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1. 发明授权

US08048427B2 Subgenomic replicons of the flavivirus dengue 有权
标题翻译：黄病毒登革热的亚基因组复制子
公开(公告)号：US08048427B2
公开(公告)日：2011-11-01
申请号：US12394822
申请日：2009-02-27
申请人： Xiaowu Pang , Andrew I. Dayton , Mingjie Zhang
发明人： Xiaowu Pang , Andrew I. Dayton , Mingjie Zhang
IPC分类号： A61K39/12 , C12N7/01 , C12N15/86
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2740/16122 , C12N2740/16134 , C12N2770/24123 , C12N2770/24143 , C12N2770/24161 , C12N2770/24162 , C12N2840/203 , Y02A50/386
摘要： The present invention discloses the construction of dengue virus subgenomic replicons containing large deletions in the structural region (C-preM-E) of the genome, which replicons are useful as vaccines to protect against dengue virus infection.
摘要翻译：本发明公开了在基因组结构域（C-preM-E）中含有大缺失的登革热病毒亚基因组复制子的构建，该复制子可用作防止登革热病毒感染的疫苗。

2. 发明授权

US06922281B2 Erbium-doped fiber amplifier and integrated module components 有权
标题翻译：掺铒光纤放大器和集成模块组件
公开(公告)号：US06922281B2
公开(公告)日：2005-07-26
申请号：US10138033
申请日：2002-05-03
申请人： Jing-Jong Pan , Xiangdong Qiu , Kejian Guan , Mingjie Zhang
发明人： Jing-Jong Pan , Xiangdong Qiu , Kejian Guan , Mingjie Zhang
IPC分类号： G02B6/26 , G02B6/32 , G02B6/34 , G02B6/42 , H01S3/067 , H01S3/094 , H01S3/0941 , H01S3/13 , H01S3/131 , H01S5/022 , H01S3/00
CPC分类号： G02B6/4201 , G02B6/2746 , G02B6/29361 , G02B6/29389 , G02B6/327 , G02B6/4204 , G02B6/4206 , G02B6/4208 , G02B6/4209 , G02B6/4215 , G02B6/424 , G02B6/4263 , G02B6/4269 , G02B6/4286 , H01S3/005 , H01S3/0064 , H01S3/0078 , H01S3/06704 , H01S3/06754 , H01S3/06766 , H01S3/094003 , H01S3/094053 , H01S3/09415 , H01S3/1301 , H01S3/1305 , H01S3/1312 , H01S3/1608 , H01S5/0064 , H01S5/02212 , H01S5/02284 , H01S5/02296 , H01S5/0683
摘要： An EDFA with integrated input and output modules is presented. The integrated input module has a packaged pump laser diode mounted to the metal EDFA package to provide a heat sink for the pump laser diode which sends the pump laser light over a optical fiber section connected to the amplifying erbium-doped optical fiber section. The fiber section is formed from an optical fiber which better matches the transmission modes in the erbium-doped optical fiber section and has an end subsection of the single mode fiber for a larger numerical aperture. Collimating lenses also increase the coupling efficiency of the laser diode to the erbium-doped fiber section. The integrated output module has a photodiode with a tap filter to monitor the output power of the EDFA, an optical isolator to prevent interference in the erbium-doped optical fiber section. With a twin optical isolator, the integrated input and output modules can be arranged in different ways and combinations with the erbium-doped optical fiber section. The resulting EDFAs can be manufactured relatively inexpensively into an very small packages compared to current EDFA packages.
摘要翻译：介绍了具有集成输入和输出模块的EDFA。集成输入模块具有安装在金属EDFA封装上的封装泵激光二极管，为泵激光二极管提供散热器，泵浦激光二极管将泵浦激光发射到与放大掺铒光纤部分连接的光纤部分上。光纤部分由光纤形成，该光纤更好地匹配掺铒光纤部分的传输模式，并且具有用于更大数值孔径的单模光纤的端部部分。准直透镜还增加了激光二极管与掺铒光纤部分的耦合效率。集成输出模块具有带有抽头滤波器的光电二极管，用于监视EDFA的输出功率，光隔离器可防止铒掺杂光纤部分的干扰。使用双光隔离器，集成输入和输出模块可以以掺铒光纤部分的不同方式和组合进行布置。与目前的EDFA封装相比，所得到的EDFA可以相对廉价地制造成非常小的封装。

