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1. 发明授权

US09095503B2 System and method for biphasic transdermal iontophreotic delivery of therapeutic agents 有权
标题翻译：用于治疗剂的双相透皮离子电渗递送的系统和方法
公开(公告)号：US09095503B2
公开(公告)日：2015-08-04
申请号：US13430662
申请日：2012-03-26
申请人： Mir Imran , Mir Hashim , Glen McLaughlin , Huma Arastu , Rekha Vaidyanathan , Joel Harris , Radhika Korupolu , Andrew Mangogna , Chang Ong , Sanjay Patel , Lu Wang , Timothy Williams
发明人： Mir Imran , Mir Hashim , Glen McLaughlin , Huma Arastu , Rekha Vaidyanathan , Joel Harris , Radhika Korupolu , Andrew Mangogna , Chang Ong , Sanjay Patel , Lu Wang , Timothy Williams
IPC分类号： A61N1/30 , A61K9/00 , A61N1/04 , A61K31/4178 , A61K31/4468 , A61K31/454 , A61K31/5415 , A61N1/32
CPC分类号： A61N1/325 , A61K9/0009 , A61K9/0014 , A61K31/4178 , A61K31/4468 , A61K31/454 , A61K31/5415 , A61N1/0436 , A61N1/044 , A61N1/0448 , A61N1/30 , A61N1/303
摘要： Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.
摘要翻译：各种实施方案提供了用于治疗剂的双相离子电渗透皮递送的方法和系统。用于这种传送的方法的实施例包括将至少一个电极组件定位成与患者的皮肤电连通。组合件包括包含被动地扩散入皮肤的治疗剂的溶液。使用具有例如极性和大小的特性的第一电流，在第一时段期间，将剂量的药剂从组合物输送到皮肤中，以将药剂排斥出组合体。在第二时段期间，使用具有吸引剂的特性的第二电流将试剂保持在组合中，使得药剂递送到皮肤中最小化。可以根据患者的输入要求递送剂量。实施方案可以用于递送由不希望的被动扩散引起不利影响的试剂。

2. 发明申请

US20120184894A1 Patches and Methods for the Transdermal Delivery of Agents to Treat Hair Loss 审中-公开
标题翻译：用于治疗脱发的药物的透皮递送的补片和方法
公开(公告)号：US20120184894A1
公开(公告)日：2012-07-19
申请号：US13342948
申请日：2012-01-03
申请人： Mir Imran , Phil Morgan , Mir Hashim , Joel Harris
发明人： Mir Imran , Phil Morgan , Mir Hashim , Joel Harris
IPC分类号： A61N1/30
CPC分类号： A61K8/0208 , A61K8/19 , A61K9/0009 , A61K9/0021 , A61K9/7046 , A61K33/26 , A61K33/42 , A61K2800/83 , A61Q7/00
摘要： Embodiments of the invention provide patches for the transdermal delivery of compositions to treat an individual suffering from hair loss. Many embodiments provide an iontophoretic patch for the transdermal delivery hair growth stimulating agents for the treatment of hair loss by stimulating the growth of new hair in areas of the scalp exhibiting hair loss. The patch comprises an electrode and a reservoir containing a composition comprising iron containing compound, such as a chelated iron compound for the delivery of the therapeutically effective amount of iron. The patch can be shaped to be placed and remain on the head. Various embodiments provide methods of using embodiments of the iontophoretic patch for delivering a hair growth stimulating agent such as a chelated iron compound, minoxidil and finasteride to the scalp and other areas exhibiting hair loss. Such methods can be used for re-growing hair, and/or preventing or slowing hair loss.
摘要翻译：本发明的实施方案提供了用于透皮递送组合物以治疗患有脱发的个体的贴剂。许多实施方案提供用于透皮递送毛发生长刺激剂的离子电渗贴剂，用于通过在头皮表现出脱发的区域中刺激新毛发的生长来治疗脱发。贴片包括电极和储存器，其含有包含含铁化合物的组合物，例如用于递送治疗有效量的铁的螯合铁化合物。该贴片的形状可被放置并保留在头部上。各种实施方案提供了使用离子电渗贴剂的实施方案将头发生长刺激剂如螯合铁化合物，米诺地尔和非那雄胺递送至头皮和其它出现脱发的区域的方法。这种方法可用于再生长毛发和/或预防或减缓脱发。

