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1. 发明授权

US09895227B2 Prosthesis adapted for placement under external imaging 有权
公开(公告)号：US09895227B2
公开(公告)日：2018-02-20
申请号：US13444238
申请日：2012-04-11
申请人： Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Ray Leonard, II
发明人： Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Ray Leonard, II
IPC分类号： A61F2/82 , A61F2/24 , A61B90/00
CPC分类号： A61F2/2475 , A61B90/39 , A61F2/2418 , A61F2230/0026 , A61F2230/0095 , A61F2250/0098
摘要： An expandable prosthesis having an imageable structure comprising one or more elements visually distinguishable by an external (e.g., radiographic or ultrasonic) imaging system, the structure being located about a first axis that corresponds to a structural feature of the prosthesis that is configured to perform a specific function particular to that axis. The imageable structure is configured to assist in the rotational orientation of the prosthesis during placement within the implantation site. In one embodiment, the prosthesis comprises a venous valve that includes imageable elements or structure, such as a pair of radiopaque markers, that defines the orifice of the valve structure such that the orifice can be oriented with a particular anatomical feature under imaging, such as to align the orifice with the long axis of the vessel.

2. 发明申请

US20130018453A1 ARTIFICIAL VALVE PROSTHESIS WITH IMPROVED FLOW DYNAMICS 审中-公开
标题翻译：人工阀具有改进的流动动力学
公开(公告)号：US20130018453A1
公开(公告)日：2013-01-17
申请号：US13550229
申请日：2012-07-16
申请人： Brian C. Case , Michael L. Garrison , Andrew Hoffa , Darin G. Schaeffer , Jacob A. Flagle
发明人： Brian C. Case , Michael L. Garrison , Andrew Hoffa , Darin G. Schaeffer , Jacob A. Flagle
IPC分类号： A61F2/82
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2002/068 , A61F2220/0008 , A61F2220/0016 , A61F2230/0054 , A61F2230/0076 , A61F2230/0078 , A61F2230/008 , A61F2250/0037 , A61F2250/0039
摘要： An expandable venous valve having a support structure that is configured to enlarge the area adjacent to the valve structure such that the flow patterns of retrograde flow are modified in a way that facilitates the flushing of the pockets at the base of the valve area to prevent stagnation of bodily fluid, which in the venous system, can lead to thrombus formation. The enlarged pocket areas can be created by forming an artificial sinus adjacent the valve structure in an unsupported section of vessel wall between two support frame sections or the support frame can comprise an expanded-diameter intermediate or proximal section that forms an artificial sinus adjacent the valve structure.
摘要翻译：一种可膨胀静脉瓣，其具有支撑结构，所述支撑结构被构造成扩大与所述瓣膜结构相邻的区域，使得逆行流的流动模式以便于在所述瓣膜区域的底部冲洗所述凹穴以防止停滞的方式被修改的体液，其在静脉系统中可导致血栓形成。可以通过在两个支撑框架部分之间的容器壁的无支撑部分中形成邻近阀结构的人造窦来形成扩大的口袋区域，或者支撑框架可以包括形成邻近瓣膜的人造窦的扩张直径的中间或近端部分结构体。

