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1. 发明授权

US09383918B2 Portable electronic device and method of controlling same 有权
标题翻译：便携式电子装置及其控制方法
公开(公告)号：US09383918B2
公开(公告)日：2016-07-05
申请号：US13243749
申请日：2011-09-23
申请人： Jeffery John Paul Dippel , Benjamin Biron , Patrick-Andre Savard , Mihal Lazaridis , Donald James Lindsay , Danny Thomas Dodge
发明人： Jeffery John Paul Dippel , Benjamin Biron , Patrick-Andre Savard , Mihal Lazaridis , Donald James Lindsay , Danny Thomas Dodge
IPC分类号： G06F3/041 , G06F3/0488
CPC分类号： G06F3/04886 , G06F3/0416 , G06F3/04883 , G06F2203/04808
摘要： A method includes detecting a touch at a plurality of touch locations on a touch-sensitive display of an electronic device, identifying when the touch is a first gesture type based on touch attributes including a first touch location of the plurality of touch locations, and at least one of speed of the touch, time between detecting the touch at consecutive ones of the touch locations, distance between the consecutive ones of the touch locations, and direction of the touch.
摘要翻译：一种方法包括检测电子设备的触敏显示器上的多个触摸位置处的触摸，基于包括多个触摸位置的第一触摸位置的触摸属性来识别触摸何时是第一手势类型，以及在触摸速度中的至少一个，在连续的触摸位置检测触摸之间的时间，触摸位置中的连续触摸位置之间的距离以及触摸方向。

2. 发明授权

US08470357B2 Methods of treatment with Syk inhibitors 有权
标题翻译： Syk抑制剂治疗方法
公开(公告)号：US08470357B2
公开(公告)日：2013-06-25
申请号：US13253899
申请日：2011-10-05
申请人： Patrick Andre , David R. Phillips , Charles Homcy
发明人： Patrick Andre , David R. Phillips , Charles Homcy
IPC分类号： A61F2/02
CPC分类号： A61K31/473 , A61K31/4745 , A61K31/52 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L2300/434
摘要： The present invention provides novel compositions and methods for inhibiting restenosis, thrombosis, and/or inflammation in a patient undergoing a vascular intervention. More particularly, the present invention provides intravascular devices coated with one or more spleen tyrosine kinase (Syk) inhibitors. Methods for inhibiting restenosis, thrombosis, and/or inflammation in a patient by treatment with such intravascular devices are also provided. In addition, the present invention provides methods for treating sickle cell disease using Syk inhibitors.
摘要翻译：本发明提供了用于在经历血管干预的患者中抑制再狭窄，血栓形成和/或炎症的新型组合物和方法。更具体地，本发明提供涂覆有一种或多种脾脏酪氨酸激酶（Syk）抑制剂的血管内装置。还提供了通过用这种血管内装置治疗来抑制患者再狭窄，血栓形成和/或炎症的方法。此外，本发明提供了使用Syk抑制剂治疗镰状细胞病的方法。

3. 发明申请

US20120098766A1 Portable Electronic Device and Method of Controlling Same 有权
标题翻译：便携式电子装置及其控制方法
公开(公告)号：US20120098766A1
公开(公告)日：2012-04-26
申请号：US13243749
申请日：2011-09-23
申请人： John Paul Dippel , Benjamin Biron , Patrick-Andre Savard , Mihal Lazaridis , Donald James Lindsay , Danny Thomas Dodge
发明人： John Paul Dippel , Benjamin Biron , Patrick-Andre Savard , Mihal Lazaridis , Donald James Lindsay , Danny Thomas Dodge
IPC分类号： G06F3/041
CPC分类号： G06F3/04886 , G06F3/0416 , G06F3/04883 , G06F2203/04808
摘要： A method includes detecting a touch at a plurality of touch locations on a touch-sensitive display of an electronic device, identifying when the touch is a first gesture type based on touch attributes including a first touch location of the plurality of touch locations, and at least one of speed of the touch, time between detecting the touch at consecutive ones of the touch locations, distance between the consecutive ones of the touch locations, and direction of the touch.
摘要翻译：一种方法包括检测电子设备的触敏显示器上的多个触摸位置处的触摸，基于包括多个触摸位置的第一触摸位置的触摸属性来识别触摸何时是第一手势类型，以及在触摸速度中的至少一个，在连续的触摸位置检测触摸之间的时间，触摸位置中的连续触摸位置之间的距离以及触摸方向。