3. 发明申请

US20120177700A1 Nanonized Iron Compositions and Methods of Use Thereof 审中-公开
标题翻译：纳米铁组合物及其使用方法
公开(公告)号：US20120177700A1
公开(公告)日：2012-07-12
申请号：US13338210
申请日：2011-12-27
申请人： Mir A. Imran , Mir Hashim , Lu Wang , Sanjay Patel , Joel M. Harris , Phil Morgan
发明人： Mir A. Imran , Mir Hashim , Lu Wang , Sanjay Patel , Joel M. Harris , Phil Morgan
IPC分类号： A61K9/00 , A61K33/42 , B82Y5/00
CPC分类号： A61K9/14 , A61K33/26
摘要： Embodiments of the invention provide nanonized iron compositions for treatment of iron deficiency such as iron deficiency anemia. Many embodiments provide nanonized iron compositions which are sized to minimize adverse reaction such as immune response, adverse GI reaction and allergic reaction to iron compound included in the composition. The nanonized iron compositions can be used in a variety of drug delivery forms, including an oral dosage form, a transdermal patch, in an intravenous solution or in a dialysate for treatment of a patient with chronic kidney disease (CKD). Embodiments of the invention also provide methods of using the nanonized iron compositions for the treatment of iron deficiency in a patient in need thereof including patients with iron deficiency anemia and CKD.
摘要翻译：本发明的实施方案提供了用于治疗铁缺乏症（例如缺铁性贫血）的纳米铁组合物。许多实施方案提供纳米级铁组合物，其尺寸设定成使包括在组合物中的铁化合物的不良反应如免疫应答，不良GI反应和过敏反应最小化。纳米铁组合物可以以各种药物递送形式使用，包括口服剂型，透皮贴剂，静脉内溶液或用于治疗慢性肾脏病（CKD）患者的透析液。本发明的实施方案还提供了使用纳米铁组合物治疗需要其的患者缺铁的方法，包括缺铁性贫血和CKD患者。

4. 发明授权

US09008765B2 System and method for biphasic transdermal iontophoretic delivery of therapeutic agents for the control of addictive cravings 有权
标题翻译：用于控制上瘾欲望的治疗剂的双相透皮离子电渗递送系统和方法
公开(公告)号：US09008765B2
公开(公告)日：2015-04-14
申请号：US13466116
申请日：2012-05-07
申请人： Mir Imran , Talat Imran , Mir Hashim
发明人： Mir Imran , Talat Imran , Mir Hashim
IPC分类号： A61N1/30 , A61K9/00 , A61N1/04 , A61N1/32 , A61K31/465
CPC分类号： A61N1/30 , A61K9/0009 , A61K9/0014 , A61K31/465 , A61N1/0432 , A61N1/0448 , A61N1/303 , A61N1/325
摘要： Embodiments of the invention provide methods for the transdermal delivery of therapeutic agents for the treatment of addictive cravings e.g., nicotine compounds for the treatment of nicotine cravings from tobacco use. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient.
摘要翻译：本发明的实施方案提供了用于治疗成瘾性渴望的治疗剂的透皮递送方法，例如用于治疗来自烟草使用的尼古丁渴望的尼古丁化合物。用于这种传送的方法的实施例包括将至少一个电极组件定位成与患者的皮肤电连通。组合件包括包含被动地扩散入皮肤的治疗剂的溶液。使用具有例如极性和大小的特性的第一电流，在第一时段期间，将剂量的药剂从组合物输送到皮肤中，以将药剂排斥出组合体。在第二时段期间，使用具有吸引剂的特性的第二电流来将药剂保持在组合中，使得药剂递送到皮肤中最小化。可以根据患者的输入要求递送剂量。