3. 发明申请

US20120203327A1 INTRALUMENALLY-IMPLANTABLE FRAMES 有权
标题翻译：内部可植入框架
公开(公告)号：US20120203327A1
公开(公告)日：2012-08-09
申请号：US13447619
申请日：2012-04-16
申请人： Brian C. Case , Jacob A. Flagle , Andrew K. Hoffa , Darin G. Schaeffer , Michael L. Garrison
发明人： Brian C. Case , Jacob A. Flagle , Andrew K. Hoffa , Darin G. Schaeffer , Michael L. Garrison
IPC分类号： A61F2/86
CPC分类号： A61F2/86 , A61F2/06 , A61F2/2418 , A61F2/2475 , A61F2/91 , A61F2/915 , A61F2002/068 , A61F2002/91508 , A61F2002/91516 , A61F2002/91533 , A61F2002/91575 , A61F2220/0016 , A61F2220/0058 , A61F2230/0054 , A61F2250/0037 , A61F2250/0039
摘要： Implantable frames for use in body passages are provided herein. The implantable frames can include a plurality of hoop members joined by a plurality of longitudinal connecting members to form a tubular frame defining a cylindrical lumen. The plurality of longitudinal connecting members may include first and second longitudinal connecting members joining a first hoop member to a second hoop member such that the first and second longitudinal connecting members extend across an entire space separating the first and second hoop members.
摘要翻译：本文提供了用于身体通道的植入框架。可植入框架可以包括由多个纵向连接构件连接以形成限定圆柱形管腔的管状框架的多个环形构件。多个纵向连接构件可以包括将第一箍构件连接到第二箍构件的第一和第二纵向连接构件，使得第一和第二纵向连接构件跨越分隔第一和第二箍构件的整个空间延伸。

4. 发明授权

US07670366B2 Intraluminal support device with graft 有权
标题翻译：腔内支持装置与移植物
公开(公告)号：US07670366B2
公开(公告)日：2010-03-02
申请号：US10820918
申请日：2004-04-08
申请人： Brian C. Case , Jacob A. Flagle , Ram H. Paul , Andrew K. Hoffa , Michael L. Garrison , Joseph F. Obermiller
发明人： Brian C. Case , Jacob A. Flagle , Ram H. Paul , Andrew K. Hoffa , Michael L. Garrison , Joseph F. Obermiller
IPC分类号： A61F2/06
CPC分类号： A61F2/2475 , A61F2/2418 , A61F2/848 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/0026 , A61F2230/0054 , A61F2230/0095
摘要： Implantable medical devices comprising a support frame and a graft member attached to the support frame. The support frame can define one or more structural features that substantially prevent migration of the graft member along the support frame.
摘要翻译：可植入医疗装置，其包括支撑框架和附接到支撑框架的移植物构件。支撑框架可以限定一个或多个结构特征，其基本上防止移植构件沿着支撑框架的移动。

5. 发明授权

US08157810B2 Prosthesis adapted for placement under external imaging 有权
标题翻译：假体适应放置在外部成像
公开(公告)号：US08157810B2
公开(公告)日：2012-04-17
申请号：US10787307
申请日：2004-02-26
申请人： Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Ray Leonard, II
发明人： Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Ray Leonard, II
IPC分类号： A61F11/00
CPC分类号： A61F2/2475 , A61B90/39 , A61F2/2418 , A61F2230/0026 , A61F2230/0095 , A61F2250/0098
摘要： A expandable prosthesis having an imageable structure comprising one or more elements visually distinguishable by an external (e.g., radiographic or ultrasonic) imaging system, the structure being located about a first axis that corresponds to a structural feature of the prosthesis that is configured to perform a specific function particular to that axis. The imageable structure is configured to assist in the rotational orientation of the prosthesis during placement within the implantation site. In one embodiment, the prosthesis comprises a venous valve that includes imageable elements or structure, such as a pair of radiopaque markers, that defines the orifice of the valve structure such that the orifice can be oriented with a particular anatomical feature under imaging, such as to align the orifice with the long axis of the vessel. In another embodiment, the imageable structure is configured to permit an aperture located about a stent graft to be oriented with a anatomical feature of the vessel, such as a branch vessel opening. The invention includes a method for using imageable structure to confirm that the orientation of the prosthesis within a delivery apparatus is consistent the desired delivery approach to be used.
摘要翻译：一种具有可成像结构的可扩张假体，其包括可由外部（例如，射线照相或超声）成像系统在视觉上区分的一个或多个元件，所述结构围绕与假体的结构特征对应的第一轴定位，所述第一轴构造成执行特定于该轴的特定功能。可成像结构构造成在放置在植入部位期间有助于假体的旋转取向。在一个实施例中，假体包括静脉瓣，其包括可成像元件或结构，例如一对不透射线的标记，其限定瓣膜结构的孔，使得孔可以在成像下具有特定解剖特征，例如以将孔与容器的长轴对准。在另一个实施例中，可成像结构被配置为允许围绕支架移植物定位的孔与容器的解剖特征（例如分支血管开口）定向。本发明包括一种使用可成像结构来确认假体在输送装置内的取向与所要使用的输送方法一致的方法。

