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1. 发明授权

US08483827B2 Method and system for delivering cardiac resynchronization therapy with variable atrio-ventricular delay 有权
公开(公告)号：US08483827B2
公开(公告)日：2013-07-09
申请号：US13398458
申请日：2012-02-16
申请人： Jiang Ding , Yinghong Yu , Milton M. Morris
发明人： Jiang Ding , Yinghong Yu , Milton M. Morris
IPC分类号： A61N1/00
CPC分类号： A61N1/36585 , A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A pacing system computes optimal cardiac resynchronization pacing parameters using intrinsic conduction intervals. In various embodiments, values for atrio-ventricular delay intervals are each computed as a function of an intrinsic atrio-ventricular interval and a parameter reflective of an interventricular conduction delay. Examples of the parameter reflective of the interventricular conduction delay include QRS width and interval between right and left ventricular senses.

2. 发明申请

US20120165893A1 METHOD AND SYSTEM FOR DELIVERING CARDIAC RESYNCHRONIZATION THERAPY WITH VARIABLE ATRIO-VENTRICULAR DELAY 有权
标题翻译：用可变ATRIO-VENTRICULAR延迟递送心脏再生治疗的方法和系统
公开(公告)号：US20120165893A1
公开(公告)日：2012-06-28
申请号：US13398458
申请日：2012-02-16
申请人： Jiang Ding , Yinghong Yu , Milton M. Morris
发明人： Jiang Ding , Yinghong Yu , Milton M. Morris
IPC分类号： A61N1/365
CPC分类号： A61N1/36585 , A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A pacing system computes optimal cardiac resynchronization pacing parameters using intrinsic conduction intervals. In various embodiments, values for atrio-ventricular delay intervals are each computed as a function of an intrinsic atrio-ventricular interval and a parameter reflective of an interventricular conduction delay. Examples of the parameter reflective of the interventricular conduction delay include QRS width and interval between right and left ventricular senses.
摘要翻译：起搏系统使用内在导电间隔计算最佳心脏再同步起搏参数。在各种实施例中，心室间隔延迟间隔的值各自被计算为内在房室间隔和反映室间传导延迟的参数的函数。反映室间传导延迟的参数的示例包括QRS宽度和右心室感觉和左心室感觉之间的间隔。

3. 发明申请

US20100069988A1 METHOD AND SYSTEM FOR DELIVERING CARDIAC RESYNCHRONIZATION THERAPY WITH VARIABLE ATRIO-VENTRICULAR DELAY 有权
标题翻译：用可变ATRIO-VENTRICULAR延迟递送心脏再生治疗的方法和系统
公开(公告)号：US20100069988A1
公开(公告)日：2010-03-18
申请号：US12622602
申请日：2009-11-20
申请人： Jiang Ding , Yinghong Yu , Milton M. Morris
发明人： Jiang Ding , Yinghong Yu , Milton M. Morris
IPC分类号： A61N1/368
CPC分类号： A61N1/36585 , A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A pacing system computes optimal cardiac resynchronization pacing parameters using intrinsic conduction intervals. In various embodiments, values for atrio-ventricular delay intervals are each computed as a function of an intrinsic atrio-ventricular interval and a parameter reflective of an interventricular conduction delay. Examples of the parameter reflective of the interventricular conduction delay include QRS width and interval between right and left ventricular senses.
摘要翻译：起搏系统使用内在导电间隔计算最佳心脏再同步起搏参数。在各种实施例中，心室间隔延迟间隔的值各自被计算为内在房室间隔和反映室间传导延迟的参数的函数。反映室间传导延迟的参数的示例包括QRS宽度和右心室感觉和左心室感觉之间的间隔。

4. 发明授权

US07142927B2 Method and system for the selection of cardiac defibrillation shocks based on discomfort 失效
标题翻译：基于不适的选择心脏除颤休克的方法和系统
公开(公告)号：US07142927B2
公开(公告)日：2006-11-28
申请号：US10234624
申请日：2002-09-04
申请人： Michael E. Benser , Raymond E. Ideker , Milton M. Morris
发明人： Michael E. Benser , Raymond E. Ideker , Milton M. Morris
IPC分类号： A61N1/39
CPC分类号： A61N1/3925 , A61N1/3906
摘要： Methods, systems and computer program products for selecting a shock profile for a defibrillator based on patient discomfort to a plurality of different defibrillating shocks include delivering a first defibrillating shock having an associated first shock profile to a patient, and measuring the associated physical displacement of a selected region in the patient. A second defibrillating shock having an associated second shock profile is delivered to the patient, and the associated physical displacement of the selected region in measured. One of the first or second shock profiles is selected based on which shock profile has the lesser amount of measured physical displacement.
摘要翻译：用于基于多个不同除颤冲击的患者不适来选择用于除颤器的冲击波形的方法，系统和计算机程序产品包括将具有相关联的第一冲击波形的第一除颤冲击传递给患者，以及测量相关联的物理位移患者的选定区域。具有相关联的第二冲击波形的第二除颤冲击传递给患者，并且所测量的所选区域的相关物理位移。基于哪个冲击分布具有较少量的物理位移量来选择第一或第二冲击曲线之一。

