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1. 发明申请

US20110022981A1 PRESENTATION OF DEVICE UTILIZATION AND OUTCOME FROM A PATIENT MANAGEMENT SYSTEM 审中-公开
标题翻译：从患者管理系统介绍设备的使用和成果
公开(公告)号：US20110022981A1
公开(公告)日：2011-01-27
申请号：US12840611
申请日：2010-07-21
申请人： Deepa Mahajan , Yanting Dong , Christopher Monnier , Nicholas Everhart , Paul Jones , Milan Seth , Haresh G. Sachanandani , Kenneth P. Hoyme
发明人： Deepa Mahajan , Yanting Dong , Christopher Monnier , Nicholas Everhart , Paul Jones , Milan Seth , Haresh G. Sachanandani , Kenneth P. Hoyme
IPC分类号： G06F3/048 , A61B5/00
CPC分类号： A61N1/37247 , A61B5/0022 , A61B5/02055 , A61B5/7435 , G06Q50/22 , G16H10/60 , G16H40/63 , G16H50/70
摘要： In a graphical user interface displayed in an electronic display of a computing device, a first device profile and second device profile are presented, the first and second device profiles each comprising at least one device parameter used to configure a medical device of a subject. A user input control is presented to select one of the first or second device profiles to provide a selected device profile. A probabilistic outcome of the subject corresponding to the selected device profile is then presented.
摘要翻译：在显示在计算设备的电子显示器中的图形用户界面中，呈现第一设备配置文件和第二设备配置文件，第一和第二设备配置文件每个包括用于配置被摄体的医疗设备的至少一个设备参数。呈现用户输入控制以选择第一或第二设备配置文件之一以提供所选择的设备配置文件。然后呈现与所选设备简档对应的主题的概率结果。

2. 发明申请

US20130150912A1 METHODS AND SYSTEMS FOR IDENTIFYING AND USING HEART RATE VARIABILITY AND HEART RATE VARIATION 有权
公开(公告)号：US20130150912A1
公开(公告)日：2013-06-13
申请号：US13707204
申请日：2012-12-06
申请人： David L. Perschbacher , Arjun D. Sharma , Craig Stolen , Kira Q. Stolen , Milan Seth , Paul W. Jones
发明人： David L. Perschbacher , Arjun D. Sharma , Craig Stolen , Kira Q. Stolen , Milan Seth , Paul W. Jones
IPC分类号： A61N1/365
CPC分类号： A61N1/36592 , A61B5/02405 , A61B5/1116 , A61B5/7275 , A61N1/36507 , A61N1/36535 , A61N1/36585
摘要： A heart rate variability or heart rate variation can be identified using sensed and/or paced heart beats. One or more patient metrics, such as a variability index or a variation index, can correspond to the identified heart rate variability or heart rate variation. The patient metrics can be used to identify a need for a particular therapy, such as a rate-responsive pacing therapy. The patient metrics can be used to identify patients at an elevated risk of death. Methods and systems to identify therapy indications or at-risk patients are provided. In an example, a patient risk profile can be adjusted, such as in response to an identified patient heart rate variability or heart rate variation. In an example, a rate-responsive pacing mode can be used to adjust the patient risk profile.

3. 发明申请

US20130237439A1 SYSTEMS AND METHODS USING BIOMARKER PANEL DATA 审中-公开
标题翻译：使用生物标记面板数据的系统和方法
公开(公告)号：US20130237439A1
公开(公告)日：2013-09-12
申请号：US13756129
申请日：2013-01-31
申请人： Craig M. Stolen , Timothy E. Meyer , Milan Seth , Francis G. Spinale , Nicholas David Wold
发明人： Craig M. Stolen , Timothy E. Meyer , Milan Seth , Francis G. Spinale , Nicholas David Wold
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , A61B5/0031 , A61B5/076 , A61B5/14503 , A61B5/14546 , A61B5/686 , A61N1/3627 , A61N1/36557 , A61N1/3956 , G01N2800/52
摘要： Embodiments of the disclosure are related to systems and methods for utilizing biomarker panel data with respect to medical devices and methods, amongst other things. In an embodiment, the disclosure can include a method of predicting the likelihood of response to CRT therapy. The method can include quantifying levels of one or more biomarkers in a biological sample of a patient, analyzing the quantified levels to determine response to CRT therapy, wherein a panel of biomarkers includes at least two selected from the group consisting of CRP, SGP-130, sIL-2R, sTNFR-II, IFNg, BNP, sST2, MMP-2, MMP-9, TIMP-1, TIMP-2, TIMP-4. Other embodiments are also included herein.
摘要翻译：本公开的实施例涉及用于利用关于医疗装置和方法的生物标志物面板数据的系统和方法。在一个实施例中，本公开可以包括预测CRT治疗的可能性的方法。该方法可以包括量化患者生物样品中的一种或多种生物标志物的水平，分析定量水平以确定对CRT治疗的反应，其中生物标志物组包括选自CRP，SGP-130 ，sIL-2R，sTNFR-Ⅱ，IFNg，BNP，sST2，MMP-2，MMP-9，TIMP-1，TIMP-2，TIMP-4。本文还包括其它实施例。