6. 发明授权

US07628803B2 Implantable vascular device 有权
公开(公告)号：US07628803B2
公开(公告)日：2009-12-08
申请号：US10642372
申请日：2003-08-15
申请人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
发明人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/24 , A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2002/8483 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0069 , A61F2230/0095
摘要： An valve prosthesis, such as an artificial venous valve, having a support frame and leaf structure comprising one or more leaflets in which the outer edge of each leaflet engages the inner circumference of the bodily passageway along a serpentine path urged against the passageway by an expandable frame, while the inner edges move in response to fluid to restrict retrograde flow. Optionally, one or more elements can extend from the support frame/leaf structure to provide centering support and/or protection from the leaflet adhering to the vessel wall. In one embodiment, the centering support structure comprises a second or third expandable frames attached to and extending from the proximal and/or distal ends of main valve structure and support frame. In another embodiment, one or more support elements extend outward from the valve support frame to engage the vessel wall to provide greater longitudinal stability.

7. 发明授权

US07604661B2 Implantable vascular device 有权
标题翻译：植入式血管装置
公开(公告)号：US07604661B2
公开(公告)日：2009-10-20
申请号：US11931182
申请日：2007-10-31
申请人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Ram H. Paul, Jr. , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
发明人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Ram H. Paul, Jr. , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/24 , A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2002/8483 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0069 , A61F2230/0095
摘要： An valve prosthesis, such as an artificial venous valve, having a support frame and leaf structure comprising one or more leaflets in which the outer edge of each leaflet engages the inner circumference of the bodily passageway along a serpentine path urged against the passageway by an expandable frame, while the inner edges move in response to fluid to restrict retrograde flow. Optionally, one or more elements can extend from the support frame/leaf structure to provide centering support and/or protection from the leaflet adhering to the vessel wall. In one embodiment, the centering support structure comprises a second or third expandable frames attached to and extending from the proximal and/or distal ends of main valve structure and support frame. In another embodiment, one or more support elements extend outward from the valve support frame to engage the vessel wall to provide greater longitudinal stability.
摘要翻译：一种阀门假体，例如人造静脉瓣，其具有支撑框架和叶结构，其包括一个或多个小叶，其中每个小叶的外边缘沿着沿着通过可扩展框架，而内边缘响应流体移动以限制逆行流。任选地，一个或多个元件可以从支撑框架/叶结构延伸，以提供定位支撑和/或防止附着在血管壁上的小叶的保护。在一个实施例中，定心支撑结构包括附接到主阀结构和支撑框架的近端和/或远端的第二或第三可膨胀框架。在另一个实施例中，一个或多个支撑元件从阀支撑框架向外延伸以接合血管壁以提供更大的纵向稳定性。

8. 发明授权

US07128759B2 Implantable medical device with constrained expansion 有权
标题翻译：植入式医疗器械具有约束扩张
公开(公告)号：US07128759B2
公开(公告)日：2006-10-31
申请号：US10849639
申请日：2004-05-19
申请人： Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Andrew K. Hoffa , Michael L. Garrison
发明人： Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Andrew K. Hoffa , Michael L. Garrison
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0026 , A61F2230/0095
摘要： Medical devices for implantation in a body vessel are provided. A medical device according to the invention comprises a support structure and one or more graft members comprising a valve portion and a constraining portion. The support structure has a first, unexpanded configuration and a second, expanded configuration. The constraining portion is adapted to substantially prevent the support structure from achieving the second, expanded configuration. The valve portion is adapted to permit fluid flow through a body vessel in a first direction and substantially prevent fluid flow through the vessel in a second, opposite direction.
摘要翻译：提供用于植入体内的医疗装置。根据本发明的医疗装置包括支撑结构和包括阀部分和约束部分的一个或多个移植部件。支撑结构具有第一，未膨胀的构造和第二扩展构型。约束部分适于基本上防止支撑结构实现第二扩张构型。阀部分适于允许流体沿第一方向流过身体容器，并且基本上防止流体沿第二相反方向流过血管。

