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1. 发明授权

US06810287B2 Implantable cardiac disease management device with trigger-stored polysomnogram and phonocardiogram 有权
标题翻译：具有触发储存多导睡眠图和心音图的植入性心脏病管理装置
公开(公告)号：US06810287B2
公开(公告)日：2004-10-26
申请号：US10006183
申请日：2001-12-03
申请人： Qingsheng Zhu , Jeffrey E. Stahmann , John Hatlestad
发明人： Qingsheng Zhu , Jeffrey E. Stahmann , John Hatlestad
IPC分类号： A61N1365
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/36542 , A61N1/3684
摘要： Currently, brady, tachy and CRT devices all provide stored electrograms that record ambulatory electrograms with programmable trigger mechanisms. The present invention comprises an implantable device with additional capability that can store polysomnograms and phonocardiograms. The polysomnograms can be obtained from an impendent sensor of the type used in minute ventilation-based rate-adaptive pacemakers. The phonocardiograms are obtained from an accelerometer transducer or other type sensors that can detect heart sound.
摘要翻译：目前，brady，tachy和CRT设备都提供存储的电描记图，记录可编程触发机制的动态电图。本发明包括具有可存储多导睡眠图和心音图的附加能力的可植入装置。多导睡眠图可以从用于基于微通气的速率自适应起搏器中使用的类型的传感器获得。心音图从加速度传感器或可以检测心音的其他类型传感器获得。

2. 发明授权

US06772009B2 Method and apparatus for adjusting the sensing threshold of a cardiac rhythm management device 失效
标题翻译：用于调节心律管理装置的感测阈值的方法和装置
公开(公告)号：US06772009B2
公开(公告)日：2004-08-03
申请号：US10152211
申请日：2002-05-20
申请人： Geng Zhang , Qingsheng Zhu , Laura Mepham , Jesse W. Hartley
发明人： Geng Zhang , Qingsheng Zhu , Laura Mepham , Jesse W. Hartley
IPC分类号： A61N1365
CPC分类号： A61N1/3704 , A61N1/368
摘要： A method and apparatus for automatically adjusting the sensing threshold of cardiac rhythm management devices. The invention is particularly suited for implementation in devices such as implantable cardiac pacemakers and implantable cardioverter/defibrillators. A method and apparatus are provided in which a noise level and signal level for a sensing channel are determined for each cardiac cycle with the sensing threshold of the channel being adjusted in accordance therewith.
摘要翻译：一种用于自动调节心律管理装置感测阈值的方法和装置。本发明特别适用于诸如可植入心脏起搏器和植入式心律转复器/去纤颤器的装置中的实现。提供了一种方法和装置，其中针对每个心动周期确定用于感测通道的噪声电平和信号电平，同时根据该通道的感测阈值进行调整。

3. 发明授权

US06754530B2 Four-chamber pacing system for optimizing cardiac output and determining heart condition 失效
标题翻译：四心室起搏系统，用于优化心输出量并确定心脏状况
公开(公告)号：US06754530B2
公开(公告)日：2004-06-22
申请号：US09946495
申请日：2001-09-06
申请人： Arnoldus Bakels , Robert Leinders , Cobus de Roos
发明人： Arnoldus Bakels , Robert Leinders , Cobus de Roos
IPC分类号： A61N1365
CPC分类号： A61N1/36521 , A61N1/3622 , A61N1/3627 , A61N1/368 , A61N1/3682
摘要： A pacing system and method for providing multiple chamber pacing of a patient's heart, and in particular, pacing programmed for treatment of various forms of heart failure. The system utilizes impedance sensing for determining optimum pacing parameters, e.g., for pacing the left ventricle so that left heart output is maximized. The impedance sensing also is used for determination of arrhythmias or progression of heart failure. Impedance sensing is provided for between selected pairs of the four chambers, to enable optimizing of information for control and diagnosis. In a preferred embodiment of the invention, impedance measurements are obtained for determining the timing of right heart valve closure or right ventricular contractions, and the timing of delivery of left ventricular pace pulses is adjusted so as to optimally synchronize left ventricular pacing with the right ventricular contractions. Impedance sensing in the left heart also provides timing of mechanical contraction, and the pacemaker controls pacing to maintain bi-ventricular mechanical synchronization adjusted for maximum cardiac output.
摘要翻译：用于提供患者心脏的多个室起搏的起搏系统和方法，特别是针对治疗各种形式的心力衰竭的起搏。系统利用阻抗感测来确定最佳起搏参数，例如用于起搏左心室，使得左心输出最大化。阻抗检测也用于确定心律失常或心力衰竭进展。在四个室的选定对之间提供阻抗感测，以实现用于控制和诊断的信息的优化。在本发明的优选实施例中，获得用于确定右心瓣膜闭合或右心室收缩的时间的阻抗测量值，并且调节左心室起搏脉冲的传递时间，以便最佳地同步左心室起搏与右心室收缩。心脏中的阻抗传感还提供机械收缩的时机，并且起搏器控制起搏以维持双心室机械同步，以调节最大心输出量。

