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1. 发明授权

US10710779B2 Multi-function container lid 有权
公开(公告)号：US10710779B2
公开(公告)日：2020-07-14
申请号：US16723305
申请日：2019-12-20
申请人： Joel Harris
发明人： Joel Harris
IPC分类号： B65D43/02 , B65D43/16 , B65D51/18 , A47G19/22
摘要： A dome-shaped lid reversibly securably sealed to the rim of a container with two opposing drinking ports die-cut in the top wall of a brim mount. A reclosable fold-back hatch cover recessed within the brim mount rotates about a U-shaped hinge between a closed and opened position quickly and reliably. When the hatch cover is rotated to its opened position it creates a hatch opening of sufficient size to access the beverage for the following purposes, including, but not limited to, dunking a confection, letting steam escape to cool a hot beverage, adding condiments, stirring the beverage, or adding and removing toppings such as whipped cream on the surface of the beverage, performed with the lid remaining fixed to the container rim.

2. 发明申请

US20200140151A1 Multi-Function Container Lid 审中-公开
公开(公告)号：US20200140151A1
公开(公告)日：2020-05-07
申请号：US16723305
申请日：2019-12-20
申请人： Joel Harris
发明人： Joel Harris
IPC分类号： B65D43/16 , B65D43/02 , B65D51/18 , A47G19/22
摘要： A dome-shaped lid reversibly securably sealed to the rim of a container with two opposing drinking ports die-cut in the top wall of a brim mount. A reclosable fold-back hatch cover recessed within the brim mount rotates about a U-shaped hinge between a closed and opened position quickly and reliably. When the hatch cover is rotated to its opened position it creates a hatch opening of sufficient size to access the beverage for the following purposes, including, but not limited to, dunking a confection, letting steam escape to cool a hot beverage, adding condiments, stirring the beverage, or adding and removing toppings such as whipped cream on the surface of the beverage, performed with the lid remaining fixed to the container rim.

3. 发明申请

US20130325108A1 BIODEGRADABLE MEDICAL IMPLANTS, POLYMER COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：生物可降解医用植入物，聚合物组合物和使用方法
公开(公告)号：US20130325108A1
公开(公告)日：2013-12-05
申请号：US13261054
申请日：2010-06-01
申请人： Mir Imran , Sanjay Patel , Joel Harris
发明人： Mir Imran , Sanjay Patel , Joel Harris
IPC分类号： A61L27/14 , A61F2/04 , A61F2/82
CPC分类号： A61L27/14 , A61F2/04 , A61F2/06 , A61F2/07 , A61F2/82 , A61F2210/0004 , A61L27/26 , A61L27/58 , A61L31/041 , A61L31/148
摘要： Embodiments of the invention provide compositions comprising bio degradable polymers, medical implants fabricated from these compositions and methods of using such implants. Many embodiments provide medical implants comprising a first polymer backbone having a first rate of biodegradation and a second polymer backbone having a second rate of biodegradation faster than the first rate. In some embodiments, the second backbone is configured to be replaced by a natural tissue layer. The first backbone provides a scaffold for the implant while the second backbone degrades. This scaffold can enhance mechanical properties of the implant including various aspects of mechanical strength such as tensile, bending, hoop and yield strength; and elasticity. The scaffold also serves to maintain a minimum level of structural support of the implant during the period of degradation of the second backbone or for the entire life of the implant so that the implant does not mechanically fail.
摘要翻译：本发明的实施方案提供了包含生物可降解聚合物，由这些组合物制造的医疗植入物和使用这种植入物的方法的组合物。许多实施方案提供医学植入物，其包含具有第一生物降解速率的第一聚合物主链和具有比第一速率快的第二生物降解速率的第二聚合物主链。在一些实施例中，第二主干被配置为由天然组织层代替。第一个骨架提供植入物的支架，而第二个骨架降解。该支架可以增强植入物的机械性能，包括机械强度的各个方面，例如拉伸，弯曲，箍和屈服强度; 和弹性。支架还用于在第二主骨架的退化期间或植入物的整个寿命期间保持植入物的最小结构支撑水平，使得植入物不会机械地失效。