9. 发明授权

US08470020B2 Intralumenally-implantable frames 有权
标题翻译：腔内可植入框架
公开(公告)号：US08470020B2
公开(公告)日：2013-06-25
申请号：US13447619
申请日：2012-04-16
申请人： Darin G. Schaeffer , Jacob A. Flagle , Michael L. Garrison , Brian C. Case , Andrew K. Hoffa
发明人： Darin G. Schaeffer , Jacob A. Flagle , Michael L. Garrison , Brian C. Case , Andrew K. Hoffa
IPC分类号： A61F2/82
CPC分类号： A61F2/86 , A61F2/06 , A61F2/2418 , A61F2/2475 , A61F2/91 , A61F2/915 , A61F2002/068 , A61F2002/91508 , A61F2002/91516 , A61F2002/91533 , A61F2002/91575 , A61F2220/0016 , A61F2220/0058 , A61F2230/0054 , A61F2250/0037 , A61F2250/0039
摘要： Implantable frames for use in body passages are provided herein. The implantable frames can include a plurality of hoop members joined by a plurality of longitudinal connecting members to form a tubular frame defining a cylindrical lumen. The plurality of longitudinal connecting members may include first and second longitudinal connecting members joining a first hoop member to a second hoop member such that the first and second longitudinal connecting members extend across an entire space separating the first and second hoop members.
摘要翻译：本文提供了用于身体通道的植入框架。可植入框架可以包括由多个纵向连接构件连接以形成限定圆柱形管腔的管状框架的多个环形构件。多个纵向连接构件可以包括将第一箍构件连接到第二箍构件的第一和第二纵向连接构件，使得第一和第二纵向连接构件跨越分隔第一和第二箍构件的整个空间延伸。

10. 发明申请

US20120253450A1 Prosthesis Adapted for Placement Under External Imaging 审中-公开
标题翻译：假体适应于外部成像下的放置
公开(公告)号：US20120253450A1
公开(公告)日：2012-10-04
申请号：US13444238
申请日：2012-04-11
申请人： Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Ray Leonard, II
发明人： Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Ray Leonard, II
IPC分类号： A61F2/82
CPC分类号： A61F2/2475 , A61B90/39 , A61F2/2418 , A61F2230/0026 , A61F2230/0095 , A61F2250/0098
摘要： An expandable prosthesis having an imageable structure comprising one or more elements visually distinguishable by an external (e.g., radiographic or ultrasonic) imaging system, the structure being located about a first axis that corresponds to a structural feature of the prosthesis that is configured to perform a specific function particular to that axis. The imageable structure is configured to assist in the rotational orientation of the prosthesis during placement within the implantation site. In one embodiment, the prosthesis comprises a venous valve that includes imageable elements or structure, such as a pair of radiopaque markers, that defines the orifice of the valve structure such that the orifice can be oriented with a particular anatomical feature under imaging, such as to align the orifice with the long axis of the vessel.
摘要翻译：一种具有可成像结构的可扩张假体，其包括通过外部（例如，射线照相或超声）成像系统在视觉上可区分的一个或多个元件，所述结构围绕与假体的结构特征相对应的第一轴定位，所述结构特征被配置为执行特定于该轴的特定功能。可成像结构构造成在放置在植入部位期间有助于假体的旋转取向。在一个实施例中，假体包括静脉瓣，其包括可成像元件或结构，例如一对不透射线的标记，其限定瓣膜结构的孔，使得孔可以在成像下具有特定解剖特征，例如以将孔与容器的长轴对准。

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