5. 发明授权

US06978177B1 Method and apparatus for using atrial discrimination algorithms to determine optimal pacing therapy and therapy timing 有权
标题翻译：使用心房辨别算法确定最佳起搏治疗和治疗时机的方法和装置
公开(公告)号：US06978177B1
公开(公告)日：2005-12-20
申请号：US09712600
申请日：2000-11-14
申请人： Victor T. Chen , David S. Wood , Milton M. Morris
发明人： Victor T. Chen , David S. Wood , Milton M. Morris
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/3622
摘要： A system and method which employs atrial discrimination algorithms to distinguish between different atrial arrhythmias occurring in a patient for selecting an optimal pacing therapy corresponding to the type of arrhythmia identified. The invention may be implemented in a bradycardia pacemaker or other implantable cardiac device. In response to the detection of an atrial rate above the atrial tracking rate, discrimination criteria are applied to a detected atrial activity signal to distinguish between different types of supraventricular tachycardia, such as fast atrial flutter and other atrial flutter at a relatively slower rate, which may be occurring in the patient. The discrimination criteria may be, for example, rate-based or morphology based. The pacer is controlled to provide pacing therapy to a heart in a manner corresponding to the type of supraventricular tachycardia identified. For example, antitachycardia pacing may be provided to the heart in response to the detection of a relatively lower rate supraventricular tachycardia/other atrial flutter, whereas another pacing control, e.g., ventricular pacing, such as ventricular rate regulation or Rate Smoothing, may be applied if a more rapid rate supraventricular tachycardia/fast atrial flutter is identified. The output of an atrial discrimination algorithm may be tracked and the trend thereof used to improve therapy timing.
摘要翻译：一种使用心房辨别算法来区分患者发生的不同心房心律不齐的系统和方法，用于选择对应于确定的心律失常类型的最佳起搏治疗。本发明可以在心动过缓起搏器或其他可植入的心脏装置中实现。响应于心房率高于心房跟踪率的检测，将鉴别标准应用于检测到的心房活动信号，以区别不同类型的室上性心动过速，例如以较慢速率的快速心房扑动和其他心房扑动，其中可能发生在患者身上。歧视标准可以是例如基于速率或基于形态的。控制起搏器以对应于所鉴定的室上性心动过速类型的方式向心脏提供起搏治疗。例如，可以响应于检测相对较低的室上性心动过速/其他心房扑动而向心脏提供抗心动过速起搏，而可以应用另一起搏控制，例如心室起搏，例如心室速率调节或速率平滑如果确定更快速的室上性心动过速/快速心房扑动。可以跟踪心房辨别算法的输出，并且其趋势用于改善治疗时机。

6. 发明授权

US06740080B2 Ablation system with selectable current path means 失效
标题翻译：消融系统具有可选择的电流通路装置
公开(公告)号：US06740080B2
公开(公告)日：2004-05-25
申请号：US09945097
申请日：2001-08-31
申请人： Mudit K. Jain , Milton M. Morris , Bruce KenKnight
发明人： Mudit K. Jain , Milton M. Morris , Bruce KenKnight
IPC分类号： A61B1812
CPC分类号： A61B18/1206 , A61B18/16 , A61B2018/00755 , A61B2018/00875 , A61B2018/1467
摘要： An apparatus for delivering energy to a biological site includes a catheter having an ablation electrode and a plurality of backplates distributed at various locations proximal the biological site. The backplates are coupled to a switching device for selecting which backplate to utilize as a return electrode to complete the circuit with the ablation electrode in order to obtain deeper, larger lesions for a given amount of energy. The backplate selection is made by determining which return electrode most closely places the biological site between the ablation electrode and the backplate. Backplate selection may be made automatically based on impedance measurements or conduction time measurements. Alternatively, the backplate selection can be made manually.
摘要翻译：用于向生物部位输送能量的装置包括具有消融电极的导管和分布在生物部位附近的各个位置处的多个背板。背板耦合到开关装置，用于选择哪个背板用作返回电极以用消融电极完成电路，以便为给定量的能量获得更深更大的损伤。通过确定哪个返回电极最接近放置消融电极和背板之间的生物位点来进行背板选择。可以基于阻抗测量或导通时间测量自动进行背板选择。或者，可以手动进行背板选择。