3. 发明授权

US06693166B1 Cdk5—specific inhibitory peptides 失效
标题翻译： Cdk5特异性抑制肽
公开(公告)号：US06693166B1
公开(公告)日：2004-02-17
申请号：US09289612
申请日：1999-04-12
申请人： Jerry H. Wang , Mingjie Zhang , Damu Tang
发明人： Jerry H. Wang , Mingjie Zhang , Damu Tang
IPC分类号： A61K3800
CPC分类号： A61K38/005 , A61K38/1709
摘要： The activation of cyclin dependent kinase 5 (Cdk5) depends on the binding of its neuronal specific activator Nck5a. The minimal activation domain of Nck5a has been experimentally determine comprise acid residues 150 to 291 of the protein. It has been demonstrated that a 28 residue peptide encompassing amino acid residues Ala 146 to Asp 173 of Nck5a is capable of binding Cdk5 and hence resulting in the inhibition of its Kinase activity. Additionally, this peptide could also inhibit Cdk2 with a similar potency as it does to Cdk5. The direct competition experiments showed that the Nck5a inhibitory peptide does not compete with Nck5a for Cdk5 or cyclin A for Cdk2. Steady state kinetic analysis indicated that the Nck5a peptide acts as a non-competitive inhibitor of Cdk5/Nck5a complex with respect to its substrate. The structure of the peptide in solution as determined by the methods of circular dichroism and two-dimensional 1H NMR spectroscopy have been performed in order to understand the molecular basis of kinase inhibition by the peptide. A segment of the peptide, corresponding to amino acid resides Ser149 to Arg169 adopts an amphipathic alpha-helical structure in solution. Four Leu residues and one Phe residue clustered on the hydrophobic face of the helix, and this hydrophobic face is likely to be the contact area when the peptide binds and inhibits both Cdk5 and Cdk2. Mutational experiments have also indicated that the C-terminal end of the peptide contributes to the inhibition of Cdk5 and Cdk2.
摘要翻译：细胞周期蛋白依赖性激酶5（Cdk5）的激活取决于其神经元特异性活化剂Nck5a的结合。 Nck5a的最小活化结构域已经通过实验测定包含蛋白质的酸残基150至291。已经证明，包含Nck5a的氨基酸残基Ala146至Asp173的28个残基肽能够结合Cdk5，因此导致其激酶活性的抑制。另外，这种肽也可以以与Cdk5相同的效力抑制Cdk2。直接竞争实验表明，Nck5a抑制肽与Cdk5或Cdk2的细胞周期蛋白A不同Nck5a竞争。稳态动力学分析表明，Nck5a肽作为Cdk5 / Nck5a复合物相对于其底物的非竞争性抑制剂。已经进行了通过圆二色性和二维1 H NMR光谱法测定的溶液中肽的结构，以了解肽激酶抑制的分子基础。肽对应于氨基酸的片段Ser149至Arg169在溶液中采用两亲性α-螺旋结构。四个Leu残基和一个Phe残基聚集在螺旋的疏水面上，当该肽结合并抑制Cdk5和Cdk2时，该疏水性面可能是接触面积。突变实验也表明肽的C末端有助于抑制Cdk5和Cdk2。

4. 发明申请

US20170037371A1 METHOD FOR PREPARING AND USING CELL GHOST WITH ACTIVE FACTORS AS SYNERGIST OF LYMPHOCYTE IN VITRO CULTURE 审中-公开
标题翻译：制备和使用细胞GHOST与活体因子作为体外培养的淋巴细胞的协同作用的方法
公开(公告)号：US20170037371A1
公开(公告)日：2017-02-09
申请号：US15106985
申请日：2014-01-13
申请人： Mingjie ZHANG
发明人： Mingjie ZHANG
IPC分类号： C12N5/0783
CPC分类号： C12N5/0638 , A61K35/17 , C12N5/0637 , C12N5/0646 , C12N2501/20 , C12N2501/2302 , C12N2501/2315 , C12N2501/2321 , C12N2501/50 , C12N2501/51 , C12N2502/11 , C12N2502/1114 , C12N2502/1164 , C12N2502/99
摘要： Provided is a method for preparing and using cell ghosts with active factors as a synergist of a lymphocyte in vitro culture. The method for preparing cell ghosts comprises: washing a cell to obtain a washed cell; and cleaving the washed cell to obtain cell ghosts, wherein the cell has cytokines capable of promoting the proliferation and differentiation of lymphocytes on their surface.
摘要翻译：提供了一种制备和使用具有活性因子的细胞幽灵作为淋巴细胞体外培养的增效剂的方法。制备细胞幽灵的方法包括：洗涤细胞以获得洗涤的细胞; 并切割洗涤的细胞以获得细胞重影，其中细胞具有能够促进淋巴细胞表面增殖和分化的细胞因子。

5. 发明授权

US09169297B2 Subgenomic replicons of the flavivirus dengue 有权
公开(公告)号：US09169297B2
公开(公告)日：2015-10-27
申请号：US13242036
申请日：2011-09-23
申请人： Xiaowu Pang , Andrew I. Dayton , Mingjie Zhang
发明人： Xiaowu Pang , Andrew I. Dayton , Mingjie Zhang
IPC分类号： C07K14/005 , C12N7/00 , C12N15/86 , A61K39/00
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2740/16122 , C12N2740/16134 , C12N2770/24123 , C12N2770/24143 , C12N2770/24161 , C12N2770/24162 , C12N2840/203 , Y02A50/386
摘要： The present invention discloses the construction of dengue virus subgenomic replicons containing large deletions in the structural region (C-preM-E) of the genome, which replicons are useful as vaccines to protect against dengue virus infection.