4. 发明申请

US20120046230A1 Combination Anticoagulant Therapy With A Compound That Acts As A Factor Xa Inhibitor 有权
标题翻译：组合抗凝治疗与作为因子Xa抑制剂的化合物
公开(公告)号：US20120046230A1
公开(公告)日：2012-02-23
申请号：US13213912
申请日：2011-08-19
申请人： Uma Sinha , Stanley J. Hollenbach , Patrick Andre
发明人： Uma Sinha , Stanley J. Hollenbach , Patrick Andre
IPC分类号： A61K31/44 , A61K31/4365 , A61K31/727 , A61P9/10 , A61P7/02 , A61P29/00 , A61P7/00 , A61P9/00 , A61K38/36 , A61K31/60
CPC分类号： A61K31/44 , A61K31/4365 , A61K31/4465 , A61K38/12 , A61K39/3955 , A61K45/06 , A61K2300/00
摘要： The present invention is directed to methods of using combination therapies containing [2-({4-[(dimethylamino)iminomethyl]phenyl}carbonylamino)-5-methoxyphenyl]-N-(5-chloro(2-pyridyl))carboxamide for the treatment of thrombotic disease(s) and pharmaceutical compositions thereof.
摘要翻译：本发明涉及使用含有[2 - （{4 - [（二甲基氨基）亚氨基甲基]苯基}羰基氨基）-5-甲氧基苯基] -N-（5-氯（2-吡啶基））甲酰胺的组合疗法的方法治疗血栓形成疾病及其药物组合物。

5. 发明申请

US20090098119A1 ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME 有权
标题翻译：因子XA抑制剂的抗体及其使用方法
公开(公告)号：US20090098119A1
公开(公告)日：2009-04-16
申请号：US12239651
申请日：2008-09-26
申请人： Genmin Lu , David R. Phillips , Patrick Andre , Uma Sinha
发明人： Genmin Lu , David R. Phillips , Patrick Andre , Uma Sinha
IPC分类号： A61K38/36 , A61P7/02 , A61K39/395 , A61K47/48 , A61K31/715 , A61K31/727 , A61K31/5377 , A61K31/4545 , C07K14/00 , C07H21/00 , C07K16/00 , C12P21/00 , C12N5/10
CPC分类号： A61K38/4846 , A61K38/00 , A61K38/4826 , A61K38/4833 , A61K38/4853 , A61K39/00 , A61K47/60 , C07K14/435 , C12N9/6432 , C12Y304/21006
摘要： The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.
摘要翻译：本发明涉及靶向因子Xa的抗凝剂的解毒剂。解毒剂是与因子Xa抑制剂结合的因子Xa蛋白衍生物，从而基本上中和它们，但不组装到凝血酶原酶复合物中。本文所述的衍生物缺乏或具有降低的内在凝结剂活性。本文公开了在目前正在进行使用因子Xa抑制剂进行抗凝治疗的患者中停止或预防出血的方法。

6. 发明申请

US20090048216A1 INTRAVENOUS AND ORAL DOSING OF A DIRECT-ACTING AND REVERSIBLE P2Y12 INHIBITOR 审中-公开
标题翻译：直接作用和可逆的P2Y12抑制剂的口服和口服剂量
公开(公告)号：US20090048216A1
公开(公告)日：2009-02-19
申请号：US12114630
申请日：2008-05-02
申请人： Daniel D. Gretler , Pamela B. Conley , Patrick Andre , Athiwat Hutchaleelaha , David R. Phillips , Anjali Pandey , Robert M. Scarborough , Caroll Scarborough , Wolin Huang
发明人： Daniel D. Gretler , Pamela B. Conley , Patrick Andre , Athiwat Hutchaleelaha , David R. Phillips , Anjali Pandey , Robert M. Scarborough , Caroll Scarborough , Wolin Huang
IPC分类号： A61K31/517 , A61K31/60 , A61P9/00
CPC分类号： A61K31/517 , A61K31/216 , A61K2300/00
摘要： The invention provides methods and compositions for rapid and reversible inhibition of platelet aggregation in human subjects in need thereof by administering compounds of the formula: alone or in combination with a second agent which can be aspirin or a thrombolytic agent.
摘要翻译：本发明提供了通过施用下式的化合物单独或与可以是阿司匹林或溶栓剂的第二药剂组合来快速和可逆地抑制有需要的人受试者血小板聚集的方法和组合物。

7. 发明申请

US20090012115A1 USE OF TP MODULATORS FOR THE TREATMENT OF CARDIOVASCULAR DISORDERS IN ASPIRIN SENSITIVE AND OTHER POPULATIONS 审中-公开
标题翻译：使用TP调节剂治疗腹泻敏感型和其他人群中的心血管疾病
公开(公告)号：US20090012115A1
公开(公告)日：2009-01-08
申请号：US12114642
申请日：2008-05-02
申请人： David R. Phillips , Patrick Andre , Charles J. Homcy
发明人： David R. Phillips , Patrick Andre , Charles J. Homcy
IPC分类号： A61K31/4365 , A61K31/422 , A61K31/4406 , A61K31/18 , A61K31/444 , A61K31/192 , A61K31/403 , A61P9/00
CPC分类号： A61K31/422 , A61K31/20 , A61K31/405 , A61K31/4406 , A61K31/444 , A61K45/06
摘要： The present invention provides methods and compositions useful in the treatment or prevention of cardiovascular disorders in individuals for whom therapy with a COX-1 enzyme inhibitor is not feasible due to sensitivity, intolerance, or resistance to the inhibitor. Additionally, the invention provides methods of treating cardiovascular disorders in an individual who is receiving a therapeutically effective dose of a TP modulator and is instructed or advised to avoid and/or not to take aspirin or another COX-1 inhibitor.
摘要翻译：本发明提供了用于治疗或预防由于敏感性，不耐受性或对抑制剂的抗性而使用COX-1酶抑制剂治疗不可行的个体的心血管疾病的方法和组合物。另外，本发明提供治疗正在接受治疗有效剂量的TP调节剂的个体的心血管疾病的方法，并被指示或建议避免和/或不服用阿司匹林或另一种COX-1抑制剂。

