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1. 发明授权

US08613763B2 Implantable vascular device 有权
标题翻译：植入式血管装置
公开(公告)号：US08613763B2
公开(公告)日：2013-12-24
申请号：US12258757
申请日：2008-10-27
申请人： Dusan Pavcnik , Frederick S. Keller , Josef Rosch , Thomas A. Osborne , Brian L. Bates , John A. DeFord , Christopher G. Dixon , Andrew K. Hoffa , Raymond B. Leonard, II , Joseph F. Obermiller
发明人： Dusan Pavcnik , Frederick S. Keller , Josef Rosch , Thomas A. Osborne , Brian L. Bates , John A. DeFord , Christopher G. Dixon , Andrew K. Hoffa , Raymond B. Leonard, II , Joseph F. Obermiller
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0095 , Y10S623/901
摘要： A multiple-sided medical device comprises a frame comprising wire or other resilient material and having a series of bends and interconnecting sides. The device has both a flat configuration and a second, folded configuration which a generally serpentine shape. The device is pushed from a delivery catheter into the lumen of a duct or vessel and may include one or more barbs for anchoring purposes. A full or partial covering of fabric or other flexible material such as DACRON, PTFE, or a collagen-based material such as small intestinal submucosa (SIS), may be sutured or attached to the frame to form an occlusion device, a stent graft, or an implantable, intraluminal valve such as for correcting incompetent veins in the lower legs and feet.
摘要翻译：多面医疗装置包括包括线或其它弹性材料并具有一系列弯曲和互连侧的框架。该装置具有扁平构型和第二折叠构造，其大致蛇形形状。该装置从输送导管推入管道或容器的内腔，并且可以包括用于锚定目的的一个或多个倒钩。织物或其他柔性材料如DACRON，PTFE或基于胶原的材料如小肠粘膜下层（SIS）的全部或部分覆盖物可以被缝合或附着到框架上以形成闭塞装置，支架移植物，或可植入的管腔内瓣膜，例如用于矫正小腿和脚部的无能力的静脉。

2. 发明授权

US08470020B2 Intralumenally-implantable frames 有权
标题翻译：腔内可植入框架
公开(公告)号：US08470020B2
公开(公告)日：2013-06-25
申请号：US13447619
申请日：2012-04-16
申请人： Darin G. Schaeffer , Jacob A. Flagle , Michael L. Garrison , Brian C. Case , Andrew K. Hoffa
发明人： Darin G. Schaeffer , Jacob A. Flagle , Michael L. Garrison , Brian C. Case , Andrew K. Hoffa
IPC分类号： A61F2/82
CPC分类号： A61F2/86 , A61F2/06 , A61F2/2418 , A61F2/2475 , A61F2/91 , A61F2/915 , A61F2002/068 , A61F2002/91508 , A61F2002/91516 , A61F2002/91533 , A61F2002/91575 , A61F2220/0016 , A61F2220/0058 , A61F2230/0054 , A61F2250/0037 , A61F2250/0039
摘要： Implantable frames for use in body passages are provided herein. The implantable frames can include a plurality of hoop members joined by a plurality of longitudinal connecting members to form a tubular frame defining a cylindrical lumen. The plurality of longitudinal connecting members may include first and second longitudinal connecting members joining a first hoop member to a second hoop member such that the first and second longitudinal connecting members extend across an entire space separating the first and second hoop members.
摘要翻译：本文提供了用于身体通道的植入框架。可植入框架可以包括由多个纵向连接构件连接以形成限定圆柱形管腔的管状框架的多个环形构件。多个纵向连接构件可以包括将第一箍构件连接到第二箍构件的第一和第二纵向连接构件，使得第一和第二纵向连接构件跨越分隔第一和第二箍构件的整个空间延伸。