6. 发明申请

US20050233377A1 Drug screening method for the treatment of brain damage 审中-公开
标题翻译：用于治疗脑损伤的药物筛选方法
公开(公告)号：US20050233377A1
公开(公告)日：2005-10-20
申请号：US10826478
申请日：2004-04-16
申请人： Mingjie Zhang , Nikolaus Sucher
发明人： Mingjie Zhang , Nikolaus Sucher
IPC分类号： C12Q1/37 , G01N33/53 , G01N33/68
CPC分类号： G01N33/6896 , G01N2500/00
摘要： NMR spectroscopy is used as an efficient and effective rapid screening method for identifying compounds that interact with PSD-95. This method includes the steps of taking a first NMR spectrum of a sample of free PDZ2; mixing a test compound with said sample of free PDZ2 to form a test sample; taking a second NMR spectrum of said test sample; and comparing said first and second spectra. An observable difference of the two spectra indicates that the test sample contains ingredient(s) capable of binding to the PDZ domains of PSD-95.
摘要翻译： NMR光谱被用作用于鉴定与PSD-95相互作用的化合物的有效和有效的快速筛选方法。该方法包括获取游离PDZ2样品的第一NMR光谱的步骤; 将测试化合物与所述游离PDZ2样品混合以形成测试样品; 取所述测试样品的第二个NMR谱; 以及比较所述第一和第二光谱。两个光谱的可观察的差异表明测试样品含有能够结合PSD-95的PDZ结构域的成分。

7. 发明申请

US20100233210A1 SUBGENOMIC REPLICONS OF THE FLAVIVIRUS DENGUE 有权
标题翻译： FLAVIVIRUS登革热的次生代谢
公开(公告)号：US20100233210A1
公开(公告)日：2010-09-16
申请号：US12394822
申请日：2009-02-27
申请人： Xiaowu Pang , Andrew I. Dayton , Mingjie Zhang
发明人： Xiaowu Pang , Andrew I. Dayton , Mingjie Zhang
IPC分类号： A61K39/12 , C12N7/01 , A61P31/12
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2740/16122 , C12N2740/16134 , C12N2770/24123 , C12N2770/24143 , C12N2770/24161 , C12N2770/24162 , C12N2840/203 , Y02A50/386
摘要： The present invention discloses the construction of dengue virus subgenomic replicons containing large deletions in the structural region (C-preM-E) of the genome, which replicons are useful as vaccines to protect against dengue virus infection.
摘要翻译：本发明公开了在基因组结构域（C-preM-E）中含有大缺失的登革热病毒亚基因组复制子的构建，该复制子可用作防止登革热病毒感染的疫苗。

8. 发明申请

US20120107358A1 SUBGENOMIC REPLICONS OF THE FLAVIVIRUS DENGUE 审中-公开
标题翻译： FLAVIVIRUS登革热的次生代谢
公开(公告)号：US20120107358A1
公开(公告)日：2012-05-03
申请号：US13242036
申请日：2011-09-23
申请人： Xiaowu Pang , Andrew I. Dayton , Mingjie Zhang
发明人： Xiaowu Pang , Andrew I. Dayton , Mingjie Zhang
IPC分类号： A61K39/12 , A61P31/14 , A61P37/04 , C07H21/00 , C12N7/00
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2740/16122 , C12N2740/16134 , C12N2770/24123 , C12N2770/24143 , C12N2770/24161 , C12N2770/24162 , C12N2840/203 , Y02A50/386
摘要： The present invention discloses the construction of dengue virus subgenomic replicons containing large deletions in the structural region (C-preM-E) of the genome, which replicons are useful as vaccines to protect against dengue virus infection.
摘要翻译：本发明公开了在基因组结构域（C-preM-E）中含有大缺失的登革热病毒亚基因组复制子的构建，该复制子可用作防止登革热病毒感染的疫苗。