7. 发明授权

US06480741B1 Heart monitors with robust interval measurements 有权
标题翻译：心脏监视器，具有鲁棒的间隔测量
公开(公告)号：US06480741B1
公开(公告)日：2002-11-12
申请号：US09391111
申请日：1999-09-07
申请人： Milton M. Morris
发明人： Milton M. Morris
IPC分类号： A61N137
CPC分类号： A61B5/04012 , A61N1/3621 , A61N1/365
摘要： Thousands of patients prone to irregular and sometimes life threatening heart rhythms have miniature heart-monitoring devices, such as defibrillators and cardioverters, implanted in their chests. These devices detect abnormal heart rhythms and automatically apply electrical therapy to restore normal heart function. Significant parts of these devices include the microprocessor and stored instructions, or algorithms, that govern how the devices interpret and react to electrical signals indicative of normal or abnormal heart rhythms. These algorithms generally use the time intervals between successive heart beats, or cardiac events, as a key factor in therapy decisions. To ensure accuracy of interval measurements, the inventor devised new methods for processing heart electrical signals, some of which ensure accurate interval measurements without unduly delaying therapy decisions or consuming significant battery power. One of these new methods detects an abnormal interval measurement and either disqualifies the abnormal interval from use in making therapy decisions or divides the abnormal interval into two or more other intervals, thereby facilitating identification and treatment of abnormal rhythmic conditions both efficiently and accurately.
摘要翻译：容易出现不规则，有时威胁生命的心脏节律的成千上万的患者将微型心脏监测装置（如除颤器和心脏复律器）植入胸部。这些装置检测异常的心律，并自动应用电疗法恢复正常的心脏功能。这些设备的重要部分包括微处理器和存储的指令或算法，其指导设备如何解释和反应指示正常或异常心律的电信号。这些算法通常将连续心跳或心脏事件之间的时间间隔用作治疗决策的关键因素。为了确保间隔测量的准确性，本发明人设计了用于处理心脏电信号的新方法，其中一些确保准确的间隔测量，而不会不适当地延迟治疗决定或消耗显着的电池电量。这些新方法中的一种检测异常间隔测量，并且取消在作出治疗决定时使用的异常间隔的资格，或将异常间隔划分为两个或更多个其他间隔，从而有效和准确地识别和治疗异常节律条件。

8. 发明授权

US06314321B1 Therapy-selection methods for implantable heart monitors 有权
标题翻译：植入式心脏监护仪的治疗选择方法
公开(公告)号：US06314321B1
公开(公告)日：2001-11-06
申请号：US09343924
申请日：1999-06-30
申请人： Milton M. Morris
发明人： Milton M. Morris
IPC分类号： A61N1365
CPC分类号： A61N1/3621 , A61N1/3962
摘要： Thousands of patients prone to irregular and sometimes life threatening heart rhythms have miniature heart-monitoring devices, such as defibrillators and cardioverters, implanted in their chests. These devices detect onset of abnormal heart rhythms and automatically apply one or more shocks to their hearts. When properly sized and timed, the shocks restore normal heart function without human intervention. A critical part of these devices is the monitoring circuitry, which includes a microprocessor and stored instructions, or algorithms, that govern how the devices interpret and react to electrical signals indicative of abnormal heart rhythms. Often, the algorithms are too simple or too complex. Algorithms that are too simple lead to unnecessary shocking of the heart, while those that are too complex consume considerable battery power. Accordingly, the inventor devised a relatively simple and accurate algorithm for determining appropriate therapy options. One version of the algorithm computes three statistics—a range statistic, a minimum interval statistic, and a dispersion index—from a set of depolarization intervals. This algorithm defines the range statistic as the difference between largest and smallest depolarization intervals, the minimum interval as the smallest of the intervals, and the dispersion index as the standard deviation of the intervals. A scalar interval dispersion assessment, based on the three statistics, is then compared to a threshold to identify a rhythm as a flutter or fibrillation. The three statistics can also define a point in a three-dimensional space, with rhythm identification based on relative position of the point and a surface in the space.
摘要翻译：容易出现不规则，有时威胁生命的心脏节律的成千上万的患者将微型心脏监测装置（如除颤器和心脏复律器）植入胸部。这些装置检测出异常心律的发作，并自动对其心脏施加一次或多次冲击。正确的尺寸和时间，震荡恢复正常的心脏功能，无需人为干预。这些设备的关键部分是监控电路，其包括微处理器和存储的指令或算法，其控制设备如何解释和反应指示异常心律的电信号。通常，算法太简单或太复杂。太简单的算法会导致心脏不必要的震动，而那些太复杂的算法会消耗大量的电池电量。因此，发明人设计了一种相对简单和准确的算法来确定适当的治疗方案。一个版本的算法从一组去极化间隔计算三个统计量 - 范围统计量，最小间隔统计量和色散指数。该算法将范围统计量定义为最大和最小去极化间隔之间的差异，间隔的最小间隔，以及作为间隔的标准偏差的色散指数。然后将基于三个统计量的标量间隔色散评估与阈值进行比较，以将节律识别为颤动或颤动。三个统计数据还可以在三维空间中定义一个点，其中基于点的相对位置和空间中的表面的节奏识别。