3. 发明申请

US20120253450A1 Prosthesis Adapted for Placement Under External Imaging 审中-公开
标题翻译：假体适应于外部成像下的放置
公开(公告)号：US20120253450A1
公开(公告)日：2012-10-04
申请号：US13444238
申请日：2012-04-11
申请人： Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Ray Leonard, II
发明人： Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Ray Leonard, II
IPC分类号： A61F2/82
CPC分类号： A61F2/2475 , A61B90/39 , A61F2/2418 , A61F2230/0026 , A61F2230/0095 , A61F2250/0098
摘要： An expandable prosthesis having an imageable structure comprising one or more elements visually distinguishable by an external (e.g., radiographic or ultrasonic) imaging system, the structure being located about a first axis that corresponds to a structural feature of the prosthesis that is configured to perform a specific function particular to that axis. The imageable structure is configured to assist in the rotational orientation of the prosthesis during placement within the implantation site. In one embodiment, the prosthesis comprises a venous valve that includes imageable elements or structure, such as a pair of radiopaque markers, that defines the orifice of the valve structure such that the orifice can be oriented with a particular anatomical feature under imaging, such as to align the orifice with the long axis of the vessel.
摘要翻译：一种具有可成像结构的可扩张假体，其包括通过外部（例如，射线照相或超声）成像系统在视觉上可区分的一个或多个元件，所述结构围绕与假体的结构特征相对应的第一轴定位，所述结构特征被配置为执行特定于该轴的特定功能。可成像结构构造成在放置在植入部位期间有助于假体的旋转取向。在一个实施例中，假体包括静脉瓣，其包括可成像元件或结构，例如一对不透射线的标记，其限定瓣膜结构的孔，使得孔可以在成像下具有特定解剖特征，例如以将孔与容器的长轴对准。

4. 发明申请

US20120232470A1 Multi-Path Catheter 有权
标题翻译：多径导管
公开(公告)号：US20120232470A1
公开(公告)日：2012-09-13
申请号：US13412064
申请日：2012-03-05
申请人： Michael Hardert , Michael Robert Kurrus , Andrew K. Hoffa
发明人： Michael Hardert , Michael Robert Kurrus , Andrew K. Hoffa
IPC分类号： A61M25/14
CPC分类号： A61M25/0032 , A61M25/0026 , A61M2025/0031 , A61M2025/0034
摘要： A multi-path catheter includes an elongate tubular member and a withdrawal pathway along which unfiltered fluid is withdrawn in a distal to proximal direction. The withdrawal pathway originates at a distal point and is at least partially defined by the elongate tubular member. The elongate tubular member also defines, at least partially, at least one infusion pathway along which filtered fluid is returned in a proximal to distal direction. The at least one infusion pathway extends distally beyond the withdrawal pathway. First and second legs of the elongate tubular member are positioned on opposing sides of the withdrawal pathway at the distal point, and the at least one infusion pathway is at least partially defined by one of the first and second legs. The first and second legs have outer walls that are unattached to one another at distal ends thereof.
摘要翻译：多路径导管包括细长的管状构件和抽出通道，未过滤的流体沿着远离近端方向被抽出。退出路径起始于远端点并且至少部分地由细长管状构件限定。至少部分地，细长管状构件至少部分地限定了过滤流体沿着该至少一个输送通道沿近端至远端方向返回。至少一个输注通道在远端延伸超出撤出途径。细长管状构件的第一和第二腿定位在远端处的撤回通道的相对侧上，并且至少一个输注通道至少部分地由第一和第二腿中的一个限定。第一和第二腿具有在其远端处彼此不相连的外壁。

5. 发明授权

US07909862B2 Delivery systems and methods for deploying expandable intraluminal medical devices 有权
标题翻译：用于部署扩张型管腔内医疗器械的输送系统和方法
公开(公告)号：US07909862B2
公开(公告)日：2011-03-22
申请号：US10804386
申请日：2004-03-19
申请人： Michael L. Garrison , Brian C. Case , Andrew K. Hoffa , Jacob A. Flagle , Dusan Pavcnik
发明人： Michael L. Garrison , Brian C. Case , Andrew K. Hoffa , Jacob A. Flagle , Dusan Pavcnik
IPC分类号： A61F2/06 , A61M29/00
CPC分类号： A61F2/95 , A61F2/013 , A61F2/966 , A61F2002/011 , A61F2002/015 , A61F2230/0006 , A61F2230/005
摘要： Methods and devices for delivering and deploying expandable intraluminal medical devices at a desired point of treatment within a body vessel are provided. A delivery device is provided, inserted into a body vessel, and navigated through the vessel to place an associated expandable intraluminal medical device at a desired point of treatment. Once the desired location is reached, an elongate member on which the expandable intraluminal medical device is disposed is spaced from a wall surface of the body vessel using an expandable wire basket, balloon, or other suitable structure. The expandable intraluminal medical device is deployed from the delivery system, which can ultimately be withdrawn from the body vessel.
摘要翻译：提供了用于在体内容器内的期望治疗点递送和部署可膨胀管腔内医疗装置的方法和装置。提供输送装置，插入体内容器，并通过血管导航，将相关的可扩张的管腔内医疗装置放置在期望的治疗点。一旦达到所需的位置，可扩张的管腔内医疗装置就位于其上的细长构件就可以使用可膨胀的丝网筐，球囊或其它合适的结构与身体容器的壁表面间隔开。可扩展的管腔内医疗装置从输送系统部署，其最终可以从体内容器中取出。