4. 发明申请

US20100191305A1 METHOD AND APPARATUS FOR THE DETECTION OF ABERRANT NEURAL-ELECTRIC ACTIVITY 有权
标题翻译：用于检测ABERRANT神经电活动的方法和装置
公开(公告)号：US20100191305A1
公开(公告)日：2010-07-29
申请号：US12359830
申请日：2009-01-26
申请人： Mir Imran , Lu Wang , Paren Shah , Joel Harris
发明人： Mir Imran , Lu Wang , Paren Shah , Joel Harris
IPC分类号： A61N1/36 , A61B5/0478 , A61M5/00
CPC分类号： A61B5/04001 , A61B5/04004 , A61B5/0478 , A61B5/0531 , A61B5/4094 , A61N1/0529 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/36064 , A61N1/36082
摘要： Embodiments provide an apparatus and method for detection of aberrant neural-electric activity (ANEA) in the brain causing an epileptic seizure or other neurologic condition. One embodiment provides an apparatus for detection of ANEA comprising an introducer having at least one lumen. The introducer is introduced into brain tissue through an opening in the skull. A reference electrode is positioned at an introducer distal portion. A plurality of electrode members are advanceable within the at least one lumen with each member having an insulated portion and an exposed distal portion. The members have a non-deployed state in the introducer and a deployed state when outwardly advanced out of the introducer. In the deployed state, the members are substantially orthogonal to each other with the exposed distal portions defining a detection volume capable of determining an electric field vector produced by the ANEA and the direction of a foci of the ANEA.
摘要翻译：实施例提供了用于检测脑中异常神经电活动（ANEA）的装置和方法，其引起癫痫发作或其他神经病症。一个实施例提供了一种用于检测ANEA的装置，包括具有至少一个内腔的导引器。导引器通过头骨中的开口引入脑组织。参考电极位于导引器远端部分。多个电极构件可在至少一个内腔内前进，每个构件具有绝缘部分和暴露的远端部分。这些构件在导引器中具有非展开状态，并且当向外推进导引器时处于展开状态。在展开状态下，构件基本上彼此正交，暴露的远侧部分限定能够确定由ANEA产生的电场矢量和ANEA焦点方向的检测体积。

5. 发明申请

US20080089858A1 AZETIDINE DERIVATIVES USEFUL IN TREATING PAIN, DIABETES AND DISORDERS OF LIPID METABOLISM 失效
标题翻译：适用于治疗脂肪代谢的疼痛，糖尿病和疾病的AZETIDINE衍生物
公开(公告)号：US20080089858A1
公开(公告)日：2008-04-17
申请号：US11854600
申请日：2007-09-13
申请人： Brian McKittrick , Elizabeth Smith , Chad Bennett , Joel Harris , Eugenia Kiselgof , Chad Knutson , Peter Korakas , Deen Tulshian , Hyunjin Kim
发明人： Brian McKittrick , Elizabeth Smith , Chad Bennett , Joel Harris , Eugenia Kiselgof , Chad Knutson , Peter Korakas , Deen Tulshian , Hyunjin Kim
IPC分类号： A61K31/438 , A61K31/565 , A61K31/57 , A61K31/573 , A61K31/675 , A61K38/20 , A61P3/10 , C07D471/10
CPC分类号： C07D471/08
摘要： Disclosed are compounds of the formula: and compounds of the formula: wherein R1, R2, R3, R4, R5, u and v are as defined herein. Also disclosed are methods of treating pain (e.g., inflammatory pain, chronic pain, and neuropathic pain), methods of treating diabetes, and methods of inhibiting the absorption of cholesterol using compounds of formula I or IIA.
摘要翻译：公开了下式的化合物和下式的化合物：其中R 1，R 2，R 3，R 4， u，v和u如本文所定义。还公开了治疗疼痛（例如炎性疼痛，慢性疼痛和神经性疼痛）的方法，治疗糖尿病的方法，以及使用式I或IIA化合物抑制胆固醇吸收的方法。