5. 发明授权

US08821945B2 Method for transdermal iontophoretic delivery of chelated agents 有权
标题翻译：螯合剂透皮离子电渗递送方法
公开(公告)号：US08821945B2
公开(公告)日：2014-09-02
申请号：US12459862
申请日：2009-07-07
申请人： Mir Imran , Mir Hashim , Sanjay Patel , Ronald J. Berenson
发明人： Mir Imran , Mir Hashim , Sanjay Patel , Ronald J. Berenson
IPC分类号： A01N59/16 , A01N59/26 , A61N1/30
CPC分类号： A61K41/0047 , A61K9/0009 , A61K9/703 , A61K9/7084 , A61K33/26 , A61K33/42 , A61K41/00 , A61N1/0496 , A61N1/30 , A61N1/325
摘要： Embodiments provide devices, systems and methods for the transdermal delivery of chelated compounds. One embodiment provides a method for the iontophoretic transdermal delivery of a chelated iron complex for the treatment of anemia. A first patch comprising an active electrode and a chelated iron complex is applied to the skin; a second patch containing an electrode is also applied. An electrical current is then delivered to the skin from the active electrode. The chelated complex is transported across the skin via electromotive force from the current, with the iron being substantially chromogenically unreactive with the skin during transport so that there is little or no tattooing of the skin due to the formation of insoluble oxidative products. The complex is then dissociated by phagocytosis or related process to release the iron where it may be bound by transferrin or ferritin and carried to other sites for storage or metabolic use.
摘要翻译：实施方案提供用于经皮递送螯合化合物的装置，系统和方法。一个实施方案提供了用于治疗贫血的螯合铁络合物的离子电渗疗法透皮递送的方法。将包含活性电极和螯合铁络合物的第一贴片施加到皮肤上; 还应用了包含电极的第二贴片。然后从活性电极将电流输送到皮肤。螯合络合物通过电流从电流传递穿过皮肤，铁在运输过程中与皮肤基本上不发生色素反应，因此由于不溶性氧化产物的形成，皮肤几乎或没有纹身。然后通过吞噬作用或相关过程解离复合物以释放铁，其中它可被转铁蛋白或铁蛋白结合并携带到其它部位用于储存或代谢使用。

6. 发明授权

US08682440B2 Swallowable capsule and method for stimulating incretin production within the intestinal tract 有权
公开(公告)号：US08682440B2
公开(公告)日：2014-03-25
申请号：US12849574
申请日：2010-08-03
申请人： Mir A. Imran , Mir Hashim , Emily Arnsdorf
发明人： Mir A. Imran , Mir Hashim , Emily Arnsdorf
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61K38/26 , A61N1/05 , A61N1/0507 , A61N1/0509 , A61N1/06 , A61N1/37217
摘要： Embodiments of the invention provide apparatus and methods for stimulating L cells in the intestinal tract to produce incretins for the treatment of conditions including diabetes and obesity. Many embodiments provide a method and apparatus for the treatment of diabetes by electrically stimulating L-cells to secrete incretins to stimulate or otherwise modulate the production of insulin. Particular embodiments provide a swallowable capsule for stimulating L-cells in the intestinal tract as the capsule moves through the tract. The capsule can include two or more electrodes for providing electrical stimulation to L-cells, a power source for powering one or more components of the capsule, a sensor for sensing the location of the capsule in the intestinal tract; a controller and a waveform generator for generating the electrical signals emitted by the electrodes to stimulate the L-cells to secrete incretins such as GLP-1 to stimulate insulin production for glucose regulation of diabetic conditions.

7. 发明申请

US20130023850A1 SYSTEM AND METHOD FOR BIPHASIC TRANSDERMAL IONTOPHORETIC DELIVERY OF THERAPEUTIC AGENTS FOR THE CONTROL OF ADDICTIVE CRAVINGS 有权
公开(公告)号：US20130023850A1
公开(公告)日：2013-01-24
申请号：US13466116
申请日：2012-05-07
申请人： Mir Imran , Talat Imran , Mir Hashim
发明人： Mir Imran , Talat Imran , Mir Hashim
IPC分类号： A61N1/30
CPC分类号： A61N1/30 , A61K9/0009 , A61K9/0014 , A61K31/465 , A61N1/0432 , A61N1/0448 , A61N1/303 , A61N1/325
摘要： Embodiments of the invention provide methods for the transdermal delivery of therapeutic agents for the treatment of addictive cravings e.g., nicotine compounds for the treatment of nicotine cravings from tobacco use. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient.

8. 发明申请

US20180037643A9 ANTI-INTERLEUKIN ANTIBODY PREPARATIONS FOR DELIVERY INTO A LUMEN OF THE INTESTINAL TRACT USING A SWALLOWABLE DRUG DELIVERY DEVICE 审中-公开
公开(公告)号：US20180037643A9
公开(公告)日：2018-02-08
申请号：US15150379
申请日：2016-05-09
申请人： Mir Imran , Radhika Korupolu , Elaine To , Mir Hashim
发明人： Mir Imran , Radhika Korupolu , Elaine To , Mir Hashim
IPC分类号： C07K16/24 , A61M25/10
CPC分类号： C07K16/244 , A61K38/26 , A61K38/28 , A61M25/10 , A61M2025/105 , C07K16/2866 , C07K2317/24 , C07K2317/76
摘要： Embodiments of the invention provide swallowable devices, preparations and methods for delivering therapeutic agents within the GI tract such as neutralizing proteins (NP) particularly antibodies which neutralize interleukins. Many embodiments provide a swallowable device e.g., a capsule for delivering various agents into the intestinal wall (IW). Embodiments also provide agent preparations that are configured to be contained within the capsule, advanced from the capsule into the IW and degrade to release the agent into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW. Embodiments of the invention are particularly useful for the delivery of interleukin NP's (INP) for treatment of inflammatory conditions where such INP's are poorly absorbed, tolerated and/or degraded within the GI tract.