6. 发明授权

US07717951B2 Delivery system that facilitates visual inspection of an intraluminal medical device 有权
标题翻译：输送系统，便于目视检查管腔内医疗器械
公开(公告)号：US07717951B2
公开(公告)日：2010-05-18
申请号：US11123312
申请日：2005-05-06
申请人： Jacob A. Flagle , Brian C. Case , Andrew K. Hoffa , Michael L. Garrison
发明人： Jacob A. Flagle , Brian C. Case , Andrew K. Hoffa , Michael L. Garrison
IPC分类号： A61F2/84
CPC分类号： A61M25/0043 , A61F2/95 , A61F2250/0091 , A61M25/10 , A61M2025/1079
摘要： Delivery systems, methods of making delivery systems, and methods of treatment are provided. A delivery system according to the invention facilitates a visual inspection of an intraluminal medical device included in the delivery system.
摘要翻译：提供交付系统，交付系统的方法和处理方法。根据本发明的递送系统便于对包括在递送系统中的管腔内医疗装置的目视检查。

7. 发明申请

US20100030314A1 IMPLANTABLE SUPPORT DEVICE WITH GRAFT 审中-公开
标题翻译：带GRAFT的可植入支撑装置
公开(公告)号：US20100030314A1
公开(公告)日：2010-02-04
申请号：US12576481
申请日：2009-10-09
申请人： Brian C. Case , Jacob A. Flagle , Ram H. Paul , Andrew K. Hoffa , Michael L. Garrison , Joseph F. Obermiller
发明人： Brian C. Case , Jacob A. Flagle , Ram H. Paul , Andrew K. Hoffa , Michael L. Garrison , Joseph F. Obermiller
IPC分类号： A61F2/06
CPC分类号： A61F2/2475 , A61F2/2418 , A61F2/848 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/0026 , A61F2230/0054 , A61F2230/0095
摘要： Implantable medical devices comprising a support frame and a graft member attached to the support frame. The support frame can define one or more structural features that substantially prevent migration of the graft member along the support frame.
摘要翻译：可植入医疗装置，其包括支撑框架和附接到支撑框架的移植物构件。支撑框架可以限定一个或多个结构特征，其基本上防止移植构件沿着支撑框架的移动。

8. 发明申请

US20100021619A1 LOW FRICTION COATED MARKED WIRE GUIDE FOR OVER THE WIRE INSERTION OF A CATHETER 有权
标题翻译：用于导线导线的低摩擦涂层标线指南
公开(公告)号：US20100021619A1
公开(公告)日：2010-01-28
申请号：US12574124
申请日：2009-10-06
申请人： Thomas A. Osborne , Andrew K. Hoffa
发明人： Thomas A. Osborne , Andrew K. Hoffa
IPC分类号： B05D5/00
CPC分类号： A61L31/14 , A61L31/10 , C08L27/18
摘要： A wire guide includes a mandrel that has a proximal portion and a distal portion. A coating having a low coefficient of friction is disposed on at least part of the proximal portion and the distal portion of the mandrel, where a part of the proximal portion and distal portion of the mandrel without the coating indicates a marking on the wire guide. This marking on the wire guide allows a user to determine a trimmable length of a catheter, and the low friction coating enables the user to easily advance the catheter over the wire guide.
摘要翻译：线引导件包括具有近端部分和远端部分的心轴。具有低摩擦系数的涂层设置在心轴的近端部分和远端部分的至少一部分上，心轴的近端部分和远端部分的一部分没有涂层，表示电线引导件上的标记。线引导件上的这种标记允许用户确定导管的可调节长度，并且低摩擦涂层使得使用者能够容易地将导管推进导线。