9. 发明授权

US07130121B2 Erbium-doped fiber amplifier and integrated module components 有权
公开(公告)号：US07130121B2
公开(公告)日：2006-10-31
申请号：US11276997
申请日：2006-03-20
申请人： Jing-Jong Pan , Xiangdong Qiu , Kejian Guan , Mingjie Zhang
发明人： Jing-Jong Pan , Xiangdong Qiu , Kejian Guan , Mingjie Zhang
IPC分类号： G02B27/28
CPC分类号： G02B6/4201 , G02B6/2746 , G02B6/29361 , G02B6/29389 , G02B6/327 , G02B6/4204 , G02B6/4206 , G02B6/4208 , G02B6/4209 , G02B6/4215 , G02B6/424 , G02B6/4263 , G02B6/4269 , G02B6/4286 , H01S3/005 , H01S3/0064 , H01S3/0078 , H01S3/06704 , H01S3/06754 , H01S3/06766 , H01S3/094003 , H01S3/094053 , H01S3/09415 , H01S3/1301 , H01S3/1305 , H01S3/1312 , H01S3/1608 , H01S5/0064 , H01S5/02212 , H01S5/02284 , H01S5/02296 , H01S5/0683
摘要： An EDFA with integrated input and output modules is presented. The integrated input module has a packaged pump laser diode mounted to the metal EDFA package to provide a heat sink for the pump laser diode which sends the pump laser light over a optical fiber section connected to the amplifying erbium-doped optical fiber section. The fiber section is formed from an optical fiber which better matches the transmission modes in the erbium-doped optical fiber section and has an end subsection of the single mode fiber for a larger numerical aperture. Collimating lenses also increase the coupling efficiency of the laser diode to the erbium-doped fiber section. The integrated output module has a photodiode with a tap filter to monitor the output power of the EDFA, an optical isolator to prevent interference in the erbium-doped optical fiber section. With a twin optical isolator, the integrated input and output modules can be arranged in different ways and combinations with the erbium-doped optical fiber section. The resulting EDFAs can be manufactured relatively inexpensively into an very small packages compared to current EDFA packages.

10. 发明申请

US20060158718A1 Erbium-Doped Fiber Amplifier and Integrated Module Components 有权
标题翻译：铒掺杂光纤放大器和集成模块组件
公开(公告)号：US20060158718A1
公开(公告)日：2006-07-20
申请号：US11276997
申请日：2006-03-20
申请人： Jing-Jong Pan , Xiangdong Qiu , Kejian Guan , Mingjie Zhang
发明人： Jing-Jong Pan , Xiangdong Qiu , Kejian Guan , Mingjie Zhang
IPC分类号： H01S3/00
CPC分类号： G02B6/4201 , G02B6/2746 , G02B6/29361 , G02B6/29389 , G02B6/327 , G02B6/4204 , G02B6/4206 , G02B6/4208 , G02B6/4209 , G02B6/4215 , G02B6/424 , G02B6/4263 , G02B6/4269 , G02B6/4286 , H01S3/005 , H01S3/0064 , H01S3/0078 , H01S3/06704 , H01S3/06754 , H01S3/06766 , H01S3/094003 , H01S3/094053 , H01S3/09415 , H01S3/1301 , H01S3/1305 , H01S3/1312 , H01S3/1608 , H01S5/0064 , H01S5/02212 , H01S5/02284 , H01S5/02296 , H01S5/0683
摘要： An EDFA with integrated input and output modules is presented. The integrated input module has a packaged pump laser diode mounted to the metal EDFA package to provide a heat sink for the pump laser diode which sends the pump laser light over a optical fiber section connected to the amplifying erbium-doped optical fiber section. The fiber section is formed from an optical fiber which better matches the transmission modes in the erbium-doped optical fiber section and has an end subsection of the single mode fiber for a larger numerical aperture. Collimating lenses also increase the coupling efficiency of the laser diode to the erbium-doped fiber section. The integrated output module has a photodiode with a tap filter to monitor the output power of the EDFA, an optical isolator to prevent interference in the erbium-doped optical fiber section. With a twin optical isolator, the integrated input and output modules can be arranged in different ways and combinations with the erbium-doped optical fiber section. The resulting EDFAs can be manufactured relatively inexpensively into an very small packages compared to current EDFA packages.
摘要翻译：介绍了具有集成输入和输出模块的EDFA。集成输入模块具有安装在金属EDFA封装上的封装泵激光二极管，为泵激光二极管提供散热器，泵浦激光二极管将泵浦激光发射到与放大掺铒光纤部分连接的光纤部分上。光纤部分由光纤形成，该光纤更好地匹配掺铒光纤部分的传输模式，并且具有用于更大数值孔径的单模光纤的端部部分。准直透镜还增加了激光二极管与掺铒光纤部分的耦合效率。集成输出模块具有带有抽头滤波器的光电二极管，用于监视EDFA的输出功率，光隔离器可防止铒掺杂光纤部分的干扰。使用双光隔离器，集成输入和输出模块可以以掺铒光纤部分的不同方式和组合进行布置。与目前的EDFA封装相比，所得到的EDFA可以相对廉价地制造成非常小的封装。

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