9. 发明授权

US08989867B2 Implantable nerve wrap for nerve stimulation configured for far field radiative powering 有权
标题翻译：用于神经刺激的植入式神经包被配置用于远场辐射动力
公开(公告)号：US08989867B2
公开(公告)日：2015-03-24
申请号：US13434119
申请日：2012-03-29
申请人： Eric Y. Chow , Milton M. Morris , David L. Thompson
发明人： Eric Y. Chow , Milton M. Morris , David L. Thompson
IPC分类号： A61N1/00 , A61N1/378 , A61N1/36
CPC分类号： A61N1/3787 , A61N1/0551 , A61N1/0556 , A61N1/3605 , A61N1/37211 , A61N1/37223
摘要： A particular implantable device may include an antenna configured to receive a far field radiative signal. The implantable device may also include a voltage rectifier configured to rectify the far field radiative signal received by the antenna to provide a rectified voltage signal. The implantable device may further include a charge storage element operative to receive the rectified voltage signal and to store charge responsive to the rectified voltage signal. The implantable device may also include a stimulation module powered by the charge storage element. The stimulation module may be operative to generate an electrical stimulation signal to stimulate a target nerve of a patient. The implantable medical device may further include a nerve wrap configured to house the voltage rectifier, the charge storage element, and the stimulation module. The nerve wrap may include one or more electrodes operative to deliver the electrical stimulation signal to the target nerve.
摘要翻译：特定的可植入装置可以包括被配置为接收远场辐射信号的天线。可植入装置还可以包括电压整流器，其被配置为对由天线接收的远场辐射信号进行整流以提供整流的电压信号。可植入装置还可以包括电荷存储元件，其可操作以接收经整流的电压信号并且响应于整流电压信号来存储电荷。可植入装置还可以包括由电荷存储元件供电的刺激模块。刺激模块可操作以产生电刺激信号以刺激患者的目标神经。可植入医疗装置还可以包括构造成容纳电压整流器，电荷存储元件和刺激模块的神经包裹物。神经包裹可以包括一个或多个电极，其可操作以将电刺激信号递送到目标神经。

10. 发明申请

US20130018439A1 IMPLANTABLE NERVE WRAP FOR NERVE STIMULATION CONFIGURED FOR FAR FIELD RADIATIVE POWERING 有权
公开(公告)号：US20130018439A1
公开(公告)日：2013-01-17
申请号：US13434119
申请日：2012-03-29
申请人： Eric Y. CHOW , Milton M. MORRIS , David L. THOMPSON
发明人： Eric Y. CHOW , Milton M. MORRIS , David L. THOMPSON
IPC分类号： A61N1/378
CPC分类号： A61N1/3787 , A61N1/0551 , A61N1/0556 , A61N1/3605 , A61N1/37211 , A61N1/37223
摘要： A particular implantable device may include an antenna configured to receive a far field radiative signal. The implantable device may also include a voltage rectifier configured to rectify the far field radiative signal received by the antenna to provide a rectified voltage signal. The implantable device may further include a charge storage element operative to receive the rectified voltage signal and to store charge responsive to the rectified voltage signal. The implantable device may also include a stimulation module powered by the charge storage element. The stimulation module may be operative to generate an electrical stimulation signal to stimulate a target nerve of a patient. The implantable medical device may further include a nerve wrap configured to house the voltage rectifier, the charge storage element, and the stimulation module. The nerve wrap may include one or more electrodes operative to deliver the electrical stimulation signal to the target nerve.

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