4. 发明授权

US06738666B1 Detection of orthostatic hypotension using positional data and cross-check data 失效
标题翻译：使用位置数据和交叉检查数据检测直立性低血压
公开(公告)号：US06738666B1
公开(公告)日：2004-05-18
申请号：US10002615
申请日：2001-11-01
申请人： Euljoon Park , Kerry Bradley
发明人： Euljoon Park , Kerry Bradley
IPC分类号： A61N1365
CPC分类号： A61N1/36542
摘要： An implantable cardiac stimulation device is programmed to administer pacing therapy in response to a postural change in a patient's position and a confirmation of that postural change using a cross-check parameter. The stimulation device is equipped with a position sensor to sense a position parameter indicative of when a patient changes from a horizontal position to an upright position. The stimulation device further monitors a cross-check parameter that is affected or modulated by position changes. When the position sensor indicates a postural change and the cross-check parameter confirms this change as being sufficient to induce orthostatic hypotension, the device administers cardiac pacing therapy to the patient.
摘要翻译：可植入心脏刺激装置被编程为响应于患者位置的姿势变化来管理起搏治疗，并且使用交叉检查参数来确认该姿势改变。刺激装置配备有位置传感器，用于感测指示患者什么时候从水平位置变化到直立位置的位置参数。刺激装置还监视受位置变化影响或调制的交叉检查参数。当位置传感器指示姿势变化并且交叉检查参数证实该变化足以引起直立性低血压时，该装置对患者进行心脏起搏治疗。

5. 发明授权

US06681134B2 Therapy-selection methods for implantable heart monitors 失效
标题翻译：植入式心脏监护仪的治疗选择方法
公开(公告)号：US06681134B2
公开(公告)日：2004-01-20
申请号：US09955491
申请日：2001-09-18
申请人： Milton M. Morris
发明人： Milton M. Morris
IPC分类号： A61N1365
CPC分类号： A61N1/3621 , A61N1/3962
摘要： Thousands of patients prone to irregular and sometimes life threatening heart rhythms have miniature heart-monitoring devices, such as defibrillators and cardioverters, implanted in their chests. These devices detect onset of abnormal heart rhythms and automatically apply one or more shocks to their hearts. When properly sized and timed, the shocks restore normal heart function without human intervention. A critical part of these devices is the monitoring circuitry, which includes a microprocessor and stored instructions, or algorithms, that govern how the devices interpret and react to electrical signals indicative of abnormal heart rhythms. Often, the algorithms are too simple or too complex. Algorithms that are too simple lead to unnecessary shocking of the heart, while those that are too complex consume considerable battery power. Accordingly, the inventor devised a relatively simple and accurate algorithm for determining appropriate therapy options. One version of the algorithm computes three statistics—a range statistic, a minimum interval statistic, and a dispersion index—from a set of depolarization intervals. This algorithm defines the range statistic as the difference between largest and smallest depolarization intervals, the minimum interval as the smallest of the intervals, and the dispersion index as the standard deviation of the intervals. A scalar interval dispersion assessment, based on the three statistics, is then compared to a threshold to identify a rhythm as a flutter or fibrillation. The three statistics can also define a point in a three-dimensional space, with rhythm identification based on relative position of the point and a surface in the space.
摘要翻译：容易出现不规则，有时威胁生命的心脏节律的成千上万的患者将微型心脏监测装置（如除颤器和心脏复律器）植入胸部。这些装置检测出异常心律的发作，并自动对其心脏施加一次或多次冲击。正确的尺寸和时间，震荡恢复正常的心脏功能，无需人为干预。这些设备的关键部分是监控电路，其包括微处理器和存储的指令或算法，其控制设备如何解释和反应指示异常心律的电信号。通常，算法太简单或太复杂。太简单的算法会导致心脏不必要的震动，而那些太复杂的算法会消耗大量的电池电量。因此，发明人设计了一种相对简单和准确的算法来确定适当的治疗方案。一个版本的算法从一组去极化间隔计算三个统计量 - 范围统计量，最小间隔统计量和色散指数。该算法将范围统计量定义为最大和最小去极化间隔之间的差异，间隔的最小间隔，以及作为间隔的标准偏差的色散指数。然后将基于三个统计量的标量间隔色散评估与阈值进行比较，以将节律识别为颤动或颤动。三个统计数据还可以在三维空间中定义一个点，其中基于点的相对位置和空间中的表面的节奏识别。

6. 发明授权

US06665564B2 Cardiac rhythm management system selecting A-V delay based on interval between atrial depolarization and mitral valve closure 有权
公开(公告)号：US06665564B2
公开(公告)日：2003-12-16
申请号：US09862763
申请日：2001-05-21
申请人： William C. Lincoln , Gerrard M. Carlson
发明人： William C. Lincoln , Gerrard M. Carlson
IPC分类号： A61N1365
CPC分类号： A61N1/368
摘要： A cardiac rhythm management system selects an atrioventricular (A-V) delay based on a time-interval between an atrial depolarization and mitral valve closure (MVC). For several different A-V delays, the system measures time intervals between atrial depolarizations (i.e., sensed or paced P-waves) and accelerometer-detected MVCs. Based on this information, the system selects a particular A-V delay for improving cardiac output during subsequent delivery of cardiac rhythm management therapy.