9. 发明申请

US20110208270A1 Swallowable Capsule and Method for Stimulating Incretin Production Within the Intestinal Tract 有权
标题翻译：吞咽胶囊和刺激肠道内营养素的方法
公开(公告)号：US20110208270A1
公开(公告)日：2011-08-25
申请号：US12849574
申请日：2010-08-03
申请人： Mir A. Imran , Mir Hashim , Emily Arnsdorf
发明人： Mir A. Imran , Mir Hashim , Emily Arnsdorf
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61K38/26 , A61N1/05 , A61N1/0507 , A61N1/0509 , A61N1/06 , A61N1/37217
摘要： Embodiments of the invention provide apparatus and methods for stimulating L cells in the intestinal tract to produce incretins for the treatment of conditions including diabetes and obesity. Many embodiments provide a method and apparatus for the treatment of diabetes by electrically stimulating L-cells to secrete incretins to stimulate or otherwise modulate the production of insulin. Particular embodiments provide a swallowable capsule for stimulating L-cells in the intestinal tract as the capsule moves through the tract. The capsule can include two or more electrodes for providing electrical stimulation to L-cells, a power source for powering one or more components of the capsule, a sensor for sensing the location of the capsule in the intestinal tract; a controller and a waveform generator for generating the electrical signals emitted by the electrodes to stimulate the L-cells to secrete incretins such as GLP-1 to stimulate insulin production for glucose regulation of diabetic conditions.
摘要翻译：本发明的实施方案提供了用于刺激肠道中的L细胞以产生用于治疗包括糖尿病和肥胖的病症的肠溶素的装置和方法。许多实施方案提供了一种用于通过电刺激L细胞分泌胰岛素来刺激或以其它方式调节胰岛素的产生来治疗糖尿病的方法和装置。具体实施方案提供了一种吞咽胶囊，用于在胶囊移动通过管道时刺激肠道中的L细胞。胶囊可以包括用于向L-细胞提供电刺激的两个或更多个电极，用于为胶囊的一个或多个部件供电的电源，用于感测胶囊在肠道中的位置的传感器; 控制器和波形发生器，用于产生由电极发射的电信号，以刺激L细胞分泌胰岛素，例如GLP-1，以刺激胰岛素产生用于糖尿病状态的葡萄糖调节。

10. 发明申请

US20180251537A9 ANTI-INTERLEUKIN ANTIBODY PREPARATIONS FOR DELIVERY INTO A LUMEN OF THE INTESTINAL TRACT USING A SWALLOWABLE DRUG DELIVERY DEVICE 审中-公开
公开(公告)号：US20180251537A9
公开(公告)日：2018-09-06
申请号：US15150379
申请日：2016-05-09
申请人： Mir Imran , Radhika Korupolu , Elaine To , Mir Hashim
发明人： Mir Imran , Radhika Korupolu , Elaine To , Mir Hashim
IPC分类号： C07K16/24 , A61M25/10
CPC分类号： C07K16/244 , A61K38/26 , A61K38/28 , A61M25/10 , A61M2025/105 , C07K16/2866 , C07K2317/24 , C07K2317/76
摘要： Embodiments of the invention provide swallowable devices, preparations and methods for delivering therapeutic agents within the GI tract such as neutralizing proteins (NP) particularly antibodies which neutralize interleukins. Many embodiments provide a swallowable device e.g., a capsule for delivering various agents into the intestinal wall (IW). Embodiments also provide agent preparations that are configured to be contained within the capsule, advanced from the capsule into the IW and degrade to release the agent into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW. Embodiments of the invention are particularly useful for the delivery of interleukin NP's (INP) for treatment of inflammatory conditions where such INP's are poorly absorbed, tolerated and/or degraded within the GI tract.

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