8. 发明授权

US07358091B2 Device and methods for identifying and treating aspirin non-responsive patients 失效
标题翻译：用于鉴定和治疗阿司匹林非反应性患者的装置和方法
公开(公告)号：US07358091B2
公开(公告)日：2008-04-15
申请号：US11304054
申请日：2005-12-14
申请人： David R. Phillips , Patrick Andre , Gillian Stephens
发明人： David R. Phillips , Patrick Andre , Gillian Stephens
IPC分类号： G01N33/86
CPC分类号： G01N33/9486 , G01N33/86
摘要： The present invention relates to methods and compositions for identifying and treating subjects in need of antithrombotic therapies but who are not responsive to aspirin.
摘要翻译：本发明涉及用于鉴定和治疗需要抗血栓治疗但是对阿司匹林不敏感的受试者的方法和组合物。

9. 发明申请

US20060211071A1 Device for aggregating, imaging and analyzing thrombi and a method of use 审中-公开
标题翻译：聚集，成像和分析血栓的装置及其使用方法
公开(公告)号：US20060211071A1
公开(公告)日：2006-09-21
申请号：US11302210
申请日：2005-12-14
申请人： Patrick Andre , Hans Luedemann , David Phillips , Golnaz Shapurian , Craig Muir
发明人： Patrick Andre , Hans Luedemann , David Phillips , Golnaz Shapurian , Craig Muir
IPC分类号： C12Q1/56 , G06F19/00 , G06K9/00 , C12M1/34
CPC分类号： G01N1/31 , B01L3/5027 , C12Q1/56 , G01N33/86 , G01N2015/0084 , G01N2015/0092 , G06T7/0012 , G06T7/62
摘要： An instrument for capturing an image of thrombus formation, blood coagulation, recruitment of circulating inflammatory or tumour cells in a blood sample. The instrument comprises a member defining a channel therethrough, a fluid handling assembly that permits the blood sample to move through the channel at a flow rate, and an imaging assembly including a microscopy device. The imaging assembly is disposed relative to the channel so as to capture light rays defining the image of thrombus formation in the channel.
摘要翻译：一种用于在血液样本中捕获血栓形成，凝血，循环炎症或肿瘤细胞募集图像的仪器。仪器包括限定穿过其中的通道的构件，允许血液样品以流速移动通过通道的流体处理组件，以及包括显微镜装置的成像组件。成像组件相对于通道设置以捕获限定通道中血栓形成图像的光线。

10. 发明授权

US6046666A Thermal actuator 失效
标题翻译：热致动器
公开(公告)号：US6046666A
公开(公告)日：2000-04-04
申请号：US91776
申请日：1998-08-17
申请人： Leif Ingvarsson , Patrick Andre
发明人： Leif Ingvarsson , Patrick Andre
IPC分类号： F16K20060101 , F16K31/68 , G05D23/13 , G05D23/19 , H01H37/36 , F24F11/053 , H01H37/40 , H01H37/44
CPC分类号： G05D23/1921
摘要： A known thermal actuator includes a capsule, which contains a diaphragm controlling the position of a stem. A thermal expansion substance like wax is contained in the capsule which operates as a thermostat in a thermostatically controlled valve such as a thermostatically controlled mixing valve. The stem of the actuator is connected with a valve body movable between two valve seats for a hot and cold medium, respectively, and the capsule is placed in the area of the mixed medium for transmitting the heat of the mixed medium to the thermal expansion substance. In order to present a simple and more effective actuator that can react promptly at changes of temperature and which does not require an extra temperature sensor, the capsule includes an oblong cuplike sensor body, the surface of which is at least partly deformed in such a way that its thermal transmittance area is increased.
摘要翻译： PCT No.PCT / SE95 / 01580 Sec。 371日期1998年8月17日第 102（e）日期1998年8月17日PCT 1995年12月22日PCT PCT。第WO97 / 23740号公报日期1997年7月3日已知的热致动器包括胶囊，其包含控制杆的位置的隔膜。在诸如恒温控制的混合阀的恒温控制阀中作为恒温器的胶囊中包含蜡等热膨胀物质。致动器的杆分别与可在两个用于热和冷介质的阀座之间移动的阀体连接，并且将胶囊放置在混合介质的区域中，以将混合介质的热传递到热膨胀物质。为了呈现一种能够在温度变化时迅速反应并且不需要额外温度传感器的简单且更有效的致动器，该胶囊包括长方形杯状传感器体，其表面至少部分地以这种方式变形其热传导率增加。

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