6. 发明申请

US20050066751A1 Motor driven sampling apparatus for material collection 失效
标题翻译：用于材料收集的电机驱动取样装置
公开(公告)号：US20050066751A1
公开(公告)日：2005-03-31
申请号：US10673287
申请日：2003-09-30
申请人： Joel Harris
发明人： Joel Harris
IPC分类号： G01N1/08
CPC分类号： G01N1/08
摘要： An apparatus to excise a sample of material and temporarily store sample has a hollow clamshell casing with a blended grip under which is a tubular sample sleeve extends downwards from the base of the grip. Within the casing an electric motor is housed which drives, via juxtaposed spur gears, the sample sleeve in a rotational manner. The end of the sample sleeve, distal from the clamshell casing, forms a cutting edge circumscribing a circular region. An ejection rod slides reciprocally within the sample sleeve between a stowed position and an expulsion position. When the ejection rod moves from the stowed position to the expulsion position it will extend past the cutting edge and expel any material sample contained within the sample sleeve. A user cuts a sample from a source material resting on a pliable substrate, using the cutting edge of the sample sleeve when the ejection rod is in the stowed position. A sample is cut when the cutting blade contacts the source material while gentle downward pressure is applied. The thumb activates the electric drive which rotates the cutting sleeve. Once the source material has been cut it is simultaneously extracted and lodged within the tubular sample sleeve. The extracted sample remains lodged in the hollow of the sample sleeve until the user extends the ejection rod through the sample sleeve to the expulsion position to eject the sample of source material. The automatic return of the eject rod is comprised of a compression spring that biases the ejection shaft which holds the ejection rod in the retracted and stowed positions.
摘要翻译：用于切除材料样品并临时储存样品的装置具有中空的蛤壳式壳体，其具有混合夹紧器，管状样品套筒从该把手的底部向下延伸。在壳体内容纳有电动马达，通过并置的正齿轮以旋转的方式驱动样品套筒。样品套筒的端部远离蛤壳式壳体形成一个围绕圆形区域的切割边缘。排出杆在收起位置和排出位置之间在样品套筒内往复滑动。当排出杆从收起位置移动到排出位置时，其将延伸超过切割边缘并排出包含在样品套筒内的任何材料样品。使用者在弹出杆处于收起位置时，使用样品套筒的切割边缘将样品从放置在柔韧基底上的源材料切下。当切割刀片接触源材料同时施加温和的向下压力时，切割样品。拇指启动旋转切割套筒的电动驱动器。一旦源材料被切割，它被同时提取并存放在管状样品套筒内。提取的样品保持在样品套筒的中空部分中，直到使用者将排出杆通过样品套筒延伸到排出位置以排出源材料样品。弹出杆的自动返回由压缩弹簧构成，该压缩弹簧将将排出杆保持在缩回和收起位置的弹出轴偏压。

7. 发明授权

US06317093B1 Satellite communication antenna pointing system 失效
标题翻译：卫星通信天线指向系统
公开(公告)号：US06317093B1
公开(公告)日：2001-11-13
申请号：US09635937
申请日：2000-08-10
申请人： Joel Harris
发明人： Joel Harris
IPC分类号： H01Q300
CPC分类号： H01Q19/19 , G01S3/38 , H01Q1/1257 , H01Q3/08 , H01Q19/132
摘要： An antenna pointing system automatically aligns an antenna with a geo-synchronous satellite using a Ku band signal, which has a relatively broad bandwidth, with sufficient accuracy for Ka band signal transmission, which has a relatively narrow bandwidth. Initially, the antenna is pointed at the selected satellite so as to receive the Ku band signal. The system obtains a series of signal strength readings over a predetermined azimuth (or elevation) region, such as plus/minus two degrees, from which a new peak location is selected. Signal strength data is then obtained over a predetermined elevation (or azimuth) region. Another signal peak location is selected based on the elevation data. Azimuth and elevation data are alternately collected for refining the peak of the Ku signal so as to optimize Ka signal transmission capability.
摘要翻译：天线指向系统使用具有相对宽的带宽的Ku波段信号自动对准天线与地球同步卫星，对于具有相对较窄带宽的Ka波段信号传输具有足够的精度。最初，天线指向所选择的卫星，以便接收Ku波段信号。该系统在预定的方位角（或高度）区域上获得一系列信号强度读数，例如正/负两度，从中选择新的峰值位置。然后在预定的高度（或方位））区域获得信号强度数据。基于高程数据选择另一个信号峰值位置。交替收集方位角和高程数据，以便优化Ku信号的峰值，从而优化Ka信号传输能力。