9. 发明授权

US07618447B2 Artificial valve prosthesis with improved flow dynamics 有权
标题翻译：具有改善流动动力学的人造瓣膜假体
公开(公告)号：US07618447B2
公开(公告)日：2009-11-17
申请号：US10828716
申请日：2004-08-30
申请人： Brian C. Case , Jacob A. Flagle , Andrew K. Hoffa , Darin G. Schaeffer , Michael L. Garrison
发明人： Brian C. Case , Jacob A. Flagle , Andrew K. Hoffa , Darin G. Schaeffer , Michael L. Garrison
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2002/068 , A61F2220/0008 , A61F2220/0016 , A61F2230/0054 , A61F2230/0076 , A61F2230/0078 , A61F2230/008 , A61F2250/0037 , A61F2250/0039
摘要： An expandable venous valve having a support structure that configured to enlarge the area adjacent to the valve structure such that the flow patterns of retrograde flow are modified in a way that facilitates the flushing of the pockets at the base of the valve area to prevent stagnation of bodily fluid, which in the venous system, can lead to thrombus formation. The enlarged pocket areas can be created by forming an artificial sinus adjacent the valve structure in an unsupported section of vessel wall between two support frame section or the support frame can comprise an expanded-diameter intermediate or proximal section that forms an artificial sinus adjacent the valve structure. In another group of embodiments, the attachment pathway between opposing leaflets and the support frame and/or vessel wall comprises a proximal portion that places the leaflets in extended contact with one another and a distal portion forms a large angle with respect to the adjacent walls such that a large pocket is created at the base of the leaflets. In one embodiment, the attachment pathway extends distally along a pair of substantially parallel longitudinal attachment struts to create an extended leaflet contact area, then angles circumferentially and distally from the former along distal attachment struts to define the bottom edge of the leaflets.
摘要翻译：一种可膨胀静脉瓣，其具有支撑结构，该支撑结构被配置为扩大邻近阀结构的区域，使逆行流的流动模式以便于冲洗瓣膜区域底部的口袋的方式进行改变，以防止滞留在静脉系统中的体液可导致血栓形成。扩大的口袋区域可以通过在两个支撑框架部分之间的容器壁的无支撑部分中形成邻近阀结构的人造窦来形成，或者支撑框架可以包括形成邻近瓣膜的人造窦的扩张直径的中间或近端部分结构体。在另一组实施例中，相对的小叶与支撑框架和/或血管壁之间的附接通路包括将小叶彼此延伸接触的近端部分，并且远侧部分相对于相邻壁形成大角度，在传单的底部创造了一个大口袋。在一个实施例中，附接通道沿着一对基本上平行的纵向连接支柱向远侧延伸，以产生延伸的小叶接触区域，然后沿着远侧连接支柱沿着周向和远端远离成形器，以限定传单的底部边缘。

10. 发明授权

US07604618B2 High pressure injection syringe 有权
标题翻译：高压注射器
公开(公告)号：US07604618B2
公开(公告)日：2009-10-20
申请号：US11166915
申请日：2005-06-23
申请人： Christopher G. Dixon , Jacob A. Flagle , Andrew K. Hoffa , Joseph P. Lane
发明人： Christopher G. Dixon , Jacob A. Flagle , Andrew K. Hoffa , Joseph P. Lane
IPC分类号： A61M5/315
CPC分类号： A61B17/8827 , A61B17/8822 , A61F2/44 , A61F2/4601 , A61F2310/00353
摘要： A pressure injection syringe with an actuator that includes a plunger for pressurizing viscous fluid material within a chamber. The plunger distal tip includes a high pressure seal defined by a seal member within a seal seat. The high pressure seal is viscoselective to permit air passage therepast for aspiration, and to prohibit viscous material passage therepast during actuation of the actuator wherein high pressure is applied to the material within the chamber. The viscoselective seal may be defined for example by small axial openings in the seal seat that permit aspiration of air therepast during initial plunger insertion into the chamber, but fluid escape is prohibited by the seal member when the seal member is pressed firmly against a collar of the plunger proximally adjacent the seal seat by initial engagement of the seal member with the viscous material, thus completely sealing the chamber at the proximal end thereof.
摘要翻译：一种具有致动器的压力注射器，该致动器包括用于对室内的粘性流体材料加压的柱塞。柱塞远端包括由密封座内的密封构件限定的高压密封。高压密封件是粘性选择性的，以允许空气通过其吸入，并且在致动器的致动期间禁止粘性材料通过，其中高压被施加到腔室内的材料。粘性选择性密封件可以例如通过密封座中的小的轴向开口来限定，其允许在初始柱塞插入室期间吸入空气，但是当密封构件被牢固地压靠在腔室柱塞通过密封构件与粘性材料的初始接合而向近侧靠近密封座，从而在其近端完全密封腔室。

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