4. 发明申请

US20130196870A1 SYSTEMS AND METHODS USING BIOMARKER PANEL DATA 审中-公开
标题翻译：使用生物标记面板数据的系统和方法
公开(公告)号：US20130196870A1
公开(公告)日：2013-08-01
申请号：US13756135
申请日：2013-01-31
申请人： Craig M. Stolen , Timothy E. Meyer , Milan Seth , Francis G. Spinale , Nicholas David Wold
发明人： Craig M. Stolen , Timothy E. Meyer , Milan Seth , Francis G. Spinale , Nicholas David Wold
IPC分类号： A61B5/145 , A61N1/365 , A61B5/00
CPC分类号： A61B5/14546 , A61B5/14503 , A61B5/4836 , A61B5/686 , A61B5/6869 , A61B5/7282 , A61N1/3627 , A61N1/36557 , A61N1/3956 , G01N33/6893 , G01N2800/32 , G01N2800/325 , G01N2800/326 , G01N2800/50
摘要： Embodiments of the disclosure are related to systems and methods for utilizing biomarker panel data and related medical devices and methods, amongst other things. An embodiment can include a method of screening patients. The method can include quantifying levels of one or more of a panel of biomarkers in a biological sample of a patient. The method can further include analyzing the quantified levels. In some embodiments, the panel of biomarkers includes at least two selected from the group consisting of CRP, SGP-130, sIL-2R, sTNFR-II, IFNg, BNP, sST2, MMP-2, MMP-9, TIMP-1, TIMP-2, TIMP-4. In an embodiment, the disclosure can include a method of diagnosing a patient. The method can include quantifying levels of one or more of a panel of biomarkers in a biological sample of a patient. The method can further include diagnosing the patient based at least in part on the quantified levels. In some embodiments, the panel of biomarkers includes at least two selected from the group consisting of CRP, SGP-130, sIL-2R, sTNFR-II, IFNg, BNP, sST2, MMP-2, MMP-9, TIMP-1, TIMP-2, TIMP-4. Other embodiments are also included herein.
摘要翻译：本公开的实施例涉及用于利用生物标志物面板数据的系统和方法以及相关的医疗装置和方法。一个实施方案可以包括筛选患者的方法。该方法可以包括定量患者生物样品中一组或多种生物标志物的水平。该方法还可以包括分析量化水平。在一些实施方案中，所述生物标志物组包括选自CRP，SGP-130，sIL-2R，sTNFR-II，IFNg，BNP，sST2，MMP-2，MMP-9，TIMP-1， TIMP-2，TIMP-4。在一个实施例中，本公开可以包括诊断患者的方法。该方法可以包括定量患者生物样品中一组或多种生物标志物的水平。该方法还可以包括至少部分地基于量化水平来诊断患者。在一些实施方案中，所述生物标志物组包括选自CRP，SGP-130，sIL-2R，sTNFR-II，IFNg，BNP，sST2，MMP-2，MMP-9，TIMP-1， TIMP-2，TIMP-4。本文还包括其它实施例。

5. 发明申请

US20130150911A1 METHODS AND SYSTEMS FOR IDENTIFYING AND USING HEART RATE VARIABILITY AND HEART RATE VARIATION 有权
标题翻译：识别和使用心率变异性和心率变异的方法和系统
公开(公告)号：US20130150911A1
公开(公告)日：2013-06-13
申请号：US13707186
申请日：2012-12-06
申请人： David L. Perschbacher , Arjun D. Sharma , Craig Stolen , Kira Q. Stolen , Milan Seth , Paul W. Jones
发明人： David L. Perschbacher , Arjun D. Sharma , Craig Stolen , Kira Q. Stolen , Milan Seth , Paul W. Jones
IPC分类号： A61N1/365
CPC分类号： A61N1/36592 , A61B5/02405 , A61B5/1116 , A61B5/7275 , A61N1/36507 , A61N1/36535 , A61N1/36585
摘要： A heart rate variability or heart rate variation can be identified using sensed and/or paced heart beats. One or more patient metrics, such as a variability index or a variation index, can correspond to the identified heart rate variability or heart rate variation. The patient metrics can be used to identify a need for a particular therapy, such as a rate-responsive pacing therapy. The patient metrics can be used to identify patients at an elevated risk of death. Methods and systems to identify therapy indications or at-risk patients are provided. In an example, a patient risk profile can be adjusted, such as in response to an identified patient heart rate variability or heart rate variation. In an example, a rate-responsive pacing mode can be used to adjust the patient risk profile.
摘要翻译：可以使用感测和/或节奏的心跳来识别心率变异性或心率变化。一个或多个患者度量，例如变异性指数或变异指数，可以对应于所识别的心率变异性或心率变化。可以使用患者指标来确定对特定治疗的需要，例如速率响应性起搏治疗。患者指标可用于识别死亡风险升高的患者。提供了确定治疗适应症或危险患者的方法和系统。在一个示例中，可以调整患者风险特征，例如响应于所识别的患者心率变异性或心率变化。在一个示例中，可以使用速率响应式起搏模式来调整患者风险特征。

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