8. 发明授权

US5709082A Modulation schemes for on-board diagnostic exhaust system 失效
标题翻译：车载诊断排气系统的调制方案
公开(公告)号：US5709082A
公开(公告)日：1998-01-20
申请号：US654049
申请日：1996-05-28
申请人： Stephen Joel Harris , David Kay Lambert
发明人： Stephen Joel Harris , David Kay Lambert
IPC分类号： G01N21/05 , G01N21/35 , F01N3/28
CPC分类号： G01N21/3504 , G01N21/05
摘要： The invention includes an on-board diagnostic system for monitoring exhaust gas from an automotive combustion engine and includes a sample port connected to the exhaust piping, preferably downstream from the catalytic converter. The exhaust port leads to a sample cell to which an infrared spectrometry system is operably connected to measure the concentration of hydrocarbons in the sample cell. An air pump is connected to the exhaust port and communicates with the sample cell. The air pump is operated to continuously purge the sample cell by pushing small amounts of clean air through the sample cell into the exhaust.
摘要翻译：本发明包括用于监测来自汽车内燃机的废气的车载诊断系统，并且包括连接到排气管道的抽样端口，优选地在催化转化器的下游。排气口通向可操作地连接红外光谱系统的样品池，以测量样品池中的烃浓度。空气泵连接到排气口并与样品池连通。操作空气泵，通过将少量清洁空气通过样品池排入排气口来连续吹扫样品池。

9. 发明申请

US20160009696A1 COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY 有权
公开(公告)号：US20160009696A1
公开(公告)日：2016-01-14
申请号：US14772290
申请日：2014-02-27
申请人： Michael MILLER , Kallol BASU , Duane DEMONG , Jack SCOTT , Wei LI , Joel HARRIS , Andrew STAMFORD , Marc POIRIER , Paul TEMPEST , MERCK SHARP & DOHME CORP.
发明人： Michael Miller , Kallol Basu , Duane DeMong , Jack Scott , Wei Li , Joel Harris , Andrew Stamford , Marc Poirier , Paul Tempest
IPC分类号： C07D403/14 , C07D401/14 , C07D491/107 , C07D417/14 , C07D471/10 , C07D413/14 , C07D498/08
CPC分类号： C07D403/14 , A61K31/505 , A61K31/506 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/10 , C07D491/107 , C07D498/08
摘要： The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

10. 发明授权

US09095503B2 System and method for biphasic transdermal iontophreotic delivery of therapeutic agents 有权
标题翻译：用于治疗剂的双相透皮离子电渗递送的系统和方法
公开(公告)号：US09095503B2
公开(公告)日：2015-08-04
申请号：US13430662
申请日：2012-03-26
申请人： Mir Imran , Mir Hashim , Glen McLaughlin , Huma Arastu , Rekha Vaidyanathan , Joel Harris , Radhika Korupolu , Andrew Mangogna , Chang Ong , Sanjay Patel , Lu Wang , Timothy Williams
发明人： Mir Imran , Mir Hashim , Glen McLaughlin , Huma Arastu , Rekha Vaidyanathan , Joel Harris , Radhika Korupolu , Andrew Mangogna , Chang Ong , Sanjay Patel , Lu Wang , Timothy Williams
IPC分类号： A61N1/30 , A61K9/00 , A61N1/04 , A61K31/4178 , A61K31/4468 , A61K31/454 , A61K31/5415 , A61N1/32
CPC分类号： A61N1/325 , A61K9/0009 , A61K9/0014 , A61K31/4178 , A61K31/4468 , A61K31/454 , A61K31/5415 , A61N1/0436 , A61N1/044 , A61N1/0448 , A61N1/30 , A61N1/303
摘要： Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.
摘要翻译：各种实施方案提供了用于治疗剂的双相离子电渗透皮递送的方法和系统。用于这种传送的方法的实施例包括将至少一个电极组件定位成与患者的皮肤电连通。组合件包括包含被动地扩散入皮肤的治疗剂的溶液。使用具有例如极性和大小的特性的第一电流，在第一时段期间，将剂量的药剂从组合物输送到皮肤中，以将药剂排斥出组合体。在第二时段期间，使用具有吸引剂的特性的第二电流将试剂保持在组合中，使得药剂递送到皮肤中最小化。可以根据患者的输入要求递送剂量。实施方案可以用于递送由不希望的被动扩散引起不利影响的试剂。

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