michael Damm
发明人： Noah Treuhaft , David Ulevitch , Michael Damm
IPC分类号： G06F15/16
CPC分类号： H04L61/1511 , H04L29/12066 , H04L29/12811 , H04L61/3025 , H04L61/35 , H04L61/6009
摘要： A recursive DNS nameserver system and related domain name resolution techniques are disclosed. The DNS nameservers utilize a local cache having previously retrieved domain name resolution to avoid recursive resolution processes and the attendant DNS requests. If a matching record is found with a valid (not expired) TTL field, the nameserver returns the cached domain name information to the client. If the TTL for the record in the cache has expired and the nameserver is unable to resolve the domain name information using DNS requests to authoritative servers, the recursive DNS nameserver returns to the cache and accesses the resource record having an expired TTL. The nameserver generates a DNS response to the client device that includes the domain name information from the cached resource record. In various embodiments, subscriber information is utilized to resolve the requested domain name information in accordance with user-defined preferences.
摘要翻译：公开了递归的DNS名称服务器系统和相关的域名解析技术。 DNS名称服务器利用具有先前检索到的域名解析的本地缓存来避免递归解决过程和伴随的DNS请求。如果找到具有有效（未过期）TTL字段的匹配记录，则名称服务器将缓存的域名信息返回给客户端。如果缓存中的记录的TTL已经过期，并且名称服务器无法使用向权威服务器的DNS请求来解析域名信息，则递归DNS名称服务器返回到缓存并访问具有过期的TTL的资源记录。名称服务器将生成DNS客户端设备的DNS响应，其中包括缓存的资源记录中的域名信息。在各种实施例中，用户信息用于根据用户定义的偏好来解析所请求的域名信息。

8. 发明申请

US20130275570A1 Cross-Protocol Communication In Domain Name Systems 有权
公开(公告)号：US20130275570A1
公开(公告)日：2013-10-17
申请号：US13448368
申请日：2012-04-16
申请人： Noah Treuhaft , Douglas Tabacco , Michael Damm
发明人： Noah Treuhaft , Douglas Tabacco , Michael Damm
IPC分类号： G06F15/173
CPC分类号： H04L61/1511 , H04L61/303 , H04L67/10
摘要： Systems and methods for processing domain name system requests in accordance with subscriber information are provided. A request for domain name information can be correlated with subscriber information using a subscriber identifier to resolve the domain name information at a domain name system (DNS) nameserver. The subscriber identifier and/or subscriber information may be transmitted from a DNS nameserver to a webserver using the domain name information provided in response to the subscriber's DNS queries. The subscriber identifier and/or information may be used in delivering a landing page or in facilitating proxying of resource requests for the requested domain.

9. 发明授权

US08431157B2 Partly neutralised anionic (meth) acrylate copolymer 有权
标题翻译：部分中和的阴离子（甲基）丙烯酸酯共聚物
公开(公告)号：US08431157B2
公开(公告)日：2013-04-30
申请号：US11815632
申请日：2005-12-15
申请人： Rosario Lizio , Hans-Ulrich Petereit , Erna Roth , Michael Damm , Ruediger Alexowsky
发明人： Rosario Lizio , Hans-Ulrich Petereit , Erna Roth , Michael Damm , Ruediger Alexowsky
IPC分类号： A61K9/16 , A61K9/20
CPC分类号： C08F220/18 , A61K9/2846 , A61K9/5026
摘要： The invention relates to a partly neutralized anionic (meth)acrylate copolymer consisting of radically polymerized units containing 25-95% by weight (meth)acrylic acid C1 to C4 alkylesters and 5-75% by weight (meth)acrylate monomer with an anionic group, wherein 0.1 to 25% contained anionic groups are neutralized by a base. Said invention is characterized in that said base is embodied in the form of an cationic organic base whose molecular weight is greater than 150. A medical form containing said partly neutralized anionic (meth)acrylate copolymer and the use of said partly neutralized anionic (meth)acrylate copolymer for producing a medical form rapidly releasing an active substance having a determined pH value are also disclosed.
摘要翻译：本发明涉及一种部分中和的阴离子（甲基）丙烯酸酯共聚物，它由含25-95％（重量）（甲基）丙烯酸C1至C4烷基酯和5-75％（重量）（甲基）丙烯酸阴离子基团单体的自由基聚合单元组成，其中0.1〜25％的阴离子基团被碱中和。所述发明的特征在于所述碱以分子量大于150的阳离子有机碱的形式实施。含有所述部分中和的阴离子（甲基）丙烯酸酯共聚物的医用形式以及所述部分中和的阴离子（甲基）丙烯酸酯共聚物的用途，丙烯酸酯共聚物，用于制备快速释放具有确定的pH值的活性物质的医用形式。

10. 发明申请

US20120143039A1 ORAL DOSAGE FORM, COMPRISING AT LEAST ONE BIOLOGICALLY ACTIVE AGENT, FORMULATION AUXILIARY SUBSTANCES AND MAGNETIZABLE PARTICLES 有权
标题翻译：口服剂型，包含至少一种生物活性剂，配方辅助物质和可磁化颗粒
公开(公告)号：US20120143039A1
公开(公告)日：2012-06-07
申请号：US13390353
申请日：2010-08-30
申请人： Benedikt Hartwig , Norbert Windhab , Melanie Liefke , Juan Tome Alcalde , Michael Damm , Rosario Lizio , Michael Gottschalk , Angela Olf , Christian Meier , Andreas Gryczke
发明人： Benedikt Hartwig , Norbert Windhab , Melanie Liefke , Juan Tome Alcalde , Michael Damm , Rosario Lizio , Michael Gottschalk , Angela Olf , Christian Meier , Andreas Gryczke
IPC分类号： A61B5/05 , A61J3/07
CPC分类号： A61K9/2072 , A61K9/0009 , A61K9/0053 , A61K9/2095 , A61K9/2813 , A61K9/2846 , A61K9/2866 , A61K9/4808 , A61K9/4816 , A61K9/4833 , A61K9/4883 , A61K9/5094
摘要： The invention relates to an oral dosage form, comprising at least one biologically active agent, formulation auxiliary substances and magnetizable particles, wherein the dosage form has an at least two phase composition, wherein the phases can dissolve in the body after oral administration due to their formulation and the magnetizable particles are bound in formulation auxiliary substances and are present in a magnetized state, wherein the magnetized particles are present in at least two phases of the dosage form and generate magnetic fields, wherein these phases dissolve at different times in the body after oral administration, and wherein the magnetic field strength with respect to time, position and movement in the body is acquired using a detection system and can be evaluated using a computer-based evaluation system.
摘要翻译：本发明涉及口服剂型，其包含至少一种生物活性剂，制剂辅助物质和可磁化颗粒，其中所述剂型具有至少两相组合物，其中所述相可以在口服给药后溶于体内，因为它们制剂和可磁化颗粒结合在制剂辅助物质中并以磁化状态存在，其中磁化颗粒存在于剂型的至少两个相中并产生磁场，其中这些相在体内不同时间溶解在体内并且其中使用检测系统获取相对于身体中的时间，位置和运动的磁场强度，并且可以使用基于计算机的评估系统进行评估。

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