7. 发明授权

US06662048B2 Implantable medical device with temperature measuring and storing capability 有权
公开(公告)号：US06662048B2
公开(公告)日：2003-12-09
申请号：US09823260
申请日：2001-03-30
申请人： Ron A. Balczewski , Jeffrey A. Von Arx , William J. Linder , Mark D. Amundson
发明人： Ron A. Balczewski , Jeffrey A. Von Arx , William J. Linder , Mark D. Amundson
IPC分类号： A61N1365
CPC分类号： G01K13/002 , A61B5/0008 , A61B5/0031 , A61B5/7285 , A61N1/3655
摘要： An implantable medical device such as a cardiac pacemaker or implantable cardioverter/defibrillator with the capability of storing body temperature measurements taken periodically and/or when triggered by particular events.

8. 发明授权

US06650940B1 Accelerometer-based heart sound detection for autocapture 有权
标题翻译：基于加速度计的心脏声音检测
公开(公告)号：US06650940B1
公开(公告)日：2003-11-18
申请号：US09496832
申请日：2000-02-02
申请人： Qingsheng Zhu , Julio C. Spinelli , Gerrard M. Carlson
发明人： Qingsheng Zhu , Julio C. Spinelli , Gerrard M. Carlson
IPC分类号： A61N1365
CPC分类号： A61N1/36542 , A61N1/3712
摘要： An implantable cardiac rhythm management device capable of automatically detecting intrinsic and evoked response of a patient's heart. The device operates in an automatic capture verification mode, wherein a global accelerometer signal is utilized to identify heart sounds (S1 and S2) of the patient's heart. The presence or absence of one or more of the heart sounds S1 and S2 in the accelerometer signal indicates whether a stimulation pulse evokes a response by the patient's heart. The device may automatically adjust the stimulation output in accordance with a step down stimulation protocol, wherein the presence of a predetermined heart sound indicates capture. Also, the device may suspend the automatic capture verification sequence if the patient's physical activity level exceeds a predetermined threshold.
摘要翻译：一种能够自动检测患者心脏的内在和诱发反应的植入式心律管理装置。该装置以自动捕获验证模式工作，其中使用全局加速度计信号来识别患者心脏的心音（S1和S2）。加速度计信号中存在或不存在一个或多个心音S1和S2表示刺激脉冲是否引起患者心脏的反应。设备可以根据降压刺激协议自动调节刺激输出，其中预定心音的存在指示捕获。此外，如果患者的身体活动水平超过预定阈值，则设备可以暂停自动捕获验证序列。

9. 发明授权

US06647295B2 Implantable cardiac stimulation device with detection and therapy for patients with vasovagal syncope 有权
公开(公告)号：US06647295B2
公开(公告)日：2003-11-11
申请号：US09849722
申请日：2001-05-03
申请人： Joseph J. Florio , Gregory Hauck , Gene A. Bornzin
发明人： Joseph J. Florio , Gregory Hauck , Gene A. Bornzin
IPC分类号： A61N1365
CPC分类号： A61N1/36514
摘要： A pacemaker or other implantable cardiac stimulation device is configured with both a rate hysteresis mode and a vasovagal syncope prevention mode. Within the rate hysteresis mode, the pacemaker detects when the intrinsic heart rate of the patient is below an escape rate, then paces the heart at a Base Rate until an intrinsic beat is detected. When programmed in the vasovagal syncope prevention mode, upon detecting the intrinsic rate falling below the Hysteresis Escape Rate, the pacemaker paces the heart at a Vasovagal Syncope Response Rate, which is considerably higher than the Base Rate. The pacemaker is preferably set to the syncope prevention mode for patients prone to recurrent vasovagal syncope. By pacing the heart at the higher Vasovagal Syncope Response Rate, the pacemaker thereby helps prevent a significant drop in blood pressure which might otherwise cause a loss of consciousness in the patient. System and method embodiments are described.

10. 发明授权

US06567701B2 Method and system for discriminating captured beats from non-captured beats in a cardiac pacing system 有权
公开(公告)号：US06567701B2
公开(公告)日：2003-05-20
申请号：US09741351
申请日：2000-12-21
申请人： Bernardus F. M. Vonk
发明人： Bernardus F. M. Vonk
IPC分类号： A61N1365
CPC分类号： A61N1/371
摘要： A method of discriminating a captured beat is provided. A pulse is transmitted and an evoked response signal is received. The evoked response signal is filtered and the filtered response signal is analyzed for at least one positive signal component. Systems and devices for discriminating a captured beat are also provided.

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